Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

Lancet

Volumn 350, Issue 9078, 1997, Pages 630-633

  Smith, Christopher A D ^a,b   Harrison, David J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; EPOXIDE HYDROLASE; MICROSOME ENZYME;

ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMPHYSEMA; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LUNG; LUNG CANCER; MAJOR CLINICAL STUDY; METABOLISM; OXIDATIVE STRESS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK; UNITED KINGDOM;

EID: 0030849415     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)08061-0     Document Type: Article

References (24)

1. Carp H, Miller F, Hoidal JR, Janoff A. Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidised methionine and has decreased elastase inhibitory capacity. Proc Natl Acad Sci USA 1982; 79: 2041-45.
2. Aaron J. Elastases and emphysema: current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 1985; 132: 417-33.
3. Tetley TD. Proteinase imbalance: its role in lung disease. Thorax 1993; 48: 560-65.
4. Garver RI, Mornex JF, Nukiwa T, et al. Alpha 1-antitrypsin deficiency and emphysema caused by homozygous inheritance of non-expressing alpha 1-antitrypsin gene. N Engl J Med 1986; 314: 762-66.
5. Cox DW, Levison H. Emphysema of early onset associated with a complete deficiency of alpha 1-antitrypsin (null homozygotes). Am Rev Respir Dis 1988; 137: 371-75.
6. Martorana PA, Brand T, Gardi C, et al. The pallid mouse: a model of genetic alphal-antitrypsin deficiency. Lab Invest 1993; 68: 233-41.
7. Foster JA, Rich CB, Miller MF. Pulmonary fibroblasts: an in vitro model of emphysema - regulation of the elastin gene expression. J Biol Chem 1990; 265: 15544-49.
8. D'Armiento J, Dalal SS, Okada Y, Berg RA, Dhada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 1992; 71: 955-61.
9. Church DF, Pryor WA. Free radical chemistry of cigarette smoke and its toxicoligical implications. Environ Health Perspect 1985; 64: 111-26.
10. Farber JL. Mechanisms of cell injury by activated oxygen species. Environ Health Perspect 1994; 102: 17-24.
11. Ogushi F, Hubbard RC, Vogelmeier C, Fells GA, Crystal RG. Risk factors for emphysema: cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase. J Clin Invest 1991; 87: 1060-65.
12. Evans MD, Pryor WA. Cigarette smoking, emphysema and damage to α 1-proteinase inhibitor. Am J Physiol 1994; 266: L593-611.
13. Omiecinski CJ, Aicher L, Holubkov R, Checkoway H. Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung. Pharmacogenetics 1993; 3: 150-58.
14. Hassett C, Aicher L, Sidhu LA, Omiecinski CJ. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet 1994; 3: 421-28.
15. Cantlay AM, Smith CAD, Wallace WA, Yap P-L, Lamb D, Harrison DJ. Heterogeneous and polymorphic expression of glutathione S-transferases in human lung. Thorax 1994; 49: 1010-14.
16. Smith CAD, Gough AC, Leigh PN, et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease. Lancet 1992; 339: 1375-77.
17. Cantlay AM, Lamb D, Gillooly M, et al. Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer. J Clin Mol Pathol 1995; 48: M210-14.
18. Kalsheker NA, Hodgson IJ, Watkins GL, White JP, Morrison HM, Stockley RA. Deoxyribonucleic acid (DNA) polymorphism of the alpha 1-antitrypsin gene in chronic lung disease. BMJ 1987; 294: 1511-14.
19. Morgan K, Scobie G, Kalsheker NA. The characterisation of a mutation of 3′ flanking sequence of the α 1-antitrypsin gene commonly associated with chronic obstuctive airways disease. Eur J Clin Invest 1992; 22: 134-37.
20. Hoffman D, Hecht SS. Advances in tobacco carcinogenesis. Handbook of Exp Pharmacol 1990; 94: 63-102.
21. Smith CAD, Smith G, Wolf CR. Genetic predisposition to cancer: polymorphisms in xenobiotic metabolising enzymes. Eur J Cancer 1994; 30A: 1921-36.
22. Tingle MD, Pirmohamed M, Templeton E, et al. An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes. Biochem Pharm 1993; 46: 1529-38.
23. Bartsch H, Petruzzelli S, De Flora S, et al. Carcinogen metabolism in human lung tissues and the effect of tobacco smoking: results from a case-control multicenter study on lung cancer patients. Environ Health Perspect 1992; 98: 119-24.
24. McGlynn KA, Rosvold EA, Lustbader EA, et al. Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of Aflatoxin B1. Proc Natl Acad Sci 1995; 92: 2384-87.