Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination

Acta Neuropathologica Communications

Volumn 2, Issue 1, 2014, Pages

  Ní Fhlathartaigh, Mary ^a   McMahon, Jill ^a   Reynolds, Richard ^b   Connolly, David ^a   Higgins, Eibhlín ^c   Counihan, Timothy ^c   FitzGerald, Una ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY HOSPITAL GALWAY   (Ireland)

Author keywords

Calreticulin; EAE; ER stress; Multiple sclerosis; Spinal cord demyelination

Indexed keywords

EID: 85005870165     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/2051-5960-1-37     Document Type: Article

References (30)

1. Antony JM, Ellestad KK, Hammond R, Imaizumi K, Mallet F, Warren KG, Power C: The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes. J Immunol 2007, 179: 1210-1224.
2. Cunnea P, Mhaille AN, McQuaid S, Farrell M, McMahon J, FitzGerald U: Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis. Mult Scler 2011, 17: 808-818. 10.1177/1352458511399114
3. McMahon J, McQuaid S, Reynolds R, Fitzgerald U: Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis. Mult Scler 2012, 17: 1437-1447.
4. Mhaille AN, McQuaid S, Windebank A, Cunnea P, McMahon J, Samali A, FitzGerald U: Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions. J Neuropathol Exp Neurol 2008, 67: 200-211. 10.1097/NEN.0b013e318165b239
5. Walter P, Ron D: The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011, 334: 1081-1086. 10.1126/science.1209038
6. Szegezdi E, Logue SE, Gorman AM, Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006, 7: 880-885. 10.1038/sj.embor.7400779
7. Michalak M, Groenendyk J, Szabo E, Gold LI, Opas M: Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 2009, 417: 651-666. 10.1042/BJ20081847
8. Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor SM, Michalak M, Murphy-Ullrich JE: Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J 2010, 24: 665-683. 10.1096/fj.09-145482
9. Wang WA, Groenendyk J, Michalak M: Calreticulin signaling in health and disease. Int J Biochem Cell Biol 2012, 44: 842-846. 10.1016/j.biocel.2012.02.009
10. Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM: Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 2005, 123: 321-334. 10.1016/j.cell.2005.08.032
11. Ogden CA, de Cathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM: C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001, 194: 781-795. 10.1084/jem.194.6.781
12. Kishore U, Sontheimer RD, Sastry KN, Zaner KS, Zappi EG, Hughes GR, Khamashta MA, Strong P, Reid KB, Eggleton P: Release of calreticulin from neutrophils may alter C1q-mediated immune functions. Biochem J 1997,322(Pt 2):543-550.
13. Peters LR, Raghavan M: Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells. J Immunol 2011, 187: 919-931. 10.4049/jimmunol.1100690
14. Holoshitz J, De Almeida DE, Ling S: A role for calreticulin in the pathogenesis of rheumatoid arthritis. Ann N Y Acad Sci 2010, 1209: 91-98. 10.1111/j.1749-6632.2010.05745.x
15. Chakrabarty A, Danley MM, LeVine SM: Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2 alpha in the central nervous system of SJL mice with experimental allergic encephalomyelitis. J Neurosci Res 2004, 76: 822-833. 10.1002/jnr.20125
16. Chakrabarty A, Fleming K, Marquis J, LeVine S: Quantifying immunohistochemical staining of phospho-eIF2alpha, heme oxygenase-2 and NADPH cytochrome P450 reductase in oligodendrocytes during experimental autoimmune encephalomyelitis. J Neurosci Methods 2005, 144: 227-234. 10.1016/j.jneumeth.2004.11.010
17. Deslauriers AM, Afkhami-Goli A, Paul AM, Bhat RK, Acharjee S, Ellestad KK, Noorbakhsh F, Michalak M, Power C: Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration. J Immunol 2011, 187: 4788-4799. 10.4049/jimmunol.1004111
18. Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B: The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest 2007, 117: 448-456. 10.1172/JCI29571
19. Lin W, Kemper A, Dupree J, Harding H, Ron D, Popko B: Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain 2006, 129: 1306-1318. 10.1093/brain/awl044
20. Lin W, Popko B: Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci 2009, 12: 379-385. 10.1038/nn.2273
21. Eggleton P, Lieu TS, Zappi EG, Sastry K, Coburn J, Zaner KS, Sontheimer RD, Capra JD, Ghebrehiwet B, Tauber AI: Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. Clin Immunol Immunopathol 1994, 72: 405-409. 10.1006/clin.1994.1160
22. Andrin C, Pinkoski MJ, Burns K, Atkinson EA, Krahenbuhl O, Hudig D, Fraser SA, Winkler U, Tschopp J, Opas M, et al.: Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. Biochemistry 1998, 37: 10386-10394. 10.1021/bi980595z
23. Sipione S, Ewen C, Shostak I, Michalak M, Bleackley RC: Impaired cytolytic activity in calreticulin-deficient CTLs. J Immunol 2005, 174: 3212-3219.
24. Paidassi H, Tacnet-Delorme P, Verneret M, Gaboriaud C, Houen G, Duus K, Ling WL, Arlaud GJ, Frachet P: Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition. J Mol Biol 2011, 408: 277-290. 10.1016/j.jmb.2011.02.029
25. Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P: A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol 2010, 401: 799-812. 10.1016/j.jmb.2010.06.064
26. Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, Castedo M, Mignot G, Panaretakis T, Casares N, et al.: Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007, 13: 54-61. 10.1038/nm1523
27. Tarr JM, Winyard PG, Ryan B, Harries LW, Haigh R, Viner N, Eggleton P: Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells. Arthritis Rheum 2010, 62: 2919-2929. 10.1002/art.27602
28. Shields AM, Panayi GS, Corrigall VM: Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis? Clin Exp Immunol 2011, 165: 292-300. 10.1111/j.1365-2249.2011.04433.x
29. Reynolds R, Dawson M, Papadopoulos D, Polito A, Di Bello IC, Pham-Dinh D, Levine J: The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS. J Neurocytol 2002, 31: 523-536. 10.1023/A:1025747832215
30. Storch MK, Piddlesden S, Haltia M, Iivanainen M, Morgan P, Lassmann H: Multiple sclerosis: in situ evidence for antibody and complement-mediated demyelination. Annals of Neurology 1998, 43: 465-471. 10.1002/ana.410430409