-
1
-
-
84874252277
-
What makes a P450 tick?
-
Munro A.W., Girvan H.M., Mason A.E., Dunford A.J., McLean K.J. What makes a P450 tick?. Trends Biochem Sci 2013, 38:140-150.
-
(2013)
Trends Biochem Sci
, vol.38
, pp. 140-150
-
-
Munro, A.W.1
Girvan, H.M.2
Mason, A.E.3
Dunford, A.J.4
McLean, K.J.5
-
2
-
-
21844434930
-
Structure and chemistry of cytochromes P450
-
Denisov I.G., Makris T.M., Sligar S.G., Schlichting I. Structure and chemistry of cytochromes P450. Chem Rev 2005, 105:2253-2277.
-
(2005)
Chem Rev
, vol.105
, pp. 2253-2277
-
-
Denisov, I.G.1
Makris, T.M.2
Sligar, S.G.3
Schlichting, I.4
-
3
-
-
33645875048
-
High-valent iron in chemical and biological oxidations
-
Groves J.T. High-valent iron in chemical and biological oxidations. J Inorg Biochem 2006, 100:434-437.
-
(2006)
J Inorg Biochem
, vol.100
, pp. 434-437
-
-
Groves, J.T.1
-
4
-
-
84879051428
-
Unusual cytochrome P450 enzymes and reactions
-
Guengerich F.P., Munro A.W. Unusual cytochrome P450 enzymes and reactions. J Biol Chem 2013, 288:17065-17073.
-
(2013)
J Biol Chem
, vol.288
, pp. 17065-17073
-
-
Guengerich, F.P.1
Munro, A.W.2
-
5
-
-
84930003805
-
Human cytochrome P450 enzymes
-
Springer, New York, P.R. Ortiz de Montellano (Ed.)
-
Guengerich F.P. Human cytochrome P450 enzymes. Cytochrome P450: structure, mechanism and biochemistry 2015, 523-785. Springer, New York. 4th ed. P.R. Ortiz de Montellano (Ed.).
-
(2015)
Cytochrome P450: structure, mechanism and biochemistry
, pp. 523-785
-
-
Guengerich, F.P.1
-
6
-
-
84945132778
-
Electron transfer partners of cytochrome P450
-
Springer, New York, P.R. Ortiz de Montellano (Ed.)
-
Waskell L., Kim J.-J. Electron transfer partners of cytochrome P450. Cytochrome P450: structure, mechanism and biochemistry 2015, 33-68. Springer, New York. 4th ed. P.R. Ortiz de Montellano (Ed.).
-
(2015)
Cytochrome P450: structure, mechanism and biochemistry
, pp. 33-68
-
-
Waskell, L.1
Kim, J.-J.2
-
7
-
-
78649442579
-
Adrenodoxin: the archetype of vertebrate [2Fe-2S] cluster ferredoxins
-
Ewen K.M., Kleser M., Bernhardt R. Adrenodoxin: the archetype of vertebrate [2Fe-2S] cluster ferredoxins. Biochim Biophys Acta 2011, 1814:111-125.
-
(2011)
Biochim Biophys Acta
, vol.1814
, pp. 111-125
-
-
Ewen, K.M.1
Kleser, M.2
Bernhardt, R.3
-
8
-
-
84945151746
-
Microbial cytochromes P450
-
Springer, New York, P.R. Ortiz de Montellano (Ed.)
-
McLean K.J., Leys D., Munro A.W. Microbial cytochromes P450. Cytochrome P450: structure, mechanism and biochemistry 2015, 261-408. Springer, New York. 4th ed. P.R. Ortiz de Montellano (Ed.).
-
(2015)
Cytochrome P450: structure, mechanism and biochemistry
, pp. 261-408
-
-
McLean, K.J.1
Leys, D.2
Munro, A.W.3
-
9
-
-
84930226479
-
Biological diversity of cytochrome P450 redox partner systems
-
McLean K.J., Luciakova D., Belcher J., Tee K.L., Munro A.W. Biological diversity of cytochrome P450 redox partner systems. Adv Exp Med Biol 2015, 851:299-317.
-
(2015)
Adv Exp Med Biol
, vol.851
, pp. 299-317
-
-
McLean, K.J.1
Luciakova, D.2
Belcher, J.3
Tee, K.L.4
Munro, A.W.5
-
10
-
-
0022878676
-
Characterization of a catalytically self-sufficient 119,000-Dalton cytochrome P450 monooxygenase induced by barbiturates in Bacillus megaterium
-
Narhi L.O., Fulco A.J. Characterization of a catalytically self-sufficient 119,000-Dalton cytochrome P450 monooxygenase induced by barbiturates in Bacillus megaterium. J Biol Chem 1986, 261:7160-7169.
