Gender-related similarities and differences in the body distribution of grape seed flavanols in rats

Molecular Nutrition and Food Research

Volumn 60, Issue 4, 2016, Pages 760-772

  Margalef, Maria ^a   Pons, Zara ^a   Iglesias Carres, Lisard ^a   Arola, Lluís ^a,b   Muguerza, Begoña ^a,b   Arola Arnal, Anna ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b TECNIO   (Spain)

Author keywords

Bioavailability; Grape seed; Metabolites; Polyphenol; Sex

Indexed keywords

3-HYDROXYFLAVONE; FLAVONOID; GRAPE SEED EXTRACT;

ANIMAL; BLOOD; BRAIN; CHEMISTRY; DRUG EFFECTS; FEMALE; LIVER; MALE; METABOLISM; SEX DIFFERENCE; TISSUE DISTRIBUTION; WHITE ADIPOSE TISSUE; WISTAR RAT;

ADIPOSE TISSUE, WHITE; ANIMALS; BRAIN; FEMALE; FLAVONOIDS; GRAPE SEED EXTRACT; LIVER; MALE; RATS, WISTAR; SEX FACTORS; TISSUE DISTRIBUTION;

EID: 84960157840     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500717     Document Type: Article

References (41)

1. Bladé, C., Arola, L., Salvadó, M. J., Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. Mol. Nutr. Food Res. 2010, 54, 37-59.
2. Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M. et al., Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid. Redox Signal. 2013, 18, 1818-1892.
3. Terra, X., Pallarés, V., Ardèvol, A., Bladé, C. et al., Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J. Nutr. Biochem. 2011, 22, 380-387.
4. Guerrero, L., Margalef, M., Pons, Z., Quiñones, M. et al., Serum metabolites of proanthocyanidin-administered rats decrease lipid synthesis in HepG2 cells. J. Nutr. Biochem. 2013, 24, 2092-2099.
5. González-Abuín, N., Martínez-Micaelo, N., Margalef, M., Blay, M. et al., A grape seed extract increases active glucagon-like peptide-1 levels after an oral glucose load in rats. Food Funct. 2014, 5, 2357-2364.
6. Quiñones, M., Guerrero, L., Suarez, M., Pons, Z. et al., Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats. Food Res. Int. 2013, 51, 587-595.
7. Monagas, M., Urpi-Sarda, M., Sánchez-Patán, F., Llorach, R. et al., Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites. Food Funct. 2010, 1, 233-253.
8. Aura, A. M., Microbial metabolism of dietary phenolic compounds in the colon. Phytochem. Rev. 2008, 7, 407-429.
9. Margalef, M., Pons, Z., Bravo, F. I., Muguerza, B., Arola-Arnal, A., Tissue distribution of rat flavanol metabolites at different doses. J. Nutr. Biochem. 2015, 26, 987-995.
10. Margalef, M., Guerrero, L., Pons, Z., Bravo, F. I. et al., A dose-response study of the bioavailability of grape seed proanthocyanidin in rat and lipid-lowering effects of generated metabolites in HepG2 cells. Food Res. Int. 2014, 64, 500-507.
11. Pons, Z., Guerrero, L., Margalef, M., Arola, L. et al., Effect of low molecular grape seed proanthocyanidins on blood pressure and lipid homeostasis in cafeteria diet-fed rats. J. Physiol. Biochem. 2014, 70, 629-637.
12. Kay, C. D., The future of flavonoid research. Br. J. Nutr. 2010, 104, s91-s95.
13. Kroon, P. A., Clifford, M. N., Crozier, A., Day, A. J. et al., How should we assess the effects of exposure to dietary polyphenols in vitro? Am. J. Clin. Nutr. 2004, 80, 15-21.
14. Varlamov, O., Bethea, C. L., Roberts, C. T., Sex-specific differences in lipid and glucose metabolism. Front. Endocrinol. (Lausanne). 2014, 5, 241-247.
15. Harrison, P. J., Tunbridge, E. M. Catechol-O-Methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology 2007, 33, 3037-3045.
16. Yahagi, K., Davis, H. R., Arbustini, E., Virmani, R., Sex differences in coronary artery disease: pathological observations. Atherosclerosis 2015, 239, 260-267.
17. Liu, H. B., Loo, K. K., Palaszynski, K., Ashouri, J. et al., Estrogen receptor mediates estrogen's immune protection in autoimmune disease. J. Immunol. 2003, 171, 6936-6940.
18. Taylor, B., Irving, H. M., Baliunas, D., Roerecke, M. et al., Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis. Addiction 2009, 104, 1981-1990.
19. DeBethizy, J. D., Hayes, J. R., in: Hayes, W. A. (Ed.), Princ. Methods Toxicol. -Metabolism: a determinant of toxicity, Raven Press, New York, NY 1994, pp. 59-100.
