Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity

British Journal of Pharmacology

Volumn 168, Issue 1, 2013, Pages 117-128

  Yu, Shan Shan ^a,c   Cai, Yi ^a   Ye, Jian Tao ^a   Pi, Rong Biao ^a   Chen, Shao Rui ^a   Liu, Pei Qing ^a   Shen, Xiao Yan ^a   Ji, Yong ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

cardiac hypertrophy; deacetylase activity; nicotinamide adenine dinucleotide; nuclear factor kappa B; sirtuin 6

Indexed keywords

ANGIOTENSIN II; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; SIRTUIN 6; TRANSCRIPTION FACTOR RELA;

ABDOMINAL AORTIC CONSTRICTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE REPORTER GENE ASSAY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; RNA INTERFERENCE; SIRTUIN 6 GENE; TRANSCRIPTION TERMINATION; UPREGULATION; WILD TYPE;

ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; CARDIOMEGALY; CELLS, CULTURED; CONSTRICTION, PATHOLOGIC; MALE; MYOCYTES, CARDIAC; NAD; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, MESSENGER; SIRTUINS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84872856805     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01903.x     Document Type: Article

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