메뉴 건너뛰기




Volumn 77, Issue , 2016, Pages 87-95

Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review

Author keywords

Cytomegalovirus; Immunosenescence; Memory T cells; T cell subsets; TEMRA

Indexed keywords

CD45RA ANTIGEN;

EID: 84960375723     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2016.02.005     Document Type: Review
Times cited : (101)

References (73)
  • 1
    • 14744281718 scopus 로고    scopus 로고
    • Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • Almanzar G., Schwaiger S., Jenewein B., Keller M., Herndler-Brandstetter D., Wurzner R., et al. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J. Virol. 2005, 79(6):3675-3683.
    • (2005) J. Virol. , vol.79 , Issue.6 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3    Keller, M.4    Herndler-Brandstetter, D.5    Wurzner, R.6
  • 2
    • 84875779164 scopus 로고    scopus 로고
    • Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system
    • Alonso Arias R., Moro-Garcia M.A., Echeverria A., Solano-Jaurrieta J.J., Suarez-Garcia F.M., Lopez-Larrea C. Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system. J. Virol. 2013, 87(8):4486-4495.
    • (2013) J. Virol. , vol.87 , Issue.8 , pp. 4486-4495
    • Alonso Arias, R.1    Moro-Garcia, M.A.2    Echeverria, A.3    Solano-Jaurrieta, J.J.4    Suarez-Garcia, F.M.5    Lopez-Larrea, C.6
  • 5
    • 0033859430 scopus 로고    scopus 로고
    • Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis
    • Borthwick N.J., Lowdell M., Salmon M., Akbar A.N. Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis. Int. Immunol. 2000, 12(7):1005-1013.
    • (2000) Int. Immunol. , vol.12 , Issue.7 , pp. 1005-1013
    • Borthwick, N.J.1    Lowdell, M.2    Salmon, M.3    Akbar, A.N.4
  • 6
    • 71649108651 scopus 로고    scopus 로고
    • Congenital cytomegalovirus (CMV) epidemiology and awareness
    • Cannon M.J. Congenital cytomegalovirus (CMV) epidemiology and awareness. J. Clin. Virol. 2009, 46(Suppl. 4):S6-10.
    • (2009) J. Clin. Virol. , vol.46 , pp. S6-10
    • Cannon, M.J.1
  • 7
    • 77954170594 scopus 로고    scopus 로고
    • Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
    • Cannon M.J., Schmid D.S., Hyde T.B. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev. Med. Virol. 2010, 20(4):202-213.
    • (2010) Rev. Med. Virol. , vol.20 , Issue.4 , pp. 202-213
    • Cannon, M.J.1    Schmid, D.S.2    Hyde, T.B.3
  • 9
    • 59249090000 scopus 로고    scopus 로고
    • Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
    • Chidrawar S., Khan N., Wei W., McLarnon A., Smith N., Nayak L., et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin. Exp. Immunol. 2009, 155(3):423-432.
    • (2009) Clin. Exp. Immunol. , vol.155 , Issue.3 , pp. 423-432
    • Chidrawar, S.1    Khan, N.2    Wei, W.3    McLarnon, A.4    Smith, N.5    Nayak, L.6
  • 10
    • 77953637386 scopus 로고    scopus 로고
    • Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates
    • Cicin-Sain L., Smyk-Pearson S., Currier N., Byrd L., Koudelka C., Robinson T., et al. Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J. Immunol. 2010, 184(12):6739-6745.
    • (2010) J. Immunol. , vol.184 , Issue.12 , pp. 6739-6745
    • Cicin-Sain, L.1    Smyk-Pearson, S.2    Currier, N.3    Byrd, L.4    Koudelka, C.5    Robinson, T.6
  • 11
    • 78650565174 scopus 로고    scopus 로고
    • [updated 2010 July 28; cited 2014 6 August]
    • Cytomegalovirus (CMV) and congenital CMV infection [Internet] Atlanta: Centers for Disease Control and Prevention 2010, [updated 2010 July 28; cited 2014 6 August]. Available from: http://www.cdc.gov.cmv/transmission.html.
    • (2010) Atlanta: Centers for Disease Control and Prevention
  • 12
    • 68149148869 scopus 로고    scopus 로고
    • Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    • Derhovanessian E., Larbi A., Pawelec G. Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr. Opin. Immunol. 2009, 21(4):440-445.
