메뉴 건너뛰기




Volumn 15, Issue 4, 2016, Pages 434-443

Harnessing the integrated stress response for the treatment of multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTE INITIATION FACTOR 2 ALPHA KINASE 3; GADD34 PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MYELIN; PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG; INITIATION FACTOR 2; NEUROPROTECTIVE AGENT;

EID: 84960480352     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(15)00381-6     Document Type: Review
Times cited : (57)

References (90)
  • 1
    • 0020683886 scopus 로고
    • Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH
    • Hauser SL, Dawson DM, Lehrich JR, et al. Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med 1983, 308:173-180.
    • (1983) N Engl J Med , vol.308 , pp. 173-180
    • Hauser, S.L.1    Dawson, D.M.2    Lehrich, J.R.3
  • 2
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • the UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group
    • Paty DW, Li DK Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993, 43:662-667. the UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 4
    • 0000361150 scopus 로고
    • Histologie de la sclérose en plaques
    • Charcot J-M Histologie de la sclérose en plaques. Gazette des Hospitaux 1868, 41:554-555.
    • (1868) Gazette des Hospitaux , vol.41 , pp. 554-555
    • Charcot, J.-M.1
  • 6
    • 84938484098 scopus 로고    scopus 로고
    • Promoting remyelination in multiple sclerosis: current drugs and future prospects
    • Kremer D, Küry P, Dutta R Promoting remyelination in multiple sclerosis: current drugs and future prospects. Mult Scler 2015, 21:541-549.
    • (2015) Mult Scler , vol.21 , pp. 541-549
    • Kremer, D.1    Küry, P.2    Dutta, R.3
  • 7
    • 84885635833 scopus 로고    scopus 로고
    • Multiple sclerosis: Prospects and promise
    • Hauser SL, Chan JR, Oksenberg JR Multiple sclerosis: prospects and promise. Ann Neurol 2013, 74:317-327.
    • (2013) Ann Neurol , vol.74 , pp. 317-327
    • Hauser, S.L.1    Chan, J.R.2    Oksenberg, J.R.3
  • 8
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis-the plaque and its pathogenesis
    • Frohman EM, Racke MK, Raine CS Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med 2006, 354:942-955.
    • (2006) N Engl J Med , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 9
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp BD, Nave KA Multiple sclerosis: an immune or neurodegenerative disorder?. Annu Rev Neurosci 2008, 31:247-269.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 10
    • 78549234073 scopus 로고    scopus 로고
    • Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis
    • Dutta R, Trapp BD Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Prog Neurobiol 2011, 93:1-12.
    • (2011) Prog Neurobiol , vol.93 , pp. 1-12
    • Dutta, R.1    Trapp, B.D.2
  • 12
    • 78149433845 scopus 로고    scopus 로고
    • Myelination and support of axonal integrity by glia
    • Nave KA Myelination and support of axonal integrity by glia. Nature 2010, 468:244-252.
    • (2010) Nature , vol.468 , pp. 244-252
    • Nave, K.A.1
  • 14
    • 0034281366 scopus 로고    scopus 로고
    • NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
    • Chang A, Nishiyama A, Peterson J, Prineas J, Trapp BD NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 2000, 20:6404-6412.
    • (2000) J Neurosci , vol.20 , pp. 6404-6412
    • Chang, A.1    Nishiyama, A.2    Peterson, J.3    Prineas, J.4    Trapp, B.D.5
  • 15
    • 0032005795 scopus 로고    scopus 로고
    • Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord
    • Keirstead HS, Levine JM, Blakemore WF Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 1998, 22:161-170.
    • (1998) Glia , vol.22 , pp. 161-170
    • Keirstead, H.S.1    Levine, J.M.2    Blakemore, W.F.3
  • 16
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang A, Tourtellotte WW, Rudick R, Trapp BD Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 2002, 346:165-173.
    • (2002) N Engl J Med , vol.346 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 18
    • 84900474913 scopus 로고    scopus 로고
    • Relapsing and progressive forms of multiple sclerosis: insights from pathology
    • Dutta R, Trapp BD Relapsing and progressive forms of multiple sclerosis: insights from pathology. Curr Opin Neurol 2014, 27:271-278.
    • (2014) Curr Opin Neurol , vol.27 , pp. 271-278
    • Dutta, R.1    Trapp, B.D.2
  • 19
    • 84938520346 scopus 로고    scopus 로고
    • The unfolded protein response in multiple sclerosis
    • Stone S, Lin W The unfolded protein response in multiple sclerosis. Front Neurosci 2015, 9:264.
