Cytotoxic impact of costunolide isolated from Costus speciosus on breast cancer via differential regulation of cell cycle - An in-vitro and in-silico approach

Phytotherapy Research

Volumn 29, Issue 10, 2015, Pages 1532-1539

  Roy, Anita ^a   Manikkam, Rajalakshmi ^a  

^a HOLY CROSS COLLEGE   (India)

Author keywords

anticancer; apoptosis; cell cycle; docking; Phytotherapy

Indexed keywords

CASPASE 3; CASPASE 9; COSTUNOLIDE; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; NITRIC OXIDE SYNTHASE; SESQUITERPENE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CELL CYCLE REGULATION; CELL VIABILITY; CHEILOCOSTUS SPECIOSUS; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG ISOLATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; PROTEIN EXPRESSION; RHIZOME; UPREGULATION; ANTAGONISTS AND INHIBITORS; BREAST; BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL CYCLE G2 PHASE; CELL DIVISION; CELL PROLIFERATION; COMPUTER SIMULATION; COSTUS; DRUG EFFECTS; FEMALE; METABOLISM; TUMOR CELL LINE;

APOPTOSIS; BREAST; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; COSTUS; FEMALE; G2 PHASE; HUMANS; NITRIC OXIDE SYNTHASE; SESQUITERPENES;

EID: 84943518763     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5408     Document Type: Article

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