Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Liu, Rong ^a,b   Liu, Hua ^c   Ha, Yonju ^b   Tilton, Ronald G ^b   Zhang, Wenbo ^b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DRUG ADMINISTRATION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROGEN PEROXIDE; MESSENGER RNA; NOS3 PROTEIN, HUMAN; PROTEIN P21; RETINOBLASTOMA PROTEIN; SIRT6 PROTEIN, HUMAN; SIRTUIN; SIRTUIN 6; SMALL INTERFERING RNA;

ARTICLE; BIOSYNTHESIS; CELL AGING; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DOWN REGULATION; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUMAN CELL; METABOLISM; OXIDATIVE STRESS; PATHOGENESIS; PATHOLOGY; PROTEIN ANALYSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE;

ADMINISTRATION AND DOSAGE; BIOSYNTHESIS; CELL AGING; DIABETIC RETINOPATHY; DRUG EFFECTS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GENETICS; HUMANS; HYDROGEN PEROXIDE; METABOLISM; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PATHOLOGY; RNA, SMALL INTERFERING; SIRTUINS;

EID: 84963941041     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/902842     Document Type: Article

References (42)

1. Y. Zhao, S. Banerjee,N.Dey et al., "Klotho depletion contributes to increased inflammation in kidney of the db/db mousemodel of diabetes via RelA (serine)536 phosphorylation," Diabetes, vol. 60, no. 7, pp. 1907-1916, 2011.
2. W. Zhang, H. Liu, M. Rojas, R. W. Caldwell, and R. B. Caldwell, "Anti-inflammatory therapy for diabetic retinopathy," Immunotherapy, vol. 3, no. 5, pp. 609-628, 2011.
3. S. C. Elms,H.A.Toque,M.Rojas,Z.Xu, R. W. Caldwell, and R. B. Caldwell, "The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes," Diabetologia, vol. 56, no. 3, pp. 654-662, 2013.
4. R. Mortuza, S. Chen, B. Feng, S. Sen, and S. Chakrabarti, "High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway," PLoS ONE, vol. 8, no. 1,Article ID e54514, 2013.
5. J. D. Erusalimsky and C. Skene, "Mechanisms of endothelial senescence," Experimental Physiology, vol. 94, no. 3, pp. 299-304, 2009.
6. C. W. Greider, "Telomeres and senescence: The history, the experiment, the future," Current Biology, vol. 8, no. 5, pp. R178-R181, 1998.
7. M. S. Goligorsky, J. Chen, and S. Patschan, "Stress-induced premature senescence of endothelial cells: A perilous state between recovery and point of no return," Current Opinion in Hematology, vol. 16, no. 3, pp. 215-219, 2009.
8. S. V. Brodsky, O. Gealekman, J. Chen et al., "Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen," Circulation Research, vol. 94, no. 3, pp. 377-384, 2004.
9. T. Minamino and I. Komuro, "Vascular cell senescence: Contribution to atherosclerosis," Circulation Research, vol. 100, no. 1, pp. 15-26, 2007.
10. K. E. Foreman and J. Tang, "Molecular mechanisms of replicative senescence in endothelial cells," Experimental Gerontology, vol. 38, no. 11-12, pp. 1251-1257, 2003.
11. H. Ota, M. Eto, M. R. Kano et al., "Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 9, pp. 1634-1639, 2008.
12. A. C. Cave, A. C. Brewer,A.Narayanapanicker et al., "NADPH oxidases in cardiovascular health and disease," Antioxidants and Redox Signaling, vol. 8, no. 5-6, pp. 691-728, 2006.
13. M. Ushio-Fukai, "Redox signaling in angiogenesis: Role of NADPH oxidase," Cardiovascular Research, vol. 71, no. 2, pp. 226-235, 2006.
14. M. Al-Shabrawey, M. Bartoli, A. B. El-Remessy et al., "Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy," Investigative Ophthalmology and Visual Science, vol. 49, no. 7, pp. 3231-3238, 2008.
15. M. Al-Shabrawey, M. Rojas, T. Sanders et al., "Role of NADPH oxidase in retinal vascular inflammation," Investigative Ophthalmology and Visual Science, vol. 49, no. 7, pp. 3239-3244, 2008.
16. M. Rojas, W. Zhang, Z. Xu et al., "Requirement of NOX2 expression in both retina and bone marrow for diabetesinduced retinal vascular injury," PLoSONE, vol. 8, no. 12, Article ID e84357, 2013.
17. Y. Du, A. Veenstra, K. Palczewski, and T. S. Kern, "Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina," Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 16586-16591, 2013.
18. M. Al-Shabrawey, M. Bartoli, A. B. El-Remessy et al., "Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy," American Journal of Pathology, vol. 167, no. 2, pp. 599-607, 2005.