20. Mugford, C. A., Kedderis, G. L., Sex-dependent metabolism of xenobiotics. Drug Metab. Rev. 1998, 30, 441-498.
21. Ardévol, A., Bladé, C., Salvadó, M. J., Arola, L., Changes in lipolysis and hormone-sensitive lipase expression caused by procyanidins in 3T3-L1 adipocytes. Int. J. Obes. Relat. Metab. Disord. 2000, 24, 319-324.
22. Margalef, M., Pons, Z., Muguerza, B., Arola-Arnal, A., A rapid method to determine colonic microbial metabolites derived from grape flavanols in rat plasma by liquid chromatography-tandem mass spectrometry. J. Agric. Food Chem. 2014, 62, 7698-7706.
23. Serra, A., Macià, A., Romero, M. P., Salvadó, M. J. et al., Determination of procyanidins and their metabolites in plasma samples by improved liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. 2009, 877, 1169-1176.
24. Quesada, H., del Bas, J. M., Pajuelo, D., Díaz, S. et al., Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int. J. Obes. (Lond). 2009, 33, 1007-1012.
25. D'Archivio, M., Filesi, C., Di Benedetto, R., Gargiulo, R. et al., Polyphenols, dietary sources and bioavailability. Ann. Ist. Super. Sanita. 2007, 43, 348-361.
26. Aherne, S. A., O'Brien, N. M., Dietary flavonols: chemistry, food content, and metabolism. Nutrition 2002, 18, 75-81.
27. Finnen, M., Hassall, K., Effects of hypophysectomy on sex differences in the induction and depression of hepatic drug-metabolizing enzymes in the rat. J. Pharmacol. Exp. Ther. 1984, 229, 250-254.
28. Shoji, T., Masumoto, S., Moriichi, N., Akiyama, H. et al., Apple procyanidin oligomers absorption in rats after oral administration: analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry. J. Agric. Food Chem. 2006, 54, 884-892.
29. Serra, A., Macià, A., Rubió, L., Anglès, N. et al., Distribution of procyanidins and their metabolites in rat plasma and tissues in relation to ingestion of procyanidin-enriched or procyanidin-rich cocoa creams. Eur. J. Nutr. 2013, 52, 1029-1038.
30. Tomas-Barberan, F. A., Cienfuegos-Jovellanos, E., Marín, A., Muguerza, B. et al., A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans. J. Agric. Food Chem. 2007, 55, 3926-3935.
31. Pinent, M., Cedó, L., Montagut, G., Blay, M., Ardévol, A., Procyanidins improve some disrupted glucose homoeostatic situations: an analysis of doses and treatments according to different animal models. Crit. Rev. Food Sci. Nutr. 2012, 52, 569-584.
32. Pons, Z., Margalef, M., Bravo, F. I., Arola-Arnal, A., Muguerza, B., Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin. Eur. J. Nutr. 2015, Epub ahead of print, DOI:10.1007/s00394-015-0895-0.
33. Sipes, I. G., Gandolfi, A. J., in: Amdur, M., Doull, J. Klasses, C. D. (Eds.), Casarett Doull's, Toxicol. - Basic Sci. Poisons, -Biotransformation of toxicants, Pergamon Press, New York, NY 1991, pp. 64-98.
34. Harris, R. Z., Benet, L. Z., Schwartz, J. B., Gender Effects in pharmacokinetics and pharmacodynamics. Drugs 1995, 50, 222-239.
35. Arola-Arnal, A., Oms-Oliu, G., Crescenti, A., Del Bas, J. M. et al., Distribution of grape seed flavanols and their metabolites in pregnant rats and their fetuses. Mol. Nutr. Food Res. 2013, 57, 1741-1752.
36. Dellinger, R. W., Garcia, A. M. G., Meyskens, Jr., F. L., Differences in the glucuronidation of resveratrol and pterostilbene: altered enzyme specificity and potential gender differences. Drug Metab. Pharmacokinet. 2014, 29, 112-119.
37. Piskula, M. K., Soy isoflavone conjugation differs in fed and food-deprived rats. J. Nutr. 2000, 130, 1766-1771.
38. Ardévol, A., Motilva, M. J., Serra, A., Blay, M., Pinent, M., Procyanidins target mesenteric adipose tissue in Wistar lean rats and subcutaneous adipose tissue in Zucker obese rat. Food Chem. 2013, 141, 160-166.
39. Faria, A., Pestana, D., Teixeira, D., Couraud, P.-O. et al., Insights into the putative catechin and epicatechin transport across blood-brain barrier. Food Funct. 2011, 2, 39-44.
40. Mannisto, P. T., Kaakkola, S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol. Rev. 1999, 51, 593-628.
41. Wang, J., Ferruzzi, M. G., Ho, L., Blount, J. et al., Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. J. Neurosci. 2012, 32, 5144-5150.