Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: Safinamide and coumarin analogs

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5848-5852

  Binda, Claudia ^a   Wang, Jin ^b   Pisani, Leonardo ^d   Caccia, Carla ^c   Carotti, Angelo ^d   Salvati, Patricia ^c   Edmondson, Dale E ^b   Mattevi, Andrea ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Newron Pharmaceuticals SpA   (Italy)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7 (3 CHLOROBENZYLOXY) 4 CARBOXALDEHYDE COUMARIN; 7 [(3 CHLOROBENZYL)OXY] 2 OXO 2H CHROMENE 4 CARBOXALDEHYDE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; COUMARIN DERIVATIVE; SAFINAMIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ALANINE; BENZYLAMINES; COUMARINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN BINDING;

EID: 36148955400     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070677y     Document Type: Article

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