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Volumn 43, Issue 1, 2016, Pages 146-153

Frugal chemoprevention: Targeting Nrf2 with foods rich in sulforaphane

Author keywords

Cancer; Chemoprevention; Nrf2; Sulforaphane

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; PLANT MEDICINAL PRODUCT; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; ANTINEOPLASTIC AGENT; GLUCORAPHANIN; GLUCOSINOLATE; IMIDOESTER; ISOTHIOCYANIC ACID DERIVATIVE; SULFORAFAN;

EID: 84960370392     PISSN: 00937754     EISSN: 15328708     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2015.09.013     Document Type: Review
Times cited : (112)

References (89)
  • 1
    • 84859132868 scopus 로고    scopus 로고
    • Applying what we know to accelerate cancer prevention
    • G.A. Colditz, K.Y. Wolin, and S. Gehlert Applying what we know to accelerate cancer prevention Sci Transl Med 4 2012 127rv4
    • (2012) Sci Transl Med , vol.4 , pp. 127rv4
    • Colditz, G.A.1    Wolin, K.Y.2    Gehlert, S.3
  • 2
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Y.J. Surh Cancer chemoprevention with dietary phytochemicals Nat Rev Cancer 3 2003 768 780
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 3
    • 84872813218 scopus 로고    scopus 로고
    • Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression
    • J.H. Lee, T.O. Khor, L. Shu, Z.Y. Su, F. Fuentes, and A.N. Kong Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression Pharmacol Ther 137 2013 153 171
    • (2013) Pharmacol Ther , vol.137 , pp. 153-171
    • Lee, J.H.1    Khor, T.O.2    Shu, L.3    Su, Z.Y.4    Fuentes, F.5    Kong, A.N.6
  • 4
    • 84893709504 scopus 로고    scopus 로고
    • Plant phytochemicals as epigenetic modulators: Role in cancer chemoprevention
    • V.S. Thakur, G. Deb, M.A. Babcook, and S. Gupta Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention AAPS J 16 2014 151 163
    • (2014) AAPS J , vol.16 , pp. 151-163
    • Thakur, V.S.1    Deb, G.2    Babcook, M.A.3    Gupta, S.4
  • 5
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • K. Itoh, N. Wakabayashi, Y. Katoh, and et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev 13 1999 76 86
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3
  • 6
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • D.D. Zhang, S.C. Lo, J.V. Cross, D.J. Templeton, and M. Hannink Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex Mol Cell Biol 24 2004 10941 10953
    • (2004) Mol Cell Biol , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 7
    • 66749112860 scopus 로고    scopus 로고
    • Genetic versus chemoprotective activation of Nrf2 signaling: Overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
    • M.S. Yates, Q.T. Tran, P.M. Dolan, and et al. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice Carcinogenesis 30 2009 1024 1031
    • (2009) Carcinogenesis , vol.30 , pp. 1024-1031
    • Yates, M.S.1    Tran, Q.T.2    Dolan, P.M.3
  • 8
    • 45549090979 scopus 로고    scopus 로고
    • Genetic or pharmacologic amplification of Nrf2 signaling inhibits acute inflammatory liver injury in mice
    • W.O. Osburn, M.S. Yates, P.D. Dolan, and et al. Genetic or pharmacologic amplification of Nrf2 signaling inhibits acute inflammatory liver injury in mice Toxicol Sci 104 2008 218 227
    • (2008) Toxicol Sci , vol.104 , pp. 218-227
    • Osburn, W.O.1    Yates, M.S.2    Dolan, P.D.3
  • 9
    • 79954424076 scopus 로고    scopus 로고
    • Nrf2: Control of sensitivity to carcinogens
    • S.L. Slocum, and T.W. Kensler Nrf2: control of sensitivity to carcinogens Arch Toxicol 85 2011 273 284
    • (2011) Arch Toxicol , vol.85 , pp. 273-284
    • Slocum, S.L.1    Kensler, T.W.2
  • 10
    • 79954416526 scopus 로고    scopus 로고
    • The cytoprotective role of the Keap1-Nrf2 pathway
    • L. Baird, and A.T. Dinkova-Kostova The cytoprotective role of the Keap1-Nrf2 pathway Arch Toxicol 85 2011 241 272