-
(1986)
J Biol Chem
, vol.261
, pp. 7160-7169
-
-
Narhi, L.O.1
Fulco, A.J.2
-
11
-
-
0033561008
-
-
Noble M.A., Miles C.S., Chapman S.K., Lysek D.A., MacKay A.C., Reid G.A., Hanzlik R.P., Munro A.W. Biochem J 1999, 339:371-379.
-
(1999)
Biochem J
, vol.339
, pp. 371-379
-
-
Noble, M.A.1
Miles, C.S.2
Chapman, S.K.3
Lysek, D.A.4
MacKay, A.C.5
Reid, G.A.6
Hanzlik, R.P.7
Munro, A.W.8
-
12
-
-
26844498754
-
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
-
Neeli R., Girvan H.M., Lawrence A., Warren M.J., Leys D., Scrutton N.S., Munro A.W. The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase. FEBS Lett 2005, 579:5582-5588.
-
(2005)
FEBS Lett
, vol.579
, pp. 5582-5588
-
-
Neeli, R.1
Girvan, H.M.2
Lawrence, A.3
Warren, M.J.4
Leys, D.5
Scrutton, N.S.6
Munro, A.W.7
-
13
-
-
84955207211
-
Process limitations of a whole-cell P450 catalyzed reaction using a CYP153A-CPR fusion construct expressed in Escherichia coli
-
Lundemo M.T., Notonier S., Striedner G., Hauer B., Woodley J.M. Process limitations of a whole-cell P450 catalyzed reaction using a CYP153A-CPR fusion construct expressed in Escherichia coli. Appl Microbiol Biotechnol 2016, 100:1197-1208.
-
(2016)
Appl Microbiol Biotechnol
, vol.100
, pp. 1197-1208
-
-
Lundemo, M.T.1
Notonier, S.2
Striedner, G.3
Hauer, B.4
Woodley, J.M.5
-
14
-
-
0034595407
-
Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains
-
Helvig C., Capdevila J.H. Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains. Biochemistry 2000, 39:5196-5205.
-
(2000)
Biochemistry
, vol.39
, pp. 5196-5205
-
-
Helvig, C.1
Capdevila, J.H.2
-
15
-
-
0036844477
-
A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes
-
De Mot R., Parret A.H. A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes. Trends Microbiol 2002, 10:502-508.
-
(2002)
Trends Microbiol
, vol.10
, pp. 502-508
-
-
De Mot, R.1
Parret, A.H.2
-
16
-
-
84860223425
-
Characterization of Cupriavidus metallidurans CYP116B1 - a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein
-
Warman A.J., Robinson J.W., Luciakova D., Lawrence A.D., Marshall K.R., Warren M.J., Cheesman M.R., Rigby S.E., Munro A.W., McLean K.J. Characterization of Cupriavidus metallidurans CYP116B1 - a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein. FEBS J 2012, 279:1675-1693.
-
(2012)
FEBS J
, vol.279
, pp. 1675-1693
-
-
Warman, A.J.1
Robinson, J.W.2
Luciakova, D.3
Lawrence, A.D.4
Marshall, K.R.5
Warren, M.J.6
Cheesman, M.R.7
Rigby, S.E.8
Munro, A.W.9
McLean, K.J.10
-
17
-
-
84924565455
-
CYP116B5: a new class VII catalytically self-sufficient cytochrome P450 from Acetinobacter radioresistens that enables growth on alkanes
-
Minerdi D., Sadeghi S.J., Di Nardo G., Rua F., Castignanò P., Gilardi G. CYP116B5: a new class VII catalytically self-sufficient cytochrome P450 from Acetinobacter radioresistens that enables growth on alkanes. Mol Microbiol 2015, 95:539-554.
-
(2015)
Mol Microbiol
, vol.95
, pp. 539-554
-
-
Minerdi, D.1
Sadeghi, S.J.2
Di Nardo, G.3
Rua, F.4
Castignanò, P.5
Gilardi, G.6
-
18
-
-
84946494846
-
A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules
-
Kulig J.K., Spandolf C., Hyde R., Ruzzini A.C., Eltis L.D., Grönberg G., Hayes M.A., Grogan G. A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules. Bioorg Med Chem 2015, 23:5603-5609.