    • (2009) Curr. Opin. Immunol. , vol.21 , Issue.4 , pp. 440-445
    • Derhovanessian, E.1    Larbi, A.2    Pawelec, G.3
  • 13
    • 84871935156 scopus 로고    scopus 로고
    • Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    • Derhovanessian E., Theeten H., Hahnel K., Van Damme P., Cools N., Pawelec G. Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine 2013, 31(4):685-690.
    • (2013) Vaccine , vol.31 , Issue.4 , pp. 685-690
    • Derhovanessian, E.1    Theeten, H.2    Hahnel, K.3    Van Damme, P.4    Cools, N.5    Pawelec, G.6
  • 14
    • 84886721150 scopus 로고    scopus 로고
    • Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people
    • Derhovanessian E., Maier A.B., Hahnel K., Zelba H., de Craen A.J., Roelofs H., et al. Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people. Age (Dordr) 2013, 35(4):1387-1399.
    • (2013) Age (Dordr) , vol.35 , Issue.4 , pp. 1387-1399
    • Derhovanessian, E.1    Maier, A.B.2    Hahnel, K.3    Zelba, H.4    de Craen, A.J.5    Roelofs, H.6
  • 15
    • 0031754739 scopus 로고    scopus 로고
    • The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions
    • Downs S., Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J. Epidemiol. Community Health 1998, 52(6):377-384.
    • (1998) J. Epidemiol. Community Health , vol.52 , Issue.6 , pp. 377-384
    • Downs, S.1    Black, N.2
  • 16
    • 84960415908 scopus 로고    scopus 로고
    • (cited 2014 February 17)
    • ERBO-Platform Formulier III voor het beoordelen van een cohortonderzoek 2014, (cited 2014 February 17). Available from: http://dcc.cochrane.org/sites/dcc.cochrane.org/files/uploads/cohort.pdf.
    • (2014) Formulier III voor het beoordelen van een cohortonderzoek
  • 17
    • 84960470345 scopus 로고    scopus 로고
    • (cited 2014 February 17)
    • ERBO-Platform Formulier IV voor het beoordelen van patiënt-controleonderzoek 2014, (cited 2014 February 17). Available from: http://dcc.cochrane.org/sites/dcc.cochrane.org/files/uploads/patient-controleonderzoek.pdf).
    • (2014) Formulier IV voor het beoordelen van patiënt-controleonderzoek
  • 18
    • 29144435156 scopus 로고    scopus 로고
    • Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion
    • Fletcher J.M., Vukmanovic-Stejic M., Dunne P.J., Birch K.E., Cook J.E., Jackson S.E., et al. Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J. Immunol. 2005, 175(12):8218-8225.
    • (2005) J. Immunol. , vol.175 , Issue.12 , pp. 8218-8225
    • Fletcher, J.M.1    Vukmanovic-Stejic, M.2    Dunne, P.J.3    Birch, K.E.4    Cook, J.E.5    Jackson, S.E.6
  • 19
    • 84886033654 scopus 로고    scopus 로고
    • Human T cell aging and the impact of persistent viral infections
    • Fulop T., Larbi A., Pawelec G. Human T cell aging and the impact of persistent viral infections. Front. Immunol. 2013, 4:271.
    • (2013) Front. Immunol. , vol.4 , pp. 271
    • Fulop, T.1    Larbi, A.2    Pawelec, G.3
  • 20
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 2013, 14(5):428-436.
    • (2013) Nat. Immunol. , vol.14 , Issue.5 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2
  • 21
    • 0035202615 scopus 로고    scopus 로고
    • Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    • Goronzy J.J., Fulbright J.W., Crowson C.S., Poland G.A., O'Fallon W.M., Weyand C.M. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J. Virol. 2001, 75(24):12182-12187.
    • (2001) J. Virol. , vol.75 , Issue.24 , pp. 12182-12187
    • Goronzy, J.J.1    Fulbright, J.W.2    Crowson, C.S.3    Poland, G.A.4    O'Fallon, W.M.5    Weyand, C.M.6
  • 22
    • 32044433093 scopus 로고    scopus 로고
    • Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly
    • Hadrup S.R., Strindhall J., Kollgaard T., Seremet T., Johansson B., Pawelec G., et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J. Immunol. 2006, 176(4):2645-2653.
    • (2006) J. Immunol. , vol.176 , Issue.4 , pp. 2645-2653
    • Hadrup, S.R.1    Strindhall, J.2    Kollgaard, T.3    Seremet, T.4    Johansson, B.5    Pawelec, G.6
  • 23
    • 85100415918 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • (updated March 2011), J. Higgins, S. Green (Eds.)
