Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes

Journal of Neurochemistry

Volumn 121, Issue 4, 2012, Pages 619-628

  Yamamoto, Naoki ^a   Matsubara, Teruhiko ^b   Sobue, Kazuya ^c   Tanida, Mamoru ^a   Kasahara, Rika ^a   Naruse, Kaori ^a   Taniura, Hideo ^a   Sato, Toshinori ^b   Suzuki, Kenji ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Alzheimer; Amyloid protein; Diabetes; GM1 ganglioside; Insulin

Indexed keywords

AMYLOID BETA PROTEIN; GANGLIOSIDE GM1; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

AGED; AGING; AMYLOID BETA PROTEIN FIBRILLOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN NERVE CELL; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENZYME PHOSPHORYLATION; GENE SILENCING; INSULIN RESISTANCE; MALE; MOUSE; NERVE CELL MEMBRANE; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; RAT; SYNAPTOSOME;

AGING; AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CELL SEPARATION; CELLS, CULTURED; CHOLESTEROL; CHROMONES; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; FLUORESCENT DYES; G(M1) GANGLIOSIDE; INSULIN RESISTANCE; MICE; MORPHOLINES; NEUROFIBRILS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, INSULIN; RECEPTORS, PRESYNAPTIC; RNA, SMALL INTERFERING; SPHINGOMYELINS; SYNAPTOSOMES;

EID: 84859757164     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07668.x     Document Type: Article

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