-
(2015)
Bioorg Med Chem
, vol.23
, pp. 5603-5609
-
-
Kulig, J.K.1
Spandolf, C.2
Hyde, R.3
Ruzzini, A.C.4
Eltis, L.D.5
Grönberg, G.6
Hayes, M.A.7
Grogan, G.8
-
19
-
-
33745966649
-
Functional expression system for cytochrome P450 genes using the reductase domain of self-sufficient P450RhF from Rhodococcus sp. NCIMB 9784
-
Nodate M., Kubota M., Misawa N. Functional expression system for cytochrome P450 genes using the reductase domain of self-sufficient P450RhF from Rhodococcus sp. NCIMB 9784. Appl Microbiol Biotechnol 2006, 71:455-462.
-
(2006)
Appl Microbiol Biotechnol
, vol.71
, pp. 455-462
-
-
Nodate, M.1
Kubota, M.2
Misawa, N.3
-
20
-
-
84924189921
-
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum
-
McLean K.J., Hans M., Meijrink B., van Scheppingen W.B., Vollebregt A., Tee K.J., van der Laan J.M., Leys D., Munro A.W., van den Berg M.A. Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc Natl Acad Sci U S A 2015, 112:2847-2852.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 2847-2852
-
-
McLean, K.J.1
Hans, M.2
Meijrink, B.3
van Scheppingen, W.B.4
Vollebregt, A.5
Tee, K.J.6
van der Laan, J.M.7
Leys, D.8
Munro, A.W.9
van den Berg, M.A.10
-
21
-
-
0037032543
-
A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily
-
Jackson C.J., Lamb D.C., Marczylo T.H., Warrilow A.G., Manning N.J., Lowe D.J., Kelly D.E., Kelly S.L. A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily. J Biol Chem 2002, 277:46959-46965.
-
(2002)
J Biol Chem
, vol.277
, pp. 46959-46965
-
-
Jackson, C.J.1
Lamb, D.C.2
Marczylo, T.H.3
Warrilow, A.G.4
Manning, N.J.5
Lowe, D.J.6
Kelly, D.E.7
Kelly, S.L.8
-
22
-
-
84914142510
-
Analysis of the xplAB-containing gene cluster involved in the bacterial degradation of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine
-
Chong C.S., Sabir D.K., Lorenz A., Bontemps C., Andeer P., Stahl D.A., Strand S.E., Rylott E.L., Bruce N.C. Analysis of the xplAB-containing gene cluster involved in the bacterial degradation of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine. Appl Environ Microbiol 2014, 80:6601-6610.
-
(2014)
Appl Environ Microbiol
, vol.80
, pp. 6601-6610
-
-
Chong, C.S.1
Sabir, D.K.2
Lorenz, A.3
Bontemps, C.4
Andeer, P.5
Stahl, D.A.6
Strand, S.E.7
Rylott, E.L.8
Bruce, N.C.9
-
23
-
-
84904094364
-
P-Link: a method for generating multicomponent cytochrome P450 fusions with variable linker length
-
Belsare K.D., Ruff A.J., Martinez R., Shivange A.V., Munhada H., Holtmann D., Schrader J., Schwanenberg U. P-Link: a method for generating multicomponent cytochrome P450 fusions with variable linker length. Biotechniques 2014, 57:13-20.
-
(2014)
Biotechniques
, vol.57
, pp. 13-20
-
-
Belsare, K.D.1
Ruff, A.J.2
Martinez, R.3
Shivange, A.V.4
Munhada, H.5
Holtmann, D.6
Schrader, J.7
Schwanenberg, U.8
-
24
-
-
84859074293
-
Fungal denitrification and nitric oxide reductase cytochrome P450nor
-
Shoun H., Fushinobu S., Jiang L., Kim S.-W., Wakagi T. Fungal denitrification and nitric oxide reductase cytochrome P450nor. Philos Trans R Soc B 2012, 367:1186-1194.
-
(2012)
Philos Trans R Soc B
, vol.367
, pp. 1186-1194
-
-
Shoun, H.1
Fushinobu, S.2
Jiang, L.3
Kim, S.-W.4
Wakagi, T.5
-
25
-
-
4143049187
-
Structural evidence for direct hydride transfer from NADH to cytochrome P450nor
-
Oshima R., Fushinobu S., Su F., Zhang L., Takaya N., Shoun H. Structural evidence for direct hydride transfer from NADH to cytochrome P450nor. J Mol Biol 2004, 342:207-217.