    • (2011) Arch Toxicol , vol.85 , pp. 241-272
    • Baird, L.1    Dinkova-Kostova, A.T.2
  • 11
    • 0034125712 scopus 로고    scopus 로고
    • Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
    • Y. Zhang Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells Carcinogenesis 21 2000 1175 1182
    • (2000) Carcinogenesis , vol.21 , pp. 1175-1182
    • Zhang, Y.1
  • 12
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, and et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proc Natl Acad Sci U S A 99 2002 11908 11913
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3
  • 13
    • 29644443964 scopus 로고    scopus 로고
    • Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane
    • F. Hong, M.L. Freeman, and D.C. Liebler Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane Chem Res Toxicol 18 2005 1917 1926
    • (2005) Chem Res Toxicol , vol.18 , pp. 1917-1926
    • Hong, F.1    Freeman, M.L.2    Liebler, D.C.3
  • 15
    • 78650509515 scopus 로고    scopus 로고
    • Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    • M. McMahon, D.J. Lamont, K.A. Beattie, and J.D. Hayes Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals Proc Natl Acad Sci U S A 107 2010 18838 18843
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18838-18843
    • McMahon, M.1    Lamont, D.J.2    Beattie, K.A.3    Hayes, J.D.4
  • 16
    • 58249117780 scopus 로고    scopus 로고
    • The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
    • M. Kobayashi, L. Li, N. Iwamoto, and et al. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds Mol Cell Biol 29 2009 493 502
    • (2009) Mol Cell Biol , vol.29 , pp. 493-502
    • Kobayashi, M.1    Li, L.2    Iwamoto, N.3
  • 17
    • 33746889956 scopus 로고    scopus 로고
    • Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    • R. Hu, C. Xu, G. Shen, and et al. Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice Cancer Lett 243 2006 170 192
    • (2006) Cancer Lett , vol.243 , pp. 170-192
    • Hu, R.1    Xu, C.2    Shen, G.3
  • 18
    • 84864461148 scopus 로고    scopus 로고
    • Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
    • K. Takaya, T. Suzuki, H. Motohashi, and et al. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system Free Radic Biol Med 53 2012 817 827
    • (2012) Free Radic Biol Med , vol.53 , pp. 817-827
    • Takaya, K.1    Suzuki, T.2    Motohashi, H.3
  • 19
    • 79955656232 scopus 로고    scopus 로고
    • The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease
    • P.C. Evans The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease EPMA J 2 2011 9 14
    • (2011) EPMA J , vol.2 , pp. 9-14
    • Evans, P.C.1
  • 21
    • 84908425948 scopus 로고    scopus 로고
    • Sulforaphane treatment of autism spectrum disorder (ASD)
    • K. Singh, S.L. Connors, E.A. Macklin, and et al. Sulforaphane treatment of autism spectrum disorder (ASD) Proc Natl Acad Sci U S A 111 2014 15550 15555
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15550-15555
    • Singh, K.1    Connors, S.L.2    Macklin, E.A.3
  • 22
    • 84897004164 scopus 로고    scopus 로고
    • Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function
    • Y. Wang, Z. Zhang, W. Sun, and et al. Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function Oxid Med Cell Longev 2014 2014 123963
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 123963
    • Wang, Y.1    Zhang, Z.2    Sun, W.3
  • 24
    • 84921262142 scopus 로고    scopus 로고
    • Modulating potential of l-sulforaphane in the expression of cytochrome P450 to identify potential targets for breast cancer chemoprevention and therapy using breast cell lines
    • Licznerska B, Szaefer H, Matuszak I, Murias M, Baer-Dubowska W. Modulating potential of l-sulforaphane in the expression of cytochrome P450 to identify potential targets for breast cancer chemoprevention and therapy using breast cell lines. Phytother Res 2015;29:93-9.
