Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss

Journal of Surgical Research

Volumn 194, Issue 2, 2015, Pages 591-598

  Yang, Chen Hsien ^a,b   Kao, Ming Chan ^a,b   Shih, Ping Cheng ^a,b   Li, Kuang Yao ^a,b   Tsai, Pei Shan ^c   Huang, Chun Jen ^a,b  

^a Taipei Ren Chi Hospital   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cecal ligation and puncture; Evans blue dye; Inflammation; Rat; Tight junction

Indexed keywords

CLAUDIN 3; CLAUDIN 5; EVANS BLUE; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; SIMVASTATIN; CXCL2 CHEMOKINE; CXCL2 PROTEIN, RAT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MALONALDEHYDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER INTEGRITY LOSS; BRAIN EDEMA; BRAIN TISSUE; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; MALE; MEAN ARTERIAL PRESSURE; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SHAM PROCEDURE; SURVIVAL RATE; TIGHT JUNCTION; ANIMAL; BLOOD; BLOOD PRESSURE; BRAIN; BRAIN DISEASES; COMPLICATION; DRUG EFFECTS; EDEMA; HEART RATE; INFLAMMATION; METABOLISM; OXIDATIVE STRESS; PRECLINICAL STUDY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD PRESSURE; BLOOD-BRAIN BARRIER; BRAIN; BRAIN DISEASES; CHEMOKINE CXCL2; CLAUDIN-3; CLAUDIN-5; DRUG EVALUATION, PRECLINICAL; EDEMA; HEART RATE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INTERLEUKIN-6; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SEPSIS; SIMVASTATIN; SURVIVAL RATE;

EID: 84924918695     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.11.030     Document Type: Article

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