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Volumn 28, Issue 5, 2016, Pages 226-240

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe -/- mice-a systems toxicology analysis

Author keywords

Data integration; inhalation toxicology; lipidomics; modified risk tobacco product; quantitative proteomics; reduced risk product; systems toxicology; transcriptomics

Indexed keywords

CIGARETTE SMOKE; IRON; PROTEOME; TRANSCRIPTOME; APOLIPOPROTEIN E; SMOKE;

EID: 84961914064     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2016.1150368     Document Type: Article
Times cited : (23)

References (93)
  • 1
    • 0024523351 scopus 로고
    • Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein
    • Abel J, de Ruiter N. (1989). Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein. Toxicol Lett 47: 191-6.
    • (1989) Toxicol Lett , vol.47 , pp. 191
    • Abel, J.1    De Ruiter, N.2
  • 2
    • 84964435569 scopus 로고    scopus 로고
    • Cigarette smoking and chronic liver diseases
    • Altamirano J, Bataller R. (2010). Cigarette smoking and chronic liver diseases. Gut 2008: 162453
    • (2010) Gut , vol.2008 , pp. 162453
    • Altamirano, J.1    Bataller, R.2
  • 3
    • 27244431824 scopus 로고    scopus 로고
    • Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke
    • Aoshiba K, Nagai A. (2003). Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke. Tob Induc Dis 1: 219-26.
    • (2003) Tob Induc Dis , vol.1 , pp. 219-226
    • Aoshiba, K.1    Nagai, A.2
  • 4
    • 0017182231 scopus 로고
    • Structural and immunological relationships of isoferritins in normal and malignant cells
    • Arosio P, Yokota M, Drysdale JW. (1976). Structural and immunological relationships of isoferritins in normal and malignant cells. Cancer Res 36: 1735-9.
    • (1976) Cancer Res , vol.36 , pp. 1735-1739
    • Arosio, P.1    Yokota, M.2    Drysdale, J.W.3
  • 5
    • 77954782963 scopus 로고    scopus 로고
    • Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: Implications in comorbidities of COPD
    • Arunachalam G, Sundar IK, Hwang JW, et al. (2010). Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. J Inflamm (Lond) 7: 34
    • (2010) J Inflamm (Lond) , vol.7 , pp. 34
    • Arunachalam, G.1    Sundar, I.K.2    Hwang, J.W.3
  • 6
    • 77951494897 scopus 로고    scopus 로고
    • Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats
    • Azzalini L, Ferrer E, Ramalho LN, et al. (2010). Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats. Hepatology 51: 1567-76.
    • (2010) Hepatology , vol.51 , pp. 1567-1576
    • Azzalini, L.1    Ferrer, E.2    Ramalho, L.N.3
  • 7
    • 0033984936 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
    • Bartsch H, Nair U, Risch A, et al. (2000). Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev 9: 3-28.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 3-28
    • Bartsch, H.1    Nair, U.2    Risch, A.3
  • 8
    • 84878582694 scopus 로고    scopus 로고
    • Apolipoprotein e deficiency and a mouse model of accelerated liver aging
    • Bonomini F, Rodella L, Moghadasian M, et al. (2013). Apolipoprotein E deficiency and a mouse model of accelerated liver aging. Biogerontology 14: 209-20.
    • (2013) Biogerontology , vol.14 , pp. 209-220
    • Bonomini, F.1    Rodella, L.2    Moghadasian, M.3
  • 9
    • 84886257013 scopus 로고    scopus 로고
    • Cigarette smoke induces molecular responses in respiratory tissues of ApoE-/-mice that are progressively deactivated upon cessation
    • Boué S, De León H, Schlage WK, et al. (2013). Cigarette smoke induces molecular responses in respiratory tissues of ApoE-/-mice that are progressively deactivated upon cessation. Toxicology 314: 112-24.
    • (2013) Toxicology , vol.314 , pp. 112-124
    • Boué, S.1    De León, H.2    Schlage, W.K.3
  • 10
    • 84869508905 scopus 로고    scopus 로고
    • Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice
    • Boué S, Tarasov K, Jänis M, et al. (2012). Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice. Atherosclerosis 225: 328-34.
