Targeted drug delivery and imaging using mobile milli/microrobots: A promising future towards theranostic pharmaceutical design

Current Pharmaceutical Design

Volumn 22, Issue 11, 2016, Pages 1418-1428

  Singh, Ajay Vikram ^a   Sitti, Metin ^a  

^a MAX PLANCK INSTITUTE FOR INTELLIGENT SYSTEMS   (Germany)

Author keywords

Drug delivery; Micromanipulation; Microrobots; Minimally invasive surgery; Theranostic

Indexed keywords

CONTRAST MEDIUM; DRUG; LIGAND; MESSENGER RNA;

BIOPSY; CELL THERAPY; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEM; DRUG TARGETING; FOLLOW UP; GENE; HUMAN; MICROMANIPULATION; MICROROBOT; MICROSURGERY; MINIMALLY INVASIVE SURGERY; MOLECULAR IMAGING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; ROBOT ASSISTED SURGERY; ROBOTICS; STOMACH ULCER; TISSUE ENGINEERING; VITREORETINAL SURGERY; DEVICES; EQUIPMENT DESIGN; IMAGE PROCESSING; MOBILE PHONE; PROCEDURES; THERANOSTIC NANOMEDICINE;

CELL PHONES; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSURGERY; MINIMALLY INVASIVE SURGICAL PROCEDURES; THERANOSTIC NANOMEDICINE;

EID: 84961754987     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612822666151210124326     Document Type: Review

References (108)

