Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: Involvement of the MAPK, NF-κB and AP-1 signaling pathways

Vascular Pharmacology

Volumn 56, Issue 3-4, 2012, Pages 131-141

  Kim, Ji Yun ^a   Park, Hye Jin ^a   Um, Sung Hee ^b   Sohn, Eun Hwa ^c   Kim, Byung Oh ^d   Moon, Eun Yi ^e   Rhee, Dong Kwon ^a   Pyo, Suhkneung ^a  

^a Sungkyunkwan University   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Kyungpook National University   (South Korea)

^d Kangwon National University   (South Korea)

^e Sejong University   (South Korea)

Author keywords

Anti inflammatory effect; AP 1; MAPK; NF B; Sulforaphane; Vascular cell adhesion molecule

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ATHEROSCLEROSIS; CELL ADHESION; CELL LINE; GENE EXPRESSION REGULATION; GENES, REPORTER; MAP KINASE SIGNALING SYSTEM; MICE; MOLECULAR TARGETED THERAPY; MONOCYTES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RNA, MESSENGER; THIOCYANATES; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84862827382     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2011.11.007     Document Type: Article

References (54)

1. Aharoni-Simon M., Reifen R., Tirosh O. ROS-production-mediated activation of AP-1 but not NF-κB inhibits glutamate-induced HT4 neuronal cell death. Antioxid. Redox Signal. 2006, 8(7-8):1339-1349.
2. Angel P., Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1991, 1072:129-157.
3. Acuna U.M., Atha D.E., Ma J., Nee M.H., Kennelly E.J. Antioxidant capacities of ten edible North American plants. Phytother. Res. 2002, 16:63-65.
4. Beg A.A., Finco T.S., Nantermet P.V., Baldwin A.S. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: a mechanism for NF-κB activation. Mol. Cell. Biol. 1993, 13:3301-3310.
5. Braun M., Pietsch P., Schror K., Baumann G., Felix S.B. Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc. Res. 1999, 41:395-401.
6. Chen C., Chou C., Sun Y., Huang W. Tumor necrosis factor α-induced activation of downstream NF-κB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion: involvement of PKCα, tyrosin kinase, and IKK2, but not MAPKs, pathway. Cell. Signal. 2001, 13:543-553.
7. Chen X.L., Dodd G., Kunsch C. Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells. Inflamm. Res. 2009, 58(8):513-521.
8. Cho S.J., Kang N.S., Park S.Y., Kim B.O., Rhee D.K., Pyo S. Induction of apoptosis and expression of apoptosis related genes in human epithelial carcinoma cells by Helicobacter pylori VacA toxin. Toxicon 2003, 42:601-611.
9. Clarke, J.D., Dashwood, R.H., Ho E., 2008. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 269(2):291-304.
10. Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., Maniatis T. Transcriptional regulation of muscle cell adhesion molecules: NF-kB and cytokine inducible enhancers. FASEB J. 1995, 9:899-909.
11. Cybulsky M.I., Iiyama K., Li H., Zhu S., Chen M., Iiyama M., Davis V., Gutierrez-Ramos J.C., Connelly P.W., Milstone D.S. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. 2001, 107:1255-1262.
12. Elbarbry F., Elrody N. Potential health benefits of sulforaphane: a review of the experimental, clinical and epidemiological evidences and underlying mechanisms. J. Med. Plant. Res. 2011, 5(4):473-484.
13. Falk E. Pathogenesis of atherosclerosis. J. Am. Coll. Cardiol. 2006, 47:C7-C12.
14. Faruqi, R.M., Poptic, E.J., Faruqi, T.R., De La Motte, C., DiCorleto, P.E., 1997. Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Am. J. Physiol. 273(2 Pt 2):H817-826.
15. Galan M.V., Kishan A.A., Silverman A.L. Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report. Dig. Dis. Sci. 2004, 49(7-8):1088-1090.
16. Gosset P., Wallaert B., Tonnel A.B., Fourneau C. Thiol regulation of the production of TNF-α, IL-6 and IL-8 by human alveolar macrophages. Eur. Respir. J. 1999, 14:98-105.
17. Griendling K.K., Sorescu D., Lassegue B., Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler. Thromb. Vasc. Biol. 2000, 20(10):2175-2183.
18. Guedes R.P., Araújo A.S., Janner D., Belló-Klein A., Ribeiro M.F., Partata W.A. Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain. Cell. Mol. Neurobiol. 2008, 28(8):1049-1056.
19. Gupta A., Rosenberger S.F., Bowden G.T. Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 1999, 20(11):2063-2073.
20. Ho A.W., Wong C.K., Lam C.W. Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways. Immunobiology 2008, 213(7):533-544.
21. Hubbard A., Rothlein R. Intercellular adhesion molecule-1 expression and cell signaling cascades. Free Rad. Biol. Med. 2000, 28:1379-1386.
22. Huo Y., Ley K. Adhesion molecules and atherogenesis. Acta Physiol. Scand. 2001, 173(1):35-43.
