메뉴 건너뛰기




Volumn 8, Issue 7, 2013, Pages

High Glucose Promotes Aβ Production by Inhibiting APP Degradation

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

EID: 84880715461     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069824     Document Type: Article
Times cited : (70)

References (90)
  • 1
    • 78049460615 scopus 로고    scopus 로고
    • World Alzheimer Report 2010: The Global Economic Impact of Dementia
    • Wimo A, Prince M (2010) World Alzheimer Report 2010: The Global Economic Impact of Dementia. Alzheimer's Disease International, London 1-56.
    • (2010) Alzheimer's Disease International, London , pp. 1-56
    • Wimo, A.1    Prince, M.2
  • 3
    • 79952574501 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer disease
    • Reitz C, Brayne C, Mayeux R, (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol 7: 137-152.
    • (2011) Nat Rev Neurol , vol.7 , pp. 137-152
    • Reitz, C.1    Brayne, C.2    Mayeux, R.3
  • 4
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC, (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235: 877-880.
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffiotti, U.4    Gajdusek, D.C.5
  • 5
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, et al. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3    Salbaum, J.M.4    Masters, C.L.5
  • 6
    • 0023109592 scopus 로고
    • Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
    • Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, et al. (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235: 880-884.
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3    Bruns, G.A.4    St George-Hyslop, P.5
  • 7
    • 2142777413 scopus 로고
    • Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides
    • Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM, (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci U S A 84: 4190-4194.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 4190-4194
    • Robakis, N.K.1    Ramakrishna, N.2    Wolfe, G.3    Wisniewski, H.M.4
  • 8
    • 0024093904 scopus 로고
    • Expression of the Alzheimer amyloid precursor gene transcripts in the human brain
    • Neve RL, Finch EA, Dawes LR, (1988) Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1: 669-677.
    • (1988) Neuron , vol.1 , pp. 669-677
    • Neve, R.L.1    Finch, E.A.2    Dawes, L.R.3
  • 9
    • 0023850791 scopus 로고
    • Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
    • Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, et al. (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 331: 528-530.
    • (1988) Nature , vol.331 , pp. 528-530
    • Tanzi, R.E.1    McClatchey, A.I.2    Lamperti, E.D.3    Villa-Komaroff, L.4    Gusella, J.F.5
  • 10
    • 0023959181 scopus 로고
    • Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle
    • Zimmermann K, Herget T, Salbaum JM, Schubert W, Hilbich C, et al. (1988) Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle. EMBO J 7: 367-372.
    • (1988) EMBO J , vol.7 , pp. 367-372
    • Zimmermann, K.1    Herget, T.2    Salbaum, J.M.3    Schubert, W.4    Hilbich, C.5
  • 11
    • 0033753842 scopus 로고    scopus 로고
    • Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility
    • Theuns J, Van Broeckhoven C, (2000) Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility. Hum Mol Genet 9: 2383-2394.
    • (2000) Hum Mol Genet , vol.9 , pp. 2383-2394
    • Theuns, J.1    Van Broeckhoven, C.2
  • 12
    • 0032517141 scopus 로고    scopus 로고
    • Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species
    • Song W, Lahiri DK, (1998) Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species. Gene 217: 151-164.
    • (1998) Gene , vol.217 , pp. 151-164
    • Song, W.1    Lahiri, D.K.2
  • 13
    • 0032517094 scopus 로고    scopus 로고
    • Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein
    • Song W, Lahiri DK, (1998) Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein. Gene 217: 165-176.
    • (1998) Gene , vol.217 , pp. 165-176
    • Song, W.1    Lahiri, D.K.2
  • 14
    • 84880750932 scopus 로고
    • Hox-1.3, amyloid β-protein precursor and aging BrainResRev
    • Goldgaber DES, Odenwald WF, (1991) Hox-1.3, amyloid β-protein precursor and aging BrainResRev. 16: 89-91.
    • (1991) , vol.16 , pp. 89-91
    • Goldgaber, D.E.S.1    Odenwald, W.F.2
  • 15
    • 0028972237 scopus 로고
    • Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene
    • Grilli M, Ribola M, Alberici A, Valerio A, Memo M, et al. (1995) Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. J Biol Chem 270: 26774-26777.