    • (2015) Front Neurosci , vol.9 , pp. 264
    • Stone, S.1    Lin, W.2
  • 21
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007, 8:519-529.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 22
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008, 29:42-61.
    • (2008) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 23
    • 84855605795 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, obesity and diabetes
    • Cnop M, Foufelle F, Velloso LA Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2012, 18:59-68.
    • (2012) Trends Mol Med , vol.18 , pp. 59-68
    • Cnop, M.1    Foufelle, F.2    Velloso, L.A.3
  • 24
    • 0032522813 scopus 로고    scopus 로고
    • Developing and mature oligodendrocytes respond differently to the immune cytokine interferon-gamma
    • Baerwald KD, Popko B Developing and mature oligodendrocytes respond differently to the immune cytokine interferon-gamma. J Neurosci Res 1998, 52:230-239.
    • (1998) J Neurosci Res , vol.52 , pp. 230-239
    • Baerwald, K.D.1    Popko, B.2
  • 25
    • 0034651029 scopus 로고    scopus 로고
    • Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities
    • Baerwald KD, Corbin JG, Popko B Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities. J Neurosci Res 2000, 59:160-169.
    • (2000) J Neurosci Res , vol.59 , pp. 160-169
    • Baerwald, K.D.1    Corbin, J.G.2    Popko, B.3
  • 26
    • 84927171571 scopus 로고    scopus 로고
    • Application of metabolomics in autoimmune diseases: insight into biomarkers and pathology
    • Kang J, Zhu L, Lu J, Zhang X Application of metabolomics in autoimmune diseases: insight into biomarkers and pathology. J Neuroimmunol 2015, 279:25-32.
    • (2015) J Neuroimmunol , vol.279 , pp. 25-32
    • Kang, J.1    Zhu, L.2    Lu, J.3    Zhang, X.4
  • 27
    • 84857786155 scopus 로고    scopus 로고
    • Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis
    • Noga MJ, Dane A, Shi S, et al. Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics 2012, 8:253-263.
    • (2012) Metabolomics , vol.8 , pp. 253-263
    • Noga, M.J.1    Dane, A.2    Shi, S.3
  • 28
    • 84930178921 scopus 로고    scopus 로고
    • T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
    • Raphael I, Nalawade S, Eagar TN, Forsthuber TG T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine 2015, 74:5-17.
    • (2015) Cytokine , vol.74 , pp. 5-17
    • Raphael, I.1    Nalawade, S.2    Eagar, T.N.3    Forsthuber, T.G.4
  • 29
    • 84862736185 scopus 로고    scopus 로고
    • Mechanisms regulating regional localization of inflammation during CNS autoimmunity
    • Pierson E, Simmons SB, Castelli L, Goverman JM Mechanisms regulating regional localization of inflammation during CNS autoimmunity. Immunol Rev 2012, 248:205-215.
    • (2012) Immunol Rev , vol.248 , pp. 205-215
    • Pierson, E.1    Simmons, S.B.2    Castelli, L.3    Goverman, J.M.4
  • 30
    • 84926369953 scopus 로고    scopus 로고
    • No quiet surrender: Molecular guardians in multiple sclerosis brain
    • Steinman L No quiet surrender: molecular guardians in multiple sclerosis brain. J Clin Invest 2015, 125:1371-1378.
    • (2015) J Clin Invest , vol.125 , pp. 1371-1378
    • Steinman, L.1
  • 32
    • 84901060663 scopus 로고    scopus 로고
    • The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression
    • Trinh MA, Ma T, Kaphzan H, et al. The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem 2014, 21:298-304.
    • (2014) Learn Mem , vol.21 , pp. 298-304
    • Trinh, M.A.1    Ma, T.2    Kaphzan, H.3
  • 33
    • 0842285401 scopus 로고    scopus 로고
    • Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
    • Lu PD, Jousse C, Marciniak SJ, et al. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J 2004, 23:169-179.
    • (2004) EMBO J , vol.23 , pp. 169-179
    • Lu, P.D.1    Jousse, C.2    Marciniak, S.J.3
  • 34
    • 0037441439 scopus 로고    scopus 로고
    • Hypoxia-like tissue injury as a component of multiple sclerosis lesions
    • Lassmann H Hypoxia-like tissue injury as a component of multiple sclerosis lesions. J Neurol Sci 2003, 206:187-191.
