The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants

Development and Psychopathology

Volumn 27, Issue 1, 2014, Pages 51-67

  Cleveland, H Harrington ^a   Schlomer, Gabriel L ^a   Vandenbergh, David J ^a   Feinberg, Mark ^a   Greenberg, Mark ^a   Spoth, Richard ^b   Redmond, Cleve ^b   Shriver, Mark D ^a   Zaidi, Arslan A ^a   Hair, Kerry L ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, HUMAN; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ALCOHOLISM; ALLELE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE DETECTION; HUMAN; MALE; MOTHER CHILD RELATION; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PATIENT CARE; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ALCOHOLISM; ALLELES; COMBINED MODALITY THERAPY; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; MOTHER-CHILD RELATIONS; PATIENT CARE TEAM; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84961288613     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579414001291     Document Type: Article

References (89)

1. Anchordoquy, H. C., McGeary, C., Liu, L., Krauter, K. S., & Smolen, A. (2003). Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behavior Genetics, 33, 73-78.
2. Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. (1995). Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry, 65, 1157-1165.
3. Bakermans-Kranenberg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to rearing environment depending on dopamine related genes: New evidence and meta-analysis. Development and Psychopathology, 23, 39-52.
4. Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (in press). The hidden efficacy of interventions: Gene-Environment experiments from a differential susceptibility perspective. Annual Review of Psychology.
5. Bakermans-Kranenberg, M. J., van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial. Developmental Psychology, 44, 293-300.
6. Barnes, J. J., Dean, A. J., Nandam, L. S., O'Connell, R. G., & Bellgrove, M. A. (2011). The molecular genetics of executive function: Role of monoamine system genes. Biological Psychiatry, 69, e127-e143.
7. Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304.
8. Belsky, J., &Pluess, M. (2009). Beyond diathesis-stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
9. Belsky, J., & Pluess, M. (2013). Beyond risk, resilience and dysregulation: Phenotypic plasticity and human development. Development and Psychopathology, 25, 1243-1261.
10. Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996). Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nature Genetics, 12, 81-84.
11. Botvin, G. J. (2000). Life Skills Training teacher's manual 3. Princeton, NJ: Princeton Heath Press, Inc.
12. Bradley, S.L., Dodelzon, K., Sandhu, H.K., &Philibert, R.A. (2005)Relationship of serotonin transporter gene polymorphisms and haplotypes tomRNA transcription. American Journal of Medical Genetics, 136B, 58-61.
13. Brody, G. H., Beach, S. R. H., Hill, K. G., Howe, G.W., & Prado, G. (2013). Using genetically informed, randomized prevention trials to test. American Journal of Public Health. Advance online publication.
14. Brody, G. H., Beach, S. R., Philibert, R. A., Chen, Y. F., & Murry, V. M. (2009) Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: Gene-Environment hypotheses tested via a randomized prevention design. Child Development, 80, 645-661.
15. Brody, G. H., Beach, S. R., Philibert, R. A., Chen, Y. F., Lei, M. K., Murry, V. M., et al. (2009). Parenting moderates a genetic vulnerability factor in longitudinal increases in youths' substance use. Journal of Consulting and Clinical Psychology, 77, 1-11. doi:10.1037/a0012996.
16. Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010). Dopamine in motivational control: Rewarding, aversive, and alerting. Neuron, 68, 815-834. doi:10.1016/j.neuron.2010.11.022.
17. Brook, J. S., Brook, D. W., Gordon, A. S., Whiteman, M., & Cohen, A. (1990). The psychosocial etiology of adolescent drug use: A family interactional approach. Genetic, Social and General Psychology Monographs, 116, 111-267.
18. Cardon, L. R., & Palmer, L. J. (2003). Population stratification and spurious allelic association. Lancet, 361, 598-604.
19. Covault, J., Tennen, H., Armeli, S., Conner, T. S., Herman, A. I., Cillessen, A. H. N., et al. (2007) Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biological Psychiatry, 61, 609-616.
20. Creswell, K. G., Sayette, M. A., Manuck, S. B., Ferrell, R. E., Hill, S. Y., Dimoff, J. D., et al. (2012). DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. PLOS ONE, 7, e28914. doi:10.1371/journal.pone.0028914.
21. Don, R. H., Cox, P. T., Wainwright, B. J., Baker, K., & Mattick, J. S. (1991). 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic Acids Research, 19, 4008.
22. Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., et al. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genetics, 12, 78-80.