    • (1995) J Biol Chem , vol.270 , pp. 26774-26777
    • Grilli, M.1    Ribola, M.2    Alberici, A.3    Valerio, A.4    Memo, M.5
  • 16
    • 0005775566 scopus 로고
    • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
    • Goldgaber D, Harris HW, Hla T, Maciag T, Donnelly RJ, et al. (1989) Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A 86: 7606-7610.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7606-7610
    • Goldgaber, D.1    Harris, H.W.2    Hla, T.3    Maciag, T.4    Donnelly, R.J.5
  • 17
    • 0025045743 scopus 로고
    • Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing pattern
    • Konig G, Masters CL, Beyreuther K, (1990) Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing pattern. FEBS Lett 269: 305-310.
    • (1990) FEBS Lett , vol.269 , pp. 305-310
    • Konig, G.1    Masters, C.L.2    Beyreuther, K.3
  • 18
    • 0001585073 scopus 로고
    • Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain
    • Mobley WC, Neve RL, Prusiner SB, McKinley MP, (1988) Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A 85: 9811-9815.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9811-9815
    • Mobley, W.C.1    Neve, R.L.2    Prusiner, S.B.3    McKinley, M.P.4
  • 19
    • 0025219026 scopus 로고
    • Genomic organization of the human amyloid beta-protein precursor gene
    • Yoshikai S-i, Sasaki H, Doh-ura K, Furuya H, Sakaki Y, (1990) Genomic organization of the human amyloid beta-protein precursor gene. Gene 87: 257-263.
    • (1990) Gene , vol.87 , pp. 257-263
    • Yoshikai, S.-i.1    Sasaki, H.2    Doh-ura, K.3    Furuya, H.4    Sakaki, Y.5
  • 20
    • 0029162472 scopus 로고
    • Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress
    • Dewji NN, Do C, Bayney RM, (1995) Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res 33: 245-253.
    • (1995) Brain Res Mol Brain Res , vol.33 , pp. 245-253
    • Dewji, N.N.1    Do, C.2    Bayney, R.M.3
  • 21
    • 0025845529 scopus 로고
    • Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells
    • Abe K, St George-Hyslop PH, Tanzi RE, Kogure K, (1991) Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells. Neurosci Lett 125: 169-171.
    • (1991) Neurosci Lett , vol.125 , pp. 169-171
    • Abe, K.1    St George-Hyslop, P.H.2    Tanzi, R.E.3    Kogure, K.4
  • 22
    • 0042634362 scopus 로고    scopus 로고
    • Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
    • Turner PR, O'Connor K, Tate WP, Abraham WC, (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70: 1-32.
    • (2003) Prog Neurobiol , vol.70 , pp. 1-32
    • Turner, P.R.1    O'Connor, K.2    Tate, W.P.3    Abraham, W.C.4
  • 23
    • 0024550204 scopus 로고
    • Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
    • Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, et al. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57: 115-126.
    • (1989) Cell , vol.57 , pp. 115-126
    • Weidemann, A.1    Konig, G.2    Bunke, D.3    Fischer, P.4    Salbaum, J.M.5
  • 24
    • 0028351791 scopus 로고
    • Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein
    • Caporaso GL, Takei K, Gandy SE, Matteoli M, Mundigl O, et al. (1994) Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. J Neurosci 14: 3122-3138.
    • (1994) J Neurosci , vol.14 , pp. 3122-3138
    • Caporaso, G.L.1    Takei, K.2    Gandy, S.E.3    Matteoli, M.4    Mundigl, O.5
  • 25
    • 0025948830 scopus 로고
    • Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites
    • Schubert W, Prior R, Weidemann A, Dircksen H, Multhaup G, et al. (1991) Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res 563: 184-194.
    • (1991) Brain Res , vol.563 , pp. 184-194
    • Schubert, W.1    Prior, R.2    Weidemann, A.3    Dircksen, H.4    Multhaup, G.5
  • 26
    • 0026784096 scopus 로고
    • Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons
    • Shigematsu K, McGeer PL, McGeer EG, (1992) Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons. Brain Res 592: 353-357.
    • (1992) Brain Res , vol.592 , pp. 353-357
    • Shigematsu, K.1    McGeer, P.L.2    McGeer, E.G.3
  • 27
    • 0028852526 scopus 로고
    • Ultrastructural localization of amyloid protein precursor in the normal and postischemic gerbil brain
    • Tomimoto H, Akiguchi I, Wakita H, Nakamura S, Kimura J, (1995) Ultrastructural localization of amyloid protein precursor in the normal and postischemic gerbil brain. Brain Res 672: 187-195.
