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Volumn 51, Issue 2, 2013, Pages 587-595

Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats

Author keywords

Grape seed procyanidin extract; Hypertension; Oxidative stress; Polyphenols; Procyanidins; Spontaneously hypertensive rats

Indexed keywords

ACE ACTIVITIES; ANTIHYPERTENSIVE EFFECT; ANTIOXIDANT CAPACITY; CARDIO-VASCULAR DISEASE; ESSENTIAL HYPERTENSION; FREEFORMS; GALLATE; GRAPE SEED EXTRACT; GRAPE SEEDS; HPLC-MS; HYPERTENSION; PHENOLIC PROFILES; POLYPHENOLS; PROCYANIDINS; SPONTANEOUSLY HYPERTENSIVE RATS; SYSTOLIC AND DIASTOLIC BLOOD PRESSURES; TOTAL PHENOLIC CONTENT; WISTAR-KYOTO RATS;

EID: 84873926187     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2013.01.023     Document Type: Article
Times cited : (88)

References (92)
  • 2
    • 0346366814 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins
    • Actis-Goretta L., Ottaviani J.I., Keen C.L., Fraga C.G. Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Letters 2003, 555(3):597-600.
    • (2003) FEBS Letters , vol.555 , Issue.3 , pp. 597-600
    • Actis-Goretta, L.1    Ottaviani, J.I.2    Keen, C.L.3    Fraga, C.G.4
  • 3
    • 0036146735 scopus 로고    scopus 로고
    • Dietary flavonols: Chemistry, food content, and metabolism
    • Aherne S.A., O'Brien N.M. Dietary flavonols: Chemistry, food content, and metabolism. Nutrition 2002, 18(1):75-81.
    • (2002) Nutrition , vol.18 , Issue.1 , pp. 75-81
    • Aherne, S.A.1    O'Brien, N.M.2
  • 5
    • 3142536557 scopus 로고    scopus 로고
    • Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: Implications for anticancer properties
    • Azam S., Hadi N., Khan N.U., Hadi S.M. Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: Implications for anticancer properties. Toxicology in Vitro 2004, 18(5):555-561.
    • (2004) Toxicology in Vitro , vol.18 , Issue.5 , pp. 555-561
    • Azam, S.1    Hadi, N.2    Khan, N.U.3    Hadi, S.M.4
  • 6
    • 84866272309 scopus 로고    scopus 로고
    • Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome
    • Barona J., Aristizabal J.C., Blesso C.N., Volek J.S., Fernandez M.L. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. Journal of Nutrition 2012, 142(9):1626-1632.
    • (2012) Journal of Nutrition , vol.142 , Issue.9 , pp. 1626-1632
    • Barona, J.1    Aristizabal, J.C.2    Blesso, C.N.3    Volek, J.S.4    Fernandez, M.L.5
  • 7
    • 39849099652 scopus 로고    scopus 로고
    • Is there a market for functional wines? Consumer preferences and willingness to pay for resveratrol-enriched red wine
    • Barreiro-Hurlé J., Colombo S., Cantos-Villar E. Is there a market for functional wines? Consumer preferences and willingness to pay for resveratrol-enriched red wine. Food Quality and Preference 2008, 19(4):360-371.
    • (2008) Food Quality and Preference , vol.19 , Issue.4 , pp. 360-371
    • Barreiro-Hurlé, J.1    Colombo, S.2    Cantos-Villar, E.3
  • 8
    • 33644599022 scopus 로고    scopus 로고
    • Cocoa intake, blood pressure, and cardiovascular mortality: The Zutphen Elderly Study
    • Buijsse B., Feskens E.J.M., Kok F.J., Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality: The Zutphen Elderly Study. Archives of Internal Medicine 2006, 166(4):411.
    • (2006) Archives of Internal Medicine , vol.166 , Issue.4 , pp. 411
    • Buijsse, B.1    Feskens, E.J.M.2    Kok, F.J.3    Kromhout, D.4
  • 9
    • 0015576365 scopus 로고
    • Validation in awake rats of a tail-cuff method for measuring systolic pressure
    • Buñag R.D. Validation in awake rats of a tail-cuff method for measuring systolic pressure. Journal of Applied Physiology 1973, 34(2):279-282.
