Deacetylase SIRT6 deaccelerates endothelial senescence

Cardiovascular Research

Volumn 97, Issue 3, 2013, Pages 391-392

  Shen, Jianzhong ^a   Ma, Wanshu ^a   Liu, Yiwei ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIRTUIN 6;

CELL AGING; CELL CYCLE ARREST; DNA DAMAGE; EDITORIAL; ENDOTHELIUM CELL; GENE REPLICATION; HOMEOSTASIS; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TELOMERE;

CELL AGING; DNA DAMAGE; ENDOTHELIUM, VASCULAR; HUMANS; SIRTUINS; TELOMERE;

EID: 84874264891     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs421     Document Type: Editorial

References (15)

1. Pasterkamp G, de Kleijn DP, Borst C. Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications. Cardiovasc Res 2000;45:843-852.
2. Stehouwer CD, Lambert J, Donker AJ, van Hinsbergh VW. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 1997;34:55-68.
3. Bhagat K. Endothelial function and myocardial infarction. Cardiovasc Res 1998;39: 312-317.
4. Zampetaki A, Kirton JP, Xu Q. Vascular repair by endothelial progenitor cells. Cardiovasc Res 2008;78:413-421.
5. Shen J, DiCorleto PE. Adenosine prompts the heart to recruit endothelial progenitors. Circ Res 2008;102:280-282.
6. Hagensen MK, Raarup MK, Mortensen MB, Thim T, Nyengaard JR, Falk E et al. Circulating endothelial progenitor cells do not contribute to regeneration of endothelium after murine arterial injury. Cardiovasc Res 2012;93:223-231.
7. Hagensen MK, Vanhoutte PM, Bentzon JF. Arterial endothelial cells: still the craftsmen of regenerated endothelium. Cardiovasc Res 2012;95:281-289.
8. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res 2005;66:286-294.
9. Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov 2012;11: 443-461.
10. Wang JC, Bennett M. Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 2012;111: 245-259.
11. Herranz D, Munoz-Martin M, Canamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 2010;1:3.
12. Cardus A, Uryga A, Walters G, Erusalimsky JD. SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res 2013;97:571-579.
13. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006;124:315-329.
14. Zhou B, Margariti A, Zeng L, Xu Q. Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis. Cardiovasc Res 2011;90:413-420.
15. Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G et al. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res 2008;80:191-199.