1. Diller E, Sitti M. Micro-scale mobile robotics. Foundations Trends Robotics 2013; 2(3): 143-259
2. Pawashe C, Floyd S, Sitti M. Modeling and experimental characterization of an untethered magnetic micro-robot. Int J Robotics Res 2009; 28(8): 1077-94
3. Sitti M, Ceylan H, Hu W, et al. Biomedical Applications of Untethered Mobile Milli/Microrobots. Proc IEEE 2015; 103(2): 205-24
4. Singh AV, Patil R, Thombre DK, Gade W. Micro nanopatterning as tool to study the role of physicochemical properties on cell-surface interactions. J Biomed Mater Res 2013; 101(10): 3019-32
5. Sitti M. Miniature devices: Voyage of the microrobots. Nature 2009; 458(7242): 1121-2
6. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today 2007; 12(23): 1068-75
7. Brenson A. Pricey Drug Trials Turn Up Few New Blockbusters. USA: The New York Times 2004
8. Rosen H, Abribat T. The rise and rise of drug delivery. Nat Rev Drug Discov 2005; 4(5): 381-5
9. Derendorf H, Meibohm B. Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives. Pharm Res 1999; 16(2): 176-85
10. Lesniak MS, Brem H. Targeted therapy for brain tumours. Nat Rev Drug Discov 2004; 3(6): 499-508
11. Singh AV, Khare M, Gade W, Zamboni P. Theranostic implications of nanotechnology in multiple sclerosis: a future perspective. Autoimmune Dis 2012; 2012
12. Gidwani M, V Singh A. Nanoparticle enabled drug delivery across the blood brain barrier: in vivo and in vitro models, opportunities and challenges. Curr Pharm Biotechnol 2013; 14(14): 1201-12
13. Singh AV, Batuwangala M, Mundra R, et al. Biomineralized anisotropic gold microplate-macrophage interactions reveal frustrated phagocytosis-like phenomenon: a novel paclitaxel drug delivery vehicle. ACS Appl Mater Interfaces 2014; 6(16): 14679-89
14. Hassan S, Singh AV. Biophysicochemical perspective of nanoparticle compatibility: A critically ignored parameter in nanomedicine. J Nanosci Nanotechnol 2014; 14(1): 402-14
15. V Singh A, N Gade W, Vats T, Lenardi C, Milani P. Nanomaterials: new generation therapeutics in wound healing and tissue repair. Curr Nanosci 2010; 6(6): 577-86
16. Timko BP, Dvir T, Kohane DS. Remotely triggerable drug delivery systems. Adv Mater 2010; 22(44): 4925-43
17. Yim S, Goyal K, Sitti M. Magnetically actuated soft capsule with the multimodal drug release function. IEEE/ASME Trans Mechatron on 2013; 18(4): 1413-8
18. Gutin PH, Phillips TL, Wara WM, et al. Brachytherapy of recurrent malignant brain tumors with removable high-activity iodine-125 sources. J Neurosurg 1984; 60(1): 61-8
19. Yim S, Sitti M. 3-D localization method for a magnetically actuated soft capsule endoscope and its applications. Robotics IEEE Trans 2013; 29(5): 1139-51
20. Grady M, Howard III M, Molloy J, Ritter R, Quate E, Gillies G. Nonlinear magnetic stereotaxis: Three dimensional, invivo remote magnetic manipulation of a small object in canine brain. Med Phys 1990; 17(3): 405-15
21. Molloy J, Ritter R, Grady M, Howard III M, Quate E, Gillies G. Experimental determination of the force required for insertion of a thermoseed into deep brain tissues. Ann Biomed Eng 1990; 18(3): 299-313
22. Kósa G, Shoham M, Zaaroor M. Propulsion method for swimming microrobots. Robotics, IEEE Trans 2007; 23(1): 137-50
23. Roy S, Ferrara LA, Fleischman AJ, Benzel EC. Microelectromechanical Systems and Neurosurgery: A New Era in a New Millennium. Neurosurgery 2001; 49(4): 779-98
24. Huang X, Jain PK, El-Sayed IH, El-Sayed MA. Plasmonic photothermal therapy (PPTT) using gold nanoparticles. Lasers Med Sci 2008; 23(3): 217-28
25. Jordan A, Scholz R, Wust P, Fähling H, Felix R. Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J Magnet Magnet Mater 1999; 201(1): 413-9
26. Carlsen RW, Sitti M. Bio-hybrid cell-based actuators for microsystems. Small 2014; 10(19): 3831-51
27. Servant A, Qiu F, Mazza M, Kostarelos K, Nelson BJ. Controlled in vivo swimming of a swarm of bacteria like microrobotic flagella. Adv Mater 2015; 27(19): 2981-8
28. Zhuang J, Wright Carlsen R, Sitti M. pH-Taxis of Biohybrid Microsystems. Sci Rep 2015; 5: 11403
29. Tottori S, Zhang L, Qiu F, Krawczyk KK, Franco Obregón A, Nelson BJ. Magnetic helical micromachines: fabrication, controlled swimming, and cargo transport. Adv Mater 2012; 24(6): 811-6
