Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 7, 2016, Pages 1528-1539

  Xie, Sai Sai ^a   Lan, Jin Shuai ^a   Wang, Xiaobing ^a   Wang, Zhi Min ^a   Jiang, Neng ^a   Li, Fan ^a   Wu, Jia Jia ^a   Wang, Jin ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Cholinesterase; Coumarin; Docking; Donepezil; Monoamine oxidase

Indexed keywords

3 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 7,8,9,10 TETRAHYDRO 6H BENZO[C]CHROMEN 6 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 3 CHLORO 4 METHYL 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 3 METHYL 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 4 (TRIFLUOROMETHYL) 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 4 CHLORO 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 4 ETHOXY 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 4 METHOXY 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [2 [(1 BENZYLPIPERIDIN 4 YL)AMINO]ETHOXY] 4 PHENYL 2H CHROMEN 2 ONE; 7 [2 [[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL]AMINO]ETHOXY] 2H CHROMEN 2 ONE; 7 [3 [(1 BENZYLPIPERIDIN 4 YL)AMINO]PROPOXY] 2H CHROMEN 2 ONE; 7 [[(1 BENZYLPIPERIDIN 4 YL)AMINO]METHYL] 4 METHYL 2H CHROMEN 2 ONE; 7 [[[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL]AMINO]METHYL] 4 METHYL 2H CHROMEN 2 ONE; ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; IPRONIAZID; OXIDOREDUCTASE INHIBITOR; TACRINE; UNCLASSIFIED DRUG; COUMARIN; COUMARIN DERIVATIVE; INDAN DERIVATIVE; PIPERIDINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CATALYTIC ANIONIC SITE; CELL VIABILITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIVER TOXICITY; MOLECULAR DOCKING; MOLECULAR MODEL; PERIPHERAL ANIONIC SITE; PHARMACOKINETICS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; EEL; METABOLISM; MOLECULARLY TARGETED THERAPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALZHEIMER DISEASE; ANIMALS; BUTYRYLCHOLINESTERASE; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EELS; HUMANS; INDANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84960361124     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.02.023     Document Type: Article

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