    • (1973) Journal of Applied Physiology , vol.34 , Issue.2 , pp. 279-282
    • Buñag, R.D.1
  • 10
    • 84863199588 scopus 로고    scopus 로고
    • Carotenoids, total polyphenols and antioxidant activity of grapes (Vitis vinifera) cultivated in organic and conventional systems
    • Bunea C.I., Pop N., Babeş A.C., Matea C., Dulf F.V., Bunea A. Carotenoids, total polyphenols and antioxidant activity of grapes (Vitis vinifera) cultivated in organic and conventional systems. Chemistry Central Journal 2012, 6(1):66.
    • (2012) Chemistry Central Journal , vol.6 , Issue.1 , pp. 66
    • Bunea, C.I.1    Pop, N.2    Babeş, A.C.3    Matea, C.4    Dulf, F.V.5    Bunea, A.6
  • 11
    • 1942417498 scopus 로고    scopus 로고
    • Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1, 2-dithiole-3-thione
    • Cao Z., Li Y. Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1, 2-dithiole-3-thione. Cardiovascular Toxicology 2004, 4(4):339-353.
    • (2004) Cardiovascular Toxicology , vol.4 , Issue.4 , pp. 339-353
    • Cao, Z.1    Li, Y.2
  • 12
    • 0347423198 scopus 로고    scopus 로고
    • Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure
    • Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003, 42(6):1206-1252.
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1206-1252
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3    Cushman, W.C.4    Green, L.A.5    Izzo, J.L.6
  • 14
    • 53149111504 scopus 로고    scopus 로고
    • Extraction of anthocyanins from grape skins assisted by high hydrostatic pressure
    • Corrales M., García A.F., Butz P., Tauscher B. Extraction of anthocyanins from grape skins assisted by high hydrostatic pressure. Journal of Food Engineering 2009, 90(4):415-421.
    • (2009) Journal of Food Engineering , vol.90 , Issue.4 , pp. 415-421
    • Corrales, M.1    García, A.F.2    Butz, P.3    Tauscher, B.4
  • 15
    • 0035749744 scopus 로고    scopus 로고
    • Role of flavonoids in oxidative stress
    • Cotelle N. Role of flavonoids in oxidative stress. Current Topics in Medicinal Chemistry 2001, 1(6):569-590.
    • (2001) Current Topics in Medicinal Chemistry , vol.1 , Issue.6 , pp. 569-590
    • Cotelle, N.1
  • 16
    • 14644438499 scopus 로고    scopus 로고
    • Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats
    • Del Bas J.M., Fernández-Larrea J., Blay M., Ardèvol A., Salvadó M.J., Arola L., et al. Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. The FASEB Journal 2005, 19(3):479-481.
    • (2005) The FASEB Journal , vol.19 , Issue.3 , pp. 479-481
    • Del Bas, J.M.1    Fernández-Larrea, J.2    Blay, M.3    Ardèvol, A.4    Salvadó, M.J.5    Arola, L.6
  • 17
    • 84875953344 scopus 로고    scopus 로고
    • Dietary (poly) phenolics in human health: structures, bioavailability and evidence of protective effects against chronic diseases
    • (Epub ahead of print)
    • Del Rio D., Mateos A.M.R., Spencer J.P.E., Massimiliano T., Borges G., Crozier A. Dietary (poly) phenolics in human health: structures, bioavailability and evidence of protective effects against chronic diseases. Antioxidants & Redox Signaling 2012, (Epub ahead of print).
    • (2012) Antioxidants & Redox Signaling
    • Del Rio, D.1    Mateos, A.M.R.2    Spencer, J.P.E.3    Massimiliano, T.4    Borges, G.5    Crozier, A.6
  • 19
    • 0035569012 scopus 로고    scopus 로고
    • Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression
    • Diebolt M., Bucher B., Andriantsitohaina R. Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension 2001, 38(2):159-165.
