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Volumn 279, Issue C, 2015, Pages 25-32

Application of metabolomics in autoimmune diseases: Insight into biomarkers and pathology

Author keywords

Autoimmune diseases; Biomarkers; Mass spectrometry; Metabolomics; Nuclear magnetic resonance

Indexed keywords

BIOLOGICAL MARKER;

EID: 84927171571     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2015.01.001     Document Type: Review
Times cited : (66)

References (83)
  • 3
    • 84904606414 scopus 로고    scopus 로고
    • Application of PTR-TOF-MS to investigate metabolites in exhaled breath of patients affected by coeliac disease under gluten free diet
    • Aprea E., Cappellin L., Gasperi F., Morisco F., Lembo V., Rispo A., et al. Application of PTR-TOF-MS to investigate metabolites in exhaled breath of patients affected by coeliac disease under gluten free diet. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2014, 966:208-213.
    • (2014) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.966 , pp. 208-213
    • Aprea, E.1    Cappellin, L.2    Gasperi, F.3    Morisco, F.4    Lembo, V.5    Rispo, A.6
  • 4
    • 55949096821 scopus 로고    scopus 로고
    • Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale
    • Bakshi R., Neema M., Healy B.C., Liptak Z., Betensky R.A., Buckle G.J., et al. Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Arch. Neurol. 2008, 65:1449-1453.
    • (2008) Arch. Neurol. , vol.65 , pp. 1449-1453
    • Bakshi, R.1    Neema, M.2    Healy, B.C.3    Liptak, Z.4    Betensky, R.A.5    Buckle, G.J.6
  • 5
    • 79955425273 scopus 로고    scopus 로고
    • Are patients with potential celiac disease really potential? The answer of metabonomics
    • Bernini P., Bertini I., Calabro A., la Marca G., Lami G., Luchinat C., et al. Are patients with potential celiac disease really potential? The answer of metabonomics. J. Proteome Res. 2011, 10:714-721.
    • (2011) J. Proteome Res. , vol.10 , pp. 714-721
    • Bernini, P.1    Bertini, I.2    Calabro, A.3    la Marca, G.4    Lami, G.5    Luchinat, C.6
  • 7
    • 84904104045 scopus 로고    scopus 로고
    • Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis
    • Bradford C.M., Ramos I., Cross A.K., Haddock G., McQuaid S., Nicholas A.P., et al. Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. J. Neuroimmunol. 2014, 273:85-95.
    • (2014) J. Neuroimmunol. , vol.273 , pp. 85-95
    • Bradford, C.M.1    Ramos, I.2    Cross, A.K.3    Haddock, G.4    McQuaid, S.5    Nicholas, A.P.6
  • 8
    • 84863815920 scopus 로고    scopus 로고
    • Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus
    • Brugnara L., Vinaixa M., Murillo S., Samino S., Rodriguez M.A., Beltran A., et al. Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus. PLoS One 2012, 7:e40600.
    • (2012) PLoS One , vol.7
    • Brugnara, L.1    Vinaixa, M.2    Murillo, S.3    Samino, S.4    Rodriguez, M.A.5    Beltran, A.6
  • 9
    • 84891801816 scopus 로고    scopus 로고
    • Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases
    • Dawiskiba T., Deja S., Mulak A., Zabek A., Jawien E., Pawelka D., et al. Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases. World J. Gastroenterol. 2014, 20:163-174.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 163-174
    • Dawiskiba, T.1    Deja, S.2    Mulak, A.3    Zabek, A.4    Jawien, E.5    Pawelka, D.6
  • 10
    • 79960659221 scopus 로고    scopus 로고
    • A targeted lipidomics approach to the study of eicosanoid release in synovial joints
    • de Grauw J.C., van de Lest C.H., van Weeren P.R. A targeted lipidomics approach to the study of eicosanoid release in synovial joints. Arthritis Res. Ther. 2011, 13:R123.