    • (2012) Atherosclerosis , vol.225 , pp. 328-334
    • Boué, S.1    Tarasov, K.2    Jänis, M.3
  • 11
    • 0015363173 scopus 로고
    • The cellular production of hydrogen peroxide
    • Boveris A, Oshino N, Chance B. (1972). The cellular production of hydrogen peroxide. Biochem J 128: 617-30.
    • (1972) Biochem J , vol.128 , pp. 617-630
    • Boveris, A.1    Oshino, N.2    Chance, B.3
  • 12
    • 34548324815 scopus 로고    scopus 로고
    • Differential expression of stress-inducible proteins in chronic hepatic iron overload
    • Brown KE, Broadhurst KA, Mathahs MM, Weydert J. (2007). Differential expression of stress-inducible proteins in chronic hepatic iron overload. Toxicol Appl Pharmacol 223: 180-6.
    • (2007) Toxicol Appl Pharmacol , vol.223 , pp. 180-186
    • Brown, K.E.1    Broadhurst, K.A.2    Mathahs, M.M.3    Weydert, J.4
  • 13
    • 67849130563 scopus 로고    scopus 로고
    • ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    • Chen J, Bardes EE, Aronow BJ, Jegga AG. (2009). ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res 37: W305-11.
    • (2009) Nucleic Acids Res , vol.37 , pp. W305-W311
    • Chen, J.1    Bardes, E.E.2    Aronow, B.J.3    Jegga, A.G.4
  • 14
    • 0022272160 scopus 로고
    • Free-radical chemistry of cigarette smoke and its toxicological implications
    • Church DF, Pryor WA. (1985). Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 64: 111
    • (1985) Environ Health Perspect , vol.64 , pp. 111
    • Church, D.F.1    Pryor, W.A.2
  • 15
    • 0024503699 scopus 로고
    • Cigarette smoking and serum lipid and lipoprotein concentrations: An analysis of published data
    • Craig WY, Palomaki GE, Haddow JE. (1989). Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data. BMJ 298: 784-8.
    • (1989) BMJ , vol.298 , pp. 784-788
    • Craig, W.Y.1    Palomaki, G.E.2    Haddow, J.E.3
  • 16
    • 0028568658 scopus 로고
    • Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility
    • Daly AK, Cholerton S, Armstrong M, Idle JR. (1994). Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility. Environ Health Perspect 102: 55-61
    • (1994) Environ Health Perspect , vol.102 , pp. 55-61
    • Daly, A.K.1    Cholerton, S.2    Armstrong, M.3    Idle, J.R.4
  • 17
    • 84941352663 scopus 로고    scopus 로고
    • Modulation of the hepatic lipidome and transcriptome of Apoe-/-mice in response to smoking cessation
    • De León H, Boué S, Peitsch M, Hoeng J. (2013). Modulation of the hepatic lipidome and transcriptome of Apoe-/-mice in response to smoking cessation. J Liver 2: 132.
    • (2013) J Liver , vol.2 , pp. 132
    • De León, H.1    Boué, S.2    Peitsch, M.3    Hoeng, J.4
  • 18
    • 33750625885 scopus 로고    scopus 로고
    • Heavy smoking and liver
    • El-Zayadi AR. (2006). Heavy smoking and liver. World J Gastroenterol 12: 6098-101
    • (2006) World J Gastroenterol , vol.12 , pp. 6098-6101
    • El-Zayadi, A.R.1
  • 19
    • 0036245208 scopus 로고    scopus 로고
    • Heavy cigarette smoking induces hypoxic polycythemia (erythrocytosis) and hyperuricemia in chronic hepatitis C patients with reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy
    • El-Zayadi AR, Selim O, Hamdy H, et al. (2002). Heavy cigarette smoking induces hypoxic polycythemia (erythrocytosis) and hyperuricemia in chronic hepatitis C patients with reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy. Am J Gastroenterol 97: 1264-5.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1264-1265
    • El-Zayadi, A.R.1    Selim, O.2    Hamdy, H.3
  • 20
  • 21
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman RC, Carey VJ, Bates DM, et al. (2004). Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80
    • (2004) Genome Biol , vol.5 , pp. R80
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3
  • 22
    • 78650288540 scopus 로고    scopus 로고
    • Effects of smoking and smoking cessation on lipids and lipoproteins: Outcomes from a randomized clinical trial
    • Gepner AD, Piper ME, Johnson HM, et al. (2011). Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial. Am Heart J 161: 145-51.