    • (2001) Hypertension , vol.38 , Issue.2 , pp. 159-165
    • Diebolt, M.1    Bucher, B.2    Andriantsitohaina, R.3
  • 20
    • 84862832846 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) activity by polyphenols from tea (Camellia sinensis) and links to processing method
    • Dong J., Xu X., Liang Y., Head R., Bennett L. Inhibition of angiotensin converting enzyme (ACE) activity by polyphenols from tea (Camellia sinensis) and links to processing method. Food and Function 2011, 2(6):310-319.
    • (2011) Food and Function , vol.2 , Issue.6 , pp. 310-319
    • Dong, J.1    Xu, X.2    Liang, Y.3    Head, R.4    Bennett, L.5
  • 21
    • 33749316344 scopus 로고    scopus 로고
    • Cultural practice and environmental impacts on the flavonoid composition of grapes and wine: A review of recent research
    • Downey M.O., Dokoozlian N.K., Krstic M.P. Cultural practice and environmental impacts on the flavonoid composition of grapes and wine: A review of recent research. American Journal of Enology and Viticulture 2006, 57(3):257-268.
    • (2006) American Journal of Enology and Viticulture , vol.57 , Issue.3 , pp. 257-268
    • Downey, M.O.1    Dokoozlian, N.K.2    Krstic, M.P.3
  • 22
    • 64549161538 scopus 로고    scopus 로고
    • Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays
    • Dudonneǐ S., Vitrac X., Coutieỳre P., Woillez M., Meǐrillon J.M. Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Journal of Agricultural and Food Chemistry 2009, 57(5):1768-1774.
    • (2009) Journal of Agricultural and Food Chemistry , vol.57 , Issue.5 , pp. 1768-1774
    • Dudonneǐ, S.1    Vitrac, X.2    Coutieỳre, P.3    Woillez, M.4    Meǐrillon, J.M.5
  • 23
    • 0035838446 scopus 로고    scopus 로고
    • Short-and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease
    • Duffy S.J., Keaney J.F., Holbrook M., Gokce N., Swerdloff P.L., Frei B., et al. Short-and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001, 104(2):151-156.
    • (2001) Circulation , vol.104 , Issue.2 , pp. 151-156
    • Duffy, S.J.1    Keaney, J.F.2    Holbrook, M.3    Gokce, N.4    Swerdloff, P.L.5    Frei, B.6
  • 26
    • 36348953898 scopus 로고    scopus 로고
    • Dark chocolate improves coronary vasomotion and reduces platelet reactivity
    • Flammer A.J., Hermann F., Sudano I., Spieker L., Hermann M., Cooper K.A., et al. Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation 2007, 116(21):2376-2382.
    • (2007) Circulation , vol.116 , Issue.21 , pp. 2376-2382
    • Flammer, A.J.1    Hermann, F.2    Sudano, I.3    Spieker, L.4    Hermann, M.5    Cooper, K.A.6
  • 28
    • 0027396786 scopus 로고
    • Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine
    • Frankel E., German J., Kinsella J., Parks E., Kanner J. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. The Lancet 1993, 341(8843):454-457.
    • (1993) The Lancet , vol.341 , Issue.8843 , pp. 454-457
    • Frankel, E.1    German, J.2    Kinsella, J.3    Parks, E.4    Kanner, J.5
  • 30
    • 84858326289 scopus 로고    scopus 로고
    • Recent applications of grape polyphenols in foods, beverages and supplements
    • Gollucke A.P. Recent applications of grape polyphenols in foods, beverages and supplements. Recent Patents on Food, Nutrition & Agriculture 2010, 2(2):105-109.
    • (2010) Recent Patents on Food, Nutrition & Agriculture , vol.2 , Issue.2 , pp. 105-109
    • Gollucke, A.P.1
  • 31
    • 80055058069 scopus 로고    scopus 로고
    • Chronic (J)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide deficient rats
    • Gómez-Guzmán M., Jiménez R., Sánchez M., Romero M., O'Valle F., Lopez-Sepulveda R., et al. Chronic (J)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide deficient rats. British Journal of Nutrition 2011, 106:1337-1348.