    • (2011) Arthritis Res. Ther. , vol.13
    • de Grauw, J.C.1    van de Lest, C.H.2    van Weeren, P.R.3
  • 11
    • 0142028206 scopus 로고    scopus 로고
    • Is Devic's neuromyelitis optica a separate disease? A comparative study with multiple sclerosis
    • de Seze J., Lebrun C., Stojkovic T., Ferriby D., Chatel M., Vermersch P. Is Devic's neuromyelitis optica a separate disease? A comparative study with multiple sclerosis. Mult. Scler. 2003, 9:521-525.
    • (2003) Mult. Scler. , vol.9 , pp. 521-525
    • de Seze, J.1    Lebrun, C.2    Stojkovic, T.3    Ferriby, D.4    Chatel, M.5    Vermersch, P.6
  • 12
    • 84904623206 scopus 로고    scopus 로고
    • Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling
    • Dieme B., Halimi J.M., Emond P., Buchler M., Nadal-Desbarat L., Blasco H., et al. Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling. Transplantation 2014, 98:195-201.
    • (2014) Transplantation , vol.98 , pp. 195-201
    • Dieme, B.1    Halimi, J.M.2    Emond, P.3    Buchler, M.4    Nadal-Desbarat, L.5    Blasco, H.6
  • 13
    • 84922391466 scopus 로고    scopus 로고
    • Metabolomics analysis of collagen-induced arthritis in rats and interventional effects of oral tolerance
    • Ding X., Hu J., Li J., Zhang Y., Shui B., Ding Z., et al. Metabolomics analysis of collagen-induced arthritis in rats and interventional effects of oral tolerance. Anal. Biochem. 2014, 458:49-57.
    • (2014) Anal. Biochem. , vol.458 , pp. 49-57
    • Ding, X.1    Hu, J.2    Li, J.3    Zhang, Y.4    Shui, B.5    Ding, Z.6
  • 15
    • 84860587743 scopus 로고    scopus 로고
    • Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes
    • Dutta T., Chai H.S., Ward L.E., Ghosh A., Persson X.M., Ford G.C., et al. Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes. Diabetes 2012, 61:1004-1016.
    • (2012) Diabetes , vol.61 , pp. 1004-1016
    • Dutta, T.1    Chai, H.S.2    Ward, L.E.3    Ghosh, A.4    Persson, X.M.5    Ford, G.C.6
  • 18
    • 84865281324 scopus 로고    scopus 로고
    • Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS
    • Giera M., Ioan-Facsinay A., Toes R., Gao F., Dalli J., Deelder A.M., et al. Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. Biochim. Biophys. Acta 2012, 1821:1415-1424.
    • (2012) Biochim. Biophys. Acta , vol.1821 , pp. 1415-1424
    • Giera, M.1    Ioan-Facsinay, A.2    Toes, R.3    Gao, F.4    Dalli, J.5    Deelder, A.M.6
  • 19
    • 84859842078 scopus 로고    scopus 로고
    • Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry
    • Gu Y., Lu C., Zha Q., Kong H., Lu X., Lu A., et al. Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry. Mol. Biosyst. 2012, 8:1535-1543.
    • (2012) Mol. Biosyst. , vol.8 , pp. 1535-1543
    • Gu, Y.1    Lu, C.2    Zha, Q.3    Kong, H.4    Lu, X.5    Lu, A.6
  • 20
    • 34548239152 scopus 로고    scopus 로고
    • Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    • Haskell W.L., Lee I.M., Pate R.R., Powell K.E., Blair S.N., Franklin B.A., et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med. Sci. Sports Exerc. 2007, 39:1423-1434.
    • (2007) Med. Sci. Sports Exerc. , vol.39 , pp. 1423-1434
    • Haskell, W.L.1    Lee, I.M.2    Pate, R.R.3    Powell, K.E.4    Blair, S.N.5    Franklin, B.A.6
  • 24
    • 84878553614 scopus 로고    scopus 로고
    • Metabolic profiling predicts response to anti-tumor necrosis factor alpha therapy in patients with rheumatoid arthritis
    • Kapoor S.R., Filer A., Fitzpatrick M.A., Fisher B.A., Taylor P.C., Buckley C.D., et al. Metabolic profiling predicts response to anti-tumor necrosis factor alpha therapy in patients with rheumatoid arthritis. Arthritis Rheum. 2013, 65:1448-1456.
