Human immunosenescence: Does it have an infectious component?

Annals of the New York Academy of Sciences

Volumn 1067, Issue 1, 2006, Pages 56-65

  Pawelec, G ^a   Koch, S ^a   Franceschi, C ^b   Wikby, A ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c JÖNKÖPING UNIVERSITY   (Sweden)

Author keywords

CD8 T lymphocyte; Cytomegalovirus; Immunosenescence; Longitudinal study

Indexed keywords

AGING; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONFERENCE PAPER; CYTOMEGALOVIRUS; HUMAN; IMMUNOPATHOLOGY; IMMUNOSENESCENCE; INFECTION; INFECTION SENSITIVITY; LONGEVITY; NONHUMAN; PHENOTYPE; SENESCENCE; SEVERE ACUTE RESPIRATORY SYNDROME;

CYTOMEGALOVIRUS;

EID: 33744462080     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1354.009     Document Type: Conference Paper

References (33)

1. Pawelec, G. et al. 2002. T cells and ageing: January 2002 update. Front. Biosci. 7: d1056-d1183.
2. Gross, P.A. et al. 1995. The efficacy of influenza vaccine in elderly persons: a meta-analysis and review of the literature. Ann. Intern. Med. 123: 518 527.
3. Pawelec, G. et al. 2005. Human immunosenescence: is it infectious¿ Immunol. Rev. 205: 257 268.
4. Wreghitt, T.G. et al. 2003. Cytomegalovirus infection in immunocompetent patients. Clin. Infect. Dis. 37: 1603 1606.
5. McVoy, M.A. & S.P. Adler. 1989. Immunologic evidence for frequent age-related cytomegalovirus reactivation in seropositive immunocompetent individuals. J. Infect. Dis. 160: 1 10.
6. Gratama, J.W. et al. 1987. Effects of herpes virus carrier status on peripheral T lymphocyte subsets. Blood 70: 516 523.
7. Looney, R.J. et al. 1999. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin. Immunol. 90: 213 219.
8. Posnett, D.N. et al. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy.' J. Exp. Med. 179: 609 618.
9. Olsson, J. et al. 2000. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 121: 187 201.
10. Wikby, A. et al. 2002. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37: 445 453.
11. Ouyang, Q. et al. 2003. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp. Gerontol. 38: 911 920.
12. Ouyang, Q. et al. 2003. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J. Clin. Immunol. 23: 247 257.
13. Ouyang, Q. et al. 2004. Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exp. Gerontol. 39: 607 613.
14. Wills, M.R. et al. 2002. Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response. J. Immunol. 168: 5455 5464.
15. Komatsu, H. et al. 2003. Population analysis of antiviral T cell responses using MHC class I-peptide tetramers. Clin. Exp. Immunol. 134: 9 12.
16. Khan, N. et al. 2002. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169: 1984 1992.
17. Almanzar, G. et al. 2002. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J. Virol. 79: 3675 3683.
18. Pawelec, G., F.G. Ferguson & A. Wikby. 2001. The SENIEUR protocol after 16 years. Mech. Ageing Dev. 122: 132 134.
19. Wikby, A. et al. 1994. Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study. Exp. Gerontol. 29: 531 541.
20. Ferguson, F.G. et al. 1995. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J. Gerontol. Biol. Sci. B 50: 378 382.
21. Wikby, A. et al. 2005. An immune risk phenotype, cognitive impairment and survival in very late life: the impact of allostatic load in Swedish octo- and nonagenarian humans. J. Gerontol. B 60: 556 565.
22. Nilsson, B.O. et al. 2003. Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA immune study using sample selection protocols. Mech. Ageing Dev. 124: 469 476.
23. Blancho, G. et al. 1992. The influence of HLA A-B-DR matching on cytomegalovirus disease after renal transplantation. Evidence that HLA-DR7-matched recipients are more susceptible to cytomegalovirus disease. Transplantation 54: 871 874.
24. Schrier, R.D. et al. 1995. Immune predispositions for cytomegalovirus retinitis in AIDS. The HNRC Group. J. Clin. Invest. 95: 1741 1746.
25. Ouyang, Q. et al. 2003. An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech. Ageing Dev. 124: 477 485.
26. Douek, D.C. & R.A. Koup. 2000. Evidence for thymic function in the elderly. Vaccine 18: 1638 1641.
27. Khan, N. et al. 2004. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 173: 7481 7489.
28. Trzonkowski, P. et al. 2003. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination: an impact of immunosenescence. Vaccine 21: 3826 3836.
29. Sinicco, A. et al. 1997. The influence of cytomegalovirus on the natural history of HIV infection: evidence of rapid course of HIV infection in HIV-positive patients infected with cytomegalovirus. Scand. J. Infect. Dis. 29: 543 549.
30. Koch, S. et al. 2005. CMV and T cell immunosenescence. Mech. Ageing Dev. In press.
31. Voehringer, D. M. Koschella & H. Pircher. 2002. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 100: 3698 3702.
32. Ibegbu, C.C. et al. 2005. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. J. Immunol. 174: 6088 6094.
33. Leung, G.M. et al. 2004. The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients. Ann. Intern. Med. 141: 662 673.