30. Ye Z, Régnier S, Sitti M. Rotating magnetic miniature swimming robots with multiple flexible flagella. Robotics IEEE Trans 2014; 30(1): 3-13
31. Ghosh A, Fischer P. Controlled propulsion of artificial magnetic nanostructured propellers. Nano Lett 2009; 9(6): 2243-5
32. Mhanna R, Qiu F, Zhang L, et al. Artificial bacterial flagella for remote controlled targeted single cell drug delivery. Small 2014; 10(10): 1953-7
33. Fusco S, Sakar MS, Kennedy S, et al. An integrated microrobotic platform for on-demand, targeted therapeutic interventions. Adv Mater 2014; 26(6): 952-7
34. Kim S, Qiu F, Kim S, et al. Fabrication and characterization of magnetic microrobots for three-dimensional cell culture and targeted transportation. Adv Mater 2013; 25(41): 5863-8
35. Sowa Y, Rowe AD, Leake MC, et al. Direct observation of steps in rotation of the bacterial flagellar motor. Nature 2005; 437(7060): 916-9
36. Martel S. Bacterial microsystems and microrobots. Biomed Microdevices 2012; 14(6): 1033-45
37. Caprari G, Balmer P, Piguet R, Siegwart R, Eds. The autonomous micro robot “alice”: a platform for scientific and commercial applications. Micromechatronics and Human Science, 1998 MHS'98 Proceedings of the 1998 International Symposium 1998
38. Lagzi I. Chemical robotics chemotactic drug carriers. Cent Eur J Med s2013; 8(4): 377-82
39. Martel S, Taherkhani S, Tabrizian M, Mohammadi M, de Lanauze D, Felfoul O. Computer 3D controlled bacterial transports and aggregations of microbial adhered nano-components. J Micro-Bio Robotics 2014; 9(1-2): 23-8
40. Carlsen RW, Edwards MR, Zhuang J, Pacoret C, Sitti M. Magnetic steering control of multi-cellular bio-hybrid microswimmers. Lab Chip 2014; 14(19): 3850-9
41. Carlsen RW, Sitti M. Bio hybrid cell based actuators for microsystems. Small 2014; 10(19): 3831-51
42. Giannoukakis N, Trucco M. Cellular therapies based on stem cells and their insulin-producing surrogates: a 2015 reality check. Pediatr Diabetes 2015; 16(3): 151-63
43. Nelson BJ, Kaliakatsos IK, Abbott JJ. Microrobots for minimally invasive medicine. Ann Rev Biomed Eng 2010; 12: 55-85
44. Masuda S, Shimizu T, Yamato M, Okano T. Cell sheet engineering for heart tissue repair. Adv Drug Deliv Rev 2008; 60(2): 277-85
45. Sart S, Tsai AC, Li Y, Ma T. Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications. Tissue Eng Rev 2013; 20(5): 365-80
46. Singh A, Ferri M, Tamplenizza M, et al. Bottom-up engineering of the surface roughness of nanostructured cubic zirconia to control cell adhesion. Nanotechnology 2012; 23(47): 475101
47. Gurkan UA, Tasoglu S, Kavaz D, Demirel MC, Demirci U. Emerging technologies for assembly of microscale hydrogels. Adv Healthcare Mater 2012; 1(2): 149-58
48. Liu JS, Gartner ZJ. Directing the assembly of spatially organized multicomponent tissues from the bottom up. Trends Cell Biol 2012; 22(12): 683-91
49. Tasoglu S, Yu CH, Gungordu HI, Guven S, Vural T, Demirci U. Guided and magnetic self-assembly of tunable magnetoceptive gels. Nat Commun 2014; 5: 4702
50. Tasoglu S, Diller E, Guven S, Sitti M, Demirci U. Untethered micro-robotic coding of three-dimensional material composition. Nat Commun 2014; 5: 3124
51. Mirsaidov U, Scrimgeour J, Timp W, et al. Live cell lithography: using optical tweezers to create synthetic tissue. Lab Chip 2008; 8(12): 2174-81
52. Diller E, Sitti M. Three dimensional programmable assembly by untethered magnetic robotic micro grippers. Adv Funct Mater 2014; 24(28): 4397-404
53. Giltinan J, Diller E, Mayda C, Sitti M, editors. Three-dimensional robotic manipulation and transport of micro-scale objects by a magnetically driven capillary micro-gripper. Robotics and Automation (ICRA). 2014 IEEE International Conference 2014
54. Zervantonakis IK, Kothapalli CR, Chung S, Sudo R, Kamm RD. Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. Biomicrofluidics 2011; 5(1): 013406
55. Sariola V, Pena-Francesch A, Jung H, et al. Segmented molecular design of self-healing proteinaceous materials. Sci Rep 2015; 5
56. Voldman J. Electrical forces for microscale cell manipulation. Ann Rev Biomed Eng 2006; 8(1): 425-54
