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Volumn 93, Issue , 2015, Pages 42-50
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Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties
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Author keywords
Alzheimer's disease; Antioxidant; Cholinesterase; Hepatotoxicity; Tacrine; Trolox
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Indexed keywords
2,2-DIPHENYL-1-PICRYLHYDRAZYL;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [10 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]DECYL]CHROMAN 2 CARBOXAMIDE;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [2 [(1,2,3,4 TETRAHYDROCRIDIN 9 YL)AMINO]ETHYL]CHROMAN 2 CARBOXAMIDE;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [4 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]BUTYL] CHROMAN 2 CARBOXAMIDE;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL]CHROMAN 2 CARBOXAMIDE;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [6 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEXYL] CHROMAN 2 CARBOXAMIDE;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [7 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]HEPTYL]CHROMAN 2 CARBOXAMIDE;
6 HYDROXY 2,5,7,8 TETRAMETHYL N [8 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]OCTYL]CHROMAN 2 CARBOXAMIDE;
6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID;
ACETYLCHOLINESTERASE;
ADVERSE DRUG REACTION;
ALANINE AMINOTRANSFERASE;
ANTIOXIDANT;
ASPARTATE AMINOTRANSFERASE;
BIPHENYL DERIVATIVE;
CHOLINERGIC RECEPTOR STIMULATING AGENT;
CHOLINESTERASE INHIBITOR;
CHROMAN DERIVATIVE;
LIVER PROTECTIVE AGENT;
NEUROPROTECTIVE AGENT;
PHARMACOKINETICS;
PHARMACOLOGY;
PICRIC ACID;
TACRINE;
TACRINE DERIVATIVE;
TROLOX C;
UNCLASSIFIED DRUG;
ALANINE AMINOTRANSFERASE BLOOD LEVEL;
ALZHEIMER DISEASE;
ANIMAL;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ANIMAL TISSUE;
ANTIOXIDANT ACTIVITY;
ARTICLE;
ASPARTATE AMINOTRANSFERASE BLOOD LEVEL;
BLOOD BRAIN BARRIER;
CELL SURVIVAL;
CELL VIABILITY;
CHEMICAL STRUCTURE;
CHEMISTRY;
CHOLINERGIC ACTIVITY;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
DRUG BINDING;
DRUG BINDING SITE;
DRUG DESIGN;
DRUG EFFECTS;
DRUG PENETRATION;
DRUG SCREENING;
DRUG SYNTHESIS;
DRUG THERAPY;
DRUG-INDUCED LIVER INJURY;
ENZYME INHIBITION;
ENZYMOLOGY;
IC50;
IN VITRO STUDY;
IN VIVO STUDY;
KINETICS;
LIVER PROTECTION;
LIVER TOXICITY;
MALE;
METABOLISM;
MOLECULAR DOCKING;
NEUROPROTECTION;
NONHUMAN;
OXIDATIVE STRESS;
PC12 CELL LINE;
PIG;
PREVENTION;
RAT;
SWINE;
SYNTHESIS;
ADVERSE EFFECTS;
ALZHEIMER DISEASE;
ANIMALS;
ANTIOXIDANTS;
BIPHENYL COMPOUNDS;
BLOOD-BRAIN BARRIER;
CELL SURVIVAL;
CHEMICAL SYNTHESIS;
CHEMISTRY;
CHOLINESTERASE INHIBITORS;
CHROMANS;
DRUG DESIGN;
DRUG EFFECTS;
DRUG THERAPY;
DRUG-INDUCED LIVER INJURY;
ENZYMOLOGY;
IN VITRO TECHNIQUES;
KINETICS;
MALE;
METABOLISM;
MOLECULAR DOCKING SIMULATION;
MOLECULAR STRUCTURE;
NEUROPROTECTIVE AGENTS;
PC12 CELLS;
PHARMACOKINETICS;
PHARMACOLOGY;
PICRATES;
PREVENTION AND CONTROL;
RATS;
SWINE;
TACRINE;
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EID: 84964310836
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2015.01.058 Document Type: Article |
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Times cited : (78)
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References (47)
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