23. Ellickson, P. L., McCaffrey, D. F., Ghosh-Dastidar, B., & Longshore, D. L. (2003). New inroads in preventing adolescent drug use: Results from a large-scale trial of Project ALERT in middle schools. American Journal of Public Health, 93, 1830-1836.
24. Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psychopathology, 23, 7-28.
25. Faraone, S. V., & Mick, E. (2010). Molecular genetics of attention deficit hyperactivity disorder. Psychiatric Clinics of North America, 33, 159-180. doi:10.1016/j.psc.2009.12.004.
26. Feinn, R., Nellissery, M., & Kranzler, H. R. (2005). Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. American Journal of Medical Genetics, 133B, 79-84.
27. Figueredo, A. J., McKnight, P. E., McKnight, K. M., & Sidani, S. (2000). Multivariate modeling of missing data within and across assessment waves. Addiction, 95, 361-380.
28. Flint, J., & Munafò, M. R. (2013). Candidate and non-candidate genes in behavior genetics. Current Opinion in Neurobiology, 23, 57-61.
29. Frazier, P. A., Tix, A. P., & Barron, K. E. (2004). Testing moderator and mediator effects in counseling psychology research. Journal of Counseling Psychology, 51, 115-134.
30. Freedman, M. L., Reich, D., Penney, K. L., McDonald, G. J., Mignault, A. A., Patterson, N., et al. (2004). Assessing the impact of population stratification on genetic association studies. Nature Genetics, 36, 388-393.
31. Freeman, B., Smith, N., Curtis, C., Huckett, L., Mill, J., & Craig, I. W. (2003). DNA from buccal swabs recruited by mail: Evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behavior Genetics, 33, 67-72.
32. Gardner, F., Hutchings, J., Bywater, T., & Whitaker, C. (2010). Who benefits and how does it work Moderators and mediators of outcome in an effectiveness trial of a parenting intervention. Journal of Clinical Child and Adolescent Psychology, 39, 568-580. doi:10.1080/15374416.2010.486315
33. Gelernter, J., Cubells, J. F., Kidd, J. R., Pakstis, A. J., & Kidd, K. K. (1999). Population studies of polymorphisms of the serotonin transporter protein gene. American Journal of Medical Genetics, 88, 61-66.
34. Gilsbach, S., Neufang, S., Scherag, S., Vloet, T. D., Fink, G. R., Herpertz-Dahlmann, B., et al. (2012) Effects of the DRD4 genotype on neural networks associated with executive functions in children and adolescents. Developmental Cognitive Neuroscience, 2, 417-427.
35. Goncy, E. A., & van Dulmen, M. H. M. (2010). Fathers do make a difference: Parental involvement and adolescent alcohol use. Fathering, 8, 93-108.
36. Guyll, M., Spoth, R. L., Chao, W., Wickrama, K. A. S., & Russell, D. (2004). Family-focused preventive interventions: Evaluating parental riskmoderation of substance use trajectories. Journal of Family Psychology, 18, 293-301.
37. Halder, I., Shriver, M., Thomas, M., Fernandez, J. R., & Frudakis, T. (2008). A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four contents: Utility and applications. Human Mutation, 29, 648-658.
38. Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., et al. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624.
39. Herman, A., Philbeck, J., Vassilopoulos, N., & Depetrillo, P. (2003) Serotonin transporter promoter polymorphism and differences in alcohol consumption behavior in a college student population. Alcohol, 38, 446-449.
40. Holmes, A. (2008). Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience & Biobehavioral Reviews, 32, 1293-1314. doi:10.1016/j.neubiorev.2008.03.006.
41. Jaffee, S. R., & Price, T. S. (2007). Gene-environment correlations: A review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12, 432-442.
42. Jasinska, A. J., Lowry, C. A., & Burmeister, M. (2012). Serotonin transporter gene, stress and raphe-raphe interactions: A molecular mechanism of depression. Trends in Neuroscience, 35, 395-402. doi:10.1016/j.tins.2012.01. 001
43. Jonassen, R., & Landro, N. I. (2014). Serotonin transporter polymorphisms (5-HTTLPR) in emotion processing implications from current neurobiology. Progress in Neurobiology, 117, 41-53.
44. Jones, D. J., Olson, A. L., Forehand, R., Gaffney, C. A., Zens, M. S., & Bau, J. J. (2005). A family-focused randomized controlled trial to prevent adolescent alcohol and tobacco use: The moderating roles of positive parenting and adolescent gender. Behavior Therapy, 36, 347-355.