    • (1995) Brain Res , vol.672 , pp. 187-195
    • Tomimoto, H.1    Akiguchi, I.2    Wakita, H.3    Nakamura, S.4    Kimura, J.5
  • 28
    • 0027055461 scopus 로고
    • An endosomal-lysosomal pathway for degradation of amyloid precursor protein
    • Cole GM, Bell L, Truong QB, Saitoh T, (1992) An endosomal-lysosomal pathway for degradation of amyloid precursor protein. Ann N Y Acad Sci 674: 103-117.
    • (1992) Ann N Y Acad Sci , vol.674 , pp. 103-117
    • Cole, G.M.1    Bell, L.2    Truong, Q.B.3    Saitoh, T.4
  • 29
    • 0026735070 scopus 로고
    • Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
    • Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ, (1992) Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357: 500-503.
    • (1992) Nature , vol.357 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 30
    • 77949764687 scopus 로고    scopus 로고
    • Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation
    • Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, et al. (2010) Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. J Neurosci 30: 3924-3932.
    • (2010) J Neurosci , vol.30 , pp. 3924-3932
    • Kaneko, M.1    Koike, H.2    Saito, R.3    Kitamura, Y.4    Okuma, Y.5
  • 31
    • 0035229960 scopus 로고    scopus 로고
    • The role of post-translational modification in beta-amyloid precursor protein processing
    • Georgopoulou N, McLaughlin M, McFarlane I, Breen KC (2001) The role of post-translational modification in beta-amyloid precursor protein processing. Biochem Soc Symp: 23-36.
    • (2001) Biochem Soc Symp , pp. 23-36
    • Georgopoulou, N.1    McLaughlin, M.2    McFarlane, I.3    Breen, K.C.4
  • 32
    • 33644920657 scopus 로고    scopus 로고
    • Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription
    • Li Y, Zhou W, Tong Y, He G, Song W, (2006) Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription. FASEB J 20: 285-292.
    • (2006) FASEB J , vol.20 , pp. 285-292
    • Li, Y.1    Zhou, W.2    Tong, Y.3    He, G.4    Song, W.5
  • 33
    • 84879218180 scopus 로고    scopus 로고
    • Amyloid-b protein (Ab) Glu11 is the major b-secretase site of b-site amyloid-b precursor protein-cleaving enzyme 1, and shifting the cleavage site to Ab Asp1 contributes to Alzheimer pathogenesis
    • Deng Y, Wang Z, Wang R, Zhang X, Zhang S, et al. (2013) Amyloid-b protein (Ab) Glu11 is the major b-secretase site of b-site amyloid-b precursor protein-cleaving enzyme 1, and shifting the cleavage site to Ab Asp1 contributes to Alzheimer pathogenesis. Eur J Neurosci.
    • (2013) Eur J Neurosci
    • Deng, Y.1    Wang, Z.2    Wang, R.3    Zhang, X.4    Zhang, S.5
  • 34
    • 84873802341 scopus 로고    scopus 로고
    • Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes
    • Ly PT, Wu Y, Zou H, Wang R, Zhou W, et al. (2013) Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest 123: 224-235.
    • (2013) J Clin Invest , vol.123 , pp. 224-235
    • Ly, P.T.1    Wu, Y.2    Zou, H.3    Wang, R.4    Zhou, W.5
  • 35
    • 46749092486 scopus 로고    scopus 로고
    • beta-Secretase as a therapeutic target for Alzheimer's disease
    • Ghosh AK, Gemma S, Tang J, (2008) beta-Secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics 5: 399-408.
    • (2008) Neurotherapeutics , vol.5 , pp. 399-408
    • Ghosh, A.K.1    Gemma, S.2    Tang, J.3
  • 36
    • 58149314221 scopus 로고    scopus 로고
    • Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
    • Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, et al. (2008) Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med 205: 2781-2789.
    • (2008) J Exp Med , vol.205 , pp. 2781-2789
    • Qing, H.1    He, G.2    Ly, P.T.3    Fox, C.J.4    Staufenbiel, M.5
  • 37
    • 0025295039 scopus 로고
    • Cleavage of amyloid beta peptide during constitutive processing of its precursor
    • Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, et al. (1990) Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248: 1122-1124.
    • (1990) Science , vol.248 , pp. 1122-1124
    • Esch, F.S.1    Keim, P.S.2    Beattie, E.C.3    Blacher, R.W.4    Culwell, A.R.5
  • 38
    • 0025373508 scopus 로고
    • Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
    • Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL, (1990) Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248: 492-495.
