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Volumn 38, Issue 4, 2016, Pages 409-423

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

Author keywords

Airway macrophage; Apoptotic cell clearance; Efferocytosis; Inflammation; Lung; Phosphatidylserine

Indexed keywords

PHOSPHOLIPID; PROTEIN AXL; PROTEIN MERTK; PROTEIN TYRO3; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CELL SURFACE RECEPTOR;

EID: 84960128253     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-016-0555-3     Document Type: Review
Times cited : (123)

References (145)
  • 1
    • 84939625807 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells in homeostasis
    • COI: 1:CAS:528:DC%2BC2MXhtlGnsr%2FE, PID: 26287597
    • Arandjelovic S, Ravichandran KS (2015) Phagocytosis of apoptotic cells in homeostasis. Nat Immunol 16:907–917. doi:10.1038/ni.3253
    • (2015) Nat Immunol , vol.16 , pp. 907-917
    • Arandjelovic, S.1    Ravichandran, K.S.2
  • 2
    • 84939504757 scopus 로고    scopus 로고
    • The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung
    • COI: 1:CAS:528:DC%2BC2MXhtFKrsLY%3D, PID: 25603826
    • Fujimori T, Grabiec AM, Kaur M, Bell TJ, Fujino N, Cook PC et al (2015) The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. Mucosal Immunol 8:1021–1030. doi:10.1038/mi.2014.129
    • (2015) Mucosal Immunol , vol.8 , pp. 1021-1030
    • Fujimori, T.1    Grabiec, A.M.2    Kaur, M.3    Bell, T.J.4    Fujino, N.5    Cook, P.C.6
  • 3
    • 70249090374 scopus 로고    scopus 로고
    • Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
    • COI: 1:CAS:528:DC%2BD1MXhtFSnt7fM, PID: 19741708
    • Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF et al (2009) Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 461:282–286. doi:10.1038/nature08296
    • (2009) Nature , vol.461 , pp. 282-286
    • Elliott, M.R.1    Chekeni, F.B.2    Trampont, P.C.3    Lazarowski, E.R.4    Kadl, A.5    Walk, S.F.6
  • 4
    • 58149398634 scopus 로고    scopus 로고
    • CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
    • COI: 1:CAS:528:DC%2BD1cXhsFWms73E, PID: 18799722
    • Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ, Dumitriu IE et al (2008) CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood 112:5026–5036. doi:10.1182/blood-2008-06-162404
    • (2008) Blood , vol.112 , pp. 5026-5036
    • Truman, L.A.1    Ford, C.A.2    Pasikowska, M.3    Pound, J.D.4    Wilkinson, S.J.5    Dumitriu, I.E.6
  • 5
    • 0038820117 scopus 로고    scopus 로고
    • Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    • COI: 1:CAS:528:DC%2BD3sXkvVekt7k%3D, PID: 12809603
    • Lauber K, Bohn E, Krober SM, Xiao YJ, Blumenthal SG, Lindemann RK et al (2003) Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113:717–730
    • (2003) Cell , vol.113 , pp. 717-730
    • Lauber, K.1    Bohn, E.2    Krober, S.M.3    Xiao, Y.J.4    Blumenthal, S.G.5    Lindemann, R.K.6
  • 6
    • 48749121214 scopus 로고    scopus 로고
    • Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal
    • COI: 1:CAS:528:DC%2BD1cXpsVygs7s%3D, PID: 18362204
    • Gude DR, Alvarez SE, Paugh SW, Mitra P, Yu J, Griffiths R et al (2008) Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal. FASEB J 22:2629–2638. doi:10.1096/fj.08-107169
    • (2008) FASEB J , vol.22 , pp. 2629-2638
    • Gude, D.R.1    Alvarez, S.E.2    Paugh, S.W.3    Mitra, P.4    Yu, J.5    Griffiths, R.6
  • 7
    • 36849080928 scopus 로고    scopus 로고
    • Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages
    • COI: 1:CAS:528:DC%2BD1cXitVygtA%3D%3D, PID: 17673941
    • Miksa M, Amin D, Wu R, Ravikumar TS, Wang P (2007) Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages. Mol Med 13:553–560. doi:10.2119/2007-00019.Miksa
    • (2007) Mol Med , vol.13 , pp. 553-560
