The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and Novelty Seeking

Molecular Psychiatry

Volumn 1, Issue 5, 1996, Pages 388-391

  Malhotra, A K ^a   Virkkunen, M ^b   Rooney, W ^a   Eggert, M ^b   Linnoila, M ^c   Goldman, D ^d  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Laboratory of Clinical Studies

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Allele; Association study; Dopamine D4 receptor; Genotype; Personality; Polymorphism

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; EXPLORATORY BEHAVIOR; FINLAND; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MALE; PERSONALITY; PERSONALITY TEST; PHYSIOLOGY;

ADULT; ALLELES; EXPLORATORY BEHAVIOR; FINLAND; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; PERSONALITY; PERSONALITY TESTS; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 0030275937     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265: 2037-2048.
2. 4 receptor (D4DR) exon III polymorphism associated with human personality trait of Novelty Seeking. Nature Genet 1996; 12: 78-80.
3. 4 receptor variants in the human population. Nature 1992; 358: 149-152.
4. 4 receptor with high affinity for the antipsychotic clozapine. Nature 1991; 350: 610-614.
5. Wise RA, Rompre PP. Brain dopamine and reward. Annu Rev Psychol 1989; 40: 191-225.
6. 4 dopamine receptor gene and measures of Novelty Seeking. Nature Genet 1996; 12: 81-84.
7. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psych 1987; 44: 573-588.
8. Adamson MD, Kennedy J, Petronis A, Dean M, Virkkunen M, Linnoila M, Goldman D. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Am J Med Genet 1995; 60: 199-205.
9. Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psych 1993; 50: 975-990.
10. Cloninger CR, Przybeck TR, Svrakic DM. The Tridimensional Personality Questionnaire: US normative data. Psychol Rep 1991; 69: 1047-1057.
11. 4 receptor locus. Hum Genet (in press).
12. 4 (DRD4) gene. Hum Mol Genet 1993; 2: 767-773.
13. 4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Molec Pharmacol 1994; 46: 364-373.
14. Pickar D, Owen RR, Litman RE, Konicki E, Gutierrez R, Rapaport MH. Clinical and biological response to clozapine in patients with schizophrenia: crossover comparison with fluphenazine. Arch Gen Psych 1992; 49: 345-353.
15. Kane J, Honigfeld G, Singer J, Meltzer H, the Clozaril Collaborative Study Group. Clozapine for the treatment resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psych 1988; 45: 789-796.