    • (1990) Science , vol.248 , pp. 492-495
    • Sisodia, S.S.1    Koo, E.H.2    Beyreuther, K.3    Unterbeck, A.4    Price, D.L.5
  • 39
    • 37549040612 scopus 로고    scopus 로고
    • A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference
    • Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, et al. (2007) A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci 27: 14459-14469.
    • (2007) J Neurosci , vol.27 , pp. 14459-14469
    • Young-Pearse, T.L.1    Bai, J.2    Chang, R.3    Zheng, J.B.4    LoTurco, J.J.5
  • 40
    • 28644449284 scopus 로고    scopus 로고
    • Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    • Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, et al. (2005) Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24: 2944-2955.
    • (2005) EMBO J , vol.24 , pp. 2944-2955
    • Leyssen, M.1    Ayaz, D.2    Hebert, S.S.3    Reeve, S.4    De Strooper, B.5
  • 41
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349: 704-706.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5
  • 42
    • 0028055038 scopus 로고
    • Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination
    • Oyama F, Cairns NJ, Shimada H, Oyama R, Titani K, et al. (1994) Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. J Neurochem 62: 1062-1066.
    • (1994) J Neurochem , vol.62 , pp. 1062-1066
    • Oyama, F.1    Cairns, N.J.2    Shimada, H.3    Oyama, R.4    Titani, K.5
  • 43
    • 49749099317 scopus 로고    scopus 로고
    • Protein expression of BACE1, BACE2 and APP in Down syndrome brains
    • Cheon MS, Dierssen M, Kim SH, Lubec G, (2008) Protein expression of BACE1, BACE2 and APP in Down syndrome brains. Amino Acids 35: 339-343.
    • (2008) Amino Acids , vol.35 , pp. 339-343
    • Cheon, M.S.1    Dierssen, M.2    Kim, S.H.3    Lubec, G.4
  • 44
    • 84871901624 scopus 로고    scopus 로고
    • Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis
    • Wu Y, Song W, (2013) Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis. FASEB J 27: 208-221.
    • (2013) FASEB J , vol.27 , pp. 208-221
    • Wu, Y.1    Song, W.2
  • 45
    • 79953168726 scopus 로고    scopus 로고
    • Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation
    • Sun X, Wu Y, Chen B, Zhang Z, Zhou W, et al. (2011) Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. J Biol Chem 286: 9049-9062.
    • (2011) J Biol Chem , vol.286 , pp. 9049-9062
    • Sun, X.1    Wu, Y.2    Chen, B.3    Zhang, Z.4    Zhou, W.5
  • 46
    • 33750588301 scopus 로고    scopus 로고
    • Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease
    • Brouwers N, Sleegers K, Engelborghs S, Bogaerts V, Serneels S, et al. (2006) Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease. Brain 129: 2984-2991.
    • (2006) Brain , vol.129 , pp. 2984-2991
    • Brouwers, N.1    Sleegers, K.2    Engelborghs, S.3    Bogaerts, V.4    Serneels, S.5
  • 47
    • 29444442794 scopus 로고    scopus 로고
    • APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
    • Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, et al. (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38: 24-26.
    • (2006) Nat Genet , vol.38 , pp. 24-26
    • Rovelet-Lecrux, A.1    Hannequin, D.2    Raux, G.3    Le Meur, N.4    Laquerriere, A.5
  • 49
    • 34447527687 scopus 로고    scopus 로고
    • Expression of APP pathway mRNAs and proteins in Alzheimer's disease
    • Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, et al. (2007) Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Res 1161: 116-123.
    • (2007) Brain Res , vol.1161 , pp. 116-123
    • Matsui, T.1    Ingelsson, M.2    Fukumoto, H.3    Ramasamy, K.4    Kowa, H.5
  • 51
    • 67649742213 scopus 로고    scopus 로고
    • Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials
    • Kopf D, Frolich L, (2009) Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials. J Alzheimers Dis 16: 677-685.
    • (2009) J Alzheimers Dis , vol.16 , pp. 677-685
    • Kopf, D.1    Frolich, L.2
  • 53
    • 28444491100 scopus 로고    scopus 로고
    • Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies
    • Cukierman T, Gerstein HC, Williamson JD, (2005) Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies. Diabetologia 48: 2460-2469.