    • (2013) Arthritis Rheum. , vol.65 , pp. 1448-1456
    • Kapoor, S.R.1    Filer, A.2    Fitzpatrick, M.A.3    Fisher, B.A.4    Taylor, P.C.5    Buckley, C.D.6
  • 25
    • 84871579721 scopus 로고    scopus 로고
    • Metabolomic profiling as a useful tool for diagnosis and treatment of chronic disease: focus on obesity, diabetes and cardiovascular diseases
    • Kim O.Y., Lee J.H., Sweeney G. Metabolomic profiling as a useful tool for diagnosis and treatment of chronic disease: focus on obesity, diabetes and cardiovascular diseases. Expert. Rev. Cardiovasc. Ther. 2013, 11:61-68.
    • (2013) Expert. Rev. Cardiovasc. Ther. , vol.11 , pp. 61-68
    • Kim, O.Y.1    Lee, J.H.2    Sweeney, G.3
  • 26
    • 84873694411 scopus 로고    scopus 로고
    • Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS
    • Kirov I.I., Tal A., Babb J.S., Herbert J., Gonen O. Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS. Neurology 2013, 80:39-46.
    • (2013) Neurology , vol.80 , pp. 39-46
    • Kirov, I.I.1    Tal, A.2    Babb, J.S.3    Herbert, J.4    Gonen, O.5
  • 28
    • 84890865912 scopus 로고    scopus 로고
    • High-resolution NMR spectroscopy of human body fluids and tissues in relation to prostate cancer
    • Kumar V., Dwivedi D.K., Jagannathan N.R. High-resolution NMR spectroscopy of human body fluids and tissues in relation to prostate cancer. NMR Biomed. 2014, 27:80-89.
    • (2014) NMR Biomed. , vol.27 , pp. 80-89
    • Kumar, V.1    Dwivedi, D.K.2    Jagannathan, N.R.3
  • 31
    • 84903579643 scopus 로고    scopus 로고
    • Cerebrospinal fluid analysis in Alzheimer's disease: technical issues and future developments
    • Lista S., Zetterberg H., Dubois B., Blennow K., Hampel H. Cerebrospinal fluid analysis in Alzheimer's disease: technical issues and future developments. J. Neurol. 2014, 261:1234-1243.
    • (2014) J. Neurol. , vol.261 , pp. 1234-1243
    • Lista, S.1    Zetterberg, H.2    Dubois, B.3    Blennow, K.4    Hampel, H.5
  • 32
    • 84867459282 scopus 로고    scopus 로고
    • Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism
    • Lu K., Knutson C.G., Wishnok J.S., Fox J.G., Tannenbaum S.R. Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism. J. Proteome Res. 2012, 11:4916-4926.
    • (2012) J. Proteome Res. , vol.11 , pp. 4916-4926
    • Lu, K.1    Knutson, C.G.2    Wishnok, J.S.3    Fox, J.G.4    Tannenbaum, S.R.5
  • 33
    • 39349098408 scopus 로고    scopus 로고
    • Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid
    • Lutz N.W., Viola A., Malikova I., Confort-Gouny S., Audoin B., Ranjeva J.P., et al. Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid. PLoS One 2007, 2:e595.
    • (2007) PLoS One , vol.2
    • Lutz, N.W.1    Viola, A.2    Malikova, I.3    Confort-Gouny, S.4    Audoin, B.5    Ranjeva, J.P.6
  • 34
    • 0027320272 scopus 로고
    • Nuclear magnetic resonance study of cerebrospinal fluid from patients with multiple sclerosis
    • Lynch J., Peeling J., Auty A., Sutherland G.R. Nuclear magnetic resonance study of cerebrospinal fluid from patients with multiple sclerosis. Can. J. Neurol. Sci. 1993, 20:194-198.