    • (2011) Am Heart J , vol.161 , pp. 145-151
    • Gepner, A.D.1    Piper, M.E.2    Johnson, H.M.3
  • 23
    • 56749097778 scopus 로고    scopus 로고
    • Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect
    • Ghio AJ, Hilborn ED, Stonehuerner JG, et al. (2008). Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect. Am J Respir Crit Care Med 178: 1130-8.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 1130-1138
    • Ghio, A.J.1    Hilborn, E.D.2    Stonehuerner, J.G.3
  • 25
    • 79960215555 scopus 로고    scopus 로고
    • Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period
    • Hamabe A, Uto H, Imamura Y, et al. (2011). Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period. J Gastroenterol 46: 769-78.
    • (2011) J Gastroenterol , vol.46 , pp. 769-778
    • Hamabe, A.1    Uto, H.2    Imamura, Y.3
  • 26
    • 0027935768 scopus 로고
    • The human microsomal epoxide hydrolase gene (EPHX1): Complete nucleotide sequence and structural characterization
    • Hassett C, Robinson KB, Beck NB, Omiecinski CJ. (1994). The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization. Genomics 23: 433-42.
    • (1994) Genomics , vol.23 , pp. 433-442
    • Hassett, C.1    Robinson, K.B.2    Beck, N.B.3    Omiecinski, C.J.4
  • 27
    • 84904881518 scopus 로고    scopus 로고
    • Association between the intrinsically disordered protein PEX19 and PEX3
    • et al
    • Hattula K, Hirschberg D, Kalkkinen N, et al. (2014). Association between the intrinsically disordered protein PEX19 and PEX3. PLoS One 9: e103101
    • (2014) PLoS One , vol.9 , pp. e103101
    • Hattula, K.1    Hirschberg, D.2    Kalkkinen, N.3
  • 29
    • 0032874845 scopus 로고    scopus 로고
    • Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
    • Hayes JD, McLellan LI. (1999). Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 31: 273-300.
    • (1999) Free Radic Res , vol.31 , pp. 273-300
    • Hayes, J.D.1    McLellan, L.I.2
  • 30
    • 84907034868 scopus 로고
    • The glutathione S-transferase supergene family: Regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II
    • Hayes JD, Pulford DJ. (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II. Crit Rev Biochem Mol Biol 30: 521-600.
    • (1995) Crit Rev Biochem Mol Biol , vol.30 , pp. 521-600
    • Hayes, J.D.1    Pulford, D.J.2
  • 31
    • 0030822111 scopus 로고    scopus 로고
    • Vitamin C supplementation on hepatic oxidative stress induced by cigarette smoke
    • Helen A, Vijayammal P. (1997). Vitamin C supplementation on hepatic oxidative stress induced by cigarette smoke. J Appl Toxicol 17: 289-95.
    • (1997) J Appl Toxicol , vol.17 , pp. 289-295
    • Helen, A.1    Vijayammal, P.2
  • 32
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. (2004). Balancing acts: molecular control of mammalian iron metabolism. Cell 117: 285-97.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 33
    • 34548390084 scopus 로고    scopus 로고
    • Human cytochrome p450 family 4 enzymes: Function, genetic variation and regulation
    • Hsu MH, Savas Ü, Griffin KJ, Johnson EF. (2007). Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation. Drug Metab Rev 39: 515-38.
    • (2007) Drug Metab Rev , vol.39 , pp. 515-538
    • Hsu, M.H.1    Savas, Ü.2    Griffin, K.J.3    Johnson, E.F.4
  • 34
  • 35
    • 84891760956 scopus 로고    scopus 로고
    • Data, information, knowledge and principle: Back to metabolism in KEGG
    • Kanehisa M, Goto S, Sato Y, et al. (2014). Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res 42: D199-205.