    • (2005) Diabetologia , vol.48 , pp. 2460-2469
    • Cukierman, T.1    Gerstein, H.C.2    Williamson, J.D.3
  • 54
    • 77952585217 scopus 로고    scopus 로고
    • Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice
    • Jolivalt CG, Hurford R, Lee CA, Dumaop W, Rockenstein E, et al. (2010) Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice. Exp Neurol 223: 422-431.
    • (2010) Exp Neurol , vol.223 , pp. 422-431
    • Jolivalt, C.G.1    Hurford, R.2    Lee, C.A.3    Dumaop, W.4    Rockenstein, E.5
  • 55
    • 70949084806 scopus 로고    scopus 로고
    • Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease
    • Ke YD, Delerue F, Gladbach A, Gotz J, Ittner LM, (2009) Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 4: e7917.
    • (2009) PLoS One , vol.4
    • Ke, Y.D.1    Delerue, F.2    Gladbach, A.3    Gotz, J.4    Ittner, L.M.5
  • 57
    • 7444250507 scopus 로고    scopus 로고
    • Degradation of BACE by the ubiquitin-proteasome pathway
    • Qing H, Zhou W, Christensen MA, Sun X, Tong Y, et al. (2004) Degradation of BACE by the ubiquitin-proteasome pathway. FASEB J 18: 1571-1573.
    • (2004) FASEB J , vol.18 , pp. 1571-1573
    • Qing, H.1    Zhou, W.2    Christensen, M.A.3    Sun, X.4    Tong, Y.5
  • 58
    • 0036200749 scopus 로고    scopus 로고
    • Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia
    • Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, et al. (2002) Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. J Cereb Blood Flow Metab 22: 271-279.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 271-279
    • Abi-Saab, W.M.1    Maggs, D.G.2    Jones, T.3    Jacob, R.4    Srihari, V.5
  • 59
    • 0034521193 scopus 로고    scopus 로고
    • Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery
    • Discussion 709-710
    • Reinstrup P, Stahl N, Mellergard P, Uski T, Ungerstedt U, et al. (2000) Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery 47: 701-709; discussion 709-710.
    • (2000) Neurosurgery , vol.47 , pp. 701-709
    • Reinstrup, P.1    Stahl, N.2    Mellergard, P.3    Uski, T.4    Ungerstedt, U.5
  • 60
    • 77950362951 scopus 로고    scopus 로고
    • Hyperglycemia impairs proteasome function by methylglyoxal
    • Queisser MA, Yao D, Geisler S, Hammes HP, Lochnit G, et al. (2010) Hyperglycemia impairs proteasome function by methylglyoxal. Diabetes 59: 670-678.
    • (2010) Diabetes , vol.59 , pp. 670-678
    • Queisser, M.A.1    Yao, D.2    Geisler, S.3    Hammes, H.P.4    Lochnit, G.5
  • 62
  • 64
    • 0033999608 scopus 로고    scopus 로고
    • Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels
    • Carantoni M, Zuliani G, Munari MR, D'Elia K, Palmieri E, et al. (2000) Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels. Dement Geriatr Cogn Disord 11: 176-180.
    • (2000) Dement Geriatr Cogn Disord , vol.11 , pp. 176-180
    • Carantoni, M.1    Zuliani, G.2    Munari, M.R.3    D'Elia, K.4    Palmieri, E.5
  • 65
    • 33846057321 scopus 로고    scopus 로고
    • The metabolic syndrome and alzheimer disease
    • Razay G VAWG, (2007) The metabolic syndrome and alzheimer disease. Archives of Neurology 64: 93-96.
    • (2007) Archives of Neurology , vol.64 , pp. 93-96
    • Razay, G.V.A.W.G.1
  • 66
    • 0028030575 scopus 로고
    • Amyloid beta-protein precursor-rich platelet microparticles in thrombotic disease
    • Nomura S, Komiyama Y, Miyake T, Miyazaki Y, Kido H, et al. (1994) Amyloid beta-protein precursor-rich platelet microparticles in thrombotic disease. Thromb Haemost 72: 519-522.
    • (1994) Thromb Haemost , vol.72 , pp. 519-522
    • Nomura, S.1    Komiyama, Y.2    Miyake, T.3    Miyazaki, Y.4    Kido, H.5
  • 67
    • 0036845661 scopus 로고    scopus 로고
    • High glucose-induced oxidative stress and mitochondrial dysfunction in neurons
    • Russell JW, Golovoy D, Vincent AM, Mahendru P, Olzmann JA, et al. (2002) High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J 16: 1738-1748.