    • (2015) Phytother Res , vol.29 , pp. 93-99
    • Licznerska, B.1    Szaefer, H.2    Matuszak, I.3    Murias, M.4    Baer-Dubowska, W.5
  • 25
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes
    • K. Maheo, F. Morel, S. Langouet, and et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes Cancer Res 57 1997 3649 3652
    • (1997) Cancer Res , vol.57 , pp. 3649-3652
    • Maheo, K.1    Morel, F.2    Langouet, S.3
  • 27
    • 23844499241 scopus 로고    scopus 로고
    • Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations
    • I. Misiewicz, A. Kozar, K. Skupinska, E. Kowalska, J. Lubinski, and T. Kasprzycka-Guttman Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations Oncol Rep 13 2005 659 665
    • (2005) Oncol Rep , vol.13 , pp. 659-665
    • Misiewicz, I.1    Kozar, A.2    Skupinska, K.3    Kowalska, E.4    Lubinski, J.5    Kasprzycka-Guttman, T.6
  • 28
    • 77958609008 scopus 로고    scopus 로고
    • Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells
    • S. Kanematsu, N. Uehara, H. Miki, and et al. Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells Anticancer Res 30 2010 3381 3390
    • (2010) Anticancer Res , vol.30 , pp. 3381-3390
    • Kanematsu, S.1    Uehara, N.2    Miki, H.3
  • 29
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
    • A. Pledgie-Tracy, M.D. Sobolewski, and N.E. Davidson Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines Mol Cancer Ther 6 2007 1013 1021
    • (2007) Mol Cancer Ther , vol.6 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 30
    • 0034162822 scopus 로고    scopus 로고
    • Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
    • L. Gamet-Payrastre, P. Li, S. Lumeau, and et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells Cancer Res 60 2000 1426 1433
    • (2000) Cancer Res , vol.60 , pp. 1426-1433
    • Gamet-Payrastre, L.1    Li, P.2    Lumeau, S.3
  • 31
    • 33845623882 scopus 로고    scopus 로고
    • D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1
    • S. Choi, K.L. Lew, H. Xiao, and et al. D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1 Carcinogenesis 28 2007 151 162
    • (2007) Carcinogenesis , vol.28 , pp. 151-162
    • Choi, S.1    Lew, K.L.2    Xiao, H.3
  • 32
    • 58149170713 scopus 로고    scopus 로고
    • Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo
    • H. Liang, B. Lai, and Q. Yuan Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo J Nat Prod 71 2008 1911 1914
    • (2008) J Nat Prod , vol.71 , pp. 1911-1914
    • Liang, H.1    Lai, B.2    Yuan, Q.3
  • 33
    • 4444326097 scopus 로고    scopus 로고
    • Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization
    • S.J. Jackson, and K.W. Singletary Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization J Nutr 134 2004 2229 2236
    • (2004) J Nutr , vol.134 , pp. 2229-2236
    • Jackson, S.J.1    Singletary, K.W.2
  • 34
    • 84899108017 scopus 로고    scopus 로고
    • Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
    • S. Labsch, L. Liu, N. Bauer, and et al. Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells Int J Oncol 44 2014 1470 1480
    • (2014) Int J Oncol , vol.44 , pp. 1470-1480
    • Labsch, S.1    Liu, L.2    Bauer, N.3
  • 35
    • 84885320859 scopus 로고    scopus 로고
    • Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells
    • Q. Li, J. Xia, Y. Yao, D.W. Gong, H. Shi, and Q. Zhou Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells Breast Cancer Res Treat 141 2013 317 324
    • (2013) Breast Cancer Res Treat , vol.141 , pp. 317-324
    • Li, Q.1    Xia, J.2    Yao, Y.3    Gong, D.W.4    Shi, H.5    Zhou, Q.6
  • 36
    • 77951730125 scopus 로고    scopus 로고
    • Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    • Y. Li, T. Zhang, H. Korkaya, and et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells Clin Cancer Res 16 2010 2580 2590