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration 2011, (updated March 2011). J. Higgins, S. Green (Eds.).
    • (2011) The Cochrane Collaboration
  • 24
    • 70350409229 scopus 로고    scopus 로고
    • Cytomegalovirus and immune senescence: culprit or innocent bystander?
    • Karrer U., Mekker A., Wanke K., Tchang V., Haeberli L. Cytomegalovirus and immune senescence: culprit or innocent bystander?. Exp. Gerontol. 2009, 44(11):689-694.
    • (2009) Exp. Gerontol. , vol.44 , Issue.11 , pp. 689-694
    • Karrer, U.1    Mekker, A.2    Wanke, K.3    Tchang, V.4    Haeberli, L.5
  • 25
    • 10344257508 scopus 로고    scopus 로고
    • Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection
    • Khan N., Hislop A., Gudgeon N., Cobbold M., Khanna R., Nayak L., et al. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 2004, 173(12):7481-7489.
    • (2004) J. Immunol. , vol.173 , Issue.12 , pp. 7481-7489
    • Khan, N.1    Hislop, A.2    Gudgeon, N.3    Cobbold, M.4    Khanna, R.5    Nayak, L.6
  • 28
    • 84873288253 scopus 로고    scopus 로고
    • Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis
    • Kuparinen T., Marttila S., Jylhava J., Tserel L., Peterson P., Jylha M., et al. Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis. Exp. Gerontol. 2013, 48(3):305-312.
    • (2013) Exp. Gerontol. , vol.48 , Issue.3 , pp. 305-312
    • Kuparinen, T.1    Marttila, S.2    Jylhava, J.3    Tserel, L.4    Peterson, P.5    Jylha, M.6
  • 29
    • 84860319767 scopus 로고    scopus 로고
    • The relationship of cytomegalovirus (CMV) infection with circulatory IFN-alpha levels and IL-7 receptor alpha expression on CD8+ T cells in human aging
    • Lee W.W., Shin M.S., Kang Y., Lee N., Jeon S., Kang I. The relationship of cytomegalovirus (CMV) infection with circulatory IFN-alpha levels and IL-7 receptor alpha expression on CD8+ T cells in human aging. Cytokine 2012, 58(3):332-335.
    • (2012) Cytokine , vol.58 , Issue.3 , pp. 332-335
    • Lee, W.W.1    Shin, M.S.2    Kang, Y.3    Lee, N.4    Jeon, S.5    Kang, I.6
  • 31
    • 79251641161 scopus 로고    scopus 로고
    • Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4 + CD45RA + CD27+ T cells: the potential involvement of interleukin-7 in this process
    • Libri V., Azevedo R.I., Jackson S.E., Di Mitri D., Lachmann R., Fuhrmann S., et al. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4 + CD45RA + CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology 2011, 132(3):326-339.
    • (2011) Immunology , vol.132 , Issue.3 , pp. 326-339
    • Libri, V.1    Azevedo, R.I.2    Jackson, S.E.3    Di Mitri, D.4    Lachmann, R.5    Fuhrmann, S.6
  • 32
    • 48749127711 scopus 로고    scopus 로고
    • Human cytomegalovirus-specific memory CD8+ and CD4+ T cell differentiation after primary infection
    • Lilleri D., Fornara C., Revello M.G., Gerna G. Human cytomegalovirus-specific memory CD8+ and CD4+ T cell differentiation after primary infection. Asian J. Infect. Dis. 2008, 198(4):536-543.
    • (2008) Asian J. Infect. Dis. , vol.198 , Issue.4 , pp. 536-543
    • Lilleri, D.1    Fornara, C.2    Revello, M.G.3    Gerna, G.4
  • 33
    • 78650925501 scopus 로고    scopus 로고
    • Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
    • Litjens N.H., de Wit E.A., Betjes M.G. Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. Immun. Ageing: I & A. 2011, 8(1):2.
    • (2011) Immun. Ageing: I & A. , vol.8 , Issue.1 , pp. 2
    • Litjens, N.H.1    de Wit, E.A.2    Betjes, M.G.3
  • 34
    • 84888059493 scopus 로고    scopus 로고
    • The who's who of T-cell differentiation: human memory T-cell subsets
    • Mahnke Y.D., Brodie T.M., Sallusto F., Roederer M., Lugli E. The who's who of T-cell differentiation: human memory T-cell subsets. Eur. J. Immunol. 2013, 43(11):2797-2809.