    • (2011) British Journal of Nutrition , vol.106 , pp. 1337-1348
    • Gómez-Guzmán, M.1    Jiménez, R.2    Sánchez, M.3    Romero, M.4    O'Valle, F.5    Lopez-Sepulveda, R.6
  • 32
    • 84655165055 scopus 로고    scopus 로고
    • Epicatechin lowers blood pressure, restores endothelial function and decreases oxidative stress, endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension
    • Gómez-Guzmán M., Jiménez R., Sánchez M., Zarzuelo M.J., Galindo P., Quintela A.M., et al. Epicatechin lowers blood pressure, restores endothelial function and decreases oxidative stress, endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension. Free Radical Biology & Medicine 2011, 52(1):70-79.
    • (2011) Free Radical Biology & Medicine , vol.52 , Issue.1 , pp. 70-79
    • Gómez-Guzmán, M.1    Jiménez, R.2    Sánchez, M.3    Zarzuelo, M.J.4    Galindo, P.5    Quintela, A.M.6
  • 33
    • 84869753385 scopus 로고    scopus 로고
    • Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies
    • Guerrero L., Castillo J., Quiñones M., Garcia-Vallvé S., Arola L., et al. Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies. PLoS ONE 2012, 7(11):e49493. 10.1371/journal.pone.0049493.
    • (2012) PLoS ONE , vol.7 , Issue.11
    • Guerrero, L.1    Castillo, J.2    Quiñones, M.3    Garcia-Vallvé, S.4    Arola, L.5
  • 34
    • 15544374084 scopus 로고    scopus 로고
    • Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease
    • Hansen A.S., Marckmann P., Dragsted L., Nielsen I.L.F., Nielsen S., Grønbaek M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. European Journal of Clinical Nutrition 2005, 59(3):449-455.
    • (2005) European Journal of Clinical Nutrition , vol.59 , Issue.3 , pp. 449-455
    • Hansen, A.S.1    Marckmann, P.2    Dragsted, L.3    Nielsen, I.L.F.4    Nielsen, S.5    Grønbaek, M.6
  • 35
    • 0037205604 scopus 로고    scopus 로고
    • High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format
    • Huang D., Ou B., Hampsch-Woodill M., Flanagan J.A., Prior R.L. High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. Journal of Agricultural and Food Chemistry 2002, 50(16):4437-4444.
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , Issue.16 , pp. 4437-4444
    • Huang, D.1    Ou, B.2    Hampsch-Woodill, M.3    Flanagan, J.A.4    Prior, R.L.5
  • 36
    • 84863060476 scopus 로고    scopus 로고
    • Antihypertensive angiotensin I-converting enzyme inhibitory activity and antioxidant activity of Vitis hybrid - Vitis coignetiae red wine made with Saccharomyces cerevisiae
    • Jang J.H., Lee J.S. Antihypertensive angiotensin I-converting enzyme inhibitory activity and antioxidant activity of Vitis hybrid - Vitis coignetiae red wine made with Saccharomyces cerevisiae. Mycobiology 2011, 39(2):137-139.
    • (2011) Mycobiology , vol.39 , Issue.2 , pp. 137-139
    • Jang, J.H.1    Lee, J.S.2
  • 39
    • 36348976270 scopus 로고    scopus 로고
    • The interaction of new plant flavonoids with rat liver mitochondria: Relation between the anti- and pro-oxidant effect and flavonoids concentration
    • Lahouel M., Amedah S., Zellagui A., Touil A., Rhouati S., Benyache F., et al. The interaction of new plant flavonoids with rat liver mitochondria: Relation between the anti- and pro-oxidant effect and flavonoids concentration. Therapie 2006, 61(4):347-355.
    • (2006) Therapie , vol.61 , Issue.4 , pp. 347-355
    • Lahouel, M.1    Amedah, S.2    Zellagui, A.3    Touil, A.4    Rhouati, S.5    Benyache, F.6
  • 40
    • 27744488160 scopus 로고    scopus 로고
    • Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress
    • Li Y., Cao Z., Zhu H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacological Research 2006, 53(1):6-15.
    • (2006) Pharmacological Research , vol.53 , Issue.1 , pp. 6-15
    • Li, Y.1    Cao, Z.2    Zhu, H.3
  • 41
    • 84862777886 scopus 로고    scopus 로고
    • Cardiovascular effects and molecular targets of resveratrol
    • Li H., Xia N., Förstermann U. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 2012, 26(2):102-110. 10.1016/j.niox.2011.12.006.