    • (1993) Can. J. Neurol. Sci. , vol.20 , pp. 194-198
    • Lynch, J.1    Peeling, J.2    Auty, A.3    Sutherland, G.R.4
  • 37
    • 84921325742 scopus 로고    scopus 로고
    • Profile of circulatory metabolites in a relapsing-remitting animal model of multiple sclerosis using global metabolomics
    • Mangalam A., Poisson L., Nemutlu E., Datta I., Denic A., Dzeja P., et al. Profile of circulatory metabolites in a relapsing-remitting animal model of multiple sclerosis using global metabolomics. J. Clin. Cell. Immunol. 2013, 4.
    • (2013) J. Clin. Cell. Immunol. , vol.4
    • Mangalam, A.1    Poisson, L.2    Nemutlu, E.3    Datta, I.4    Denic, A.5    Dzeja, P.6
  • 39
    • 84872373700 scopus 로고    scopus 로고
    • A metabonomics investigation of multiple sclerosis by nuclear magnetic resonance
    • Mehrpour M., Kyani A., Tafazzoli M., Fathi F., Joghataie M.T. A metabonomics investigation of multiple sclerosis by nuclear magnetic resonance. Magn. Reson. Chem. 2013, 51:102-109.
    • (2013) Magn. Reson. Chem. , vol.51 , pp. 102-109
    • Mehrpour, M.1    Kyani, A.2    Tafazzoli, M.3    Fathi, F.4    Joghataie, M.T.5
  • 40
    • 84890185204 scopus 로고    scopus 로고
    • Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach
    • Menni C., Fauman E., Erte I., Perry J.R., Kastenmuller G., Shin S.Y., et al. Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes 2013, 62:4270-4276.
    • (2013) Diabetes , vol.62 , pp. 4270-4276
    • Menni, C.1    Fauman, E.2    Erte, I.3    Perry, J.R.4    Kastenmuller, G.5    Shin, S.Y.6
  • 42
    • 77954795886 scopus 로고    scopus 로고
    • Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis
    • Mohanty S.T., Kottam L., Gambardella A., Nicklin M.J., Coulton L., Hughes D., et al. Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis. Arthritis Res. Ther. 2010, 12:R149.
    • (2010) Arthritis Res. Ther. , vol.12
    • Mohanty, S.T.1    Kottam, L.2    Gambardella, A.3    Nicklin, M.J.4    Coulton, L.5    Hughes, D.6
  • 44
    • 67349119500 scopus 로고    scopus 로고
    • Bile acids conjugation in human bile is not random: new insights from (1)H-NMR spectroscopy at 800MHz
    • Nagana Gowda G.A., Shanaiah N., Cooper A., Maluccio M., Raftery D. Bile acids conjugation in human bile is not random: new insights from (1)H-NMR spectroscopy at 800MHz. Lipids 2009, 44:527-535.
    • (2009) Lipids , vol.44 , pp. 527-535
    • Nagana Gowda, G.A.1    Shanaiah, N.2    Cooper, A.3    Maluccio, M.4    Raftery, D.5
  • 45
    • 84903169829 scopus 로고    scopus 로고
    • Method validation strategies involved in non-targeted metabolomics
    • Naz S., Vallejo M., Garcia A., Barbas C. Method validation strategies involved in non-targeted metabolomics. J. Chromatogr. A 2014, 1353:99-105.
    • (2014) J. Chromatogr. A , vol.1353 , pp. 99-105
    • Naz, S.1    Vallejo, M.2    Garcia, A.3    Barbas, C.4
  • 46
    • 0029786339 scopus 로고    scopus 로고
    • Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy
    • Nicoli F., Vion-Dury J., Confort-Gouny S., Maillet S., Gastaut J.L., Cozzone P.J. Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy. C. R. Acad. Sci. III 1996, 319:623-631.
    • (1996) C. R. Acad. Sci. III , vol.319 , pp. 623-631
    • Nicoli, F.1    Vion-Dury, J.2    Confort-Gouny, S.3    Maillet, S.4    Gastaut, J.L.5    Cozzone, P.J.6
  • 47
    • 84857786155 scopus 로고    scopus 로고
    • Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis
    • Noga M.J., Dane A., Shi S., Attali A., van Aken H., Suidgeest E., et al. Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics 2012, 8:253-263.
    • (2012) Metabolomics , vol.8 , pp. 253-263
    • Noga, M.J.1    Dane, A.2    Shi, S.3    Attali, A.4    van Aken, H.5    Suidgeest, E.6
  • 48
    • 81555223869 scopus 로고    scopus 로고
    • (1)H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus
    • Ouyang X., Dai Y., Wen J.L., Wang L.X. (1)H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus. Lupus 2011, 20:1411-1420.
    • (2011) Lupus , vol.20 , pp. 1411-1420
    • Ouyang, X.1    Dai, Y.2    Wen, J.L.3    Wang, L.X.4
  • 49
    • 84884352609 scopus 로고    scopus 로고
    • Rethinking mechanisms of autoimmune pathogenesis
    • Pillai S. Rethinking mechanisms of autoimmune pathogenesis. J. Autoimmun. 2013, 45:97-103.
    • (2013) J. Autoimmun. , vol.45 , pp. 97-103
    • Pillai, S.1
  • 50
    • 79956144004 scopus 로고    scopus 로고
    • Metabolite profiling of hemodialysate using gas chromatography time-of-flight mass spectrometry
    • Qi X., Zhang Y., Gao J., Chen T., Zhao A., Yan Y., et al. Metabolite profiling of hemodialysate using gas chromatography time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 2011, 55:1142-1147.
    • (2011) J. Pharm. Biomed. Anal. , vol.55 , pp. 1142-1147
    • Qi, X.1    Zhang, Y.2    Gao, J.3    Chen, T.4    Zhao, A.5    Yan, Y.6
  • 51
    • 55649118665 scopus 로고    scopus 로고
    • Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression
    • Regenold W.T., Phatak P., Makley M.J., Stone R.D., Kling M.A. Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression. J. Neurol. Sci. 2008, 275:106-112.
    • (2008) J. Neurol. Sci. , vol.275 , pp. 106-112
    • Regenold, W.T.1    Phatak, P.2    Makley, M.J.3    Stone, R.D.4    Kling, M.A.5
  • 52
    • 84924043802 scopus 로고    scopus 로고
    • Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis
    • Reinke S., Broadhurst D., Sykes B., Baker G., Catz I., Warren K., et al. Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis. Mult. Scler. 2014, 20:1396-1400.
    • (2014) Mult. Scler. , vol.20 , pp. 1396-1400
    • Reinke, S.1    Broadhurst, D.2    Sykes, B.3    Baker, G.4    Catz, I.5    Warren, K.6
  • 54
    • 85016485003 scopus 로고    scopus 로고
    • Influence of freezing and storage procedure on human urine samples in NMR-based metabolomics
    • Rist M.J., Muhle-Goll C., Gorling B., Bub A., Heissler S., Watzl B., et al. Influence of freezing and storage procedure on human urine samples in NMR-based metabolomics. Metabolites 2013, 3:243-258.
    • (2013) Metabolites , vol.3 , pp. 243-258
    • Rist, M.J.1    Muhle-Goll, C.2    Gorling, B.3    Bub, A.4    Heissler, S.5    Watzl, B.6
  • 56
    • 84861808541 scopus 로고    scopus 로고
    • Quantitative metabolomic profiling of serum, plasma, and urine by (1)H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals
    • Schicho R., Shaykhutdinov R., Ngo J., Nazyrova A., Schneider C., Panaccione R., et al. Quantitative metabolomic profiling of serum, plasma, and urine by (1)H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals. J. Proteome Res. 2012, 11:3344-3357.
    • (2012) J. Proteome Res. , vol.11 , pp. 3344-3357
    • Schicho, R.1    Shaykhutdinov, R.2    Ngo, J.3    Nazyrova, A.4    Schneider, C.5    Panaccione, R.6
  • 57
    • 80052331120 scopus 로고    scopus 로고
    • Questions persist: environmental factors in autoimmune disease
    • Schmidt C.W. Questions persist: environmental factors in autoimmune disease. Environ. Health Perspect. 2011, 119:A249-A253.