    • (2014) Nucleic Acids Res , vol.42 , pp. D199-205
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3
  • 36
    • 84898889450 scopus 로고    scopus 로고
    • A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes
    • Kogel U, Schlage WK, Martin F, et al. (2014). A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes. Food Chem Toxicol 68: 204-17.
    • (2014) Food Chem Toxicol , vol.68 , pp. 204-217
    • Kogel, U.1    Schlage, W.K.2    Martin, F.3
  • 37
    • 0020492266 scopus 로고
    • Failure of metallothionein to bind iron or act as an iron mobilizing agent
    • Kojima N, Young CR, Bates GW. (1982). Failure of metallothionein to bind iron or act as an iron mobilizing agent. Biochim Biophys Acta 716: 273-5.
    • (1982) Biochim Biophys Acta , vol.716 , pp. 273-275
    • Kojima, N.1    Young, C.R.2    Bates, G.W.3
  • 38
    • 80051675851 scopus 로고    scopus 로고
    • Epigenetic mechanisms of mouse inter-strain variability in genotoxicity of the environmental toxicant 1, 3-butadiene
    • Koturbash I, Scherhag A, Sorrentino J, et al. (2011). Epigenetic mechanisms of mouse inter-strain variability in genotoxicity of the environmental toxicant 1, 3-butadiene. Toxicol Sci 122: 448-56
    • (2011) Toxicol Sci , vol.122 , pp. 448-456
    • Koturbash, I.1    Scherhag, A.2    Sorrentino, J.3
  • 39
    • 0023857514 scopus 로고
    • Effect of exposure of rats to cigarette smoke on the metabolism of lipids
    • Latha M, Vijayammal P, Kurup P. (1988). Effect of exposure of rats to cigarette smoke on the metabolism of lipids. Atherosclerosis 70: 225-31.
    • (1988) Atherosclerosis , vol.70 , pp. 225-231
    • Latha, M.1    Vijayammal, P.2    Kurup, P.3
  • 40
    • 70350694448 scopus 로고    scopus 로고
    • IntegrOmics: An R package to unravel relationships between two omics datasets
    • Lê Cao KA, González I, Déjean S. (2009). integrOmics: an R package to unravel relationships between two omics datasets. Bioinformatics 25: 2855-6.
    • (2009) Bioinformatics , vol.25 , pp. 2855-2856
    • Lê Cao, K.A.1    González, I.2    Déjean, S.3
  • 41
  • 42
    • 84879409128 scopus 로고    scopus 로고
    • Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation
    • Lietz M, Berges A, Lebrun S, et al. (2013). Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation. Atherosclerosis 229: 86-93.
    • (2013) Atherosclerosis , vol.229 , pp. 86-93
    • Lietz, M.1    Berges, A.2    Lebrun, S.3
  • 44
    • 84879788408 scopus 로고    scopus 로고
    • Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver
    • Lu Y, Ward SC, Cederbaum AI. (2013). Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver. Alcohol 47: 353-7.
    • (2013) Alcohol , vol.47 , pp. 353-357
    • Lu, Y.1    Ward, S.C.2    Cederbaum, A.I.3
  • 45
    • 13044312086 scopus 로고    scopus 로고
    • Human PEX19: CDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly
    • Matsuzono Y, Kinoshita N, Tamura S, et al. (1999). Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proc Natl Acad Sci USA 96: 2116-21.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2116-2121
    • Matsuzono, Y.1    Kinoshita, N.2    Tamura, S.3
  • 47
    • 84894557263 scopus 로고    scopus 로고
    • Smoking and cardiovascular disease: Mechanisms of endothelial dysfunction and early atherogenesis
    • Messner B, Bernhard D. (2014). Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol 34: 509-15.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 509-515
    • Messner, B.1    Bernhard, D.2
  • 48
    • 45849088449 scopus 로고    scopus 로고
    • Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: Subchronic inhalation toxicology
    • Moennikes O, Vanscheeuwijck PM, Friedrichs B, et al. (2008). Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology. Inhal Toxicol 20: 647-63.