    • (2012) Nitric Oxide , vol.26 , Issue.2 , pp. 102-110
    • Li, H.1    Xia, N.2    Förstermann, U.3
  • 42
    • 80955152001 scopus 로고    scopus 로고
    • Changes of polyphenols, sugars, and organic acid in 5 Vitis genotypes during berry ripening
    • Liang Z., Sang M., Fan P., Wu B., Wang L., Duan W., et al. Changes of polyphenols, sugars, and organic acid in 5 Vitis genotypes during berry ripening. Journal of Food Science 2011, 76(9):C1231-C1238.
    • (2011) Journal of Food Science , vol.76 , Issue.9
    • Liang, Z.1    Sang, M.2    Fan, P.3    Wu, B.4    Wang, L.5    Duan, W.6
  • 43
    • 84863067744 scopus 로고    scopus 로고
    • Characterization of polyphenolic metabolites in the seeds of Vitis germplasm
    • Liang Z., Yang Y., Cheng L., Zhong G.Y. Characterization of polyphenolic metabolites in the seeds of Vitis germplasm. Journal of Agricultural and Food Chemistry 2012, 60(5):1291-1299. 10.1021/jf2046637.
    • (2012) Journal of Agricultural and Food Chemistry , vol.60 , Issue.5 , pp. 1291-1299
    • Liang, Z.1    Yang, Y.2    Cheng, L.3    Zhong, G.Y.4
  • 45
    • 34250350040 scopus 로고    scopus 로고
    • 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    • Mancia G., De Backer G., Dominiczak A., Cifkova R., Fagard R., Germano G., et al. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Journal of Hypertension 2007, 25(6):1105.
    • (2007) Journal of Hypertension , vol.25 , Issue.6 , pp. 1105
    • Mancia, G.1    De Backer, G.2    Dominiczak, A.3    Cifkova, R.4    Fagard, R.5    Germano, G.6
  • 46
    • 79953890273 scopus 로고    scopus 로고
    • Food grade lingonberry extract: Polyphenolic composition and in vivo protective effect against oxidative stress
    • Mane C., Loonis M., Juhel C., Dufour C., Malien-Aubert C. Food grade lingonberry extract: Polyphenolic composition and in vivo protective effect against oxidative stress. Journal of Agricultural and Food Chemistry 2011, 59(7):3330-3339.
    • (2011) Journal of Agricultural and Food Chemistry , vol.59 , Issue.7 , pp. 3330-3339
    • Mane, C.1    Loonis, M.2    Juhel, C.3    Dufour, C.4    Malien-Aubert, C.5
  • 47
    • 39749199411 scopus 로고    scopus 로고
    • Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats
    • Manso M.A., Miguel M., Even J., Hernández R., Aleixandre A., López-Fandiño R. Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats. Food Chemistry 2008, 109(2):361-367.
    • (2008) Food Chemistry , vol.109 , Issue.2 , pp. 361-367
    • Manso, M.A.1    Miguel, M.2    Even, J.3    Hernández, R.4    Aleixandre, A.5    López-Fandiño, R.6
  • 50
  • 51
    • 34147167071 scopus 로고    scopus 로고
    • Antihypertensive, ACE-inhibitory and vasodilator properties of an egg white hydrolysate: Effect of a simulated intestinal digestion
    • Miguel M., Alonso M.J., Salaices M., Aleixandre A., López-Fandiño R. Antihypertensive, ACE-inhibitory and vasodilator properties of an egg white hydrolysate: Effect of a simulated intestinal digestion. Food Chemistry 2007, 104(1):163-168.
    • (2007) Food Chemistry , vol.104 , Issue.1 , pp. 163-168
    • Miguel, M.1    Alonso, M.J.2    Salaices, M.3    Aleixandre, A.4    López-Fandiño, R.5
  • 53
    • 67650727981 scopus 로고    scopus 로고
    • Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension
    • Mukai Y., Sato S. Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutrition, Metabolism, and Cardiovascular Diseases 2009, 19(7):491-497.