-
(2004)
J Mol Biol
, vol.342
, pp. 207-217
-
-
Oshima, R.1
Fushinobu, S.2
Su, F.3
Zhang, L.4
Takaya, N.5
Shoun, H.6
-
26
-
-
84870301242
-
Cytochrome P450-catalyzed l-tryptophan nitration in thaxtomin phytotoxin biosynthesis
-
Barry S.M., Kers J.A., Johnson E.G., Song L., Aston P.R., Patel B., Krasnoff S.B., Crane B.R., Gibson D.M., Loria R., Challis G.L. Cytochrome P450-catalyzed l-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nat Chem Biol 2012, 8:814-816.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 814-816
-
-
Barry, S.M.1
Kers, J.A.2
Johnson, E.G.3
Song, L.4
Aston, P.R.5
Patel, B.6
Krasnoff, S.B.7
Crane, B.R.8
Gibson, D.M.9
Loria, R.10
Challis, G.L.11
-
27
-
-
84941144686
-
Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE
-
Dodani S.C., Cahn J.K., Heinisch T., Brinkmann-Chen S., McIntosh J.A., Arnold F.H. Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE. ChemBioChem 2014, 15:2259-2267.
-
(2014)
ChemBioChem
, vol.15
, pp. 2259-2267
-
-
Dodani, S.C.1
Cahn, J.K.2
Heinisch, T.3
Brinkmann-Chen, S.4
McIntosh, J.A.5
Arnold, F.H.6
-
28
-
-
84959387687
-
An artificial self-sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio-selectivity
-
(in press)
-
Zuo R., Zhang Y., Huquet-Tapia J.C., Mehta M., Dedic E., Bruner S.D., Loria R., Ding Y. An artificial self-sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio-selectivity. Biotechnol J 2016, (in press).
-
(2016)
Biotechnol J
-
-
Zuo, R.1
Zhang, Y.2
Huquet-Tapia, J.C.3
Mehta, M.4
Dedic, E.5
Bruner, S.D.6
Loria, R.7
Ding, Y.8
-
29
-
-
84930227374
-
Monooxygenase, peroxidase and peroxygenase properties and reaction mechanisms of cytochrome P450 enzymes
-
Hrycay E.G., Bandiera S.M. Monooxygenase, peroxidase and peroxygenase properties and reaction mechanisms of cytochrome P450 enzymes. Adv Exp Med Biol 2015, 851:1-61.
-
(2015)
Adv Exp Med Biol
, vol.851
, pp. 1-61
-
-
Hrycay, E.G.1
Bandiera, S.M.2
-
30
-
-
79953214587
-
Terminal olefin (1-alkene) biosynthesis by a novel P450 fatty acid decarboxylase from Jeotgalicoccus species (2011)
-
Rude M.A., Baron T.S., Brubaker S., Alibhai M., Del Cardayre S.B., Schirmer A. Terminal olefin (1-alkene) biosynthesis by a novel P450 fatty acid decarboxylase from Jeotgalicoccus species (2011). Appl Environ Microbiol 2011, 77:1718-1727.
-
(2011)
Appl Environ Microbiol
, vol.77
, pp. 1718-1727
-
-
Rude, M.A.1
Baron, T.S.2
Brubaker, S.3
Alibhai, M.4
Del Cardayre, S.B.5
Schirmer, A.6
-
31
-
-
84896795640
-
JE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium
-
JE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium. J Biol Chem 2014, 289:6535-6550.
-
(2014)
J Biol Chem
, vol.289
, pp. 6535-6550
-
-
Belcher, J.1
McLean, K.J.2
Matthews, S.3
Woodward, L.S.4
Fisher, K.5
Rigby, S.E.6
Nelson, D.R.7
Potts, D.8
Baynham, M.T.9
Parker, D.A.10
Leys, D.11
Munro, A.W.12
-
32
-
-
84942544091
-
Oxidative decarboxylation of short-chain fatty acids to 1-alkenes
-
Dennig A., Kuhn M., Tassoti S., Thiessenhusen A., Gilch S., Bülter T., Haas T., Hall M., Faber K. Oxidative decarboxylation of short-chain fatty acids to 1-alkenes. Angew Chem Int Ed Engl 2015, 54:8819-8822.