    • (2003) J Neurol Sci , vol.206 , pp. 187-191
    • Lassmann, H.1
  • 35
    • 14244254361 scopus 로고    scopus 로고
    • Mitochondrial damage and histotoxic hypoxia: A pathway of tissue injury in inflammatory brain disease?
    • Aboul-Enein F, Lassmann H Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease?. Acta Neuropathol 2005, 109:49-55.
    • (2005) Acta Neuropathol , vol.109 , pp. 49-55
    • Aboul-Enein, F.1    Lassmann, H.2
  • 37
    • 2442679165 scopus 로고    scopus 로고
    • Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter
    • Law M, Saindane AM, Ge Y, et al. Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology 2004, 231:645-652.
    • (2004) Radiology , vol.231 , pp. 645-652
    • Law, M.1    Saindane, A.M.2    Ge, Y.3
  • 38
    • 84912574604 scopus 로고    scopus 로고
    • White matter injury: Ischemic and nonischemic
    • Fern RF, Matute C, Stys PK White matter injury: ischemic and nonischemic. Glia 2014, 62:1780-1789.
    • (2014) Glia , vol.62 , pp. 1780-1789
    • Fern, R.F.1    Matute, C.2    Stys, P.K.3
  • 39
    • 84903206748 scopus 로고    scopus 로고
    • Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases
    • Ghasemi M, Fatemi A Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases. Neurosci Biobehav Rev 2014, 45:168-182.
    • (2014) Neurosci Biobehav Rev , vol.45 , pp. 168-182
    • Ghasemi, M.1    Fatemi, A.2
  • 40
    • 84924228289 scopus 로고    scopus 로고
    • Nitric oxide synthase in innate and adaptive immunity: An update
    • Bogdan C Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol 2015, 36:161-178.
    • (2015) Trends Immunol , vol.36 , pp. 161-178
    • Bogdan, C.1
  • 41
    • 84907024513 scopus 로고    scopus 로고
    • Pathogenesis of multiple sclerosis: Insights from molecular and metabolic imaging
    • Ciccarelli O, Barkhof F, Bodini B, et al. Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging. Lancet Neurol 2014, 13:807-822.
    • (2014) Lancet Neurol , vol.13 , pp. 807-822
    • Ciccarelli, O.1    Barkhof, F.2    Bodini, B.3
  • 42
    • 84906934485 scopus 로고    scopus 로고
    • Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models
    • Schuh C, Wimmer I, Hametner S, et al. Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol 2014, 128:247-266.
    • (2014) Acta Neuropathol , vol.128 , pp. 247-266
    • Schuh, C.1    Wimmer, I.2    Hametner, S.3
  • 43
    • 84873289305 scopus 로고    scopus 로고
    • Heat shock protein 70: Roles in multiple sclerosis
    • Mansilla MJ, Montalban X, Espejo C Heat shock protein 70: roles in multiple sclerosis. Mol Med 2012, 18:1018-1028.
    • (2012) Mol Med , vol.18 , pp. 1018-1028
    • Mansilla, M.J.1    Montalban, X.2    Espejo, C.3
  • 44
    • 84915825982 scopus 로고    scopus 로고
    • Positive or negative involvement of heat shock proteins in multiple sclerosis pathogenesis: an overview
    • Turturici G, Tinnirello R, Sconzo G, et al. Positive or negative involvement of heat shock proteins in multiple sclerosis pathogenesis: an overview. J Neuropathol Exp Neurol 2014, 73:1092-1106.
    • (2014) J Neuropathol Exp Neurol , vol.73 , pp. 1092-1106
    • Turturici, G.1    Tinnirello, R.2    Sconzo, G.3
  • 45
    • 79958728110 scopus 로고    scopus 로고
    • The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
    • Pender MP The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis. Neuroscientist 2011, 17:351-367.
    • (2011) Neuroscientist , vol.17 , pp. 351-367
    • Pender, M.P.1
  • 47
    • 41649097176 scopus 로고    scopus 로고
    • Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
    • Mháille AN, McQuaid S, Windebank A, et al. Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions. J Neuropathol Exp Neurol 2008, 67:200-211.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 200-211
    • Mháille, A.N.1    McQuaid, S.2    Windebank, A.3
  • 48
    • 84867007198 scopus 로고    scopus 로고
    • Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis
    • McMahon JM, McQuaid S, Reynolds R, FitzGerald UF Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis. Mult Scler 2012, 18:1437-1447.