    • (2009) Nutrition, Metabolism, and Cardiovascular Diseases , vol.19 , Issue.7 , pp. 491-497
    • Mukai, Y.1    Sato, S.2
  • 54
    • 0242570130 scopus 로고    scopus 로고
    • Analysis of proanthocyanidins in grape seed extracts, health foods and grape seed oils
    • Nakamura Y., Tsuji S., Tonogai Y. Analysis of proanthocyanidins in grape seed extracts, health foods and grape seed oils. Journal of Health Science 2003, 49(1):45-54.
    • (2003) Journal of Health Science , vol.49 , Issue.1 , pp. 45-54
    • Nakamura, Y.1    Tsuji, S.2    Tonogai, Y.3
  • 55
    • 0011910306 scopus 로고
    • Development of a strain of spontaneously hypertensive rats
    • Okamoto K., Aoki K. Development of a strain of spontaneously hypertensive rats. Japanese Circulation Journal 1963, 27(3):282-293.
    • (1963) Japanese Circulation Journal , vol.27 , Issue.3 , pp. 282-293
    • Okamoto, K.1    Aoki, K.2
  • 56
    • 33645980616 scopus 로고    scopus 로고
    • Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition
    • Ottaviani J.I., Actis-Goretta L., Villordo J.J., Fraga C.G. Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition. Biochimie 2006, 88(3):359-365.
    • (2006) Biochimie , vol.88 , Issue.3 , pp. 359-365
    • Ottaviani, J.I.1    Actis-Goretta, L.2    Villordo, J.J.3    Fraga, C.G.4
  • 57
    • 16244423306 scopus 로고    scopus 로고
    • Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: Double blind, placebo controlled intervention trial
    • Park Y.K., Kim J.S., Kang M.H. Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: Double blind, placebo controlled intervention trial. Biofactors 2004, 22(1-4):145-147.
    • (2004) Biofactors , vol.22 , Issue.1-4 , pp. 145-147
    • Park, Y.K.1    Kim, J.S.2    Kang, M.H.3
  • 60
    • 23044499248 scopus 로고    scopus 로고
    • Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation
    • Pinent M., Blade M., Salvado M., Arola L., Hackl H., Quackenbush J., et al. Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation. International Journal of Obesity 2005, 29(8):934-941.
    • (2005) International Journal of Obesity , vol.29 , Issue.8 , pp. 934-941
    • Pinent, M.1    Blade, M.2    Salvado, M.3    Arola, L.4    Hackl, H.5    Quackenbush, J.6
  • 61
    • 9244249143 scopus 로고    scopus 로고
    • Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines
    • Pinent M., Blay M., Blade M., Salvado M., Arola L., Ardevol A. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology 2004, 145(11):4985-4990.
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4985-4990
    • Pinent, M.1    Blay, M.2    Blade, M.3    Salvado, M.4    Arola, L.5    Ardevol, A.6
  • 63
    • 84856598023 scopus 로고    scopus 로고
    • Effect of a cocoa polyphenol extract in spontaneously hypertensive rats
    • Quiñones M., Miguel M., Muguerza B., Aleixandre A. Effect of a cocoa polyphenol extract in spontaneously hypertensive rats. Food and Function 2011, 2(11):649-653.
    • (2011) Food and Function , vol.2 , Issue.11 , pp. 649-653
    • Quiñones, M.1    Miguel, M.2    Muguerza, B.3    Aleixandre, A.4
  • 64
    • 80055020879 scopus 로고    scopus 로고
    • Evidence that nitric oxide mediates the blood pressure lowering effect of a polyphenol-rich cocoa powder in spontaneously hypertensive rats
    • Quiñones M., Muguerza B., Miguel M., Aleixandre A. Evidence that nitric oxide mediates the blood pressure lowering effect of a polyphenol-rich cocoa powder in spontaneously hypertensive rats. Pharmacological Research 2011, 64(5):478-481. 10.1016/j.phrs.2011.06.005.