    • (2008) Inhal Toxicol , vol.20 , pp. 647-663
    • Moennikes, O.1    Vanscheeuwijck, P.M.2    Friedrichs, B.3
  • 49
    • 84865762072 scopus 로고    scopus 로고
    • Elevated hepatic iron activates NF-E2-related factor 2 (NRF2) regulated pathway in a dietary iron overload mouse model
    • Moon MS, McDevitt E, Zhu J, et al. (2012). Elevated hepatic iron activates NF-E2-related factor 2 (NRF2) regulated pathway in a dietary iron overload mouse model. Toxicol Sci 129: 74-85
    • (2012) Toxicol Sci , vol.129 , pp. 74-85
    • Moon, M.S.1    McDevitt, E.2    Zhu, J.3
  • 50
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al. (2003). PGC-1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34: 267-73.
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 51
    • 0027958084 scopus 로고
    • ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    • Nakashima Y, Plump AS, Raines EW, et al. (1994). ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 14: 133-40.
    • (1994) Arterioscler Thromb , vol.14 , pp. 133-140
    • Nakashima, Y.1    Plump, A.S.2    Raines, E.W.3
  • 52
    • 33846945701 scopus 로고    scopus 로고
    • Carbonyl reductases: The complex relationships of mammalian carbonyl-and quinone-reducing enzymes and their role in physiology
    • Oppermann U. (2007). Carbonyl reductases: the complex relationships of mammalian carbonyl-and quinone-reducing enzymes and their role in physiology. Annu Rev Pharmacol Toxicol 47: 293-322.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 293-322
    • Oppermann, U.1
  • 53
    • 41549114526 scopus 로고    scopus 로고
    • Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues
    • Pavek P, Dvorak Z. (2008). Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab 9: 129-43.
    • (2008) Curr Drug Metab , vol.9 , pp. 129-143
    • Pavek, P.1    Dvorak, Z.2
  • 54
    • 0034951029 scopus 로고    scopus 로고
    • Cigarette smoking and hepatic lesions in patients with chronic hepatitis C
    • Pessione F, Ramond MJ, Njapoum C, et al. (2001). Cigarette smoking and hepatic lesions in patients with chronic hepatitis C. Hepatology 34: 121-5.
    • (2001) Hepatology , vol.34 , pp. 121-125
    • Pessione, F.1    Ramond, M.J.2    Njapoum, C.3
  • 55
    • 84927607692 scopus 로고    scopus 로고
    • A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product
    • Phillips B, Veljkovic E, Peck MJ, et al. (2015). A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. Food Chem Toxicol 80: 328-45.
    • (2015) Food Chem Toxicol , vol.80 , pp. 328-345
    • Phillips, B.1    Veljkovic, E.2    Peck, M.J.3
  • 56
    • 84960118088 scopus 로고    scopus 로고
    • An 8-month systems toxicology inhalation/cessation study in ApoE-/-mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes
    • Phillips B, Veljkovic E, Boué S, et al. (2016). An 8-month systems toxicology inhalation/cessation study in ApoE-/-mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes. Toxicol Sci 149: 411-32
    • (2016) Toxicol Sci , vol.149 , pp. 411-432
    • Phillips, B.1    Veljkovic, E.2    Boué, S.3
  • 57
    • 0028917419 scopus 로고
    • The molecular biology of the flavin-containing monooxygenases of man
    • Phillips IR, Dolphin CT, Clair P, et al. (1995). The molecular biology of the flavin-containing monooxygenases of man. Chem Biol Interact 96: 17-32.
    • (1995) Chem Biol Interact , vol.96 , pp. 17-32
    • Phillips, I.R.1    Dolphin, C.T.2    Clair, P.3
  • 58
    • 79961218626 scopus 로고
    • Clotting factors and rheology: Mechanisms of damage and intervention
    • In: Poulter N, Sever P, Thom S, eds. Oxford: Radcliffe Medical Press
    • Rampling MW. (1993) Clotting factors and rheology: mechanisms of damage and intervention. In: Poulter N, Sever P, Thom S., eds. Cardiovascular disease: risk factors and intervention. Oxford: Radcliffe Medical Press, 201-13
    • (1993) Cardiovascular Disease: Risk Factors and Intervention , pp. 201-213
    • Rampling, M.W.1
  • 59
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie ME, Phipson B, Wu D, et al. (2015). limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43: e47
    • (2015) Nucleic Acids Res , vol.43 , pp. e47
    • Ritchie, M.E.1    Phipson, B.2    Wu, D.3
  • 60
    • 0024431698 scopus 로고
    • Effect of body mass and other factors on serum liver enzyme levels in men attending for well population screening
    • Robinson D, Whitehead T. (1989). Effect of body mass and other factors on serum liver enzyme levels in men attending for well population screening. Ann Clin Biochem 26: 393-400.
