Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species

Apoptosis

Volumn 16, Issue 4, 2011, Pages 347-358

  Kim, Joo Young ^a   Yu, Su Jin ^a   Oh, Hyun Ju ^a   Lee, Ji Young ^a   Kim, Yongjin ^a   Sohn, Jeongwon ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Apoptosis; Calcium; MAP kinase; NADPH oxidase; Panaxydol; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE P38; PANAXYDOL; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL;

APOPTOSIS; CALCIUM; CASPASES; CELL LINE, TRANSFORMED; DIYNES; ENZYME ACTIVATION; FATTY ALCOHOLS; HUMANS; INTRACELLULAR SPACE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIA; NADPH OXIDASE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

PANAX GINSENG;

EID: 79955750108     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0567-8     Document Type: Article

References (33)

1. J Moon SJ Yu HS Kim J Sohn 2000 Induction of G(1) cell cycle arrest and p27(KIP1) increase by panaxydol isolated from Panax ginseng Biochem Pharmacol 59 1109 1116 10704940 10.1016/S0006-2952(00)00235-5 1:CAS:528:DC%2BD3cXhsFGqt78%3D (Pubitemid 30110503)
2. J Hai Q Lin Y Lu H Zhang J Yi 2007 Induction of apoptosis in rat C6 glioma cells by panaxydol Cell Biol Int 31 711 715 17320424 10.1016/j.cellbi. 2007.01.003 1:CAS:528:DC%2BD2sXlvFaltLc%3D (Pubitemid 46765127)
3. SW Ryter HP Kim A Hoetzel, et al. 2007 Mechanisms of cell death in oxidative stress Antioxid Redox Signal 9 49 89 17115887 10.1089/ars.2007.9.49 1:CAS:528:DC%2BD28Xht1Wqur3L (Pubitemid 44901874)
4. TM Buttke PA Sandstrom 1994 Oxidative stress as a mediator of apoptosis Immunol Today 15 7 10 8136014 10.1016/0167-5699(94)90018-3 1:CAS:528: DyaK2cXhvVygsb8%3D (Pubitemid 24035087)
5. MD Jacobson 1996 Reactive oxygen species and programmed cell death Trends Biochem Sci 21 83 86 8882579 1:CAS:528:DyaK28Xhsl2htrk%3D (Pubitemid 26088517)
6. A Miyajima J Nakashima K Yoshioka 1997 Role of reactive oxygen species in cis-dichlorodiammineplatium-induced cytotoxicity on bladder cancer cells Br J Cancer 76 206 210 10.1038/bjc.1997.363 1:CAS:528:DyaK2sXltlSmur0%3D (Pubitemid 27279660)
7. Y Zhou EO Hileman W Plunkett MJ Keating P Huang 2003 Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents Blood 101 4098 4104 12531810 10.1182/blood-2002-08-2512 1:CAS:528:DC%2BD3sXktVGnu7k%3D (Pubitemid 36857891)
8. H Pelicano L Feng Y Zhou, et al. 2003 Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism J Biol Chem 278 37832 37839 12853461 10.1074/jbc.M301546200 1:CAS:528:DC%2BD3sXnsV2ltL8%3D (Pubitemid 37175311)
9. K Schulze-Osthoff AC Bakker B Vanhaesebroeck R Beyaert WA Jacob W Fiers 1992 Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation J Biol Chem 267 5317 5323 1312087 1:CAS:528:DyaK38Xhslajtr0%3D
10. A Quillet-Mary JP Jaffrezou V Mansat C Bordier J Naval G Laurent 1997 Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis J Biol Chem 272 21388 21395 9261153 10.1074/jbc.272.34.21388 1:CAS:528:DyaK2sXls1Ojurs%3D (Pubitemid 27374008)
11. C Fleury B Mignotte JL Vayssiere 2002 Mitochondrial reactive oxygen species in cell death signaling Biochimie 84 131 141 12022944 10.1016/S0300-9084(02)01369-X 1:CAS:528:DC%2BD38XktVCqsr0%3D (Pubitemid 34946949)
12. M Ott V Gogvadze S Orrenius B Zhivotovsky 2007 Mitochondria, oxidative stress and cell death Apoptosis 12 913 922 17453160 10.1007/s10495-007-0756-2 1:CAS:528:DC%2BD2sXksFamtrw%3D (Pubitemid 46653300)
13. W Hiraoka N Vazquez W Nieves-Neira SJ Chanock Y Pommier 1998 Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells J Clin Invest 102 1961 1968 9835621 10.1172/JCI3437 1:CAS:528:DyaK1cXnvVertbo%3D (Pubitemid 29001842)
14. F Qin R Patel C Yan W Liu 2006 NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin Free Radic Biol Med 40 236 246 16413406 10.1016/j.freeradbiomed.2005.08.010 1:CAS:528:DC%2BD28XksVehsA%3D%3D (Pubitemid 43069349)