    • (2010) Clin Cancer Res , vol.16 , pp. 2580-2590
    • Li, Y.1    Zhang, T.2    Korkaya, H.3
  • 37
    • 84887000882 scopus 로고    scopus 로고
    • Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells
    • L. Yang, M. Zahid, Y. Liao, and et al. Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells Carcinogenesis 34 2013 2587 2592
    • (2013) Carcinogenesis , vol.34 , pp. 2587-2592
    • Yang, L.1    Zahid, M.2    Liao, Y.3
  • 38
    • 84862827382 scopus 로고    scopus 로고
    • Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-alpha-stimulated mouse vascular smooth muscle cells: Involvement of the MAPK, NF-KappaB and AP-1 signaling pathways
    • J.Y. Kim, H.J. Park, S.H. Um, and et al. Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-alpha-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-KappaB and AP-1 signaling pathways Vascul Pharmacol 56 2012 131 141
    • (2012) Vascul Pharmacol , vol.56 , pp. 131-141
    • Kim, J.Y.1    Park, H.J.2    Um, S.H.3
  • 39
  • 40
    • 84897130844 scopus 로고    scopus 로고
    • Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane
    • Z.Y. Su, C. Zhang, J.H. Lee, and et al. Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane Cancer Prev Res (Phila) 7 2014 319 329
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 319-329
    • Su, Z.Y.1    Zhang, C.2    Lee, J.H.3
  • 42
    • 77955352742 scopus 로고    scopus 로고
    • Sulforaphane causes epigenetic repression of HTERT expression in human breast cancer cell lines
    • S.M. Meeran, S.N. Patel, and T.O. Tollefsbol Sulforaphane causes epigenetic repression of HTERT expression in human breast cancer cell lines PLoS One 5 2010 e11457
    • (2010) PLoS One , vol.5
    • Meeran, S.M.1    Patel, S.N.2    Tollefsbol, T.O.3
  • 43
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    • M.C. Myzak, K. Hardin, R. Wang, R.H. Dashwood, and E. Ho Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells Carcinogenesis 27 2006 811 819
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4    Ho, E.5
  • 44
    • 84891691403 scopus 로고    scopus 로고
    • HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates
    • P. Rajendran, A.I. Kidane, T.W. Yu, and et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates Epigenetics 8 2013 612 623
    • (2013) Epigenetics , vol.8 , pp. 612-623
    • Rajendran, P.1    Kidane, A.I.2    Yu, T.W.3
  • 45
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • M.C. Myzak, P.A. Karplus, F.L. Chung, and R.H. Dashwood A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase Cancer Res 64 2004 5767 5774
    • (2004) Cancer Res , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 46
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    • M.C. Myzak, W.M. Dashwood, G.A. Orner, E. Ho, and R.H. Dashwood Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice FASEB J 20 2006 506 508
    • (2006) FASEB J , vol.20 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3    Ho, E.4    Dashwood, R.H.5
  • 47
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    • M.C. Myzak, P. Tong, W.M. Dashwood, R.H. Dashwood, and E. Ho Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects Exp Biol Med (Maywood) 232 2007 227 234
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.M.3    Dashwood, R.H.4    Ho, E.5
  • 48
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Y. Zhang, P. Talalay, C.G. Cho, and G.H. Posner A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure Proc Natl Acad Sci U S A 89 1992 2399 2403
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4
  • 49
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • J.W. Fahey, Y. Zhang, and P. Talalay Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens Proc Natl Acad Sci U S A 94 1997 10367 10372