    • (1989) Ann Clin Biochem , vol.26 , pp. 393-400
    • Robinson, D.1    Whitehead, T.2
  • 61
    • 70349644493 scopus 로고    scopus 로고
    • Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum
    • et al
    • Rodriguez A, Luukkaala T, Fleming RE, et al. (2009). Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum. PLoS One 4: e7212
    • (2009) PLoS One , vol.4 , pp. e7212
    • Rodriguez, A.1    Luukkaala, T.2    Fleming, R.E.3
  • 62
    • 0026755850 scopus 로고
    • Cholesterol biosynthesis and metabolism
    • Russell DW. (1992). Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther 6: 103-10.
    • (1992) Cardiovasc Drugs Ther , vol.6 , pp. 103-110
    • Russell, D.W.1
  • 63
    • 0034611003 scopus 로고    scopus 로고
    • PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
    • Sacksteder KA, Jones JM, South ST, et al. (2000). PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol 148: 931-44.
    • (2000) J Cell Biol , vol.148 , pp. 931-944
    • Sacksteder, K.A.1    Jones, J.M.2    South, S.T.3
  • 64
    • 84937496036 scopus 로고    scopus 로고
    • Systems toxicology: The future of risk assessment
    • Sauer JM, Hartung T, Leist M, et al. (2015). Systems toxicology: the future of risk assessment. Int J Toxicol 34: 346-8.
    • (2015) Int J Toxicol , vol.34 , pp. 346-348
    • Sauer, J.M.1    Hartung, T.2    Leist, M.3
  • 65
    • 84868342268 scopus 로고    scopus 로고
    • Reduced exposure evaluation of an electrically heated cigarette smoking system. Part 1: Non-clinical and clinical insights
    • Schorp MK, Tricker AR, Dempsey R. (2012). Reduced exposure evaluation of an electrically heated cigarette smoking system. Part 1: non-clinical and clinical insights. Regul Toxicol Pharmacol 64: S1-10.
    • (2012) Regul Toxicol Pharmacol , vol.64 , pp. S1-10
    • Schorp, M.K.1    Tricker, A.R.2    Dempsey, R.3
  • 66
    • 33845292901 scopus 로고    scopus 로고
    • Peroxisomes and oxidative stress
    • Schrader M, Fahimi HD. (2006). Peroxisomes and oxidative stress. Biochim Biophys Acta 1763: 1755-66.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 1755-1766
    • Schrader, M.1    Fahimi, H.D.2
  • 68
    • 0030849415 scopus 로고    scopus 로고
    • Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
    • Smith CA, Harrison DJ. (1997). Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet 350: 630-3.
    • (1997) Lancet , vol.350 , pp. 630-633
    • Smith, C.A.1    Harrison, D.J.2
  • 69
    • 84896366331 scopus 로고    scopus 로고
    • Systems toxicology: From basic research to risk assessment
    • Sturla SJ, Boobis AR, FitzGerald RE, et al. (2014). Systems toxicology: from basic research to risk assessment. Chem Res Toxicol 27: 314-29.
    • (2014) Chem Res Toxicol , vol.27 , pp. 314-329
    • Sturla, S.J.1    Boobis, A.R.2    FitzGerald, R.E.3
  • 70
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102: 15545-50.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 71
    • 84941051170 scopus 로고    scopus 로고
    • STRING v10: Protein-protein interaction networks, integrated over the tree of life
    • Szklarczyk D, Franceschini A, Wyder S, et al. (2015). STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43: D447-52.