    • (2011) Pharmacological Research , vol.64 , Issue.5 , pp. 478-481
    • Quiñones, M.1    Muguerza, B.2    Miguel, M.3    Aleixandre, A.4
  • 65
    • 79957602092 scopus 로고    scopus 로고
    • Mechanisms for antihypertensive effect of CocoanOX, a polyphenol-rich cocoa powder, in spontaneously hypertensive rats
    • Quiñones M., Sánchez D., Muguerza B., Miguel M., Aleixandre A. Mechanisms for antihypertensive effect of CocoanOX, a polyphenol-rich cocoa powder, in spontaneously hypertensive rats. Food Research International 2011, 44(5):1203-1208.
    • (2011) Food Research International , vol.44 , Issue.5 , pp. 1203-1208
    • Quiñones, M.1    Sánchez, D.2    Muguerza, B.3    Miguel, M.4    Aleixandre, A.5
  • 67
    • 0033867415 scopus 로고    scopus 로고
    • Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status
    • Rein D., Lotito S., Holt R.R., Keen C.L., Schmitz H.H., Fraga C.G. Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. The Journal of Nutrition 2000, 130(8):2109S-2114S.
    • (2000) The Journal of Nutrition , vol.130 , Issue.8
    • Rein, D.1    Lotito, S.2    Holt, R.R.3    Keen, C.L.4    Schmitz, H.H.5    Fraga, C.G.6
  • 68
    • 79953682240 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathophysiology of hypertension
    • Rodrigo R., González J., Paoletto F. The role of oxidative stress in the pathophysiology of hypertension. Hypertension Research 2011, 34(4):431-440.
    • (2011) Hypertension Research , vol.34 , Issue.4 , pp. 431-440
    • Rodrigo, R.1    González, J.2    Paoletto, F.3
  • 69
    • 0026498159 scopus 로고
    • Homeostasis between lipid peroxidation and antioxidant enzyme activities in healthy human aging
    • Rodriguez-Martinez M., Ruiz-Torres A. Homeostasis between lipid peroxidation and antioxidant enzyme activities in healthy human aging. Mechanisms of Ageing and Development 1992, 66(2):213-222.
    • (1992) Mechanisms of Ageing and Development , vol.66 , Issue.2 , pp. 213-222
    • Rodriguez-Martinez, M.1    Ruiz-Torres, A.2
  • 70
    • 33845197949 scopus 로고    scopus 로고
    • Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase
    • Sarr M., Chataigneau M., Martins S., Schott C., El Bedoui J., Oak M.H., et al. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovascular Research 2006, 71(4):794-802.
    • (2006) Cardiovascular Research , vol.71 , Issue.4 , pp. 794-802
    • Sarr, M.1    Chataigneau, M.2    Martins, S.3    Schott, C.4    El Bedoui, J.5    Oak, M.H.6
  • 72
    • 0035746624 scopus 로고    scopus 로고
    • By-products of plant food processing as a source of functional compounds - Recent developments
    • Schieber A., Stintzing F., Carle R. By-products of plant food processing as a source of functional compounds - Recent developments. Trends in Food Science & Technology 2001, 12(11):401-413.
    • (2001) Trends in Food Science & Technology , vol.12 , Issue.11 , pp. 401-413
    • Schieber, A.1    Stintzing, F.2    Carle, R.3
  • 74
    • 79958132625 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction in hypertension
    • Schulz E., Gori T., Münzel T. Oxidative stress and endothelial dysfunction in hypertension. Hypertension Research 2011, 34(6):665-673.
    • (2011) Hypertension Research , vol.34 , Issue.6 , pp. 665-673
    • Schulz, E.1    Gori, T.2    Münzel, T.3
  • 76
    • 0033919377 scopus 로고    scopus 로고
    • Wine by-products with health benefits
    • Shrikhande A.J. Wine by-products with health benefits. Food Research International 2000, 33(6):469-474.
    • (2000) Food Research International , vol.33 , Issue.6 , pp. 469-474
    • Shrikhande, A.J.1
  • 77
    • 0019765202 scopus 로고
    • Naturally occurring food toxicants: Phenolic substances of plant origin common in foods
    • Singleton V.L. Naturally occurring food toxicants: Phenolic substances of plant origin common in foods. Advances in Food Research 1981, 27:149-242.