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, pp. 8819-8822
-
-
Dennig, A.1
Kuhn, M.2
Tassoti, S.3
Thiessenhusen, A.4
Gilch, S.5
Bülter, T.6
Haas, T.7
Hall, M.8
Faber, K.9
-
33
-
-
84930206427
-
Terpene hydroxylation with microbial cytochrome P450 monooxygenases
-
Janocha S., Scmitz D., Bernhardt R. Terpene hydroxylation with microbial cytochrome P450 monooxygenases. Adv Biochem Eng Biotechnol 2015, 148:215-250.
-
(2015)
Adv Biochem Eng Biotechnol
, vol.148
, pp. 215-250
-
-
Janocha, S.1
Scmitz, D.2
Bernhardt, R.3
-
34
-
-
84896415445
-
Functional characterization of steroid hydroxylase CYP106A1 derived from Bacillus megaterium
-
Lee G.Y., Kim D.H., Kim D., Ahn T., Yun C.H. Functional characterization of steroid hydroxylase CYP106A1 derived from Bacillus megaterium. Acc Pharm Res 2015, 38:98-107.
-
(2015)
Acc Pharm Res
, vol.38
, pp. 98-107
-
-
Lee, G.Y.1
Kim, D.H.2
Kim, D.3
Ahn, T.4
Yun, C.H.5
-
35
-
-
84883401015
-
Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias
-
Butler C.F., Peet C., Mason A.E., Voice M.W., Leys D., Munro A.W. Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias. J Biol Chem 2013, 288:25387-25399.
-
(2013)
J Biol Chem
, vol.288
, pp. 25387-25399
-
-
Butler, C.F.1
Peet, C.2
Mason, A.E.3
Voice, M.W.4
Leys, D.5
Munro, A.W.6
-
36
-
-
84900466289
-
Human P450-like oxidation of diverse proton pump inhibitor drugs by "gatekeeper" mutants of flavocytochrome P450 BM3
-
Butler C.F., Peet C., McLean K.J., Baynham M.T., Blankley R.T., Fisher K., Rigby S.E., Leys D., Voice M.W., Munro A.W. Human P450-like oxidation of diverse proton pump inhibitor drugs by "gatekeeper" mutants of flavocytochrome P450 BM3. Biochem J 2014, 460:247-259.
-
(2014)
Biochem J
, vol.460
, pp. 247-259
-
-
Butler, C.F.1
Peet, C.2
McLean, K.J.3
Baynham, M.T.4
Blankley, R.T.5
Fisher, K.6
Rigby, S.E.7
Leys, D.8
Voice, M.W.9
Munro, A.W.10
-
37
-
-
84943817256
-
Drug oxidation by cytochrome P450 BM3: metabolite synthesis and discovering new P450 reaction types
-
Ren X., Yorke J.A., Taylor E., Zhang T., Zhou W.H., Wong L.L. Drug oxidation by cytochrome P450 BM3: metabolite synthesis and discovering new P450 reaction types. Chem Eur J 2015, 21:15039-15047.
-
(2015)
Chem Eur J
, vol.21
, pp. 15039-15047
-
-
Ren, X.1
Yorke, J.A.2
Taylor, E.3
Zhang, T.4
Zhou, W.H.5
Wong, L.L.6
-
38
-
-
84911977066
-
Regioselective hydroxylation of 17 beta-estradiol by mutants of CYP102A1 from Bacillus megaterium
-
Cha G.S., Ryu S.H., Ahn T., Yun C.H. Regioselective hydroxylation of 17 beta-estradiol by mutants of CYP102A1 from Bacillus megaterium. Biotechnol Lett 2014, 36:2501-2506.
-
(2014)
Biotechnol Lett
, vol.36
, pp. 2501-2506
-
-
Cha, G.S.1
Ryu, S.H.2
Ahn, T.3
Yun, C.H.4
-
39
-
-
84946494846
-
A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules
-
Kulig J.K., Spandolf C., Hyde R., Ruzzini A.C., Eltis L.D., Grönberg G., Hayes M.A., Grogan G. A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules. Bioorg Med Chem 2015, 23:5603-5609.