    • (2015) Nucleic Acids Res , vol.43 , pp. D447-D452
    • Szklarczyk, D.1    Franceschini, A.2    Wyder, S.3
  • 72
    • 84903733786 scopus 로고    scopus 로고
    • MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice
    • Tao Y, Wu Q, Guo X, et al. (2014). MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice. Br J Haematol 166: 279-91.
    • (2014) Br J Haematol , vol.166 , pp. 279-291
    • Tao, Y.1    Wu, Q.2    Guo, X.3
  • 73
    • 12444340879 scopus 로고    scopus 로고
    • Toxicological evaluation of an electrically heated cigarette. Part 4: Subchronic inhalation toxicology
    • Terpstra PM, Teredesai A, Vanscheeuwijck PM, et al. (2003). Toxicological evaluation of an electrically heated cigarette. Part 4: subchronic inhalation toxicology. J Appl Toxicol 23: 349-62.
    • (2003) J Appl Toxicol , vol.23 , pp. 349-362
    • Terpstra, P.M.1    Teredesai, A.2    Vanscheeuwijck, P.M.3
  • 74
    • 68949105901 scopus 로고    scopus 로고
    • Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: Implications for diseases associated with iron accumulation
    • Thomas C, Mackey MM, Diaz AA, Cox DP. (2009). Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation. Redox Rep 14: 102-8.
    • (2009) Redox Rep , vol.14 , pp. 102-108
    • Thomas, C.1    MacKey, M.M.2    Diaz, A.A.3    Cox, D.P.4
  • 75
    • 0021944046 scopus 로고
    • Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
    • Thornalley PJ, Vašák M. (1985). Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 827: 36-44.
    • (1985) Biochim Biophys Acta , vol.827 , pp. 36-44
    • Thornalley, P.J.1    Vašák, M.2
  • 76
    • 84960131851 scopus 로고    scopus 로고
    • Effects of cigarette smoke, cessation and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/-mice-an integrative systems toxicology analysis
    • Titz B, Boué S, Phillips B, et al. (2016). Effects of cigarette smoke, cessation and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/-mice-an integrative systems toxicology analysis. Toxicol Sci 149: 441-57
    • (2016) Toxicol Sci , vol.149 , pp. 441-457
    • Titz, B.1    Boué, S.2    Phillips, B.3
  • 78
    • 67651174801 scopus 로고    scopus 로고
    • Smoking is associated with steatosis and severe fibrosis in chronic hepatitis C but not B
    • Tsochatzis E, Papatheodoridis GV, Manolakopoulos S, et al. (2009). Smoking is associated with steatosis and severe fibrosis in chronic hepatitis C but not B. Scand J Gastroenterol 44: 752-9.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 752-759
    • Tsochatzis, E.1    Papatheodoridis, G.V.2    Manolakopoulos, S.3
  • 79
    • 79952213804 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health
    • U.S. Department of Health and Human Services. (2010). How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health
    • (2010) How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-attributable Disease: A Report of the Surgeon General
  • 80
    • 0021995553 scopus 로고
    • Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary
    • Van der Valk P, Gille J, Oostra A, et al. (1985). Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary. Cell Tissue Res 239: 61-8.
    • (1985) Cell Tissue Res , vol.239 , pp. 61-68
    • Van Der Valk, P.1    Gille, J.2    Oostra, A.3
  • 81
    • 84877309040 scopus 로고    scopus 로고
    • Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods
    • Väremo L, Nielsen J, Nookaew I. (2013). Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods. Nucleic Acids Res 41: 4378-91.
    • (2013) Nucleic Acids Res , vol.41 , pp. 4378-4391
    • Väremo, L.1    Nielsen, J.2    Nookaew, I.3
  • 82
    • 84891796097 scopus 로고    scopus 로고
    • ProteomeXchange provides globally coordinated proteomics data submission and dissemination
    • Vizcaíno JA, Deutsch EW, Wang R, et al. (2014). ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Nat Biotechnol 32: 223-6.
    • (2014) Nat Biotechnol , vol.32 , pp. 223-226
    • Vizcaíno, J.A.1    Deutsch, E.W.2    Wang, R.3
  • 83
    • 56149123124 scopus 로고    scopus 로고
    • Smoke chemistry, in vitro and in vivo toxicology evaluations of the electrically heated cigarette smoking system series K
    • Werley MS, Freelin SA, Wrenn SE, et al. (2008). Smoke chemistry, in vitro and in vivo toxicology evaluations of the electrically heated cigarette smoking system series K. Regul Toxicol Pharmacol 52: 122-39.
    • (2008) Regul Toxicol Pharmacol , vol.52 , pp. 122-139
    • Werley, M.S.1    Freelin, S.A.2    Wrenn, S.E.3
  • 84
    • 0029957916 scopus 로고    scopus 로고
    • The effects of cigarette smoking and alcohol consumption on serum liver enzyme activities: A dose-related study in men
    • Whitehead T, Robinson D, Allaway S. (1996). The effects of cigarette smoking and alcohol consumption on serum liver enzyme activities: a dose-related study in men. Ann Clin Biochem 33: 530-5.
    • (1996) Ann Clin Biochem , vol.33 , pp. 530-535
    • Whitehead, T.1    Robinson, D.2    Allaway, S.3
  • 85
    • 0017202555 scopus 로고
    • Relationships between cigarette smoking, oral contraceptives, and plasma vitamins A, E, C, and plasma triglycerides and cholesterol
    • Yeung D. (1976). Relationships between cigarette smoking, oral contraceptives, and plasma vitamins A, E, C, and plasma triglycerides and cholesterol. Am J Clin Nutr 29: 1216-21.
    • (1976) Am J Clin Nutr , vol.29 , pp. 1216-1221
    • Yeung, D.1
  • 86
    • 0024847162 scopus 로고
    • Smoke inhalation: Diagnosis and treatment
    • Young CJ, Moss J. (1989). Smoke inhalation: diagnosis and treatment. J Clin Anesth 1: 377-86.
    • (1989) J Clin Anesth , vol.1 , pp. 377-386
    • Young, C.J.1    Moss, J.2
  • 87
    • 0030919894 scopus 로고    scopus 로고
    • Prospective study of hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B virus carriers
    • Yu MW, Hsu FC, Sheen IS, et al. (1997). Prospective study of hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B virus carriers. Am J Epidemiol 145: 1039-47.
    • (1997) Am J Epidemiol , vol.145 , pp. 1039-1047
    • Yu, M.W.1    Hsu, F.C.2    Sheen, I.S.3
  • 88
    • 33845600793 scopus 로고    scopus 로고
    • Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessment
    • Zein CO, Beatty K, Post AB, et al. (2006). Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: a cross validated retrospective assessment. Hepatology 44: 1564-71.
    • (2006) Hepatology , vol.44 , pp. 1564-1571
    • Zein, C.O.1    Beatty, K.2    Post, A.B.3
  • 89
    • 79952701706 scopus 로고    scopus 로고
    • Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease
    • Zein CO, Unalp A, Colvin R, et al. (2011). Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease. J Hepatol 54: 753-9.
    • (2011) J Hepatol , vol.54 , pp. 753-759
    • Zein, C.O.1    Unalp, A.2    Colvin, R.3
  • 90
    • 0033055995 scopus 로고    scopus 로고
    • Drug interactions with tobacco smoking
    • Zevin S, Benowitz NL. (1999). Drug interactions with tobacco smoking. Clin Pharmacokinet 36: 425-38.
    • (1999) Clin Pharmacokinet , vol.36 , pp. 425-438
    • Zevin, S.1    Benowitz, N.L.2
  • 91
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein e
    • Zhang SH, Reddick RL, Piedrahita JA, Maeda N. (1992). Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258: 468-71.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 92
    • 76749151814 scopus 로고    scopus 로고
    • Role of CYP2A5 in the clearance of nicotine and cotinine: Insights from studies on a Cyp2a5-null mouse model
    • Zhou X, Zhuo X, Xie F, et al. (2010). Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther 332: 578-87.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 578-587
    • Zhou, X.1    Zhuo, X.2    Xie, F.3
  • 93
    • 84905274836 scopus 로고    scopus 로고
    • Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments
    • Zuo L, He F, Sergakis GG, et al. (2014). Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol 307: L205-18.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.307 , pp. L205-L218
    • Zuo, L.1    He, F.2    Sergakis, G.G.3


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