    • (2011) Environ. Health Perspect. , vol.119 , pp. A249-A253
    • Schmidt, C.W.1
  • 59
    • 84863393163 scopus 로고    scopus 로고
    • Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants
    • Sellitto M., Bai G., Serena G., Fricke W.F., Sturgeon C., Gajer P., et al. Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS One 2012, 7:e33387.
    • (2012) PLoS One , vol.7
    • Sellitto, M.1    Bai, G.2    Serena, G.3    Fricke, W.F.4    Sturgeon, C.5    Gajer, P.6
  • 60
    • 0030459305 scopus 로고    scopus 로고
    • High resolution proton MR spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaques
    • Simone I.L., Federico F., Trojano M., Tortorella C., Liguori M., Giannini P., et al. High resolution proton MR spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaques. J. Neurol. Sci. 1996, 144:182-190.
    • (1996) J. Neurol. Sci. , vol.144 , pp. 182-190
    • Simone, I.L.1    Federico, F.2    Trojano, M.3    Tortorella, C.4    Liguori, M.5    Giannini, P.6
  • 61
    • 77149179378 scopus 로고    scopus 로고
    • NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases-a diagnostic tool?
    • Sinclair A.J., Viant M.R., Ball A.K., Burdon M.A., Walker E.A., Stewart P.M., et al. NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases-a diagnostic tool?. NMR Biomed. 2010, 23:123-132.
    • (2010) NMR Biomed. , vol.23 , pp. 123-132
    • Sinclair, A.J.1    Viant, M.R.2    Ball, A.K.3    Burdon, M.A.4    Walker, E.A.5    Stewart, P.M.6
  • 62
    • 80053901173 scopus 로고    scopus 로고
    • NMR and pattern recognition can distinguish neuroinflammation and peripheral inflammation
    • Smolinska A., Attali A., Blanchet L., Ampt K., Tuinstra T., van Aken H., et al. NMR and pattern recognition can distinguish neuroinflammation and peripheral inflammation. J. Proteome Res. 2011, 10:4428-4438.
    • (2011) J. Proteome Res. , vol.10 , pp. 4428-4438
    • Smolinska, A.1    Attali, A.2    Blanchet, L.3    Ampt, K.4    Tuinstra, T.5    van Aken, H.6
  • 63
    • 77954543178 scopus 로고    scopus 로고
    • Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
    • Surolia I., Pirnie S.P., Chellappa V., Taylor K.N., Cariappa A., Moya J., et al. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 2010, 466:243-247.
    • (2010) Nature , vol.466 , pp. 243-247
    • Surolia, I.1    Pirnie, S.P.2    Chellappa, V.3    Taylor, K.N.4    Cariappa, A.5    Moya, J.6
  • 64
    • 84875207012 scopus 로고    scopus 로고
    • Metabonomic analysis of rats with acute heart rejection
    • Tao M., Xiu D.R. Metabonomic analysis of rats with acute heart rejection. Transplant. Proc. 2013, 45:618-624.
    • (2013) Transplant. Proc. , vol.45 , pp. 618-624
    • Tao, M.1    Xiu, D.R.2
  • 65
    • 84879901141 scopus 로고    scopus 로고
    • Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease
    • Tso V.K., Sydora B.C., Foshaug R.R., Churchill T.A., Doyle J., Slupsky C.M., et al. Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. PLoS One 2013, 8:e67654.
    • (2013) PLoS One , vol.8
    • Tso, V.K.1    Sydora, B.C.2    Foshaug, R.R.3    Churchill, T.A.4    Doyle, J.5    Slupsky, C.M.6
  • 66
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: etiology, immunology, and therapeutic strategies
    • van Belle T.L., Coppieters K.T., von Herrath M.G. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol. Rev. 2011, 91:79-118.