    • Miksa, M.1    Amin, D.2    Wu, R.3    Ravikumar, T.S.4    Wang, P.5
  • 8
    • 77956913114 scopus 로고    scopus 로고
    • Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells
    • PID: 20157780
    • Peter C, Wesselborg S, Herrmann M, Lauber K (2010) Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells. Apoptosis 15:1007–1028. doi:10.1007/s10495-010-0472-1
    • (2010) Apoptosis , vol.15 , pp. 1007-1028
    • Peter, C.1    Wesselborg, S.2    Herrmann, M.3    Lauber, K.4
  • 9
    • 77952944942 scopus 로고    scopus 로고
    • The distribution and function of phosphatidylserine in cellular membranes
    • COI: 1:CAS:528:DC%2BC3cXotFKjsb8%3D, PID: 20192774
    • Leventis PA, Grinstein S (2010) The distribution and function of phosphatidylserine in cellular membranes. Annu Rev Biophys 39:407–427. doi:10.1146/annurev.biophys.093008.131234
    • (2010) Annu Rev Biophys , vol.39 , pp. 407-427
    • Leventis, P.A.1    Grinstein, S.2
  • 10
    • 4344715014 scopus 로고    scopus 로고
    • Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
    • COI: 1:CAS:528:DC%2BD2cXmvFehtrs%3D, PID: 15302904
    • Asano K, Miwa M, Miwa K, Hanayama R, Nagase H, Nagata S et al (2004) Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med 200:459–467. doi:10.1084/jem.20040342
    • (2004) J Exp Med , vol.200 , pp. 459-467
    • Asano, K.1    Miwa, M.2    Miwa, K.3    Hanayama, R.4    Nagase, H.5    Nagata, S.6
  • 11
    • 0021828779 scopus 로고
    • In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes
    • COI: 1:CAS:528:DyaL2MXitVWksr8%3D, PID: 3988747
    • Schroit AJ, Madsen JW, Tanaka Y (1985) In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes. J Biol Chem 260:5131–5138
    • (1985) J Biol Chem , vol.260 , pp. 5131-5138
    • Schroit, A.J.1    Madsen, J.W.2    Tanaka, Y.3
  • 12
    • 84901849205 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
    • COI: 1:CAS:528:DC%2BC2cXptVajtrg%3D, PID: 24904167
    • Segawa K, Kurata S, Yanagihashi Y, Brummelkamp TR, Matsuda F, Nagata S (2014) Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science 344:1164–1168. doi:10.1126/science.1252809
    • (2014) Science , vol.344 , pp. 1164-1168
    • Segawa, K.1    Kurata, S.2    Yanagihashi, Y.3    Brummelkamp, T.R.4    Matsuda, F.5    Nagata, S.6
  • 13
    • 84880758440 scopus 로고    scopus 로고
    • Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells
    • COI: 1:CAS:528:DC%2BC3sXhtFClsLjI, PID: 23845944
    • Suzuki J, Denning DP, Imanishi E, Horvitz HR, Nagata S (2013) Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 341:403–406. doi:10.1126/science.1236758
    • (2013) Science , vol.341 , pp. 403-406
    • Suzuki, J.1    Denning, D.P.2    Imanishi, E.3    Horvitz, H.R.4    Nagata, S.5
  • 14
    • 77956255766 scopus 로고    scopus 로고
    • Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
    • COI: 1:CAS:528:DC%2BC3cXhtFensrzL, PID: 20805564
    • Ravichandran KS (2010) Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums. J Exp Med 207:1807–1817. doi:10.1084/jem.20101157
    • (2010) J Exp Med , vol.207 , pp. 1807-1817
    • Ravichandran, K.S.1
  • 15
    • 84893587799 scopus 로고    scopus 로고
    • The interaction between signal regulatory protein alpha (SIRPalpha) and CD47: structure, function, and therapeutic target
    • COI: 1:CAS:528:DC%2BC2cXovVemtro%3D, PID: 24215318
    • Barclay AN, Van den Berg TK (2014) The interaction between signal regulatory protein alpha (SIRPalpha) and CD47: structure, function, and therapeutic target. Annu Rev Immunol 32:25–50. doi:10.1146/annurev-immunol-032713-120142
    • (2014) Annu Rev Immunol , vol.32 , pp. 25-50
    • Barclay, A.N.1    Van den Berg, T.K.2
  • 16
    • 0037062989 scopus 로고    scopus 로고
    • Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    • COI: 1:CAS:528:DC%2BD38XltFGlsr4%3D, PID: 12110892
    • Brown S, Heinisch I, Ross E, Shaw K, Buckley CD, Savill J (2002) Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 418:200–203. doi:10.1038/nature00811
    • (2002) Nature , vol.418 , pp. 200-203
    • Brown, S.1    Heinisch, I.2    Ross, E.3    Shaw, K.4    Buckley, C.D.5    Savill, J.6
  • 17
    • 84863386988 scopus 로고    scopus 로고
    • Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells
    • COI: 1:CAS:528:DC%2BC38XkvFaltLo%3D, PID: 22302738
    • Simhadri VR, Andersen JF, Calvo E, Choi SC, Coligan JE, Borrego F (2012) Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells. Blood 119:2799–2809. doi:10.1182/blood-2011-08-372425
    • (2012) Blood , vol.119 , pp. 2799-2809
    • Simhadri, V.R.1    Andersen, J.F.2    Calvo, E.3    Choi, S.C.4    Coligan, J.E.5    Borrego, F.6
  • 18
    • 57349174406 scopus 로고    scopus 로고
    • Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers
    • COI: 1:CAS:528:DC%2BD1cXhsVKit77M, PID: 18587056
    • Kazeros A, Harvey BG, Carolan BJ, Vanni H, Krause A, Crystal RG (2008) Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. Am J Respir Cell Mol Biol 39:747–757. doi:10.1165/rcmb.2007-0306OC
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 747-757
    • Kazeros, A.1    Harvey, B.G.2    Carolan, B.J.3    Vanni, H.4    Krause, A.5    Crystal, R.G.6
  • 19
    • 84861866738 scopus 로고    scopus 로고
    • RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation
    • COI: 1:CAS:528:DC%2BC38XhtVGlsrjE, PID: 22505673
    • Robinson AB, Johnson KD, Bennion BG, Reynolds PR (2012) RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation. Am J Physiol Lung Cell Mol Physiol 302:L1192–L1199. doi:10.1152/ajplung.00099.2012
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , pp. L1192-L1199
    • Robinson, A.B.1    Johnson, K.D.2    Bennion, B.G.3    Reynolds, P.R.4
  • 20
    • 77952307233 scopus 로고    scopus 로고
    • Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BC3cXhtFahsb%2FP, PID: 20133931
    • Ferhani N, Letuve S, Kozhich A, Thibaudeau O, Grandsaigne M, Maret M et al (2010) Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 181:917–927. doi:10.1164/rccm.200903-0340OC
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 917-927
    • Ferhani, N.1    Letuve, S.2    Kozhich, A.3    Thibaudeau, O.4    Grandsaigne, M.5    Maret, M.6
  • 21
    • 33751296731 scopus 로고    scopus 로고
    • Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages
    • COI: 1:CAS:528:DC%2BD28XhtVWhu7bE, PID: 16737992
    • Hodge S, Hodge G, Brozyna S, Jersmann H, Holmes M, Reynolds PN (2006) Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages. Eur Respir J 28:486–495. doi:10.1183/09031936.06.00001506
    • (2006) Eur Respir J , vol.28 , pp. 486-495
    • Hodge, S.1    Hodge, G.2    Brozyna, S.3    Jersmann, H.4    Holmes, M.5    Reynolds, P.N.6
  • 22
    • 36749021632 scopus 로고    scopus 로고
    • Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BD2sXhsVahur3O, PID: 17630319
    • Hodge S, Hodge G, Ahern J, Jersmann H, Holmes M, Reynolds PN (2007) Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 37:748–755. doi:10.1165/rcmb.2007-0025OC
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 748-755
    • Hodge, S.1    Hodge, G.2    Ahern, J.3    Jersmann, H.4    Holmes, M.5    Reynolds, P.N.6
  • 23
    • 84940763775 scopus 로고    scopus 로고
    • TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
    • COI: 1:CAS:528:DC%2BC2MXovVyrurg%3D, PID: 25897174
    • Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC et al (2015) TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med 212:681–697. doi:10.1084/jem.20141732
