Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

Aging Cell

Volumn 14, Issue 6, 2015, Pages 1003-1013

  Raj, Divya D A ^a   Moser, Jill ^a   van der Pol, Susanne M A ^b   van Os, Ronald P ^a   Holtman, Inge R ^a   Brouwer, Nieske ^a   Oeseburg, Hisko ^a   Schaafsma, Wandert ^a   Wesseling, Evelyn M ^a   den Dunnen, Wilfred ^a   Biber, Knut P H ^a,c   de Vries, Helga E ^b   Eggen, Bart J L ^a   Boddeke, Hendrikus W G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Aging; Blood brain barrier; Microglia; Neuroimmune response; Priming; Telomerase; Telomere

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; ENCEPHALITIS; ENDOTOXEMIA; ENZYME DEFICIENCY; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; HOMOZYGOSITY; IMMUNOCOMPETENT CELL; INFLAMMATION; INFLAMMATORY INFILTRATE; MICROGLIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA GENE; TELOMERE SHORTENING; AGING; ANIMAL; BRAIN; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; PATHOLOGY; PATHOPHYSIOLOGY; TELOMERE;

AGING; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; TELOMERASE; TELOMERE; TELOMERE SHORTENING;

EID: 84954394319     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12370     Document Type: Article

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