    • (2012) Mult Scler , vol.18 , pp. 1437-1447
    • McMahon, J.M.1    McQuaid, S.2    Reynolds, R.3    FitzGerald, U.F.4
  • 49
    • 79959503183 scopus 로고    scopus 로고
    • Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis
    • Cunnea P, Mháille AN, McQuaid S, Farrell M, McMahon J, FitzGerald U Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis. Mult Scler 2011, 17:808-818.
    • (2011) Mult Scler , vol.17 , pp. 808-818
    • Cunnea, P.1    Mháille, A.N.2    McQuaid, S.3    Farrell, M.4    McMahon, J.5    FitzGerald, U.6
  • 50
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • Kutzelnigg A, Lucchinetti CF, Stadelmann C, et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 2005, 128:2705-2712.
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3
  • 51
    • 0035321510 scopus 로고    scopus 로고
    • Pathological abnormalities in the normal-appearing white matter in multiple sclerosis
    • Allen IV, McQuaid S, Mirakhur M, Nevin G Pathological abnormalities in the normal-appearing white matter in multiple sclerosis. Neurol Sci 2001, 22:141-144.
    • (2001) Neurol Sci , vol.22 , pp. 141-144
    • Allen, I.V.1    McQuaid, S.2    Mirakhur, M.3    Nevin, G.4
  • 52
    • 80555133285 scopus 로고    scopus 로고
    • Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration
    • Deslauriers AM, Afkhami-Goli A, Paul AM, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration. J Immunol 2011, 187:4788-4799.
    • (2011) J Immunol , vol.187 , pp. 4788-4799
    • Deslauriers, A.M.1    Afkhami-Goli, A.2    Paul, A.M.3
  • 53
    • 85005870165 scopus 로고    scopus 로고
    • Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination
    • Ni Fhlathartaigh M, McMahon J, Reynolds R, et al. Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination. Acta Neuropathol Commun 2013, 1:37.
    • (2013) Acta Neuropathol Commun , vol.1 , pp. 37
    • Ni Fhlathartaigh, M.1    McMahon, J.2    Reynolds, R.3
  • 54
    • 0023677710 scopus 로고
    • Multiple sclerosis: Involvement of interferons in lesion pathogenesis
    • Traugott U, Lebon P Multiple sclerosis: involvement of interferons in lesion pathogenesis. Ann Neurol 1988, 24:243-251.
    • (1988) Ann Neurol , vol.24 , pp. 243-251
    • Traugott, U.1    Lebon, P.2
  • 55
    • 22344435167 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma
    • Lin W, Harding HP, Ron D, Popko B Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol 2005, 169:603-612.
    • (2005) J Cell Biol , vol.169 , pp. 603-612
    • Lin, W.1    Harding, H.P.2    Ron, D.3    Popko, B.4
  • 56
    • 8544260349 scopus 로고    scopus 로고
    • Interferon-gamma induced medulloblastoma in the developing cerebellum
    • Lin W, Kemper A, McCarthy KD, et al. Interferon-gamma induced medulloblastoma in the developing cerebellum. J Neurosci 2004, 24:10074-10083.
    • (2004) J Neurosci , vol.24 , pp. 10074-10083
    • Lin, W.1    Kemper, A.2    McCarthy, K.D.3
  • 57
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding HP, Zhang Y, Ron D Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999, 397:271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 58
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
    • Harding HP, Zeng H, Zhang Y, et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 2001, 7:1153-1163.
    • (2001) Mol Cell , vol.7 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3
  • 59
    • 84896319455 scopus 로고    scopus 로고
    • Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination
    • Hussien Y, Cavener DR, Popko B Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination. Glia 2014, 62:680-691.
    • (2014) Glia , vol.62 , pp. 680-691
    • Hussien, Y.1    Cavener, D.R.2    Popko, B.3
  • 60
    • 33846811702 scopus 로고    scopus 로고
    • The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
    • Lin W, Bailey SL, Ho H, et al. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest 2007, 117:448-456.
    • (2007) J Clin Invest , vol.117 , pp. 448-456
    • Lin, W.1    Bailey, S.L.2    Ho, H.3
  • 61
    • 84876001820 scopus 로고    scopus 로고
    • Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis
    • Lin W, Lin Y, Li J, et al. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci 2013, 33:5980-5991.
