Loss of CD28 expression on CD8+ T cells in induced by IL-2 receptor γ chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis

International Immunology

Volumn 12, Issue 7, 2000, Pages 1005-1013

  Borthwick, Nicola J ^a,d   Lowdell, Mark ^b   Salmon, Mike ^c   Akbar, Arne N ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Activation induced apoptosis; CD28; CD8; Cytotoxic T lymphocytes; Type 1 interferon

Indexed keywords

CD18 ANTIGEN; CD28 ANTIGEN; CD8 ANTIGEN; INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 7; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PERFORIN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

EID: 0033859430     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.7.1005     Document Type: Article

References (48)

1. Immunological memory and protective immunity: Understanding their relation
2. Cellular environments and apoptosis: Tissue microenvironments control activated T-cell death
3. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
4. + T-cell apoptosis in patients with acute herpesvirus infections: Loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression
5. Immunological and virological markers in individuals progressing from seroconversion to AIDS
6. - T cells
7. + lymphocyte phenotype and cytokine production in long-term non-progressor and in progressor patients with HIV-1 infection
8. - T-cells and delayed engraftment associated with cyclosporine-induced autologous GVHD
9. + lymphocytes in the antibody deficiency disease
10. Chagasic patients lack CD28 expression on many of their circulating T lymphocytes
11. - lymphocytes in human immunodeficiency virus-specific cytotoxic activity
12. + T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status
13. + T-cell subsets isolated from chronic adult periodontitis tissue differ in surface phenotype and biological functions
14. - T cells
15. Functional expression of CD28 on T cell antigen receptor gamma/delta-bearing T lymphocytes
16. Recombinant interferon alpha can induce rearrangement of T-cell antigen receptor alpha-chain genes and maturation to cytotoxicity in T-lymphocyte clones in vitro
17. Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes
18. The JAM test: A simple assay for DNA fragmentation and cell death
19. - T lymphocytes: Antigenic and functional properties
20. Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice
21. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory
22. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-x(L)) but not pro-apoptotic (bax, bcl-x(S)) gene e
23. Selective migration of highly differentiated primed T cells, defined by low expression of CD45RB, across human umbilical vein endothelial cells: Effects of viral infection on transmigration
24. Lymphocyte subset analysis to predict progression to AIDS in a cohort of homosexual men in San Francisco
25. Clonal populations of T cells in normal elderly humans: The T cell equivalent to 'benign monoclonal gammapathy'
26. + subset
27. + counterparts
28. - T cell subsets in HIV type 1-infected individuals
29. Role of IL-2 and interferon in the generation of natural cytotoxic activity in influenza virus-stimulated PBL cultures: Analysis with the use of prednisolone
30. Cytotoxicity of autologous Epstein-Barr virus-transformed cells mediated by interleukin-2 dependent, long-term T cell cultures is augmented by beta, but not alpha, recombinant interferon
31. + T cells in vivo by IL-15
32. Type I interferons keep activated T cells alive
33. Interferon-beta mediates stromal cell rescue of T cells from apoptosis
34. Inhibition of T cell apoptosis by interferon beta rapidly reverses nuclear translocation of protein kinase C
35. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
36. Co-stimulation in T cell responses
37. -mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis
38. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
39. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells
40. Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation
41. TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization
42. Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation
43. Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells
44. Cross-linking of the TCR-CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: The signal is canceled by FK506
45. Up-regulation of LFA-3 and ICAM-1 on the surface of fibroblasts infected with cytomegalovirus
46. Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones
47. + T cells during the primary immune response to Epstein-Barr virus in vivo
48. + T cells of HIV-seropositive patients