Cytochrome P450 compound I: Capture, characterization, and C-H bond activation kinetics

Science

Volumn 330, Issue 6006, 2010, Pages 933-937

  Rittle, Jonathan ^a   Green, Michael T ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLOROPERBENZOIC ACID; CARBON; CHLORIDE PEROXIDASE; CYTOCHROME P450; CYTOCHROME P450 119; CYTOCHROME P450 119 I; CYTOCHROME P450 I; HYDROGEN; LAURIC ACID; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

CYTOCHROME; ENZYME ACTIVITY; ISOTOPIC ANALYSIS; METABOLISM; REACTION KINETICS; SPECTROSCOPY; SUBSTRATE;

ARTICLE; CHEMICAL BOND; DRUG METABOLISM; ELECTRON CAPTURE DETECTION; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; MASS SPECTROMETRY; MOLAR TOOTH; MOSSBAUER SPECTROSCOPY; PRIORITY JOURNAL;

BIOCATALYSIS; CATALYTIC DOMAIN; CHLOROBENZOATES; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; FATTY ACIDS; FREEZING; HYDROXYLATION; KINETICS; LAURIC ACIDS; LIGANDS; OXIDATION-REDUCTION; OXYGEN; PHYSICOCHEMICAL PROCESSES; SPECTROSCOPY, MOSSBAUER; SULFOLOBUS ACIDOCALDARIUS;

EID: 78149373621     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1193478     Document Type: Article

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47. This work was supported by NSF. We thank T. Grove and J. C. Calixto Moreno for assistance with GC-MS and C. Krest for help with preliminary EPR experiments. The CYP119 plasmid was graciously provided by P. R. Ortiz de Montellano.