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10367-10372
    • Fahey, J.W.1    Zhang, Y.2    Talalay, P.3
  • 50
    • 0034928041 scopus 로고    scopus 로고
    • Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans
    • T.A. Shapiro, J.W. Fahey, K.L. Wade, K.K. Stephenson, and P. Talalay Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans Cancer Epidemiol Biomarkers Prev 10 2001 501 508
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 501-508
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 51
    • 0032189659 scopus 로고    scopus 로고
    • Sub-cellular immunolocalization of the glucosinolate sinigrin in seedlings of Brassica juncea
    • P.J. Kelly, A. Bones, and J.T. Rossiter Sub-cellular immunolocalization of the glucosinolate sinigrin in seedlings of Brassica juncea Planta 206 1998 370 377
    • (1998) Planta , vol.206 , pp. 370-377
    • Kelly, P.J.1    Bones, A.2    Rossiter, J.T.3
  • 52
    • 85047683218 scopus 로고    scopus 로고
    • Different myrosinase and idioblast distribution in arabidopsis and Brassica napus
    • E. Andreasson, J.L. Bolt, A.S. Hoglund, L. Rask, and J. Meijer Different myrosinase and idioblast distribution in arabidopsis and Brassica napus Plant Physiol 127 2001 1750 1763
    • (2001) Plant Physiol , vol.127 , pp. 1750-1763
    • Andreasson, E.1    Bolt, J.L.2    Hoglund, A.S.3    Rask, L.4    Meijer, J.5
  • 53
    • 0036010642 scopus 로고    scopus 로고
    • Guard cell- and phloem idioblast-specific expression of thioglucoside glucohydrolase 1 (myrosinase) in arabidopsis
    • H. Husebye, S. Chadchawan, P. Winge, O.P. Thangstad, and A.M. Bones Guard cell- and phloem idioblast-specific expression of thioglucoside glucohydrolase 1 (myrosinase) in arabidopsis Plant Physiol 128 2002 1180 1188
    • (2002) Plant Physiol , vol.128 , pp. 1180-1188
    • Husebye, H.1    Chadchawan, S.2    Winge, P.3    Thangstad, O.P.4    Bones, A.M.5
  • 54
    • 43149099706 scopus 로고    scopus 로고
    • The cancer chemopreventive actions of phytochemicals derived from glucosinolates
    • J.D. Hayes, M.O. Kelleher, and I.M. Eggleston The cancer chemopreventive actions of phytochemicals derived from glucosinolates Eur J Nutr 47 Suppl 2 2008 73 88
    • (2008) Eur J Nutr , vol.47 , pp. 73-88
    • Hayes, J.D.1    Kelleher, M.O.2    Eggleston, I.M.3
  • 55
    • 0037311116 scopus 로고    scopus 로고
    • Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana
    • P.D. Brown, J.G. Tokuhisa, M. Reichelt, and J. Gershenzon Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana Phytochemistry 62 2003 471 481
    • (2003) Phytochemistry , vol.62 , pp. 471-481
    • Brown, P.D.1    Tokuhisa, J.G.2    Reichelt, M.3    Gershenzon, J.4
  • 56
    • 0036483662 scopus 로고    scopus 로고
    • Composition and content of glucosinolates in developing Arabidopsis thaliana
    • B.L. Petersen, S. Chen, C.H. Hansen, C.E. Olsen, and B.A. Halkier Composition and content of glucosinolates in developing Arabidopsis thaliana Planta 214 2002 562 571
    • (2002) Planta , vol.214 , pp. 562-571
    • Petersen, B.L.1    Chen, S.2    Hansen, C.H.3    Olsen, C.E.4    Halkier, B.A.5
  • 57
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • J.W. Fahey, Y. Zhang, and P. Talalay Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens Proc Natl Acad Sci U S A 94 1997 10367 10372
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10367-10372
    • Fahey, J.W.1    Zhang, Y.2    Talalay, P.3
  • 58
    • 3042688047 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat
    • R. Hu, V. Hebbar, B.R. Kim, and et al. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat J Pharmacol Exp Ther 310 2004 263 271
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 263-271
    • Hu, R.1    Hebbar, V.2    Kim, B.R.3