    • (2015) J Exp Med , vol.212 , pp. 681-697
    • Wu, K.1    Byers, D.E.2    Jin, X.3    Agapov, E.4    Alexander-Brett, J.5    Patel, A.C.6
  • 24
    • 77249100867 scopus 로고    scopus 로고
    • Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung
    • COI: 1:CAS:528:DC%2BC3cXivFChtrw%3D, PID: 19448156
    • Hoogerwerf JJ, de Vos AF, van’t Veer C, Bresser P, de Boer A, Tanck MW et al (2010) Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung. Am J Respir Cell Mol Biol 42:349–356. doi:10.1165/rcmb.2008-0362OC
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 349-356
    • Hoogerwerf, J.J.1    de Vos, A.F.2    van’t Veer, C.3    Bresser, P.4    de Boer, A.5    Tanck, M.W.6
  • 25
    • 0036195343 scopus 로고    scopus 로고
    • Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    • COI: 1:CAS:528:DC%2BD38XitVeqtb8%3D, PID: 11877474
    • Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK et al (2002) Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 109:661–670. doi:10.1172/JCI13572
    • (2002) J Clin Invest , vol.109 , pp. 661-670
    • Vandivier, R.W.1    Fadok, V.A.2    Hoffmann, P.R.3    Bratton, D.L.4    Penvari, C.5    Brown, K.K.6
  • 26
    • 84881238056 scopus 로고    scopus 로고
    • Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung
    • COI: 1:CAS:528:DC%2BC3sXhs1KjsbvK, PID: 23672262
    • Misharin AV, Morales-Nebreda L, Mutlu GM, Budinger GR, Perlman H (2013) Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol 49:503–510. doi:10.1165/rcmb.2013-0086MA
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 503-510
    • Misharin, A.V.1    Morales-Nebreda, L.2    Mutlu, G.M.3    Budinger, G.R.4    Perlman, H.5
  • 27
    • 17244375811 scopus 로고    scopus 로고
    • Phenotypic characterisation of alveolar macrophages and peripheral blood monocytes in COPD
    • COI: 1:STN:280:DC%2BD2M7ntVKiuw%3D%3D, PID: 15802338
    • Pons AR, Noguera A, Blanquer D, Sauleda J, Pons J, Agusti AG (2005) Phenotypic characterisation of alveolar macrophages and peripheral blood monocytes in COPD. Eur Respir J 25:647–652. doi:10.1183/09031936.05.00062304
    • (2005) Eur Respir J , vol.25 , pp. 647-652
    • Pons, A.R.1    Noguera, A.2    Blanquer, D.3    Sauleda, J.4    Pons, J.5    Agusti, A.G.6
  • 28
    • 46849097573 scopus 로고    scopus 로고
    • Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BD1cXpsFOrsLY%3D, PID: 18420960
    • Hodge S, Hodge G, Jersmann H, Matthews G, Ahern J, Holmes M et al (2008) Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 178:139–148. doi:10.1164/rccm.200711-1666OC
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 139-148
    • Hodge, S.1    Hodge, G.2    Jersmann, H.3    Matthews, G.4    Ahern, J.5    Holmes, M.6
  • 29
    • 0036785571 scopus 로고    scopus 로고
    • Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex
    • COI: 1:CAS:528:DC%2BD38XnsFelurw%3D, PID: 12244199
    • Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M et al (2002) Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol 169:3978–3986. doi:10.4049/jimmunol.169.7.3978
    • (2002) J Immunol , vol.169 , pp. 3978-3986
    • Vandivier, R.W.1    Ogden, C.A.2    Fadok, V.A.3    Hoffmann, P.R.4    Brown, K.K.5    Botto, M.6
  • 30
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • COI: 1:CAS:528:DC%2BD2MXhs1Kmsbk%3D, PID: 15728241
    • Takahashi K, Rochford CD, Neumann H (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 201:647–657. doi:10.1084/jem.20041611
    • (2005) J Exp Med , vol.201 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.2    Neumann, H.3
  • 31
    • 84932168045 scopus 로고    scopus 로고
    • CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition
    • COI: 1:CAS:528:DC%2BC2cXht1WlsrnP, PID: 25034781