    • (1981) Advances in Food Research , vol.27 , pp. 149-242
    • Singleton, V.L.1
  • 78
  • 79
    • 0033533593 scopus 로고    scopus 로고
    • Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease
    • Stein J.H., Keevil J.G., Wiebe D.A., Aeschlimann S., Folts J.D. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999, 100(10):1050-1055.
    • (1999) Circulation , vol.100 , Issue.10 , pp. 1050-1055
    • Stein, J.H.1    Keevil, J.G.2    Wiebe, D.A.3    Aeschlimann, S.4    Folts, J.D.5
  • 84
    • 0242654867 scopus 로고    scopus 로고
    • Effects of different blood-pressure-lowering regimens on major cardiovascular events: Results of prospectively-designed overviews of randomised trials
    • Turnbull F., Neal B., Algert C., Chalmers J., Woodward M., MacMahon S., et al. Effects of different blood-pressure-lowering regimens on major cardiovascular events: Results of prospectively-designed overviews of randomised trials. Lancet 2003, 362(9395):1527-1535.
    • (2003) Lancet , vol.362 , Issue.9395 , pp. 1527-1535
    • Turnbull, F.1    Neal, B.2    Algert, C.3    Chalmers, J.4    Woodward, M.5    MacMahon, S.6
  • 85
    • 0037167677 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
    • Wallerath T., Deckert G., Ternes T., Anderson H., Li H., Witte K., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002, 106(13):1652-1658.
    • (2002) Circulation , vol.106 , Issue.13 , pp. 1652-1658
    • Wallerath, T.1    Deckert, G.2    Ternes, T.3    Anderson, H.4    Li, H.5    Witte, K.6
  • 86
    • 13844271387 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • Williamson G., Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. The American Journal of Clinical Nutrition 2005, 81(1):243S-255S.
    • (2005) The American Journal of Clinical Nutrition , vol.81 , Issue.1
    • Williamson, G.1    Manach, C.2
  • 88
    • 40949141088 scopus 로고    scopus 로고
    • Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats
    • Yamamoto M., Suzuki A., Hase T. Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. Journal of Nutritional Science and Vitaminology 2008, 54(1):95-98.
    • (2008) Journal of Nutritional Science and Vitaminology , vol.54 , Issue.1 , pp. 95-98
    • Yamamoto, M.1    Suzuki, A.2    Hase, T.3
  • 89
    • 0033795031 scopus 로고    scopus 로고
    • Characterization of grape procyanidins using high-performance liquid chromatography/mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    • Yang Y., Chien M. Characterization of grape procyanidins using high-performance liquid chromatography/mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Agricultural and Food Chemistry 2000, 48(9):3990-3996.
    • (2000) Journal of Agricultural and Food Chemistry , vol.48 , Issue.9 , pp. 3990-3996
    • Yang, Y.1    Chien, M.2
  • 90
    • 64449088061 scopus 로고    scopus 로고
    • Phytochemical profiles and antioxidant activities of wine grapes
    • Yang J., Martinson T.E., Liu R.H. Phytochemical profiles and antioxidant activities of wine grapes. Food Chemistry 2009, 116(1):332-339.
    • (2009) Food Chemistry , vol.116 , Issue.1 , pp. 332-339
    • Yang, J.1    Martinson, T.E.2    Liu, R.H.3
  • 91
    • 0041926763 scopus 로고    scopus 로고
    • Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity
    • Zenebe W., Pechanova O., Andriantsitohaina R. Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity. Physiological Research 2003, 52(4):425-432.
    • (2003) Physiological Research , vol.52 , Issue.4 , pp. 425-432
    • Zenebe, W.1    Pechanova, O.2    Andriantsitohaina, R.3
  • 92
    • 54149103338 scopus 로고    scopus 로고
    • Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
    • Zhang Q., Wang Z., Chen H., Zhou S., Zheng W., Liu G., et al. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovascular Research 2008, 80(2):191-199.
    • (2008) Cardiovascular Research , vol.80 , Issue.2 , pp. 191-199
    • Zhang, Q.1    Wang, Z.2    Chen, H.3    Zhou, S.4    Zheng, W.5    Liu, G.6


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