Effects of blood transfusion on exercise capacity in thalassemia major patients

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Benedetto, Daniela ^a   Rao, Carmelo Massimo ^b   Cefalù, Claudia ^a   Aguglia, Demetrio Oreste ^b   Cattadori, Gaia ^a   D'ascola, Domenico Giuseppe ^c   Benedetto, Frank Antonio ^b   Agostoni, Piergiuseppe ^a,d   Sciomer, Susanna ^e  

^a CENTRO CARDIOLOGICO MONZINO   (Italy)

^b Cardiology Department   (Italy)

^c Hematology Department   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; HEMOGLOBIN; OXYGEN;

ADULT; ANAEROBIC THRESHOLD; ARTICLE; BLOOD TRANSFUSION; BODY MASS; BODY WEIGHT; BREATHING RATE; CARDIOPULMONARY EXERCISE TEST; CLINICAL ARTICLE; ERYTHROCYTE CONCENTRATE; EXERCISE; FEMALE; HEART RATE; HUMAN; LUNG VENTILATION; MALE; THALASSEMIA MAJOR; WORKLOAD; BETA-THALASSEMIA; BLOOD; METABOLISM; PATHOPHYSIOLOGY;

ADULT; ANAEROBIC THRESHOLD; BETA-THALASSEMIA; BLOOD TRANSFUSION; EXERCISE; FEMALE; HEMOGLOBINS; HUMANS; MALE; OXYGEN;

EID: 84959260455     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127553     Document Type: Article

References (27)