    • Murakami Y, Tian L, Voss OH, Margulies DH, Krzewski K, Coligan JE (2014) CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition. Cell Death Differ 21:1746–1757. doi:10.1038/cdd.2014.86
    • (2014) Cell Death Differ , vol.21 , pp. 1746-1757
    • Murakami, Y.1    Tian, L.2    Voss, O.H.3    Margulies, D.H.4    Krzewski, K.5    Coligan, J.E.6
  • 32
    • 79958032955 scopus 로고    scopus 로고
    • Participation of the receptor for advanced glycation end products in efferocytosis
    • COI: 1:CAS:528:DC%2BC3MXmtlyksbs%3D, PID: 21502377
    • Friggeri A, Banerjee S, Biswas S, de Freitas A, Liu G, Bierhaus A et al (2011) Participation of the receptor for advanced glycation end products in efferocytosis. J Immunol 186:6191–6198. doi:10.4049/jimmunol.1004134
    • (2011) J Immunol , vol.186 , pp. 6191-6198
    • Friggeri, A.1    Banerjee, S.2    Biswas, S.3    de Freitas, A.4    Liu, G.5    Bierhaus, A.6
  • 33
    • 37349029518 scopus 로고    scopus 로고
    • Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor
    • COI: 1:CAS:528:DC%2BD2sXhsVegur3N, PID: 17962816
    • Park SY, Jung MY, Kim HJ, Lee SJ, Kim SY, Lee BH et al (2008) Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ 15:192–201. doi:10.1038/sj.cdd.4402242
    • (2008) Cell Death Differ , vol.15 , pp. 192-201
    • Park, S.Y.1    Jung, M.Y.2    Kim, H.J.3    Lee, S.J.4    Kim, S.Y.5    Lee, B.H.6
  • 34
    • 36248987290 scopus 로고    scopus 로고
    • BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
    • COI: 1:CAS:528:DC%2BD2sXhtlajsrfE, PID: 17960134
    • Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z et al (2007) BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450:430–434. doi:10.1038/nature06329
    • (2007) Nature , vol.450 , pp. 430-434
    • Park, D.1    Tosello-Trampont, A.C.2    Elliott, M.R.3    Lu, M.4    Haney, L.B.5    Ma, Z.6
  • 35
    • 36248944555 scopus 로고    scopus 로고
    • Identification of Tim4 as a phosphatidylserine receptor
    • COI: 1:CAS:528:DC%2BD2sXhtlajs77P, PID: 17960135
    • Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, Nagata S (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450:435–439. doi:10.1038/nature06307
    • (2007) Nature , vol.450 , pp. 435-439
    • Miyanishi, M.1    Tada, K.2    Koike, M.3    Uchiyama, Y.4    Kitamura, T.5    Nagata, S.6
  • 36
    • 37049004424 scopus 로고    scopus 로고
    • TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
    • COI: 1:CAS:528:DC%2BD1cXotFan, PID: 18082433
    • Kobayashi N, Karisola P, Pena-Cruz V, Dorfman DM, Jinushi M, Umetsu SE et al (2007) TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27:927–940. doi:10.1016/j.immuni.2007.11.011
    • (2007) Immunity , vol.27 , pp. 927-940
    • Kobayashi, N.1    Karisola, P.2    Pena-Cruz, V.3    Dorfman, D.M.4    Jinushi, M.5    Umetsu, S.E.6
  • 37
    • 84882311715 scopus 로고    scopus 로고
    • Biology of the TAM receptors
    • PID: 24186067, COI: 1:CAS:528:DC%2BC3sXhvFeiurvE
    • Lemke G (2013) Biology of the TAM receptors. Cold Spring Harb Perspect Biol 5:a009076. doi:10.1101/cshperspect.a009076
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , pp. a009076
    • Lemke, G.1
  • 38
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    • COI: 1:CAS:528:DyaK2MXktV2it74%3D, PID: 7867073
    • Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C et al (1995) The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80:661–670
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1    Conn, G.2    Gore, M.3    Lai, C.4    Bruno, J.5    Radziejewski, C.6
  • 39
    • 80755180853 scopus 로고    scopus 로고
    • Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways
    • COI: 1:CAS:528:DC%2BC3MXhtlyjs7%2FJ, PID: 22035837