    • (2002) FASEB J , vol.16 , pp. 1738-1748
    • Russell, J.W.1    Golovoy, D.2    Vincent, A.M.3    Mahendru, P.4    Olzmann, J.A.5
  • 68
    • 0032544526 scopus 로고    scopus 로고
    • Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species
    • Yang Y, Quitschke WW, Brewer GJ, (1998) Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. Molecular Brain Research 60: 40-49.
    • (1998) Molecular Brain Research , vol.60 , pp. 40-49
    • Yang, Y.1    Quitschke, W.W.2    Brewer, G.J.3
  • 69
    • 0026589836 scopus 로고
    • Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein
    • Caporaso GL, Gandy SE, Buxbaum JD, Greengard P, (1992) Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci U S A 89: 2252-2256.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 2252-2256
    • Caporaso, G.L.1    Gandy, S.E.2    Buxbaum, J.D.3    Greengard, P.4
  • 70
    • 0026674585 scopus 로고
    • Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate
    • Knops J, Lieberburg I, Sinha S, (1992) Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate. J Biol Chem 267: 16022-16024.
    • (1992) J Biol Chem , vol.267 , pp. 16022-16024
    • Knops, J.1    Lieberburg, I.2    Sinha, S.3
  • 71
    • 0032974408 scopus 로고    scopus 로고
    • The role of the protein glycosylation state in the control of cellular transport of the amyloid β precursor protein
    • McFarlane I, Georgopoulou N, Coughlan CM, Gillian AM, Breen KC, (1999) The role of the protein glycosylation state in the control of cellular transport of the amyloid β precursor protein. Neuroscience 90: 15-25.
    • (1999) Neuroscience , vol.90 , pp. 15-25
    • McFarlane, I.1    Georgopoulou, N.2    Coughlan, C.M.3    Gillian, A.M.4    Breen, K.C.5
  • 72
    • 10144263284 scopus 로고    scopus 로고
    • The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein
    • Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, et al. (1996) The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. EMBO J 15: 5218-5229.
    • (1996) EMBO J , vol.15 , pp. 5218-5229
    • Tienari, P.J.1    De Strooper, B.2    Ikonen, E.3    Simons, M.4    Weidemann, A.5
  • 73
    • 0030604231 scopus 로고    scopus 로고
    • Mutation of potential N-linked glycosylation sites in the Alzheimer's disease amyloid precursor protein (APP)
    • Yazaki M, Tagawa K, Maruyama K, Sorimachi H, Tsuchiya T, et al. (1996) Mutation of potential N-linked glycosylation sites in the Alzheimer's disease amyloid precursor protein (APP). Neuroscience Letters 221: 57-60.
    • (1996) Neuroscience Letters , vol.221 , pp. 57-60
    • Yazaki, M.1    Tagawa, K.2    Maruyama, K.3    Sorimachi, H.4    Tsuchiya, T.5
  • 74
    • 33745201406 scopus 로고    scopus 로고
    • Intracellular pathways of folded and misfolded amyloid precursor protein degradation
    • Hare JF, (2006) Intracellular pathways of folded and misfolded amyloid precursor protein degradation. Archives of Biochemistry and Biophysics 451: 79-90.
    • (2006) Archives of Biochemistry and Biophysics , vol.451 , pp. 79-90
    • Hare, J.F.1
  • 75
    • 0033151572 scopus 로고    scopus 로고
    • Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation
    • Ando K, Oishi M, Takeda S, Iijima K, Isohara T, et al. (1999) Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci 19: 4421-4427.
    • (1999) J Neurosci , vol.19 , pp. 4421-4427
    • Ando, K.1    Oishi, M.2    Takeda, S.3    Iijima, K.4    Isohara, T.5
  • 76
    • 84865191062 scopus 로고    scopus 로고
    • Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688
    • El Ayadi A, Stieren ES, Barral JM, Boehning D, (2012) Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688. Proc Natl Acad Sci U S A 109: 13416-13421.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 13416-13421
    • El Ayadi, A.1    Stieren, E.S.2    Barral, J.M.3    Boehning, D.4
  • 77
    • 26444607532 scopus 로고    scopus 로고
    • Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
    • Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, et al. (2005) Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 102: 13461-13466.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13461-13466
    • Andersen, O.M.1    Reiche, J.2    Schmidt, V.3    Gotthardt, M.4    Spoelgen, R.5
  • 78
    • 0037383052 scopus 로고    scopus 로고
    • Relationship between beta-amyloid degradation and the 26S proteasome in neural cells
    • Lopez Salon M, Pasquini L, Besio Moreno M, Pasquini JM, Soto E, (2003) Relationship between beta-amyloid degradation and the 26S proteasome in neural cells. Exp Neurol 180: 131-143.
