Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

Nature Chemical Biology

Volumn 11, Issue 9, 2015, Pages 728-732

  Farrow, Scott C ^a   Hagel, Jillian M ^a   Beaudoin, Guillaume A W ^a,c   Burns, Darcy C ^b   Facchini, Peter J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DEHYDRORETICULINE; ALDO KETO REDUCTASE; CYTOCHROME P450; EPIMERASE; OPIATE; OXIDOREDUCTASE; RETICULINE; RETICULINE EPIMERASE; THEBAINE; UNCLASSIFIED DRUG; ALDEHYDE REDUCTASE; ALKALOID; BENZYLISOQUINOLINE DERIVATIVE; CARBONYL REDUCTASE; LIGASE; MORPHINAN DERIVATIVE; MORPHINE; RECOMBINANT PROTEIN; SALUTARIDINE; VEGETABLE PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; EPIMERIZATION; GENE FUSION; GENE SILENCING; INTRON; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PAPAVER; PAPAVER BRACTEATUM; PAPAVER RHOEAS; PRIORITY JOURNAL; STEREOCHEMICAL INVERSION; STEREOCHEMISTRY; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BROMOVIRIDAE; CHEMISTRY; ESCHERICHIA COLI; EXON; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; OPEN READING FRAME; OXIDATION REDUCTION REACTION; SACCHAROMYCES CEREVISIAE; STEREOISOMERISM;

PAPAVER BRACTEATUM; PAPAVER RHOEAS; PAPAVER SOMNIFERUM;

ALDEHYDE REDUCTASE; ALKALOIDS; BASE SEQUENCE; BENZYLISOQUINOLINES; BROMOVIRIDAE; CARBOHYDRATE EPIMERASES; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; EXONS; GENE EXPRESSION REGULATION, PLANT; GENE FUSION; INTRONS; LIGASES; MOLECULAR SEQUENCE DATA; MORPHINANS; MORPHINE; OPEN READING FRAMES; OPIUM; OXIDATION-REDUCTION; PAPAVER; PLANT PROTEINS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; STEREOISOMERISM;

EID: 84939563893     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1879     Document Type: Article

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