    • Ravichandran KS (2011) Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways. Immunity 35:445–455. doi:10.1016/j.immuni.2011.09.004
    • (2011) Immunity , vol.35 , pp. 445-455
    • Ravichandran, K.S.1
  • 40
    • 0029910706 scopus 로고    scopus 로고
    • Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
    • COI: 1:CAS:528:DyaK28XntFOitb8%3D, PID: 8939948
    • Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H et al (1996) Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 271:30022–30027
    • (1996) J Biol Chem , vol.271 , pp. 30022-30027
    • Nagata, K.1    Ohashi, K.2    Nakano, T.3    Arita, H.4    Zong, C.5    Hanafusa, H.6
  • 41
    • 60349123136 scopus 로고    scopus 로고
    • The phosphatidylserine receptor TIM-4 does not mediate direct signaling
    • PID: 19217291, COI: 1:CAS:528:DC%2BD1MXitlWktbw%3D
    • Park D, Hochreiter-Hufford A, Ravichandran KS (2009) The phosphatidylserine receptor TIM-4 does not mediate direct signaling. Curr Biol 19:346–351. doi:10.1016/j.cub.2009.01.042
    • (2009) Curr Biol , vol.19 , pp. 346-351
    • Park, D.1    Hochreiter-Hufford, A.2    Ravichandran, K.S.3
  • 42
    • 0032473968 scopus 로고    scopus 로고
    • Human CD14 mediates recognition and phagocytosis of apoptotic cells
    • COI: 1:CAS:528:DyaK1cXisFelsLg%3D, PID: 9548256
    • Devitt A, Moffatt OD, Raykundalia C, Capra JD, Simmons DL, Gregory CD (1998) Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392:505–509. doi:10.1038/33169
    • (1998) Nature , vol.392 , pp. 505-509
    • Devitt, A.1    Moffatt, O.D.2    Raykundalia, C.3    Capra, J.D.4    Simmons, D.L.5    Gregory, C.D.6
  • 43
    • 84902127449 scopus 로고    scopus 로고
    • Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia
    • COI: 1:CAS:528:DC%2BC2MXksVerurk%3D, PID: 24898390
    • Mazaheri F, Breus O, Durdu S, Haas P, Wittbrodt J, Gilmour D et al (2014) Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia. Nat Commun 5:4046. doi:10.1038/ncomms5046
    • (2014) Nat Commun , vol.5 , pp. 4046
    • Mazaheri, F.1    Breus, O.2    Durdu, S.3    Haas, P.4    Wittbrodt, J.5    Gilmour, D.6
  • 44
    • 65649114773 scopus 로고    scopus 로고
    • A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
    • COI: 1:CAS:528:DC%2BD1MXlsFyks78%3D, PID: 19302484
    • Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC et al (2009) A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem 109:1144–1156. doi:10.1111/j.1471-4159.2009.06042.x
    • (2009) J Neurochem , vol.109 , pp. 1144-1156
    • Hsieh, C.L.1    Koike, M.2    Spusta, S.C.3    Niemi, E.C.4    Yenari, M.5    Nakamura, M.C.6
  • 45
    • 84937516592 scopus 로고    scopus 로고
    • The resolution of inflammation: principles and challenges
    • COI: 1:CAS:528:DC%2BC2MXmslCqt70%3D, PID: 25911383
    • Headland SE, Norling LV (2015) The resolution of inflammation: principles and challenges. Semin Immunol 27:149–160. doi:10.1016/j.smim.2015.03.014
    • (2015) Semin Immunol , vol.27 , pp. 149-160
    • Headland, S.E.1    Norling, L.V.2
  • 46
    • 84908322844 scopus 로고    scopus 로고
    • Diversification of TAM receptor tyrosine kinase function
    • COI: 1:CAS:528:DC%2BC2cXhsFGksr3J, PID: 25194421
    • Zagorska A, Traves PG, Lew ED, Dransfield I, Lemke G (2014) Diversification of TAM receptor tyrosine kinase function. Nat Immunol 15:920–928. doi:10.1038/ni.2986
    • (2014) Nat Immunol , vol.15 , pp. 920-928
    • Zagorska, A.1    Traves, P.G.2    Lew, E.D.3    Dransfield, I.4    Lemke, G.5
  • 47
    • 84992570470 scopus 로고    scopus 로고
    • Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities
    • Lew ED, Oh J, Burrola PG, Lax I, Zagorska A, Traves PG et al. (2014) Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Elife 3. doi:10.7554/eLife.03385
    • (2014) Elife , pp. 3