45. Jordan, L. C., & Lewis, M. L. (2005). Paternal relationship quality as a protective factor: Preventing alcohol use among African American adolescents. Journal of Black Psychology, 31, 152-171.
46. Kaufman, J., Gelernter, J., Kaffman, A., Caspi, A., & Moffitt, T. (2010) Arguable assumptions, debatable conclusions. Biological Psychiatry, 67, e19-e20.
47. Keller, M., (2014). Gene-Environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution. Biological Psychiatry, 75, 18-24.
48. Kenna, G. A., Roder-Hanna, N., Leggio, L., Zywiak, W. H., Clifford, J., Edwards, S., et al. (2012). Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: Review of psychopathology and pharmacotherapy. Pharmacogenomics and Personalized Medicine, 5, 19-35. doi:10.2147/PGPM.S23462.
49. Kluger, A. N., Siegfried, Z., & Ebstein, R. P. (2002). A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Molecular Psychiatry, 7, 712-717.
50. Kochanska, G., Kim, S., Barry, R. A., & Philibert, R. A. (2011). Children's genotypes interact with maternal responsive care in predicting children's competence: Diathesis-stress or differential susceptibility Development and Psychopathology, 23, 605-616.
51. Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8, 1450-1457.
52. Larsen, H., van der Zwaluw, C. S., Overbeek, G., Granic, I., Franke, B., & Engels, R. C. (2010). A variable-number-of-tandem-repeats polymorphism in the dopamine D4 receptor gene affects social adaptation of alcohol use: Investigation of a gene-environment interaction. Psychological Science, 21, 1064-1068. doi:10.1177/0956797610376654
53. Le Moal, M., &Simon, H. (1991) Mesocorticolimbic dopaminergic network: Functional and regulatory roles. Physiology Review, 71, 155-234.
54. Lesch, K.P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
55. Lichter, J. B., Barr, C. L., Kennedy, J. L., Van Tol, H. H., Kidd, K. K., & Livak, K. J. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics, 2, 767-773.
56. Lippold, M. A., Greenberg, M. T., & Collins, L. (in press). Youths' substance use and changes in parental knowledge-related behaviors during middle school: A person-oriented approach. Journal of Youth and Adolescence.
57. Little, K. Y., Mclaughlin, D. P., Zhang, L., Livermore, C. S., Dalack, G. W., McFinton, P. R., et al. (1998) Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. American Journal of Psychiatry, 155, 207-213.
58. Mackie, J. L. (1965), Causes and conditionals. American Philosophical Quarterly, 2, 245-265.
59. Malhotra, A. K., Virkkunen, M., Rooney, W., Eggert, M., Linnoila, M., & Goldman, D. (1996). The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Molecular Psychiatry, 1, 388-391.
60. Marshal, M. P., & Chassin, L. (2000). Peer influence on adolescent alcohol use: The moderating role of parental support and discipline. Applied Developmental Science, 4, 80-88.
61. McClelland, G. H., & Judd, C. M. (1993). Statistical difficulties of detecting interactions and moderator effects. Psychological Bulletin, 114, 376-390.
62. McNeal, R. B., Hansen, W. B., Harrington, N. G., & Giles, S. M. (2004). How All Stars works: An examination of program effects on mediating variables. Health Education & Behavior, 31, 165-178.
63. Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009) Gene-Environment interactions at the serotonin transporter locus. Biological Psychiatry, 65, 211-219.
64. Munafò, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008). Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: Meta-analysis and new data. Biological Psychiatry, 63, 197-206.
65. Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2011). Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology, 36, 1940-1947.
66. Odgers, C
67. Pérez-Edgar, K., Hardee, J. E., Guyer, A. E., Benson, B. E., Nelson, E. E., Gorodetsky, E., et al. (2013). DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety. Social Cognitive and Affective Neuroscience, 9, 445-453. doi:10.1093/scan/nst001.
68. Petraitis, J., Flay, B. R., & Miller, T. Q. (1995). Reviewing theories of adolescent substance use: Organizing pieces of the puzzle. Psychological Bulletin, 117, 67-86.
69. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828-834.
70. Pilgrim, C. C., Schulenberg, J. E., O'Malley, P. M., Bachman, J. G., & Johnston, L. D. (2006). Mediatiors and moderators of parental involvement on substance use: A national study of adolescents. Prevention Science, 7, 75-89.
71. Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006). Computational tools for probing interaction effects in multiple linear regression, multilevel modeling, and latent curve analysis. Journal of Educational and Behavioral Statistics, 31, 437-448.