  • 59
    • 0030781225 scopus 로고    scopus 로고
    • Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: Identification of phase I metabolites and glutathione conjugates
    • K. Kassahun, M. Davis, P. Hu, B. Martin, and T. Baillie Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates Chem Res Toxicol 10 1997 1228 1233
    • (1997) Chem Res Toxicol , vol.10 , pp. 1228-1233
    • Kassahun, K.1    Davis, M.2    Hu, P.3    Martin, B.4    Baillie, T.5
  • 60
    • 84872032765 scopus 로고    scopus 로고
    • Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: Implications for cancer prevention
    • O.L. Veeranki, A. Bhattacharya, J.R. Marshall, and Y. Zhang Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention Br J Nutr 109 2013 25 32
    • (2013) Br J Nutr , vol.109 , pp. 25-32
    • Veeranki, O.L.1    Bhattacharya, A.2    Marshall, J.R.3    Zhang, Y.4
  • 61
    • 83555173511 scopus 로고    scopus 로고
    • Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    • J.D. Clarke, A. Hsu, D.E. Williams, and et al. Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice Pharm Res 28 2011 3171 3179
    • (2011) Pharm Res , vol.28 , pp. 3171-3179
    • Clarke, J.D.1    Hsu, A.2    Williams, D.E.3
  • 62
    • 0028203252 scopus 로고
    • Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
    • Y. Zhang, T.W. Kensler, C.G. Cho, G.H. Posner, and P. Talalay Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates Proc Natl Acad Sci U S A 91 1994 3147 3150
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3147-3150
    • Zhang, Y.1    Kensler, T.W.2    Cho, C.G.3    Posner, G.H.4    Talalay, P.5
  • 63
    • 34547795788 scopus 로고    scopus 로고
    • Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    • B.S. Cornblatt, L. Ye, A.T. Dinkova-Kostova, and et al. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast Carcinogenesis 28 2007 1485 1490
    • (2007) Carcinogenesis , vol.28 , pp. 1485-1490
    • Cornblatt, B.S.1    Ye, L.2    Dinkova-Kostova, A.T.3
  • 64
    • 33746239394 scopus 로고    scopus 로고
    • Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    • A.T. Dinkova-Kostova, S.N. Jenkins, J.W. Fahey, and et al. Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts Cancer Lett 240 2006 243 252
    • (2006) Cancer Lett , vol.240 , pp. 243-252
    • Dinkova-Kostova, A.T.1    Jenkins, S.N.2    Fahey, J.W.3
  • 65
    • 70149093188 scopus 로고    scopus 로고
    • Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the CFos DNA-binding domain: Implications for chemoprevention of UVB-induced skin cancer
    • S.E. Dickinson, T.F. Melton, E.R. Olson, J. Zhang, K. Saboda, and G.T. Bowden Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the CFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer Cancer Res 69 2009 7103 7110
    • (2009) Cancer Res , vol.69 , pp. 7103-7110
    • Dickinson, S.E.1    Melton, T.F.2    Olson, E.R.3    Zhang, J.4    Saboda, K.5    Bowden, G.T.6
  • 67
    • 33748089664 scopus 로고    scopus 로고
    • Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    • C. Xu, M.T. Huang, G. Shen, and et al. Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 Cancer Res 66 2006 8293 8296
    • (2006) Cancer Res , vol.66 , pp. 8293-8296
    • Xu, C.1    Huang, M.T.2    Shen, G.3
  • 68
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • J.W. Fahey, X. Haristoy, P.M. Dolan, and et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors Proc Natl Acad Sci U S A 99 2002 7610 7615
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3
  • 69
    • 1642545614 scopus 로고    scopus 로고
    • Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
    • A.V. Singh, D. Xiao, K.L. Lew, R. Dhir, and S.V. Singh Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo Carcinogenesis 25 2004 83 90