    • Lew, E.D.1    Oh, J.2    Burrola, P.G.3    Lax, I.4    Zagorska, A.5    Traves, P.G.6
  • 48
    • 84896786643 scopus 로고    scopus 로고
    • An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
    • COI: 1:CAS:528:DC%2BC2cXkt1WrtLo%3D, PID: 24509082
    • Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J et al (2014) An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J Clin Invest 124:1296–1308. doi:10.1172/JCI72051
    • (2014) J Clin Invest , vol.124 , pp. 1296-1308
    • Subramanian, M.1    Hayes, C.D.2    Thome, J.J.3    Thorp, E.4    Matsushima, G.K.5    Herz, J.6
  • 49
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • COI: 1:CAS:528:DC%2BD1cXksFGgug%3D%3D, PID: 18083102
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G (2007) TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131:1124–1136. doi:10.1016/j.cell.2007.10.034
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 50
    • 0031454570 scopus 로고    scopus 로고
    • Immunosuppressive effects of apoptotic cells
    • COI: 1:CAS:528:DyaK2sXnslSit74%3D, PID: 9389474
    • Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I (1997) Immunosuppressive effects of apoptotic cells. Nature 390:350–351. doi:10.1038/37022
    • (1997) Nature , vol.390 , pp. 350-351
    • Voll, R.E.1    Herrmann, M.2    Roth, E.A.3    Stach, C.4    Kalden, J.R.5    Girkontaite, I.6
  • 51
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    • COI: 1:CAS:528:DC%2BD1cXotFal, PID: 18093541
    • Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M et al (2007) Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity 27:952–964. doi:10.1016/j.immuni.2007.11.014
    • (2007) Immunity , vol.27 , pp. 952-964
    • Chung, E.Y.1    Liu, J.2    Homma, Y.3    Zhang, Y.4    Brendolan, A.5    Saggese, M.6
  • 52
    • 0033485401 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells
    • COI: 1:CAS:528:DyaK1MXns12rt74%3D, PID: 10570307
    • McDonald PP, Fadok VA, Bratton D, Henson PM (1999) Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J Immunol 163:6164–6172
    • (1999) J Immunol , vol.163 , pp. 6164-6172
    • McDonald, P.P.1    Fadok, V.A.2    Bratton, D.3    Henson, P.M.4
  • 53
    • 77952490280 scopus 로고    scopus 로고
    • TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages
    • COI: 1:CAS:528:DC%2BC3cXmvVCht7Y%3D, PID: 20103767
    • Alciato F, Sainaghi PP, Sola D, Castello L, Avanzi GC (2010) TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. J Leukoc Biol 87:869–875. doi:10.1189/jlb.0909610
    • (2010) J Leukoc Biol , vol.87 , pp. 869-875
    • Alciato, F.1    Sainaghi, P.P.2    Sola, D.3    Castello, L.4    Avanzi, G.C.5
  • 54
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • COI: 1:CAS:528:DyaK1cXht1Wrt70%3D, PID: 9466984
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101:890–898. doi:10.1172/JCI1112
    • (1998) J Clin Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 55
    • 0026453281 scopus 로고
    • Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    • COI: 1:CAS:528:DyaK38XmsV2mt7w%3D, PID: 1383273
    • Savill J, Hogg N, Ren Y, Haslett C (1992) Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest 90:1513–1522. doi:10.1172/JCI116019
    • (1992) J Clin Invest , vol.90 , pp. 1513-1522
    • Savill, J.1    Hogg, N.2    Ren, Y.3    Haslett, C.4
  • 56
    • 60549103394 scopus 로고    scopus 로고
    • Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling
    • COI: 1:CAS:528:DC%2BD1MXhtVOhtbg%3D, PID: 19124657
    • Medeiros AI, Serezani CH, Lee SP, Peters-Golden M (2009) Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med 206:61–68. doi:10.1084/jem.20082058
    • (2009) J Exp Med , vol.206 , pp. 61-68
    • Medeiros, A.I.1    Serezani, C.H.2    Lee, S.P.3    Peters-Golden, M.4