    • (2013) Eur. J. Immunol. , vol.43 , Issue.11 , pp. 2797-2809
    • Mahnke, Y.D.1    Brodie, T.M.2    Sallusto, F.3    Roederer, M.4    Lugli, E.5
  • 36
    • 68149179573 scopus 로고    scopus 로고
    • Immunosenescence: what does it mean to health outcomes in older adults?
    • McElhaney J.E., Effros R.B. Immunosenescence: what does it mean to health outcomes in older adults?. Curr. Opin. Immunol. 2009, 21(4):418-424.
    • (2009) Curr. Opin. Immunol. , vol.21 , Issue.4 , pp. 418-424
    • McElhaney, J.E.1    Effros, R.B.2
  • 38
    • 0030468317 scopus 로고    scopus 로고
    • Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors
    • Mendelson M., Monard S., Sissons P., Sinclair J. Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors. J. Gen. Virol. 1996, 77(Pt 12):3099-3102.
    • (1996) J. Gen. Virol. , vol.77 , pp. 3099-3102
    • Mendelson, M.1    Monard, S.2    Sissons, P.3    Sinclair, J.4
  • 39
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: primer and prospectus
    • Miller R.A. The aging immune system: primer and prospectus. Science 1996, 273(5271):70-74.
    • (1996) Science , vol.273 , Issue.5271 , pp. 70-74
    • Miller, R.A.1
  • 40
    • 77955653003 scopus 로고    scopus 로고
    • The emerging role of cytomegalovirus in driving immune senescence: a novel therapeutic opportunity for improving health in the elderly
    • Moss P. The emerging role of cytomegalovirus in driving immune senescence: a novel therapeutic opportunity for improving health in the elderly. Curr. Opin. Immunol. 2010, 22(4):529-534.
    • (2010) Curr. Opin. Immunol. , vol.22 , Issue.4 , pp. 529-534
    • Moss, P.1
  • 41
    • 46249132015 scopus 로고    scopus 로고
    • Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    • Nikolich-Zugich J. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nat. Rev. Immunol. 2008, 8(7):512-522.
    • (2008) Nat. Rev. Immunol. , vol.8 , Issue.7 , pp. 512-522
    • Nikolich-Zugich, J.1
  • 42
    • 16344374892 scopus 로고    scopus 로고
    • Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection
    • Northfield J., Lucas M., Jones H., Young N.T., Klenerman P. Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection. Immunol. Cell Biol. 2005, 83(2):182-188.
    • (2005) Immunol. Cell Biol. , vol.83 , Issue.2 , pp. 182-188
    • Northfield, J.1    Lucas, M.2    Jones, H.3    Young, N.T.4    Klenerman, P.5
  • 43
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
    • Olsson J., Wikby A., Johansson B., Lofgren S., Nilsson B.O., Ferguson F.G. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 2000, 121(1-3):187-201.
    • (2000) Mech. Ageing Dev. , vol.121 , Issue.1-3 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.G.6
  • 44
    • 0042206627 scopus 로고    scopus 로고
    • Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
    • Ouyang Q., Wagner W.M., Voehringer D., Wikby A., Klatt T., Walter S., et al. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp. Gerontol. 2003, 38(8):911-920.
    • (2003) Exp. Gerontol. , vol.38 , Issue.8 , pp. 911-920
    • Ouyang, Q.1    Wagner, W.M.2    Voehringer, D.3    Wikby, A.4    Klatt, T.5    Walter, S.6
  • 45
    • 84864927213 scopus 로고    scopus 로고
    • Hallmarks of human "immunosenescence": adaptation or dysregulation?
    • Pawelec G. Hallmarks of human "immunosenescence": adaptation or dysregulation?. Immun. Ageing: I & A. 2012, 9(1):15.
    • (2012) Immun. Ageing: I & A. , vol.9 , Issue.1 , pp. 15
    • Pawelec, G.1
  • 46
    • 79955011716 scopus 로고    scopus 로고
    • Role of CMV in immune senescence
    • Pawelec G., Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2011, 157(2):175-179.
    • (2011) Virus Res. , vol.157 , Issue.2 , pp. 175-179
    • Pawelec, G.1    Derhovanessian, E.2
  • 47
    • 33744462080 scopus 로고    scopus 로고
    • Human immunosenescence: does it have an infectious component?
