Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

Age

Volumn 35, Issue 4, 2013, Pages 1387-1399

  Derhovanessian, Evelyna ^a   Maier, Andrea B ^b   Hahnel, Karin ^a   Zelba, Henning ^a   De Craen, Anton J M ^b   Roelofs, Helene ^b   Slagboom, Eline P ^b   Westendorp, Rudi G J ^b   Pawelec, Graham ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Immunosenescence; Mortality .CMV; T cell subsets

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOMEGALOVIRUS ANTIGEN PP65; CYTOMEGALOVIRUS IE1 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS ANTIGEN;

AGED; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; EFFECTOR CELL; EX VIVO STUDY; FEMALE; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOSENESCENCE; IMMUNOSURVEILLANCE; INFECTION RESISTANCE; INFLAMMATION; LONGEVITY; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; PHENOTYPE; PREVALENCE; SURVIVAL RATE; VERY ELDERLY; AGING; CELLULAR IMMUNITY; COMPARATIVE STUDY; CYTOMEGALOVIRUS; EPIDEMIOLOGY; FLOW CYTOMETRY; FOLLOW UP; HEALTH SURVEY; IMMUNOLOGY; METABOLISM; NETHERLANDS; PATHOLOGY; PROCEDURES; PROSPECTIVE STUDY; TRENDS; METHODOLOGY;

AGED, 80 AND OVER; AGING; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; IMMUNITY, CELLULAR; LONGEVITY; MALE; NETHERLANDS; POPULATION SURVEILLANCE; PROSPECTIVE STUDIES; SURVIVAL RATE; VIRAL PROTEINS;

EID: 84886721150     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9425-7     Document Type: Article

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