Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease

Neuroscience Letters

Volumn 309, Issue 2, 2001, Pages 138-140

  Bhojak, Tejal J ^a   DeKosky, Steven T ^a,b   Ganguli, Mary ^a,b   Kamboh, M Ilyas ^a,b  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Alzheimer's disease; Association studies; Cathepsin G

Indexed keywords

ASPARTIC ACID; BETA SECRETASE; CATHEPSIN G; CELL DNA; SERINE; SERINE PROTEINASE;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; CODON; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CARRIER; EXON; FEMALE; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

AGED; ALZHEIMER DISEASE; CATHEPSINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS; SERINE ENDOPEPTIDASES;

EID: 0035943525     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02033-X     Document Type: Article

References (23)

1. Genetic polymorphisms in the cathepsin D and interleukin-6 genes and the risk of Alzheimer's disease
2. Evaluation of cathepsins D and G and EC 3.4.24.25 as candidate β-secretase proteases using peptide and amyloid precursor protein substrates
3. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer's brain
4. Generation of amyloid β-protein from its precursor is sequence-specific
5. Effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease
6. Genomic organization and chromosomal localization of the human cathepsin G gene
7. The relationship of the APOE polymorphism and cholesterol levels in normoglycemic and diabetic subjects in a biethnic population from the San Luis Valley Colorado
8. Exploring the etiology of Alzheimer's disease using molecular genetics
9. Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII
10. Sequence variant of the human cathepsin G gene
11. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS/ARDA workgroup under the auspices of Department of Health and Human Service Task Force on Alzheimer's disease
12. Cathepsin D. gene exon 2 polymorphism and sporadic Alzheimer's disease
13. Nucleotide sequence of human bone marrow serine protease (medullasin) gene
14. Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
15. A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease
16. A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
17. Effect of oxidation of β-amyloid precursor protein on its beta-secretase cleavage. A model study with synthetic peptides and candidate beta-secretases
18. A calcium-stimulated serine protease from monkey brain degrades the β-amyloid precursor protein
19. The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis
20. Localization in human cerebral cortex and generation of amyloidogenic fragments from the β-amyloid precursor protein
21. Structure of the human neutrophil elastase
22. 1-antichymotrypsin) with Alzheimer's Disease
23. Mutation of the gene for human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease