Elevated hepatic iron activates NF-E2-related factor 2-regulated pathway in a dietary iron overload mouse model

Toxicological Sciences

Volumn 129, Issue 1, 2012, Pages 74-85

  Moon, Mi Sun ^a   Mcdevitt, Emily I ^a   Zhu, Junjia ^a   Stanley, Bruce ^a   Krzeminski, Jacek ^a   Amin, Shantu ^a   Aliaga, Cesar ^a   Miller, Thomas G ^a   Isom, Harriet C ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Antioxidant proteins; Glutathione metabolism; NRF2 mediated oxidative stress response; Phase I II metabolism

Indexed keywords

3,5,5 TRIMETHYL HEXANOYL FERROCENE; EPOXIDE HYDROLASE; EPOXIDE HYDROLASE 1; FERROCENE DERIVATIVE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M4; HEME OXYGENASE 1; IRON; LIVER PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE QUINONE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IRON LIVER LEVEL; IRON OVERLOAD; LIVER CELL; LIVER LEVEL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION;

ANIMALS; DISEASE MODELS, ANIMAL; FERROUS COMPOUNDS; HEXANOLS; IMMUNOHISTOCHEMISTRY; IRON; IRON OVERLOAD; LIVER; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2;

MUS;

EID: 84865762072     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs193     Document Type: Article

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