23. Iademarco M.F., McQuillan J.J., Rosen G.D., Dean D.C. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 1992, 267:16323-16329.
24. Jang Y., Lincoff A.M., Plow E.F., Topol E.J. Cell adhesion molecules in coronary artery disease. J. Am. Coll. Cardiol. 1994, 24(7):1591-1601.
25. Ju J.W., Kim S.J., Jun C.D., Chun J.S. p38 kinase and c-Jun N-terminal kinase oppositely regulates tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 expression and cell adhesion in chondrosarcoma cells. IUBMB Life 2002, 54:293-299.
26. Kang J.S., Yoon Y.D., Han M.H., Han S.B., Lee K., Lee K.H., Park S.K., Kim H.M. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. Mol. Pharmacol. 2006, 69(3):941-949.
27. Kasper H.U., Schmidt A., Roessner A. Expression of the adhesion molecules ICAM, VCAM, and ELAM in the arteriosclerotic plaque. Gen. Diagn. Pathol. 1996, 141(5-6):289-294.
28. Kong L., Chen G.D., Zhou X., McGinnis J.F., Li F., Cao W. Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane. Neurochem. Int. 2009, 54:172-179.
29. Kunsh C., Medford R.M. Oxidative stress as a regulator of gene expression in the vasculature. Circ. Res. 1999, 85(8):753-766.
30. Ledebur H.C., Parks T.P. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers. J. Biol. Chem. 1995, 270(2):933-943.
31. Lee S.R., Kwak J.H., Kim H.J., Pyo S. Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells. Bioorg. Med. Chem. Lett. 2007, 17(7):1879-1882.
32. Libby P., Li H. Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis. J. Clin. Invest. 1993, 92(2):538-539.
33. Liu Y.C., Hsieh C.W., Weng Y.C., Chuang S.H., Hsieh C.Y., Wung B.S. Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells. Vascul. Pharmacol. 2008, 48(1):54-61.
34. Lusis A.J. Atherosclerosis. Nature 2000, 407:233-241.
35. McCoy M.K., Tansey M.G. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J. Neuroinflamm. 2008, 5:45-58.
36. Minami T., Abid M.R., Zhang J., King G., Kodama T., Aird W.C. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-κB and PKC-zeta-GATA signaling pathways. J. Biol. Chem. 2003, 278:6976-6984.
37. Mo S.J., Son E.W., Lee S.R., Lee S.M., Shin D.H., Pyo S. CML-1 inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in endothelial cells through inhibition of IkBalpha kinase. J. Ethnopharmacol. 2007, 109(1):78-86.
38. Neish A.S., Read M.A., Thanos D., Pine R., Maniatis T., Collins T. Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1. Mol. Cell. Biol. 1995, 15:2558-2569.
39. Neish A.S., Khachigian L.M., Park A., Baichwal V.R., Collins T. Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1. J. Biol. Chem. 1995, 270:28903-28909.
40. Oh J.H., Kwon T.K. Withaferin A inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules by inactivation of Akt and NF-kappaB in human pulmonary epithelial cells. Int. Immunopharmacol. 2009, 9(5):614-619.
41. Owens G.K., Kumar M.S., Wamhoff B.R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev. 2004, 84:767-801.
42. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866.
43. Qin P., Tang X., Elloso M.M., Harnish D.C. Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38. Am. J. Physiol. Heart Circ. Physiol. 2006, 291(2):H741-H747.
44. Roebuck K.A. Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-κB. Int. J. Mol. Med. 1999, 4:223-230.
45. Sprague A.H., Khalil R.A. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem. Pharmacol. 2009, 78(6):539-552.
46. Stocker R., Keaney J.F. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 2004, 84:1381-1478.
47. Talalay P., Fahey J.W., Healy Z.R., Wehage S.L., Benedict A.L., Min C. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc. Natl. Acad. Sci. USA 2007, 104:17500-17505.
48. Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer 1980, 26:171-176.
49. Waddick K.G., Uckun F.M. Innovative treatment programs against cancer. II. Nuclear factor-kappa B (NF-κB) as a molecular target. Biochem. Pharmacol. 1999, 57:9-17.
50. Xie Q.W., Whisnant R., Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 1993, 177:1779-1784.
51. Yoon J.J., Lee Y.J., Kim J.S., Kang D.G., Lee H.S. Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells. Biochem. Biophys. Res. Commun. 2010, 391(1):96-101.
52. Zafarullah, M., Li, W.Q., Sylvester, J., Ahmad, M., 2003. Molecular mechanisms of N-acetylcysteine actions. Cell Mol. Life Sci. 60(1):6-20.
53. Zhang H.S., Wang S.Q. Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic. Biol. Med. 2006, 40(9):1664-1674.
54. Zhu W., Zhang J., Young C. Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. Carcinogenesis 2001, 22(9):1399-1403.