    • Pawelec G., Koch S., Franceschi C., Wikby A. Human immunosenescence: does it have an infectious component?. Ann. N. Y. Acad. Sci. 2006, 1067:56-65.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1067 , pp. 56-65
    • Pawelec, G.1    Koch, S.2    Franceschi, C.3    Wikby, A.4
  • 50
    • 34447260501 scopus 로고    scopus 로고
    • The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire
    • Pourgheysari B., Khan N., Best D., Bruton R., Nayak L., Moss P.A. The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire. J. Virol. 2007, 81(14):7759-7765.
    • (2007) J. Virol. , vol.81 , Issue.14 , pp. 7759-7765
    • Pourgheysari, B.1    Khan, N.2    Best, D.3    Bruton, R.4    Nayak, L.5    Moss, P.A.6
  • 51
    • 42249103647 scopus 로고    scopus 로고
    • Aspects of human cytomegalovirus latency and reactivation
    • Reeves M., Sinclair J. Aspects of human cytomegalovirus latency and reactivation. Curr. Top. Microbiol. Immunol. 2008, 325:297-313.
    • (2008) Curr. Top. Microbiol. Immunol. , vol.325 , pp. 297-313
    • Reeves, M.1    Sinclair, J.2
  • 52
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999, 401(6754):708-712.
    • (1999) Nature , vol.401 , Issue.6754 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 53
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: function, generation, and maintenance
    • Sallusto F., Geginat J., Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 2004, 22:745-763.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 54
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl M., Lung T.L., Marx F., Gschosser C., Asch E., Blasko I., et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 2002, 168(11):5893-5899.
    • (2002) J. Immunol. , vol.168 , Issue.11 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3    Gschosser, C.4    Asch, E.5    Blasko, I.6
  • 55
    • 84867893617 scopus 로고    scopus 로고
    • Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection
    • Seckert C.K., Griessl M., Buttner J.K., Scheller S., Simon C.O., Kropp K.A., et al. Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection. Med. Microbiol. Immunol. 2012, 201(4):551-566.
    • (2012) Med. Microbiol. Immunol. , vol.201 , Issue.4 , pp. 551-566
    • Seckert, C.K.1    Griessl, M.2    Buttner, J.K.3    Scheller, S.4    Simon, C.O.5    Kropp, K.A.6
  • 56
    • 0029912732 scopus 로고    scopus 로고
    • Human cytomegalovirus suppression of and latency in early hematopoietic progenitor cells
    • Sindre H., Tjoonnfjord G.E., Rollag H., Ranneberg-Nilsen T., Veiby O.P., Beck S., et al. Human cytomegalovirus suppression of and latency in early hematopoietic progenitor cells. Blood 1996, 88(12):4526-4533.
    • (1996) Blood , vol.88 , Issue.12 , pp. 4526-4533
    • Sindre, H.1    Tjoonnfjord, G.E.2    Rollag, H.3    Ranneberg-Nilsen, T.4    Veiby, O.P.5    Beck, S.6
  • 57
    • 0020402889 scopus 로고
    • Prevalence and importance of congenital cytomegalovirus infection in three different populations
    • Stagno S., Dworsky M.E., Torres J., Mesa T., Hirsh T. Prevalence and importance of congenital cytomegalovirus infection in three different populations. J. Pediatr. 1982, 101(6):897-900.
    • (1982) J. Pediatr. , vol.101 , Issue.6 , pp. 897-900
    • Stagno, S.1    Dworsky, M.E.2    Torres, J.3    Mesa, T.4    Hirsh, T.5
  • 59
    • 84866511458 scopus 로고    scopus 로고
    • Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age
    • Stowe R.P., Peek M.K., Cutchin M.P., Goodwin J.S. Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age. J. Med. Virol. 2012, 84(11):1797-1802.
    • (2012) J. Med. Virol. , vol.84 , Issue.11 , pp. 1797-1802
    • Stowe, R.P.1    Peek, M.K.2    Cutchin, M.P.3    Goodwin, J.S.4
  • 61
    • 84880571275 scopus 로고    scopus 로고
    • The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study
    • Strindhall J., Skog M., Ernerudh J., Bengner M., Lofgren S., Matussek A., et al. The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study. Age (Dordr) 2013, 35(3):985-991.
