Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells

Breast Cancer Research and Treatment

Volumn 141, Issue 2, 2013, Pages 317-324

  Li, Qinglin ^a   Xia, Jixiang ^a   Yao, Yuan ^a   Gong, Da Wei ^a   Shi, Hongfei ^b   Zhou, Qun ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Adipogenesis; Adipose; Breast cancer cells; Mammary; Mesenchymal stem cells; Sulforaphane

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; SULFORAPHANE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL FUNCTION; CELL INTERACTION; CELL RENEWAL; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR MICROENVIRONMENT;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; BREAST NEOPLASMS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HETEROGRAFTS; HUMANS; ISOTHIOCYANATES; MAMMARY GLANDS, HUMAN; MESENCHYMAL STROMAL CELLS; MICE;

EID: 84885320859     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-013-2672-1     Document Type: Article

References (20)

1. Galic S, Oakhill JS, Steinberg GR (2010) Adipose tissue as an endocrine organ. Mol Cell Endocrinol 316:129-139
2. Cristancho AG, Lazar MA (2011) Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 12:722-734
3. Kolf CM, Cho E, Tuan RS (2009) Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthr res ther 9:204
4. Sul HS (2009) Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate. Mol Endocrinol 23:1717-1725
5. Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert CJ Jr, Liu XS et al (2008) PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 22:2941-2952
6. Yeh WC, Cao Z, Classon M, McKnight SL (1995) Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 9:168-181
7. Wang Y, Sul HS (2009) Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9. Cell Metab 9:287-302
8. Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP et al (2009) Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 22:6408-6423
9. Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, Majed B, Wang YY, Meulle A, Salles B, Le Gonidec S et al (2011) Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res 71:2455-2465
10. Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C (2001) Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276:32008-32015
11. Gamet-Payrastre L (2006) Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets 6:135-145
12. Lee JH, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY (2012) Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway. Biochem Biophys Res Commun 426:492-497
13. Boquest AC, Shahdadfar A, Frønsdal K, Sigurjonsson O, Tunheim SH, Collas P, Brinchmann JE (2005) Isolation and transcription profiling of purified uncultured human stromal stem cells: alteration of gene expression after in vitro cell culture. Mol Biol Cell 16:1131-1141
14. Li Q, Yao Y, Eades G, Liu Z, Zhang Y, Zhou Q (2013) Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. Oncogene. doi: 10.1038/onc.2013.226 Epub ahead of print
15. Castells M, Thibault B, Delord JP, Couderc B (2012) Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int J Mol Sci 13:9545-9571
16. Bochet L, Meulle A, Imbert S, Salles B, Valet P, Muller C (2011) Cancer-associated adipocytes promotes breast tumor radioresistance. Biochem Biophys Res Commun 411:102-106
17. Bechara C, Chai H, Lin PH, Yao Q, Chen C (2007) Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med sci monit: Int Med J Exp Clin Res 13:RA87-RA90
18. Zhu Q, Han X, Peng J, Qin H, Wang Y (2012) The role of CXC chemokines and their receptors in the progression and treatment of tumors. J Mol Histol 43:699-713
19. Deshmane SL, Kremlev S, Amini S, Sawaya BE (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interf Cytokine Res 29:313-326
20. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813:878-888