57. Di Carlo D, Tse HTK, Gossett DR. Introduction: why analyze single cells? Single-Cell Analysis: Methods and Protocols. USA: Springer 2012; pp. 1-10
58. Lu Z, Moraes C, Ye G, Simmons CA, Sun Y. Single cell deposition and patterning with a robotic system. PLoS One 2010; 5(10): e13542
59. Steager EB, Sakar MS, Magee C, Kennedy M, Cowley A, Kumar V. Automated biomanipulation of single cells using magnetic microrobots. Int J Robotics Res 2013; 32(3): 346-59
60. Hu W, Ishii KS, Fan Q, Ohta AT. Hydrogel microrobots actuated by optically generated vapour bubbles. Lab Chip 2012; 12(19): 3821-6
61. Thalhammer G, Steiger R, Bernet S, Ritsch-Marte M. Optical macro-tweezers: trapping of highly motile micro-organisms. J Optics 2011; 13(4): 044024
62. Zhang H, Liu K-K. Optical tweezers for single cells. J R Soc Interface 2008; 5(24): 671-90
63. Ye Z, Sitti M. Dynamic trapping and two-dimensional transport of swimming microorganisms using a rotating magnetic microrobot. Lab Chip 2014; 14(13): 2177-82
64. Kim D-H, Wong PK, Park J, Levchenko A, Sun Y. Microengineered platforms for cell mechanobiology. Ann Rev Biomed Eng 2009; 11: 203-33
65. Kawahara T, Sugita M, Hagiwara M, et al. On-chip microrobot for investigating the response of aquatic microorganisms to mechanical stimulation. Lab Chip 2013; 13(6): 1070-8
66. Hagiwara M, Kawahara T, Yamanishi Y, Masuda T, Feng L, Arai F. On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations. Lab Chip 2011; 11(12): 2049-54
67. Feng L, Hagiwara M, Ichikawa A, Arai F. On-chip enucleation of bovine oocytes using microrobot-assisted flow-speed control. Micromachines 2013; 4(2): 272-85
68. Hajba L, Guttman A. Circulating tumor-cell detection and capture using microfluidic devices. TrAC Trends Analytical Chem 2014; 59: 9-16
69. Klotz L-O, Giehl K. Special Issue: Cell-cell communication in development and disease. Arch Biochem Biophys 2012; 524(1): 1
70. Jensen PS, Grace KW, Attariwala R, Colgate JE, Glucksberg MR. Toward robot-assisted vascular microsurgery in the retina. Graefe's Arch Clin Exp Ophthalmol 1997; 235(11): 696-701
71. Patronik N, Zenati M, Riviere C, editors. A Study Ex Vivo of the Effect of Epicardial Fat on the HeartLander Robotic Crawler. 5th European Conference of the International Federation for Medical and Biological Engineering. USA: Springer 2012
72. Tortora G, Glass P, Wood N, et al. Eds. Investigation of bioinspired gecko fibers to improve adhesion of Heart Lander surgical robot. Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE 2012
73. Liu A, Tendick F, Cleary K, Kaufmann C. A survey of surgical simulation: applications, technology, and education. Presence: Teleoperators Virtual Environ 2003; 12(6): 599-614
74. Cooper J, Taqueti V. A brief history of the development of mannequin simulators for clinical education and training. Quality Safety Health Care 2004; 13(suppl 1): i11-8
75. Davies B, Jakopec M, Harris SJ, et al. Active-constraint robotics for surgery. Proc IEEE 2006; 94(9): 1696-704
76. Payandeh S, Stanisic Z, Eds. On application of virtual fixtures as an aid for telemanipulation and training. Haptic Interfaces for Virtual Environment and Teleoperator Systems, 2002 HAPTICS 2002 Proceedings 10th Symposium 2002
77. Madhani AJ, Niemeyer G, Salisbury JK, Eds. The black falcon: a teleoperated surgical instrument for minimally invasive surgery. Intelligent Robots and Systems. 1998 Proceedings, 1998 IEEE/RSJ International Conference 1998
78. Lee MH, Nicholls HR. Review Article Tactile sensing for mechatronics-a state of the art survey. Mechatronics 1999; 9(1): 1-31
79. Benali-Khoudja M, Hafez M, Alexandre J-M, Kheddar A, Eds. Tactile interfaces: a state-of-the-art survey. Int Symp Robotics Citeseer 2004
80. Wellman PS, Dalton EP, Krag D, Kern KA, Howe RD. Tactile imaging of breast masses: first clinical report. Arch Surg 2001; 136(2): 204-8
81. Khare M, Singh A, Zamboni P. Prospect of brain-machine interface in motor disabilities: The future support for multiple sclerosis patient to improve quality of life. Ann Med Health Sci Res 2014; 4(3): 305
82. Dogangil G, Ergeneman O, Abbott JJ, et al. Eds. Toward targeted retinal drug delivery with wireless magnetic microrobots. Intelligent Robots and Systems. 2008 IROS 2008 IEEE/RSJ International Conference 2008