    • (2004) Carcinogenesis , vol.25 , pp. 83-90
    • Singh, A.V.1    Xiao, D.2    Lew, K.L.3    Dhir, R.4    Singh, S.V.5
  • 70
    • 38449089515 scopus 로고    scopus 로고
    • Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo
    • T.A. Matsui, H. Murata, T. Sakabe, and et al. Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo Oncol Rep 18 2007 1263 1268
    • (2007) Oncol Rep , vol.18 , pp. 1263-1268
    • Matsui, T.A.1    Murata, H.2    Sakabe, T.3
  • 71
    • 84872728610 scopus 로고    scopus 로고
    • Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-Ras and xenograft mouse models of lung cancer
    • P. Kombairaju, J. Ma, R.K. Thimmulappa, and et al. Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-Ras and xenograft mouse models of lung cancer J Carcinog 11 2012 8
    • (2012) J Carcinog , vol.11 , pp. 8
    • Kombairaju, P.1    Ma, J.2    Thimmulappa, R.K.3
  • 72
    • 74149084423 scopus 로고    scopus 로고
    • Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy
    • D.P. Do, S.B. Pai, S.A. Rizvi, and M.J. D'Souza Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy Int J Pharm 386 2010 114 121
    • (2010) Int J Pharm , vol.386 , pp. 114-121
    • Do, D.P.1    Pai, S.B.2    Rizvi, S.A.3    D'Souza, M.J.4
  • 73
    • 0032406798 scopus 로고    scopus 로고
    • Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
    • T.A. Shapiro, J.W. Fahey, K.L. Wade, K.K. Stephenson, and P. Talalay Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables Cancer Epidemiol Biomarkers Prev 7 1998 1091 1100
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 1091-1100
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 74
    • 33749165612 scopus 로고    scopus 로고
    • Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: A clinical phase I study
    • T.A. Shapiro, J.W. Fahey, A.T. Dinkova-Kostova, and et al. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study Nutr Cancer 55 2006 53 62
    • (2006) Nutr Cancer , vol.55 , pp. 53-62
    • Shapiro, T.A.1    Fahey, J.W.2    Dinkova-Kostova, A.T.3
  • 75
    • 0036135910 scopus 로고    scopus 로고
    • Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans
    • L. Ye, A.T. Dinkova-Kostova, K.L. Wade, Y. Zhang, T.A. Shapiro, and P. Talalay Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans Clin Chim Acta 316 2002 43 53
    • (2002) Clin Chim Acta , vol.316 , pp. 43-53
    • Ye, L.1    Dinkova-Kostova, A.T.2    Wade, K.L.3    Zhang, Y.4    Shapiro, T.A.5    Talalay, P.6
  • 76
    • 84857918033 scopus 로고    scopus 로고
    • Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
    • A.S. Agyeman, R. Chaerkady, P.G. Shaw, and et al. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles Breast Cancer Res Treat 132 2012 175 187
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 175-187
    • Agyeman, A.S.1    Chaerkady, R.2    Shaw, P.G.3
  • 77
    • 28644450910 scopus 로고    scopus 로고
    • Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    • T.W. Kensler, J.G. Chen, P.A. Egner, and et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China Cancer Epidemiol Biomarkers Prev 14 2005 2605 2613
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 2605-2613
    • Kensler, T.W.1    Chen, J.G.2    Egner, P.A.3
  • 78
    • 84887899631 scopus 로고    scopus 로고
    • Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China
    • J.G. Chen, P.A. Egner, D. Ng, and et al. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China Cancer Prev Res (Phila) 6 2013 1038 1045
    • (2013) Cancer Prev Res (Phila) , vol.6 , pp. 1038-1045
    • Chen, J.G.1    Egner, P.A.2    Ng, D.3
  • 79
    • 79955834680 scopus 로고    scopus 로고
    • Bioavailability of sulforaphane from two broccoli sprout beverages: Results of a short-term, cross-over clinical trial in Qidong, China