15. AM Brennan SW Suh SJ Won, et al. 2009 NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation Nat Neurosci 12 857 863 19503084 10.1038/nn.2334 1:CAS:528:DC%2BD1MXntVWjtL0%3D
16. P Nicotera S Orrenius 1998 The role of calcium in apoptosis Cell Calcium 23 173 180 9601613 10.1016/S0143-4160(98)90116-6 1:CAS:528:DyaK1cXisFymtLo%3D (Pubitemid 28188002)
17. 2+ influx and activation of the neutrophil respiratory burst. Different regulation of plasma membrane- and granule-localized NADPH-oxidase J Leukoc Biol 71 611 617 11927647 1:CAS:528:DC%2BD38XivFGktro%3D
18. 2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitaries Hypertension 48 482 489 16894058 10.1161/01.HYP.0000236647.55200.07 1:CAS:528:DC%2BD28XnvFOjsr4%3D (Pubitemid 44253744)
19. AJ Klein-Szanto T Iizasa S Momiki, et al. 1992 A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells Proc Natl Acad Sci USA 89 6693 6697 1323115 10.1073/pnas.89.15.6693 1:CAS:528:DyaK38XlvVKnt78%3D
20. JE Kim KH Koo YH Kim J Sohn YG Park 2008 Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model Exp Mol Med 40 709 720 19116456 10.3858/emm.2008.40.6.709 1:CAS:528:DC%2BD1MXns1Wgsg%3D%3D
21. GF Kelso CM Porteous CV Coulter, et al. 2001 Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties J Biol Chem 276 4588 4596 11092892 10.1074/jbc. M009093200 1:CAS:528:DC%2BD3MXhtlOqsb0%3D
22. JY Lee SJ Yu YG Park J Kim J Sohn 2007 Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation Mol Cell Biol 27 3187 3198 17283049 10.1128/MCB.01461-06 1:CAS:528: DC%2BD2sXkt1Ogur4%3D (Pubitemid 46581329)
23. A Matsuzawa H Ichijo 2008 Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling Biochim Biophys Acta 1780 1325 1336 18206122 1:CAS:528:DC%2BD1cXhtVarsbfF
24. P Kuppusamy H Li G Ilangovan, et al. 2002 Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels Cancer Res 62 307 312 11782393 1:CAS:528:DC%2BD38XntV2gtQ%3D%3D (Pubitemid 34074020)
25. MD Jacobson MC Raff 1995 Programmed cell death and Bcl-2 protection in very low oxygen Nature 374 814 816 7536895 10.1038/374814a0 1:CAS:528: DyaK2MXlt1Orsrc%3D
26. 2+: a control point for apoptosis Science 300 135 139 12624178 10.1126/science.1081208 1:CAS:528:DC%2BD3sXis1Cgt7Y%3D (Pubitemid 36423046)
27. JH Yu JW Lim KH Kim T Morio H Kim 2005 NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells Free Radic Biol Med 39 590 602 16085178 10.1016/j.freeradbiomed.2005.04.019 1:CAS:528:DC%2BD2MXns1Wiu7c%3D (Pubitemid 41112101)
28. S Gandhi A Wood-Kaczmar Z Yao, et al. 2009 PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death Mol Cell 33 627 638 19285945 10.1016/j.molcel.2009.02.013 1:CAS:528: DC%2BD1MXltFSmsrY%3D
29. M Benhar I Dalyot D Engelberg A Levitzki 2001 Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress Mol Cell Biol 21 6913 6926 11564875 10.1128/MCB.21.20.6913-6926.2001 1:CAS:528:DC%2BD3MXntFChtrk%3D (Pubitemid 32911252)
30. K Saeki N Kobayashi Y Inazawa, et al. 2002 Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis Biochem J 368 705 720 12206715 10.1042/BJ20020101 1:CAS:528:DC%2BD38Xptlykt70%3D (Pubitemid 36042672)
31. T Noguchi K Ishii H Fukutomi, et al. 2008 Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage J Biol Chem 283 7657 7665 18211888 10.1074/jbc.M708402200 1:CAS:528:DC%2BD1cXjt1elsrk%3D
32. T Yamamori O Inanami H Sumimoto, et al. 2002 Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils Biochem Biophys Res Commun 293 1571 1578 12054696 10.1016/S0006-291X(02)00418-7 1:CAS:528:DC%2BD38Xks1Ggsbk%3D (Pubitemid 34681058)
33. GE Brown MQ Stewart SA Bissonnette AE Elia E Wilker MB Yaffe 2004 Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase J Biol Chem 279 27059 27068 15102856 10.1074/jbc.M314258200 1:CAS:528:DC%2BD2cXkvFGns7s%3D (Pubitemid 38812542)