72. Price, T. S., Jaffee, S. R. (2008). Effects of the family environment: Gene-environment interaction and passive gene-environment correlation. Developmental Psychology, 44, 305-315. http://dx.doi.org/10.1037/0012-1649.44.2.305
73. Roisman, G. I., Newman, D. A., Fraley, C., Haltigan, J. D., Groh, A. M., & Haydon, K. C. (2012). Distinguishing differential susceptibility from diathesis-stress: Recommendations for evaluating interaction effects. Development and Psychopathology, 24, 389-409.
74. Rowe, D. C., Stever, C. L., Giedinghagen, N., Gard, J. M. C., Cleveland, H. H., Terris, S. T., et al. (1999). Dopamine DRD4 receptor polymorphism and attention deficit disorder. Molecular Psychiatry, 3, 419-426.
75. Rutter, M., Thapar, A., & Pickles, A. (2009). Gene-environment interactions: Biologically valid pathway or artifact Archives of General Psychiatry, 66, 1287-1289.
76. Ryan, S. M., Jorm, A. F., & Lubman, D. I. (2010). Parenting factors associated with reduced adolescent alcohol use: A systematic review of longitudinal studies. Australian and New Zealand Journal of Psychiatry, 44, 774-783.
77. Sander, T., Harms, H., Dufeu, P., Kuhn, S., Rommelspacher, H., &Schmidt, L. G. (1997). Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics. American Journal ofMedical Genetics, 74, 483-487.
78. Schoots, O., & Van Tol, H. H. (2003). The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics Journal, 3, 343-348.
79. Sheese, B. E., Voelker, P. M., Rothbart, M. K., & Posner, M. I. (2007). Parenting quality interacts with genetic variation in dopamine receptor D4 to influence temperament in early childhood. Developmental Psychopathology, 19, 1039-1048.
80. Skowronek, M. H., Laucht, M., Hohm, E., Becker, K., & Schmidt, M. H. (2006). Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds. Neurogenetics, 7, 239-246.
81. Smit, E., Verdumen, J., Monshouwer, K., &Smit, F. (2008). Family interventions and their effect on adolescent alcohol use in general populations: A meta-analysis of randomized controlled trials. Drug and Alcohol Dependence, 97, 195-206.
82. Spoth, R., Greenberg, M., Bierman, K., & Redmond, C. (2004) PROSPER community-university partnership model for public education systems: Capacity-building for evidence-based, competence-building prevention. Prevention Science, 5, 31-39.
83. Spoth, R., Greenberg, M., & Turrisi, R. (2008). Preventive interventions addressing underage drinking: State of the evidence and steps toward public health impact. Pediatrics, 121(Suppl. 4), S311-S336.
84. Spoth, R., Guyll, M., Lillehoj, C. J., Redmond, C., & Greenberg, M. (2007). PROSPER study of evidence-based intervention implementation quality by community-university partnerships. Journal of Community Psychology, 35, 981-999. doi:10.1002/jcop.20207
85. Spoth, R., Redmond, C., Clair, S., Shin, C., Greenberg, M., & Feinberg, M. (2011). Preventing substance misuse through community-university partnerships: Randomized controlled trial outcomes 412 years past baseline. American Journal of Preventive Medicine, 40, 440-447.
86. Spoth, R., Redmond, C., Shin, C., Greenberg, M., Feinberg, M., & Schainker, L. (2013). Longitudinal effects of universal PROSPER community-university partnership delivery system effects on substance misuse through 6 1/2 years past baseline from a cluster randomized controlled intervention trial. Preventive Medicine, 56, 190-196.
87. van IJzendoorn, M., Bakermans-Kranenburg, M., Belsky, J., Beach, S., Brody, G., Dodge, K., et al. (2011). Gene by environment experiments: A new approach to find missing heritability. Nature Reviews Genetics, 12, 881.
88. Windle, M., Spear, L. P., Fulgni, A. J., Angold, A., Brown, J. D., Pine, D., et al. (2008). Transitions into underage and problem drinking: Developmental processes and mechanisms between 10 and 15 years of age. Pediatrics, 121, s273-s289.
89. Zohsel, K., Buchmann, A. F., Blomeyer, D., Hohm, E., Schmidt, M. H., Esser, G., et al. (2014). Mothers' prenatal stress and their children's antisocial outcomes-A moderating role for the dopamine D4 receptor (DRD4) gene. Journal of Child Psychology and Psychiatry, 55, 69-76. doi:10.1111/jcpp.12138.