Evaluation of anticancer activity of dehydrocostuslactone in vitro

Molecular Medicine Reports

Volumn 3, Issue 1, 2010, Pages 185-188

  Choi, Jeong Choi ^a   Kim, Gun Hee ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Apoptosis; Cell cycle arrest; Cell proliferation; Dehydrocostuslactone; IC 50

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIMITOTIC AGENT; DEHYDROCOSTUS LACTONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL POPULATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPOSURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; OVARY CANCER; SAUSSUREA; SAUSSUREA LAPPA;

SAUSSUREA LAPPA;

EID: 76149090818     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr-00000238     Document Type: Article

References (21)

1. Daly MB, Axilbund JE, Bryant E, et al: Genetic/familial high-risk assessment: breast and ovarian. J Natl Compr Canc Netw 4: 156-176, 2006.
2. Eliassen AH and Hankinson SE: Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies. Adv Exp Med Biol 630: 142-165, 2008.
3. Hussain RF, Nouti AM and Oliver RT: A new approach for measurement of cytotoxicity using colorimetric assay. J Immunol Methods 160: 89-96, 1993.
4. Jung JH, Kim Y, Lee CO, Kang SS, Park JH and Im KS: Cytotoxic constituents of Saussurea lappa. Arch Pharm Res 21: 153-156, 1993.
5. Robles M, Aregullin M, West J and Rodriguez E: Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Med 61: 199-203, 1995.
6. Choi JY, Park J, Yoo ES, et al: Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells. Planta Med 64: 594-597, 1998.
7. Uemura K, Yamamoto H, Nakagawa T, et al: Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). Glycocon J 21: 79-84, 2004.
8. Ko SG, Kim HP, Jin DH, et al: Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. Cancer Lett 220: 11-19, 2005.
9. Agarwal R, Linch M and Kaye SB: Novel therapeutic agents in ovarian cancer. Eur J Surg Oncol 32: 875-886, 2006.
10. Fader AN and Rose PG: Role of surgery in ovarian carcinoma. Role of surgery in ovarian carcinoma. J Clin Oncol 25: 2873-2883, 2007.
11. Sun CM, Syu WJ, Don MJ, Lu JJ and Lee GH: Cytotoxic sesquiterpenc lactones from the root of Saussurea lappa. J Nat Prod 66: 1175-1180, 2003.
12. Robinson A, Kumar TV, Sreedhar E, et al: A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study. Bioorg Med Chem Lett 18: 4015-4017, 2008.
13. Choi JY, Choi EH, Jung HW, et al: Melanogenesis inhibitory compounds from Saussureae Radix. Arch Pharm Res 31: 294-299, 2008.
14. Kuo PL, Ni WC, Tsai EM and Hsu YL: Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells. Mol Cancer Ther: April, 2009 (E-pub ahead of print).
15. Choi EJ and Ahn WS: Melanogenesis inhibitory compounds from Saussureae Radix. Int J Mol Med 23: 211-216, 2009.
16. Kim EJ, Lim SS, Park SY, Shin HK, Kim JS and Park JH: Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food Chem Toxicol 46: 3651-3658, 2008.
17. Hsu YL, Wu LY and Kuo PL: Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells. J Pharmacol Exp Ther 329: 808-819, 2009.
18. Yu J and Zhang L: Apoptosis in human cancer cells. Curr Opin Oncol 16: 19-24, 2004.
19. Sun SY, Hail N and Lotan R Jr: Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96: 662-672, 2004.
20. Zhang Z, Li M, Rayburn ER, Hill DL, Zhang R and Wang H: Oncogenes as novel targets for cancer therapy (part IV): regulators of the cell cycle and apoptosis. Am J Pharmacogenomics 5: 397-407, 2005.
21. Fesik SW. Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-885, 2005.