-
(2015)
Bioorg Med Chem
, vol.23
, pp. 5603-5609
-
-
Kulig, J.K.1
Spandolf, C.2
Hyde, R.3
Ruzzini, A.C.4
Eltis, L.D.5
Grönberg, G.6
Hayes, M.A.7
Grogan, G.8
-
40
-
-
84911948397
-
Biooxidation of n-butane to 1-butanol by engineered P450 monooxygenase under increased pressure
-
Nebel B.A., Scheps D., Honda Malca S., Nestl B.M., Breuer M., Wagner H.G., Breitscheidel B., Kratz D., Hauer B. Biooxidation of n-butane to 1-butanol by engineered P450 monooxygenase under increased pressure. J Biotechnol 2014, 191:86-92.
-
(2014)
J Biotechnol
, vol.191
, pp. 86-92
-
-
Nebel, B.A.1
Scheps, D.2
Honda Malca, S.3
Nestl, B.M.4
Breuer, M.5
Wagner, H.G.6
Breitscheidel, B.7
Kratz, D.8
Hauer, B.9
-
41
-
-
84884533513
-
Semi-rational engineering of cytochrome P450sca-2 for enhanced catalytic activity: insights into the important role of electron transfer
-
Ba L., Li P., Zhang H., Duan Y., Lin Z. Semi-rational engineering of cytochrome P450sca-2 for enhanced catalytic activity: insights into the important role of electron transfer. Biotechnol Bioeng 2013, 110:2815-2825.
-
(2013)
Biotechnol Bioeng
, vol.110
, pp. 2815-2825
-
-
Ba, L.1
Li, P.2
Zhang, H.3
Duan, Y.4
Lin, Z.5
-
42
-
-
84876784070
-
High level semi-synthetic production of the potent antimalarial artemisinin
-
Paddon C.J., Westfall P.J., Pitera D.J., Benjamin K., Fisher K., et al. High level semi-synthetic production of the potent antimalarial artemisinin. Nature 2013, 496:528-532.
-
(2013)
Nature
, vol.496
, pp. 528-532
-
-
Paddon, C.J.1
Westfall, P.J.2
Pitera, D.J.3
Benjamin, K.4
Fisher, K.5
-
43
-
-
84939563893
-
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy
-
Farrow S.C., Hagel J.M., Beaudoin G.A., Burns D.C., Facchini P.J. Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy. Nat Chem Biol 2015, 11:728-732.
-
(2015)
Nat Chem Biol
, vol.11
, pp. 728-732
-
-
Farrow, S.C.1
Hagel, J.M.2
Beaudoin, G.A.3
Burns, D.C.4
Facchini, P.J.5
-
44
-
-
84941346066
-
Complete biosynthesis of opioids in yeast
-
Galanie S., Thodey K., Trenchard I.J., Filsinger Interrante M., Smolke C.D. Complete biosynthesis of opioids in yeast. Science 2015, 349:1095-1100.
-
(2015)
Science
, vol.349
, pp. 1095-1100
-
-
Galanie, S.1
Thodey, K.2
Trenchard, I.J.3
Filsinger Interrante, M.4
Smolke, C.D.5
-
45
-
-
69949174213
-
CYP719B1 is salutaridine synthase, the CC phenol-coupling enzyme of morphine biosynthesis in opium poppy
-
Gesell A., Rolf M., Ziegler J., Chávez M.L.D., Huang F.-C., Kutchan T.M. CYP719B1 is salutaridine synthase, the CC phenol-coupling enzyme of morphine biosynthesis in opium poppy. J Biol Chem 2009, 284:24432-24442.
-
(2009)
J Biol Chem
, vol.284
, pp. 24432-24442
-
-
Gesell, A.1
Rolf, M.2
Ziegler, J.3
Chávez, M.L.D.4
Huang, F.-C.5
Kutchan, T.M.6
-
46
-
-
84938397207
-
Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli
-
Stalhut S.G., Siedler S., Malla S., Harrison S.J., Maury J., Neves A.R., Forster J. Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli. Metab Eng 2015, 31:84-93.
-
(2015)
Metab Eng
, vol.31
, pp. 84-93
-
-
Stalhut, S.G.1
Siedler, S.2
Malla, S.3
Harrison, S.J.4
Maury, J.5
Neves, A.R.6
Forster, J.7
-
47
-
-
84922987874
-
Heterologous production of caffeic acid from tyrosine in Escherichia coli
-
Rodrigues J.L., Araújo R.G., Prather K.L., Kluskens L.D., Rodrigues L.R. Heterologous production of caffeic acid from tyrosine in Escherichia coli. Enzyme Microbiol Technol 2015, 71:36-44.