1. Bishop JM, Donald KW, Wade OL. Circulatory dynamics at rest and on exercise in the hyperkinetic states. Clin Sci (Lond). 1955; 14(2):329-60. PMID: 14379516.
2. Agostoni P, Salvioni E, Debenedetti C, Vignati C, Cattadori G, Contini M, et al. Relationship of resting hemoglobin concentration to peak oxygen uptake in heart failure patients. American journal of hematology. 2010; 85(6):414-7. doi:10.1002/ajh.21698 PMID: 20513118.
3. Toblli JE, Lombrana A, Duarte P, Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. Journal of the American College of Cardiology. 2007; 50(17):1657-65. PMID: 17950147.
4. Mancini DM, Katz SD, Lang CC, LaManca J, Hudaihed A, Androne AS. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation. 2003; 107(2):294-9. PMID: 12538431.
5. Palazzuoli A, Silverberg D, Iovine F, Capobianco S, Giannotti G, Calabro A, et al. Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. American heart journal. 2006; 152(6):1096 e9-15. PMID: 17161060.
6. Ponikowski P, Anker SD, Szachniewicz J, Okonko D, Ledwidge M, Zymlinski R, et al. Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: A randomized, double-blind, placebo-controlled trial. Journal of the American College of Cardiology. 2007; 49 (7):753-62. PMID: 17306703.
7. Okonko DO, Grzeslo A, Witkowski T, Mandal AK, Slater RM, Roughton M, et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: A randomized, controlled, observer-blinded trial. Journal of the American College of Cardiology. 2008; 51(2):103-12. doi:10.1016/j.jacc.2007.09.036 PMID: 18191732.
8. Nanas S, Vasileiadis I, Dimopoulos S, Sakellariou D, Kapsimalakou S, Papazachou O, et al. New insights into the exercise intolerance of beta-thalassemia major patients. Scandinavian journal of medicine & science in sports. 2009; 19(1):96-102. doi:10.1136/bjsports-2015-094781 PMID: 25878072.
9. Agostoni P, Cerino M, Palermo P, Magini A, Bianchi M, Bussotti M, et al. Exercise capacity in patients with beta-thalassaemia intermedia. British journal of haematology. 2005; 131(2):278-81. PMID: 16197461.
10. Sohn EY, Kato R, Noetzli LJ, Gera A, Coates T, Harmatz P, et al. Exercise performance in thalassemia major: correlation with cardiac iron burden. American journal of hematology. 2013; 88(3):193-7. doi:10.1002/ajh.23370PMID: 23339082.
11. Marsella M, Borgna-Pignatti C, Meloni A, Caldarelli V, Dell'Amico MC, Spasiano A, et al. Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: A T2∗ magnetic resonance imaging study. Haematologica. 2011; 96(4):515-20. doi:10.3324/haematol.2010.025510 PMID: 21228034.
12. Tanner MA, He T, Westwood MA, Firmin DN, Pennell DJ. Multi-center validation of the transferability of the magnetic resonance T2∗ technique for the quantification of tissue iron. Haematologica. 2006; 91 (10):1388-91. PMID: 17018390.
13. Tocco F, Crisafulli A, Melis F, Loviselli A, Lai C, Concu A. Exercise capacity and cardiovascular changes in patients with beta-thalassaemia major. Clinical physiology and functional imaging. 2006; 26 (6):319-22. PMID: 17042895.
14. Positano V, Pepe A, Santarelli MF, Ramazzotti A, Meloni A, De Marchi D, et al. Multislice multiecho T2∗ cardiac magnetic resonance for the detection of heterogeneous myocardial iron distribution in thalassaemia patients. NMR in biomedicine. 2009; 22(7):707-15. doi:10.1002/nbm.1382 PMID: 19322807.
15. Pepe A, Positano V, Capra M, Maggio A, Pinto CL, Spasiano A, et al. Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major. Heart. 2009; 95(20):1688- 93. doi:10.1136/hrt.2008.156497 PMID: 19491092.
16. Pepe A, Meloni A, Rossi G, Caruso V, Cuccia L, Spasiano A, et al. Cardiac complications and diabetes in thalassaemia major: A large historical multicentre study. British journal of haematology. 2013; 163 (4):520-7. doi:10.1111/bjh.12557 PMID: 24111905.
17. Wasserman K, Hansen JE, Sue DY, Stringer W, Whipp BJ. Principles of exercise testing and interpretation including pathophysiology and clinical applications. Lippincott Williams & Wilkins; 2012. p. 154- 80.
18. Hansen JE, Sue DY, Wasserman K. Predicted values for clinical exercise testing. The American review of respiratory disease. 1984; 129(2 Pt 2):S49-S55. PMID: 6421218.
19. Vasileiadis I, Roditis P, Dimopoulos S, Ladis V, Pangalis G, Aessopos A, et al. Impaired oxygen kinetics in beta-thalassaemia major patients. Acta Physiol (Oxf). 2009; 196(3):357-63. doi:10.1111/j.1748-1716.2008.01937.xPMID: 19040710.
20. Pennell DJ, Carpenter JP, Roughton M, Cabantchik Z. On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure. Journal of cardiovascular magnetic resonance: official journal of the Society for Cardiovascular Magnetic Resonance. 2011; 13:45.
21. Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, et al. Clinician's Guide to cardiopulmonary exercise testing in adults: A scientific statement from the American Heart Association. Circulation. 2010; 122(2):191-225. doi:10.1161/CIR.0b013e3181e52e69 PMID: 20585013.
22. Perego GB, Marenzi GC, Guazzi M, Sganzerla P, Assanelli E, Palermo P, et al. Contribution of PO2, P50, and Hb to changes in arteriovenous O2 content during exercise in heart failure. J Appl Physiol (1985). 1996; 80(2):623-31. PMID: 8929607.
23. Koike A, Weiler-Ravell D, McKenzie DK, Zanconato S, Wasserman K. Evidence that the metabolic acidosis threshold is the anaerobic threshold. J Appl Physiol. 1990; 68(6):2521-6. PMID: 2384430.
24. Robertson HT, Pellegrino R, Pini D, Oreglia J, DeVita S, Brusasco V, et al. Exercise response after rapid intravenous infusion of saline in healthy humans. J Appl Physiol (1985). 2004; 97(2):697-703. PMID: 15090479.
25. Gargiulo P, Apostolo A, Perrone-Filardi P, Sciomer S, Palange P, Agostoni P. A non invasive estimate of dead space ventilation from exercise measurements. PloS one. 2014; 9(1):e87395. doi:10.1371/journal.pone.0087395PMID: 24498096.
26. Guazzi M, Agostoni P, Guazzi MD. Alveolar-capillary gas exchange and exercise performance in heart failure. The American journal of cardiology. 2001; 88(4):452-7. PMID: 11545778.
27. Agostoni P, Wasserman K, Guazzi M, Cattadori G, Palermo P, Marenzi G, et al. Exercise-induced hemoconcentration in heart failure due to dilated cardiomyopathy. The American journal of cardiology. 1999; 83(2):278-80, A6. PMID: 10073838.