    • (2011) Physiol. Rev. , vol.91 , pp. 79-118
    • van Belle, T.L.1    Coppieters, K.T.2    von Herrath, M.G.3
  • 67
    • 84866316346 scopus 로고    scopus 로고
    • Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements
    • van Wietmarschen H.A., Dai W., van der Kooij A.J., Reijmers T.H., Schroen Y., Wang M., et al. Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements. PLoS One 2012, 7:e44331.
    • (2012) PLoS One , vol.7
    • van Wietmarschen, H.A.1    Dai, W.2    van der Kooij, A.J.3    Reijmers, T.H.4    Schroen, Y.5    Wang, M.6
  • 68
    • 84880034564 scopus 로고    scopus 로고
    • Metabolomic approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis
    • Vingara L.K., Yu H.J., Wagshul M.E., Serafin D., Christodoulou C., Pelczer I., et al. Metabolomic approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis. Neuroimage 2013, 82:586-594.
    • (2013) Neuroimage , vol.82 , pp. 586-594
    • Vingara, L.K.1    Yu, H.J.2    Wagshul, M.E.3    Serafin, D.4    Christodoulou, C.5    Pelczer, I.6
  • 69
    • 84907810821 scopus 로고    scopus 로고
    • The importance of sulfur-containing metabolites in discriminating fecal extracts between normal and type 2 diabetic mice
    • Walker A., Lucio M., Pfitzner B., Scheerer M.F., Neschen S., Hrabe de Angelis M., et al. The importance of sulfur-containing metabolites in discriminating fecal extracts between normal and type 2 diabetic mice. J. Proteome Res. 2014, 13:4220-4231.
    • (2014) J. Proteome Res. , vol.13 , pp. 4220-4231
    • Walker, A.1    Lucio, M.2    Pfitzner, B.3    Scheerer, M.F.4    Neschen, S.5    Hrabe de Angelis, M.6
  • 70
    • 0033925221 scopus 로고    scopus 로고
    • Epidemiology of multiple sclerosis in US veterans. VIII. Long-term survival after onset of multiple sclerosis
    • Wallin M.T., Page W.F., Kurtzke J.F. Epidemiology of multiple sclerosis in US veterans. VIII. Long-term survival after onset of multiple sclerosis. Brain 2000, 123(Pt 8):1677-1687.
    • (2000) Brain , vol.123 , pp. 1677-1687
    • Wallin, M.T.1    Page, W.F.2    Kurtzke, J.F.3
  • 71
    • 84865789779 scopus 로고    scopus 로고
    • (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis
    • Wang Z., Chen Z., Yang S., Wang Y., Yu L., Zhang B., et al. (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis. Exp. Ther. Med. 2012, 4:165-171.
    • (2012) Exp. Ther. Med. , vol.4 , pp. 165-171
    • Wang, Z.1    Chen, Z.2    Yang, S.3    Wang, Y.4    Yu, L.5    Zhang, B.6
  • 72
    • 84905401826 scopus 로고    scopus 로고
    • Metabolomic profiling of autoimmune hepatitis: the diagnostic utility of nuclear magnetic resonance spectroscopy
    • Wang J.B., Pu S.B., Sun Y., Li Z.F., Niu M., Yan X.Z., et al. Metabolomic profiling of autoimmune hepatitis: the diagnostic utility of nuclear magnetic resonance spectroscopy. J. Proteome Res. 2014, 13:3792-3801.
    • (2014) J. Proteome Res. , vol.13 , pp. 3792-3801
    • Wang, J.B.1    Pu, S.B.2    Sun, Y.3    Li, Z.F.4    Niu, M.5    Yan, X.Z.6
  • 74
    • 36148989929 scopus 로고    scopus 로고
    • High-throughput tissue extraction protocol for NMR- and MS-based metabolomics
    • Wu H., Southam A.D., Hines A., Viant M.R. High-throughput tissue extraction protocol for NMR- and MS-based metabolomics. Anal. Biochem. 2008, 372:204-212.
    • (2008) Anal. Biochem. , vol.372 , pp. 204-212
    • Wu, H.1    Southam, A.D.2    Hines, A.3    Viant, M.R.4
  • 75
    • 84862509819 scopus 로고    scopus 로고
    • Metabolic disturbances associated with systemic lupus erythematosus
    • Wu T., Xie C., Han J., Ye Y., Weiel J., Li Q., et al. Metabolic disturbances associated with systemic lupus erythematosus. PLoS One 2012, 7:e37210.