-
(2015)
Enzyme Microbiol Technol
, vol.71
, pp. 36-44
-
-
Rodrigues, J.L.1
Araújo, R.G.2
Prather, K.L.3
Kluskens, L.D.4
Rodrigues, L.R.5
-
48
-
-
84947064612
-
Metabolic engineering of the light-driven cytochrome P450 dependent pathways into Synechocystis sp. PCC 6803
-
Wlodarczyk A., Gnanasekaran T., Nielsen A.Z., Zulu N.N., Mellor S.B., Luckner M., Thøfner J.F., Olsen C.E., Mottawie M.S., Burow M., Pribil M., Feussner I., Møller B.L., Jensen P.E. Metabolic engineering of the light-driven cytochrome P450 dependent pathways into Synechocystis sp. PCC 6803. Metab Eng 2016, 33:1-11.
-
(2016)
Metab Eng
, vol.33
, pp. 1-11
-
-
Wlodarczyk, A.1
Gnanasekaran, T.2
Nielsen, A.Z.3
Zulu, N.N.4
Mellor, S.B.5
Luckner, M.6
Thøfner, J.F.7
Olsen, C.E.8
Mottawie, M.S.9
Burow, M.10
Pribil, M.11
Feussner, I.12
Møller, B.L.13
Jensen, P.E.14
-
49
-
-
78149373621
-
Cytochrome P450 compound I: capture, characterization and CH bond activation kinetics
-
Rittle J., Green M.T. Cytochrome P450 compound I: capture, characterization and CH bond activation kinetics. Science 2010, 330:933-937.
-
(2010)
Science
, vol.330
, pp. 933-937
-
-
Rittle, J.1
Green, M.T.2
-
50
-
-
0028963395
-
Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide - implication for its nitric oxide reduction mechanism
-
Shiro Y., Fujii M., Iizuka T., Adachi S., Tsukamoto K., Nakahara K., Shoun H. Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide - implication for its nitric oxide reduction mechanism. J Biol Chem 1995, 270:1617-1623.
-
(1995)
J Biol Chem
, vol.270
, pp. 1617-1623
-
-
Shiro, Y.1
Fujii, M.2
Iizuka, T.3
Adachi, S.4
Tsukamoto, K.5
Nakahara, K.6
Shoun, H.7
-
51
-
-
84896510382
-
Model complexes of key intermediates in fungal nitric oxide reductase (P450nor)
-
McQuarters A.B., Wirgau N.E., Lehnert N. Model complexes of key intermediates in fungal nitric oxide reductase (P450nor). Curr Opin Chem Biol 2014, 19:82-89.
-
(2014)
Curr Opin Chem Biol
, vol.19
, pp. 82-89
-
-
McQuarters, A.B.1
Wirgau, N.E.2
Lehnert, N.3
-
52
-
-
84895060545
-
New insights into the nature of observable reaction intermediates in cytochrome P450 NO reductase by using a combination of spectroscopy and quantum mechanics/molecular mechanics calculations
-
Riplinger C., Bill E., Daiber A., Ullrich V., Shoun H., Neese F. New insights into the nature of observable reaction intermediates in cytochrome P450 NO reductase by using a combination of spectroscopy and quantum mechanics/molecular mechanics calculations. Chem Eur J 2014, 20:1602-1614.
-
(2014)
Chem Eur J
, vol.20
, pp. 1602-1614
-
-
Riplinger, C.1
Bill, E.2
Daiber, A.3
Ullrich, V.4
Shoun, H.5
Neese, F.6
-
53
-
-
0037646516
-
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis - crystallographic, spectroscopic, and mutational studies
-
Lee D.S., Yamada A., Sugimoto H., Matsunaga I., Ogura H., Ichihara K., Adachi S., Park S.Y., Shiro Y. Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis - crystallographic, spectroscopic, and mutational studies. J Biol Chem 2003, 278:9761-9767.
-
(2003)
J Biol Chem
, vol.278
, pp. 9761-9767
-
-
Lee, D.S.1
Yamada, A.2
Sugimoto, H.3
Matsunaga, I.4
Ogura, H.5
Ichihara, K.6
Adachi, S.7
Park, S.Y.8
Shiro, Y.9
-
54
-
-
80051950067
-
2-dependent cytochrome P450 (SPα) with its bound fatty acid substrate, insight into the regioselective hydroxylation of fatty acids at the alpha position
-
2-dependent cytochrome P450 (SPα) with its bound fatty acid substrate, insight into the regioselective hydroxylation of fatty acids at the alpha position. J Biol Chem 2011, 286:29941-29950.