19. S. A. Madsen-Bouterse and R. A. Kowluru, "Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives," Reviews in Endocrine and Metabolic Disorders, vol. 9, no. 4, pp. 315-327, 2008.
20. Z.Ungvari,G.Kaley,R. deCabo,W. E. Sonntag, and A.Csiszar, "Mechanisms of vascular aging: New perspectives," Journals of Gerontology A Biological Sciences and Medical Sciences, vol. 65, no. 10, pp. 1028-1041, 2010.
21. R. Mostoslavsky, K. F. Chua, D. B. Lombard et al., "Genomic instability and aging-like phenotype in the absence of mammalian SIRT6," Cell, vol. 124, no. 2, pp. 315-329, 2006.
22. D. B. Lombard, B. Schwer, F. W. Alt, and R. Mostoslavsky, "SIRT6 in DNA repair, metabolism and ageing," Journal of Internal Medicine, vol. 263, no. 2, pp. 128-141, 2008.
23. T. L. Kawahara, E. Michishita, A. S. Adler et al., "SIRT6 links histone H3 lysine 9 deacetylation to NF-κB-dependent gene expression and organismal life span," Cell, vol. 136, no. 1, pp. 62-74, 2009.
24. L. Zhong, A. DUrso, D. Toiber et al., "The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α," Cell, vol. 140, no. 2, pp. 280-293, 2010.
25. N. R. Sundaresan, P. Vasudevan, L. Zhong et al., "The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun," Nature Medicine, vol. 18, no. 11, pp. 1643-1650, 2012.
26. C. Xiao, R. Wang, T. J. Lahusen et al., "Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice," The Journal of Biological Chemistry, vol. 287, no. 50, pp. 41903-41913, 2012.
27. H. Ameri, H. Liu, R. Liu et al., "TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization," Investigative Ophthalmology & Visual Science, vol. 55,no. 2, pp. 801-813, 2014.
28. M. Byun, K. Jeon, J. Choi, J. Shim, and D. Jue, "Dual effect of oxidative stress on NF-κB activation in HeLa cells," Experimental and Molecular Medicine, vol. 34, no. 5, pp. 332-339, 2002.
29. A. A. Fatokun, T. W. Stone, and R. A. Smith, "Hydrogen peroxide-induced oxidative stress inMC3T3-E1 cells: The effects of glutamate and protection by purines," Bone, vol. 39, no. 3, pp. 542-551, 2006.
30. A. Gutiérrez-Uzquiza, M. Arechederra, P. Bragado, J. A. Aguirre-Ghiso, and A. Porras, p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: Effect on the p70S6K pathway, The Journal of Biological Chemistry, vol. 287, no. 4, pp. 26322642, 2012.
31. H. Ota, M. Akishita, M. Eto, K. Iijima, M. Kaneki, and Y. Ouchi, "Sirt1 modulates premature senescence-like phenotype in human endothelial cells," Journal of Molecular and Cellular Cardiology, vol. 43, no. 5, pp. 571-579, 2007.
32. INK4a/Rb-pathway in cell cycle control," Cell Division, vol. 2, article 10, 2007.
33. M. Lappas, "Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells," Mediators of Inflammation, vol. 2012, Article ID597514, 11 pages, 2012.
34. A. Cardus, A. K. Uryga, G. Walters, and J. D. Erusalimsky, "SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence," Cardiovascular Research, vol. 97, no. 3, pp. 571-579, 2013.
35. E.Michishita, R. A.McCord, E. Berber et al., "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin," Nature, vol. 452, no. 7186, pp. 492-496, 2008.
36. G. Natoli, "When Sirtuins and NF-κB Collide," Cell, vol. 136, no. 1, pp. 19-21, 2009.
37. I. Ben-Porath and R. A. Weinberg, "The signals and pathways activating cellular senescence," International Journal of Biochemistry and Cell Biology, vol. 37, no. 5, pp. 961-976, 2005.
38. Z. Mao, C. Hine, X. Tian et al., "SIRT6 promotes DNA repair under stress by activating PARP1," Science, vol. 332, no. 6036, pp. 1443-1446, 2011.
39. S. M. Ronnebaum, Y. Wu, H. McDonough, and C. Patterson, "The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination," Molecular and Cellular Biology, vol. 33, pp. 4461-4472, 2013.
40. J. S. Lee, T. W. Seo, J. H. Yi, K. S. Shin, and S. J. Yoo, "CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G," Cell Death and Disease, vol. 4, no. 6, article e666, 2013.
41. A. Salminen, K. Kaarniranta, and A. Kauppinen, "Crosstalk between oxidative stress and SIRT1: Impact on the aging process," International Journal ofMolecular Sciences, vol. 14, no. 2, pp. 3834-3859, 2013.
42. C. Sebastián, B. M. M. Zwaans, D. M. Silberman et al., "The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism," Cell, vol. 151, no. 6, pp. 1185-1199, 2012.