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Volumn 23, Issue 17, 2015, Pages 5603-5609
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A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules
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Author keywords
Biotransformation; Diltiazem; Drug metabolism; Imipramine; N demethylation; P450; P450Rhf
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Indexed keywords
BACTERIAL PROTEIN;
CYTOCHROME P450;
DILTIAZEM;
HYBRID PROTEIN;
IMIPRAMINE;
INDOMETACIN;
P450RHA1 RHFRED FUSION PROTEIN;
ROSIGLITAZONE;
UNCLASSIFIED DRUG;
ZAFIRLUKAST;
HEME;
ARTICLE;
BACTERIAL CELL;
BACTERIAL GENE;
BACTERIAL STRAIN;
CARBOXY TERMINAL SEQUENCE;
CATALYSIS;
CONTROLLED STUDY;
DE3 CELL;
DEMETHYLATION;
DRUG TRANSFORMATION;
ENZYME ACTIVITY;
ENZYME SPECIFICITY;
FUSION GENE;
GENE EXPRESSION;
GENE TECHNOLOGY;
HEME DOMAIN;
HYDROXYLATION;
IN VITRO STUDY;
LIGATION INDEPENDENT CLONING VECTOR TECHNOLOGY;
MOLECULAR CLONING;
MOLECULAR DYNAMICS;
MOLECULAR LIBRARY;
MOLECULAR STABILITY;
NONHUMAN;
P450 FUSION LIBRARY;
P450 GENE;
P450RHA1 RHFRED FUSION GENE;
PROTEIN ANALYSIS;
PROTEIN DOMAIN;
PROTEIN EXPRESSION;
PROTEIN PURIFICATION;
RHODOCOCCUS JOSTII;
RO02604 GENE;
RO04667 GENE;
RO04671 GENE;
RO08984 GENE;
RO11069 GENE;
RO11277 GENE;
RO11320 GENE;
BIOCATALYSIS;
CHEMICAL STRUCTURE;
GENE LIBRARY;
METABOLISM;
RHODOCOCCUS;
BIOCATALYSIS;
CYTOCHROME P-450 ENZYME SYSTEM;
GENE LIBRARY;
HEME;
MOLECULAR STRUCTURE;
RHODOCOCCUS;
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EID: 84946494846
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.07.025 Document Type: Article |
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Times cited : (19)
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References (31)
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