Type i Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

Cell Host and Microbe

Volumn 19, Issue 3, 2016, Pages 375-387

  Castiglia, Virginia ^a   Piersigilli, Alessandra ^b,c   Ebner, Florian ^a   Janos, Marton ^a   Goldmann, Oliver ^d   Damböck, Ursula ^a   Kröger, Andrea ^d,e   Weiss, Sigfried ^d   Knapp, Sylvia ^f,g   Jamieson, Amanda M ^h   Kirschning, Carsten ⁱ   Kalinke, Ulrich ^j   Strobl, Birgit ^k   Müller, Mathias ^k   Stoiber, Dagmar ^g,l   Lienenklaus, Stefan ^j,m   Kovarik, Pavel ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF BERN   (Switzerland)

^c EPFL   (Switzerland)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

^f ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^g MEDICAL UNIVERSITY OF VIENNA   (Austria)

^h BROWN UNIVERSITY   (United States)

ⁱ UNIVERSITY OF DUISBURG ESSEN   (Germany)

^j INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^k UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^l MEDICAL UNIVERSITY OF VIENNA   (Austria)

^m HANNOVER MEDICAL SCHOOL   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 1BETA; RNA 23S;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; BONE MARROW CELL; BONE MARROW DERIVED MACROPHAGE; CYTOKINE PRODUCTION; DENDRITIC CELL; GROUP A STREPTOCOCCAL INFECTION; HOST RESISTANCE; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMATION; LETHALITY; LYMPHOCYTIC INFILTRATION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOFT TISSUE INFECTION; SYSTEMIC HYPERINFLAMMATION; ANIMAL; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; STREPTOCOCCUS INFECTION; SURVIVAL ANALYSIS;

ANIMALS; DISEASE MODELS, ANIMAL; INTERFERON TYPE I; INTERLEUKIN-1BETA; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SOFT TISSUE INFECTIONS; STREPTOCOCCAL INFECTIONS; SURVIVAL ANALYSIS;

EID: 84961784283     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2016.02.003     Document Type: Article

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