    • (2003) Exp Neurol , vol.180 , pp. 131-143
    • Lopez Salon, M.1    Pasquini, L.2    Besio Moreno, M.3    Pasquini, J.M.4    Soto, E.5
  • 79
    • 0034797234 scopus 로고    scopus 로고
    • The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
    • Nunan J, Shearman MS, Checler F, Cappai R, Evin G, et al. (2001) The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase. Eur J Biochem 268: 5329-5336.
    • (2001) Eur J Biochem , vol.268 , pp. 5329-5336
    • Nunan, J.1    Shearman, M.S.2    Checler, F.3    Cappai, R.4    Evin, G.5
  • 80
    • 0242330370 scopus 로고    scopus 로고
    • Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein
    • Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, et al. (2003) Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein. J Neurosci Res 74: 378-385.
    • (2003) J Neurosci Res , vol.74 , pp. 378-385
    • Nunan, J.1    Williamson, N.A.2    Hill, A.F.3    Sernee, M.F.4    Masters, C.L.5
  • 83
    • 0037390039 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    • Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, et al. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 100: 4162-4167.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4162-4167
    • Farris, W.1    Mansourian, S.2    Chang, Y.3    Lindsley, L.4    Eckman, E.A.5
  • 84
    • 0034161516 scopus 로고    scopus 로고
    • Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
    • Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, et al. (2000) Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci 20: 1657-1665.
    • (2000) J Neurosci , vol.20 , pp. 1657-1665
    • Vekrellis, K.1    Ye, Z.2    Qiu, W.Q.3    Walsh, D.4    Hartley, D.5
  • 85
    • 67650697447 scopus 로고    scopus 로고
    • Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells
    • Pivovarova O, Gogebakan O, Pfeiffer AF, Rudovich N, (2009) Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells. Diabetologia 52: 1656-1664.
    • (2009) Diabetologia , vol.52 , pp. 1656-1664
    • Pivovarova, O.1    Gogebakan, O.2    Pfeiffer, A.F.3    Rudovich, N.4
  • 86
    • 4143110556 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of diabetic neuropathy
    • Vincent AM, Russell JW, Low P, Feldman EL, (2004) Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 25: 612-628.
    • (2004) Endocr Rev , vol.25 , pp. 612-628
    • Vincent, A.M.1    Russell, J.W.2    Low, P.3    Feldman, E.L.4
  • 87
    • 20944444768 scopus 로고    scopus 로고
    • Oxidative stress potentiates BACE1 gene expression and Abeta generation
    • Tong Y, Zhou W, Fung V, Christensen MA, Qing H, et al. (2005) Oxidative stress potentiates BACE1 gene expression and Abeta generation. J Neural Transm 112: 455-469.
    • (2005) J Neural Transm , vol.112 , pp. 455-469
    • Tong, Y.1    Zhou, W.2    Fung, V.3    Christensen, M.A.4    Qing, H.5
  • 88
    • 69349091132 scopus 로고    scopus 로고
    • Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression
    • Quiroz-Baez R, Rojas E, Arias C, (2009) Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression. Neurochem Int 55: 662-670.
    • (2009) Neurochem Int , vol.55 , pp. 662-670
    • Quiroz-Baez, R.1    Rojas, E.2    Arias, C.3
  • 89
    • 38049098793 scopus 로고    scopus 로고
    • Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein
    • Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, et al. (2008) Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem 104: 683-695.
    • (2008) J Neurochem , vol.104 , pp. 683-695
    • Tamagno, E.1    Guglielmotto, M.2    Aragno, M.3    Borghi, R.4    Autelli, R.5
  • 90
    • 77950131689 scopus 로고    scopus 로고
    • Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells
    • Oda A, Tamaoka A, Araki W, (2010) Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. J Neurosci Res 88: 1137-1145.
    • (2010) J Neurosci Res , vol.88 , pp. 1137-1145
    • Oda, A.1    Tamaoka, A.2    Araki, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.