Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: Implications for cardiovascular risk factor development

Basic Research in Cardiology

Volumn 109, Issue 1, 2014, Pages

  Winnik, Stephan ^a,b,c   Gaul, Daniel S ^a,b   Preitner, Frédéric ^d   Lohmann, Christine ^a,b   Weber, Julien ^a,b   Miranda, Melroy X ^a,b,e   Liu, Yilei ^a,b   Van Tits, Lambertus J ^a,b   Mateos, José María ^b   Brokopp, Chad E ^a   Auwerx, Johan ^e   Thorens, Bernard ^d   Lüscher, Thomas F ^a,b   Matter, Christian M ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Division of Cardiology and Department of Medicine   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e EPFL   (Switzerland)

Author keywords

Atherosclerosis; Metabolism; Oxidative stress; SIRTUIN 3

Indexed keywords

LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; MALONALDEHYDE; MITOCHONDRIAL PROTEIN; SIRTUIN 3;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA ROOT; ARTERIAL WALL THICKNESS; ARTICLE; CALORIMETRY; CARDIOVASCULAR RISK; CELL ACTIVATION; CHOLESTEROL DIET; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; GLUCOSE TOLERANCE; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; NUTRIENT SUPPLY; OXIDATIVE STRESS; PROTEIN DEPLETION; WEIGHT GAIN;

ANIMALS; BLOTTING, WESTERN; CORONARY ARTERY DISEASE; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; SIRTUIN 3;

EID: 84890845988     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0399-0     Document Type: Article

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