-
(2011)
J Biol Chem
, vol.286
, pp. 29941-29950
-
-
Fujishiro, T.1
Shoji, O.2
Nagano, S.3
Sugimoto, H.4
Shiro, Y.5
Watanabe, Y.6
-
55
-
-
79958696989
-
An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1
-
Seifert A., Antonovici M., Hauer B., Pleiss J. An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. ChemBioChem 2011, 12:1346-1351.
-
(2011)
ChemBioChem
, vol.12
, pp. 1346-1351
-
-
Seifert, A.1
Antonovici, M.2
Hauer, B.3
Pleiss, J.4
-
56
-
-
84924251136
-
Chemo-, regio-, and stereoselective oxidation of the monocyclic diterpenoid beta-cembrenediol by P450 BM3
-
Le-Huu P., Heidt T., Claasen B., Laschat S., Urlacher V.B. Chemo-, regio-, and stereoselective oxidation of the monocyclic diterpenoid beta-cembrenediol by P450 BM3. ACS Catal 2015, 5:1772-1780.
-
(2015)
ACS Catal
, vol.5
, pp. 1772-1780
-
-
Le-Huu, P.1
Heidt, T.2
Claasen, B.3
Laschat, S.4
Urlacher, V.B.5
-
57
-
-
84908497725
-
Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs
-
Venkataraman H., Verkade-Vreeker M.C.A., Capoferri L., Geerke D.P., Vermeulen N.P.E., Commandeur J.N.M. Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Bioorg Med Chem 2014, 22:5613-5620.
-
(2014)
Bioorg Med Chem
, vol.22
, pp. 5613-5620
-
-
Venkataraman, H.1
Verkade-Vreeker, M.C.A.2
Capoferri, L.3
Geerke, D.P.4
Vermeulen, N.P.E.5
Commandeur, J.N.M.6
-
58
-
-
84908239021
-
CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity
-
Roiban G.D., Agudo R., Ilie A., Lonsdale R., Reetz M.T. CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity. Chem Commun 2014, 50:14310-14313.
-
(2014)
Chem Commun
, vol.50
, pp. 14310-14313
-
-
Roiban, G.D.1
Agudo, R.2
Ilie, A.3
Lonsdale, R.4
Reetz, M.T.5
-
59
-
-
31344438135
-
Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450BM-3
-
Kubo T., Peters M.W., Meinhold P., Arnold F.H. Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450BM-3. Chem Eur J 2006, 12:1216-1220.
-
(2006)
Chem Eur J
, vol.12
, pp. 1216-1220
-
-
Kubo, T.1
Peters, M.W.2
Meinhold, P.3
Arnold, F.H.4
-
60
-
-
11844256914
-
Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450 BM-3
-
Sowden R.J., Yasmin S., Rees N.H., Bell S.G., Wong L.L. Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450 BM-3. Org Biomol Chem 2005, 3:57-64.
-
(2005)
Org Biomol Chem
, vol.3
, pp. 57-64
-
-
Sowden, R.J.1
Yasmin, S.2
Rees, N.H.3
Bell, S.G.4
Wong, L.L.5
-
61
-
-
84925534129
-
Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase
-
Xu L.H., Ikeda H., Liu L., Arakawa T., Wakagi T., Shoun H., Fushinobu S. Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase. Appl Microbiol Biotechnol 2015, 99:3081-3091.
-
(2015)
Appl Microbiol Biotechnol
, vol.99
, pp. 3081-3091
-
-
Xu, L.H.1
Ikeda, H.2
Liu, L.3
Arakawa, T.4
Wakagi, T.5
Shoun, H.6
Fushinobu, S.7
-
62
-
-
84890998798
-
Structure of the quinoline N-hydroxylating cytochrome P450 RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids
-
Yasutake Y., Kitagawa W., Hata M., Nishioka T., Ozaki T., Nishiyama M., Kuzuyama T., Tamura T. Structure of the quinoline N-hydroxylating cytochrome P450 RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids. FEBS Lett 2014, 588:105-110.
-
(2014)
FEBS Lett
, vol.588
, pp. 105-110
-
-
Yasutake, Y.1
Kitagawa, W.2
Hata, M.3
Nishioka, T.4
Ozaki, T.5
Nishiyama, M.6
Kuzuyama, T.7
Tamura, T.8
|