    • (2012) PLoS One , vol.7
    • Wu, T.1    Xie, C.2    Han, J.3    Ye, Y.4    Weiel, J.5    Li, Q.6
  • 76
    • 84878494552 scopus 로고    scopus 로고
    • Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics
    • Xu F., Tavintharan S., Sum C.F., Woon K., Lim S.C., Ong C.N. Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics. J. Clin. Endocrinol. Metab. 2013, 98:E1060-E1065.
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. E1060-E1065
    • Xu, F.1    Tavintharan, S.2    Sum, C.F.3    Woon, K.4    Lim, S.C.5    Ong, C.N.6
  • 77
    • 84904294918 scopus 로고    scopus 로고
    • The incidence of inflammatory bowel disease in northern china: a prospective population-based study
    • Yang H., Li Y., Wu W., Sun Q., Zhang Y., Zhao W., et al. The incidence of inflammatory bowel disease in northern china: a prospective population-based study. PLoS One 2014, 9:e101296.
    • (2014) PLoS One , vol.9
    • Yang, H.1    Li, Y.2    Wu, W.3    Sun, Q.4    Zhang, Y.5    Zhao, W.6
  • 79
    • 84889246623 scopus 로고    scopus 로고
    • Single-cell metabolomics: analytical and biological perspectives
    • Zenobi R. Single-cell metabolomics: analytical and biological perspectives. Science 2013, 342:1243259.
    • (2013) Science , vol.342 , pp. 1243259
    • Zenobi, R.1
  • 80
    • 84862580679 scopus 로고    scopus 로고
    • Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics-a pilot study
    • Zhang X., Choi F.F., Zhou Y., Leung F.P., Tan S., Lin S., et al. Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics-a pilot study. FEBS J. 2012, 279:2322-2338.
    • (2012) FEBS J. , vol.279 , pp. 2322-2338
    • Zhang, X.1    Choi, F.F.2    Zhou, Y.3    Leung, F.P.4    Tan, S.5    Lin, S.6
  • 81
    • 84876477982 scopus 로고    scopus 로고
    • 1H NMR-based spectroscopy detects metabolic alterations in serum of patients with early-stage ulcerative colitis
    • 1H NMR-based spectroscopy detects metabolic alterations in serum of patients with early-stage ulcerative colitis. Biochem. Biophys. Res. Commun. 2013, 433:547-551.
    • (2013) Biochem. Biophys. Res. Commun. , vol.433 , pp. 547-551
    • Zhang, Y.1    Lin, L.2    Xu, Y.3    Lin, Y.4    Jin, Y.5    Zheng, C.6
  • 82
    • 84896403272 scopus 로고    scopus 로고
    • Metabolomics study of type 2 diabetes using ultra-performance LC-ESI/quadrupole-TOF high-definition MS coupled with pattern recognition methods
    • Zhang A.H., Sun H., Yan G.L., Yuan Y., Han Y., Wang X.J. Metabolomics study of type 2 diabetes using ultra-performance LC-ESI/quadrupole-TOF high-definition MS coupled with pattern recognition methods. J. Physiol. Biochem. 2014, 70:117-128.
    • (2014) J. Physiol. Biochem. , vol.70 , pp. 117-128
    • Zhang, A.H.1    Sun, H.2    Yan, G.L.3    Yuan, Y.4    Han, Y.5    Wang, X.J.6
  • 83
    • 84900458302 scopus 로고    scopus 로고
    • Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang
    • Zhang H., Fu P., Ke B., Wang S., Li M., Han L., et al. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang. J. Ethnopharmacol. 2014, 154:55-64.
    • (2014) J. Ethnopharmacol. , vol.154 , pp. 55-64
    • Zhang, H.1    Fu, P.2    Ke, B.3    Wang, S.4    Li, M.5    Han, L.6


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