83. Singh AV, Vyas V, Patil R, et al. Quantitative characterization of the influence of the nanoscale morphology of nanostructured surfaces on bacterial adhesion and biofilm formation. PLoS One 2011; 6(9): e25029
84. Singh AV, Vyas V, Salve TS, et al. Biofilm formation on nanostructured titanium oxide surfaces and a micro/nanofabrication-based preventive strategy using colloidal lithography. Biofabrication 2012; 4(2): 025001
85. Singh AV, Galluzzi M, Borghi F, et al. Interaction of bacterial cells with cluster-assembled nanostructured titania surfaces: An atomic force microscopy study. J Nanosci Nanotechnol 2013; 13(1): 77-85
86. Singh AV. Biotechnological applications of supersonic cluster beam-deposited nanostructured thin films: Bottom-up engineering to optimize cell-protein-surface interactions. J Biomed Mater Res 2013; 101(10): 2994-3008
87. Üneri A, Balicki MA, Handa J, Gehlbach P, Taylor RH, Iordachita I, Eds. New steady-hand eye robot with micro-force sensing for vitreoretinal surgery. Proceedings of the IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics IEEE/RAS-EMBS 2010
88. Singh AV, Patil R, Thombre DK, Gade WN. Micro-nanopatterning as tool to study the role of physicochemical properties on cellsurface interactions. J Biomed Mater Res 2013; 101(10): 3019-32
89. Qureshi WA. Current and future applications of the capsule camera. Nat Rev Drug Discov 2004; 3(5): 447-50
90. Quirini M, Webster R, Menciassi A, Dario P, Eds. Design of a pillsized 12-legged endoscopic capsule robot. Robotics and Automation. 2007 IEEE International Conference 2007
91. Davis SS. Formulation strategies for absorption windows. Drug Discov Today 2005; 10(4): 249-57
92. Munoz F, Alici G, Li W. A review of drug delivery systems for capsule endoscopy. Adv Drug Deliv Rev 2014; 71(0): 77-85
93. Carpi F, Kastelein N, Talcott M, Pappone C. Magnetically controllable gastrointestinal steering of video capsules. Biomed Eng IEEE Trans 2011; 58(2): 231-4
94. Joshi BP, Wang TD. Imaging: Dynamic imaging of gut function [mdash] allowing the blind to see. Nat Rev Gastroenterol Hepatol 2014; 11(10): 584-6
95. Edd J, Payen S, Rubinsky B, Stoller ML, Sitti M, Eds. Biomimetic propulsion for a swimming surgical micro-robot. Intelligent Robots and Systems, 2003(IROS 2003) Proceedings 2003 IEEE/RSJ International Conference 2003
96. Sydorak RM, Albanese CT. Minimal access techniques for fetal surgery. World J Surg 2003; 27(1): 95-102
97. Berris M, Shoham M. Febotics-a marriage of fetal surgery and robotics. Comput Aided Surg 2006; 11(4): 175-80
98. Adzick NS, Harrison MR, Flake AW, et al. Fetal surgery for cystic adenomatoid malformation of the lung. J Pediatr Surg 1993; 28(6): 806-12
99. Harrison MR, Langer JC, Adzick NS, et al. Correction of congenital diaphragmatic hernia in utero, V. Initial clinical experience. J Pediatr Surg 1990; 25(1): 47-57
100. Lingeman JE, Coury TA, Newman DM, et al. Comparison of results and morbidity of percutaneous nephrostolithotomy and extracorporeal shock wave lithotripsy. J Urol 1987; 138(3): 485-90
101. Xie T, Xie H, Fedder GK, Pan Y. Endoscopic optical coherence tomography with a modified microelectromechanical systems mirror for detection of bladder cancers. Appl Optics 2003; 42(31): 6422-6
102. Izumikawa M, Minoda R, Kawamoto K, et al. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med 2005; 11(3): 271-6
103. Stratigouleas ED, Perry BP, King SM, Syms CA. Complication rate of minimally invasive cochlear implantation. Otolaryngol Head Neck Surg 2006; 135(3): 383-6
104. Sakr W, Haas G, Cassin B, Pontes J, Crissman J. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J Urol 1993; 150(2 Pt 1): 379-85
105. Lendlein A, Kelch S. Shape memory polymers. Angew Chem Int Ed 2002; 41(12): 2034-57
106. Singh AV, Rahman A, Kumar NS, et al. Bio-inspired approaches to design smart fabrics. Mater Des 2012; 36: 829-39
107. Singh AV, Batuwangala M, Mundra R, et al. Biomineralized anisotropic gold microplate-macrophage interactions reveal frustrated phagocytosis-like phenomenon: a novel paclitaxel drug delivery vehicle. ACS Appl Mater Interfaces 2014; 6(16): 14679-89
108. Yoo J-W, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov 2011; 10(7): 521-35