    • (2013) Age (Dordr) , vol.35 , Issue.3 , pp. 985-991
    • Strindhall, J.1    Skog, M.2    Ernerudh, J.3    Bengner, M.4    Lofgren, S.5    Matussek, A.6
  • 62
    • 24344489044 scopus 로고    scopus 로고
    • Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    • Sylwester A.W., Mitchell B.L., Edgar J.B., Taormina C., Pelte C., Ruchti F., et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 2005, 202(5):673-685.
    • (2005) J. Exp. Med. , vol.202 , Issue.5 , pp. 673-685
    • Sylwester, A.W.1    Mitchell, B.L.2    Edgar, J.B.3    Taormina, C.4    Pelte, C.5    Ruchti, F.6
  • 63
    • 0242317690 scopus 로고    scopus 로고
    • Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence
    • Trzonkowski P., Mysliwska J., Szmit E., Wieckiewicz J., Lukaszuk K., Brydak L.B., et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 2003, 21(25-26):3826-3836.
    • (2003) Vaccine , vol.21 , Issue.25-26 , pp. 3826-3836
    • Trzonkowski, P.1    Mysliwska, J.2    Szmit, E.3    Wieckiewicz, J.4    Lukaszuk, K.5    Brydak, L.B.6
  • 64
    • 77951889646 scopus 로고    scopus 로고
    • Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status
    • Vescovini R., Biasini C., Telera A.R., Basaglia M., Stella A., Magalini F., et al. Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J. Immunol. 2010, 184(6):3242-3249.
    • (2010) J. Immunol. , vol.184 , Issue.6 , pp. 3242-3249
    • Vescovini, R.1    Biasini, C.2    Telera, A.R.3    Basaglia, M.4    Stella, A.5    Magalini, F.6
  • 65
  • 66
    • 33847120921 scopus 로고    scopus 로고
    • Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly
    • Weinberger B., Lazuardi L., Weiskirchner I., Keller M., Neuner C., Fischer K.H., et al. Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. Hum. Immunol. 2007, 68(2):86-90.
    • (2007) Hum. Immunol. , vol.68 , Issue.2 , pp. 86-90
    • Weinberger, B.1    Lazuardi, L.2    Weiskirchner, I.3    Keller, M.4    Neuner, C.5    Fischer, K.H.6
  • 68
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: how much can the adaptive immune system adapt?
    • Weng N.P. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006, 24(5):495-499.
    • (2006) Immunity , vol.24 , Issue.5 , pp. 495-499
    • Weng, N.P.1
  • 69
    • 84896501298 scopus 로고    scopus 로고
    • Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
    • Wertheimer A.M., Bennett M.S., Park B., Uhrlaub J.L., Martinez C., Pulko V., et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J. Immunol. 2014, 192(5):2143-2155.
    • (2014) J. Immunol. , vol.192 , Issue.5 , pp. 2143-2155
    • Wertheimer, A.M.1    Bennett, M.S.2    Park, B.3    Uhrlaub, J.L.4    Martinez, C.5    Pulko, V.6
  • 70
    • 20544476197 scopus 로고    scopus 로고
    • An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans
    • Wikby A., Ferguson F., Forsey R., Thompson J., Strindhall J., Lofgren S., et al. An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J. Gerontol. A Biol. Sci. Med. Sci. 2005, 60(5):556-565.
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , Issue.5 , pp. 556-565
    • Wikby, A.1    Ferguson, F.2    Forsey, R.3    Thompson, J.4    Strindhall, J.5    Lofgren, S.6
  • 71
    • 0036604316 scopus 로고    scopus 로고
    • Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response
    • Wills M.R., Okecha G., Weekes M.P., Gandhi M.K., Sissons P.J., Carmichael A.J. Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response. J. Immunol. 2002, 168(11):5455-5464.
    • (2002) J. Immunol. , vol.168 , Issue.11 , pp. 5455-5464
    • Wills, M.R.1    Okecha, G.2    Weekes, M.P.3    Gandhi, M.K.4    Sissons, P.J.5    Carmichael, A.J.6
  • 72
    • 34347405728 scopus 로고    scopus 로고
    • Lower GrB+ CD62L high CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes
    • Xie D., McElhaney J.E. Lower GrB+ CD62L high CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes. Mech. Ageing Dev. 2007, 128(5-6):392-400.
    • (2007) Mech. Ageing Dev. , vol.128 , Issue.5-6 , pp. 392-400
    • Xie, D.1    McElhaney, J.E.2
  • 73


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.