    • (2013) J Neurosci , vol.33 , pp. 5980-5991
    • Lin, W.1    Lin, Y.2    Li, J.3
  • 62
    • 70450214826 scopus 로고    scopus 로고
    • CHOP and the endoplasmic reticulum stress response in myelinating glia
    • Gow A, Wrabetz L CHOP and the endoplasmic reticulum stress response in myelinating glia. Curr Opin Neurobiol 2009, 19:505-510.
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 505-510
    • Gow, A.1    Wrabetz, L.2
  • 63
    • 35348827324 scopus 로고    scopus 로고
    • That which does not kill me makes me stronger: Adapting to chronic ER stress
    • Rutkowski DT, Kaufman RJ That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci 2007, 32:469-476.
    • (2007) Trends Biochem Sci , vol.32 , pp. 469-476
    • Rutkowski, D.T.1    Kaufman, R.J.2
  • 64
    • 84887620237 scopus 로고    scopus 로고
    • ER stress-induced cell death mechanisms
    • Sano R, Reed JC ER stress-induced cell death mechanisms. Biochim Biophys Acta 2013, 1833:3460-3470.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 3460-3470
    • Sano, R.1    Reed, J.C.2
  • 65
    • 0037079142 scopus 로고    scopus 로고
    • The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease
    • Southwood CM, Garbern J, Jiang W, Gow A The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease. Neuron 2002, 36:585-596.
    • (2002) Neuron , vol.36 , pp. 585-596
    • Southwood, C.M.1    Garbern, J.2    Jiang, W.3    Gow, A.4
  • 66
    • 0035947778 scopus 로고    scopus 로고
    • Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    • Novoa I, Zeng H, Harding HP, Ron D Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 2001, 153:1011-1022.
    • (2001) J Cell Biol , vol.153 , pp. 1011-1022
    • Novoa, I.1    Zeng, H.2    Harding, H.P.3    Ron, D.4
  • 67
    • 55349142516 scopus 로고    scopus 로고
    • Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma
    • Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Am J Pathol 2008, 173:1508-1517.
    • (2008) Am J Pathol , vol.173 , pp. 1508-1517
    • Lin, W.1    Kunkler, P.E.2    Harding, H.P.3    Ron, D.4    Kraig, R.P.5    Popko, B.6
  • 68
    • 13644256191 scopus 로고    scopus 로고
    • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    • Boyce M, Bryant KF, Jousse C, et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005, 307:935-939.
    • (2005) Science , vol.307 , pp. 935-939
    • Boyce, M.1    Bryant, K.F.2    Jousse, C.3
  • 69
    • 79953288480 scopus 로고    scopus 로고
    • Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
    • Tsaytler P, Harding HP, Ron D, Bertolotti A Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 2011, 332:91-94.
    • (2011) Science , vol.332 , pp. 91-94
    • Tsaytler, P.1    Harding, H.P.2    Ron, D.3    Bertolotti, A.4
  • 70
    • 84924891315 scopus 로고    scopus 로고
    • Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic
    • Way SW, Podojil JR, Clayton BL, et al. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun 2015, 6:6532.
    • (2015) Nat Commun , vol.6 , pp. 6532
    • Way, S.W.1    Podojil, J.R.2    Clayton, B.L.3
  • 71
  • 72
    • 0034142394 scopus 로고    scopus 로고
    • Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination
    • Hisahara S, Araki T, Sugiyama F, et al. Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination. EMBO J 2000, 19:341-348.
    • (2000) EMBO J , vol.19 , pp. 341-348
    • Hisahara, S.1    Araki, T.2    Sugiyama, F.3
  • 73
    • 78650652403 scopus 로고    scopus 로고
    • Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination
    • Mc Guire C, Volckaert T, Wolke U, et al. Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J Immunol 2010, 185:7646-7653.
    • (2010) J Immunol , vol.185 , pp. 7646-7653
    • Mc Guire, C.1    Volckaert, T.2    Wolke, U.3
  • 74
    • 33646232737 scopus 로고    scopus 로고
    • Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress
    • Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain 2006, 129:1306-1318.
    • (2006) Brain , vol.129 , pp. 1306-1318
    • Lin, W.1    Kemper, A.2    Dupree, J.L.3    Harding, H.P.4    Ron, D.5    Popko, B.6
  • 75
    • 84892179950 scopus 로고    scopus 로고
    • PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases
    • Lin Y, Huang G, Jamison S, et al. PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases. Am J Pathol 2014, 184:507-519.
