Notum deacylates Wnt proteins to suppress signalling activity

Nature

Volumn 519, Issue 7542, 2015, Pages 187-192

  Kakugawa, Satoshi ^a   Langton, Paul F ^a   Zebisch, Matthias ^b,e   Howell, Steven A ^a   Chang, Tao Hsin ^b   Liu, Yan ^c   Feizi, Ten ^c   Bineva, Ganka ^d   O'Reilly, Nicola ^d   Snijders, Ambrosius P ^d   Jones, E Yvonne ^b   Vincent, Jean Paul ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e EVOTEC UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; GLYCOSAMINOGLYCAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; GLYPICAN; NOTUM PROTEIN; PALMITOLEIC ACID; UNCLASSIFIED DRUG; WNT PROTEIN; DROSOPHILA PROTEIN; ESTERASE; GLYCOSYLPHOSPHATIDYLINOSITOL; LIGAND; MONOUNSATURATED FATTY ACID; NOTUM PROTEIN, DROSOPHILA; NOTUM PROTEIN, HUMAN; PROTEIN BINDING;

ALCOHOL; CANCER; DISEASE PREVALENCE; ENZYME ACTIVITY; FLY; HOMEOSTASIS; HYDROPHOBICITY; LIGAND; PROTEIN; SIGNALING; SPECTROMETRY;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DROSOPHILA; GENE REPRESSION; HUMAN; INSECT GENETICS; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; WNT SIGNALING PATHWAY; ACYLATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM;

DROSOPHILA NOTUM;

ACYLATION; ANIMALS; BINDING SITES; CARBOXYLESTERASE; DROSOPHILA PROTEINS; ESTERASES; FATTY ACIDS, MONOUNSATURATED; GLYCOSYLPHOSPHATIDYLINOSITOLS; GLYPICANS; HUMANS; KINETICS; LIGANDS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN BINDING; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84924651313     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14259     Document Type: Article

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