    • P.A. Egner, J.G. Chen, J.B. Wang, and et al. Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China Cancer Prev Res (Phila) 4 2011 384 395
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 384-395
    • Egner, P.A.1    Chen, J.G.2    Wang, J.B.3
  • 80
    • 84855409443 scopus 로고    scopus 로고
    • Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
    • T.W. Kensler, D. Ng, S.G. Carmella, and et al. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China Carcinogenesis 33 2012 101 107
    • (2012) Carcinogenesis , vol.33 , pp. 101-107
    • Kensler, T.W.1    Ng, D.2    Carmella, S.G.3
  • 81
    • 84905824183 scopus 로고    scopus 로고
    • Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: Results of a randomized clinical trial in China
    • P.A. Egner, J.G. Chen, A.T. Zarth, and et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China Cancer Prev Res (Phila) 7 2014 813 823
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 813-823
    • Egner, P.A.1    Chen, J.G.2    Zarth, A.T.3
  • 82
    • 84857674733 scopus 로고    scopus 로고
    • Notes from the field: "green" chemoprevention as frugal medicine
    • J.W. Fahey, P. Talalay, and T.W. Kensler Notes From the field: "green" chemoprevention as frugal medicine Cancer Prev Res (Phila) 5 2012 179 188
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 179-188
    • Fahey, J.W.1    Talalay, P.2    Kensler, T.W.3
  • 83
    • 84866355653 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
    • R.J. Fox, D.H. Miller, J.T. Phillips, and et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis N Engl J Med 367 2012 1087 1097
    • (2012) N Engl J Med , vol.367 , pp. 1087-1097
    • Fox, R.J.1    Miller, D.H.2    Phillips, J.T.3
  • 84
    • 79960855656 scopus 로고    scopus 로고
    • Bardoxolone methyl and kidney function in CKD with type 2 diabetes
    • P.E. Pergola, P. Raskin, R.D. Toto, and et al. Bardoxolone methyl and kidney function in CKD with type 2 diabetes N Engl J Med 365 2011 327 336
    • (2011) N Engl J Med , vol.365 , pp. 327-336
    • Pergola, P.E.1    Raskin, P.2    Toto, R.D.3
  • 85
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • C.C. Conaway, C.X. Wang, B. Pittman, and et al. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice Cancer Res 65 2005 8548 8557
    • (2005) Cancer Res , vol.65 , pp. 8548-8557
    • Conaway, C.C.1    Wang, C.X.2    Pittman, B.3
  • 86
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • F.L. Chung, C.C. Conaway, C.V. Rao, and B.S. Reddy Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate Carcinogenesis 21 2000 2287 2291
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 87
    • 40449129950 scopus 로고    scopus 로고
    • Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    • R. Munday, P. Mhawech-Fauceglia, C.M. Munday, and et al. Inhibition of urinary bladder carcinogenesis by broccoli sprouts Cancer Res 68 2008 1593 1600
    • (2008) Cancer Res , vol.68 , pp. 1593-1600
    • Munday, R.1    Mhawech-Fauceglia, P.2    Munday, C.M.3
  • 88
    • 62449233418 scopus 로고    scopus 로고
    • Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
    • S.V. Singh, R. Warin, D. Xiao, and et al. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells Cancer Res 69 2009 2117 2125
    • (2009) Cancer Res , vol.69 , pp. 2117-2125
    • Singh, S.V.1    Warin, R.2    Xiao, D.3
  • 89
    • 84874489560 scopus 로고    scopus 로고
    • Keap1-Nrf2 signaling: A target for cancer prevention by sulforaphane
    • T.W. Kensler, P.A. Egner, A.S. Agyeman, and et al. Keap1-Nrf2 signaling: a target for cancer prevention by sulforaphane Top Curr Chem 329 2013 163 177
    • (2013) Top Curr Chem , vol.329 , pp. 163-177
    • Kensler, T.W.1    Egner, P.A.2    Agyeman, A.S.3


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