    • (2014) Am J Pathol , vol.184 , pp. 507-519
    • Lin, Y.1    Huang, G.2    Jamison, S.3
  • 77
    • 0035198691 scopus 로고    scopus 로고
    • The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    • Matsushima GK, Morell P The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 2001, 11:107-116.
    • (2001) Brain Pathol , vol.11 , pp. 107-116
    • Matsushima, G.K.1    Morell, P.2
  • 78
    • 0037416211 scopus 로고    scopus 로고
    • Stress-induced gene expression requires programmed recovery from translational repression
    • Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D Stress-induced gene expression requires programmed recovery from translational repression. EMBO J 2003, 22:1180-1187.
    • (2003) EMBO J , vol.22 , pp. 1180-1187
    • Novoa, I.1    Zhang, Y.2    Zeng, H.3    Jungreis, R.4    Harding, H.P.5    Ron, D.6
  • 80
    • 84876442021 scopus 로고    scopus 로고
    • Oligodendrocyte dynamics in the healthy adult CNS: Evidence for myelin remodeling
    • Young KM, Psachoulia K, Tripathi RB, et al. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 2013, 77:873-885.
    • (2013) Neuron , vol.77 , pp. 873-885
    • Young, K.M.1    Psachoulia, K.2    Tripathi, R.B.3
  • 81
    • 55049091909 scopus 로고    scopus 로고
    • Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system
    • Watkins TA, Emery B, Mulinyawe S, Barres BA Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron 2008, 60:555-569.
    • (2008) Neuron , vol.60 , pp. 555-569
    • Watkins, T.A.1    Emery, B.2    Mulinyawe, S.3    Barres, B.A.4
  • 82
    • 84927619395 scopus 로고    scopus 로고
    • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
    • Das I, Krzyzosiak A, Schneider K, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 2015, 348:239-242.
    • (2015) Science , vol.348 , pp. 239-242
    • Das, I.1    Krzyzosiak, A.2    Schneider, K.3
  • 83
    • 0017140340 scopus 로고
    • Studies on the centrally mediated hypotensive activity of guanabenz
    • Baum T, Shropshire AT Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol 1976, 37:31-44.
    • (1976) Eur J Pharmacol , vol.37 , pp. 31-44
    • Baum, T.1    Shropshire, A.T.2
  • 84
    • 84908019225 scopus 로고    scopus 로고
    • Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost α2-adrenergic receptor agonistic activity
    • Nguyen PH, Hammoud H, Halliez S, et al. Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost α2-adrenergic receptor agonistic activity. ACS Chem Neurosci 2014, 5:1075-1082.
    • (2014) ACS Chem Neurosci , vol.5 , pp. 1075-1082
    • Nguyen, P.H.1    Hammoud, H.2    Halliez, S.3
  • 86
    • 84922823156 scopus 로고    scopus 로고
    • Human oligodendrocytes in remyelination research
    • Czepiel M, Boddeke E, Copray S Human oligodendrocytes in remyelination research. Glia 2015, 63:513-530.
    • (2015) Glia , vol.63 , pp. 513-530
    • Czepiel, M.1    Boddeke, E.2    Copray, S.3
  • 88
    • 84939128477 scopus 로고    scopus 로고
    • An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies
    • McClorey G, Wood MJ An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies. Curr Opin Pharmacol 2015, 24:52-58.
    • (2015) Curr Opin Pharmacol , vol.24 , pp. 52-58
    • McClorey, G.1    Wood, M.J.2
  • 89
    • 84879958098 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Treating neurodegeneration at the level of RNA
    • DeVos SL, Miller TM Antisense oligonucleotides: treating neurodegeneration at the level of RNA. Neurotherapeutics 2013, 10:486-497.
    • (2013) Neurotherapeutics , vol.10 , pp. 486-497
    • DeVos, S.L.1    Miller, T.M.2
  • 90
    • 84929687810 scopus 로고    scopus 로고
    • Choosing the right tool for the job: RNAi, TALEN, or CRISPR
    • Boettcher M, McManus MT Choosing the right tool for the job: RNAi, TALEN, or CRISPR. Mol Cell 2015, 58:575-585.
    • (2015) Mol Cell , vol.58 , pp. 575-585
    • Boettcher, M.1    McManus, M.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.