Role of CYP2A5 in the clearance of nicotine and cotinine: Insights from studies on a Cyp2a5-null mouse model

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 2, 2010, Pages 578-587

  Zhou, Xin ^a   Zhuo, Xiaoliang ^b   Xie, Fang ^a   Kluetzman, Kerri ^a   Shu, Yue Zhong ^b   Humphreys, W Griffith ^b   Ding, Xinxin ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COTININE; COTININE OXIDASE; CYTOCHROME P450 2A5; NICOTINE; OXIDOREDUCTASE; PROGESTERONE; RNA; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GENE DELETION; HOMOZYGOSITY; HYDROXYLATION; IN VIVO CULTURE; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CLEARANCE; LIVER FUNCTION; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TESTOSTERONE BLOOD LEVEL; WILD TYPE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COTININE; FEMALE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; NICOTINE; PROGESTERONE; RECOMBINATION, GENETIC; TESTOSTERONE; TISSUE DISTRIBUTION;

EID: 76749151814     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.162610     Document Type: Article

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