  • 57
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    • COI: 1:CAS:528:DC%2BD38Xjtlaktw%3D%3D, PID: 11781349
    • Huynh ML, Fadok VA, Henson PM (2002) Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 109:41–50. doi:10.1172/JCI11638
    • (2002) J Clin Invest , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 58
    • 84937686737 scopus 로고    scopus 로고
    • PPARgamma activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines
    • COI: 1:CAS:528:DC%2BC2MXnvVSrtQ%3D%3D, PID: 25586556
    • Yoon YS, Kim SY, Kim MJ, Lim JH, Cho MS, Kang JL (2015) PPARgamma activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines. Mucosal Immunol 8:1031–1046. doi:10.1038/mi.2014.130
    • (2015) Mucosal Immunol , vol.8 , pp. 1031-1046
    • Yoon, Y.S.1    Kim, S.Y.2    Kim, M.J.3    Lim, J.H.4    Cho, M.S.5    Kang, J.L.6
  • 59
    • 51549085896 scopus 로고    scopus 로고
    • Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide
    • COI: 1:CAS:528:DC%2BD1cXhtVSiu7jF, PID: 18713999
    • Ren G, Su J, Zhao X, Zhang L, Zhang J, Roberts AI et al (2008) Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 181:3277–3284
    • (2008) J Immunol , vol.181 , pp. 3277-3284
    • Ren, G.1    Su, J.2    Zhao, X.3    Zhang, L.4    Zhang, J.5    Roberts, A.I.6
  • 60
    • 80054840252 scopus 로고    scopus 로고
    • CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen
    • COI: 1:CAS:528:DC%2BC3MXhtFeqsbbK, PID: 21859845
    • Desch AN, Randolph GJ, Murphy K, Gautier EL, Kedl RM, Lahoud MH et al (2011) CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med 208:1789–1797. doi:10.1084/jem.20110538
    • (2011) J Exp Med , vol.208 , pp. 1789-1797
    • Desch, A.N.1    Randolph, G.J.2    Murphy, K.3    Gautier, E.L.4    Kedl, R.M.5    Lahoud, M.H.6
  • 61
    • 0035724035 scopus 로고    scopus 로고
    • Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma
    • COI: 1:CAS:528:DC%2BD3MXjvVegsbc%3D, PID: 11359432
    • Balbo P, Silvestri M, Rossi GA, Crimi E, Burastero SE (2001) Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma. Clin Exp Allergy 31:625–636
    • (2001) Clin Exp Allergy , vol.31 , pp. 625-636
    • Balbo, P.1    Silvestri, M.2    Rossi, G.A.3    Crimi, E.4    Burastero, S.E.5
  • 62
    • 84893652705 scopus 로고    scopus 로고
    • Alveolar macrophages: plasticity in a tissue-specific context
    • COI: 1:CAS:528:DC%2BC2cXps1ekuw%3D%3D, PID: 24445666
    • Hussell T, Bell TJ (2014) Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol 14:81–93. doi:10.1038/nri3600
    • (2014) Nat Rev Immunol , vol.14 , pp. 81-93
    • Hussell, T.1    Bell, T.J.2
  • 63
    • 41449087956 scopus 로고    scopus 로고
    • The prolonged life-span of alveolar macrophages
    • COI: 1:CAS:528:DC%2BD1cXkt1aisLk%3D, PID: 18192503
    • Murphy J, Summer R, Wilson AA, Kotton DN, Fine A (2008) The prolonged life-span of alveolar macrophages. Am J Respir Cell Mol Biol 38:380–385. doi:10.1165/rcmb.2007-0224RC
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 380-385
    • Murphy, J.1    Summer, R.2    Wilson, A.A.3    Kotton, D.N.4    Fine, A.5
  • 64
    • 80052472550 scopus 로고    scopus 로고
    • Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury
    • COI: 1:CAS:528:DC%2BC3MXhtlWqtrbL, PID: 21471090
    • Janssen WJ, Barthel L, Muldrow A, Oberley-Deegan RE, Kearns MT, Jakubzick C et al (2011) Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med 184:547–560. doi:10.1164/rccm.201011-1891OC
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 547-560
    • Janssen, W.J.1    Barthel, L.2    Muldrow, A.3    Oberley-Deegan, R.E.4    Kearns, M.T.5    Jakubzick, C.6
  • 65
    • 84880666005 scopus 로고    scopus 로고
    • Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections
    • COI: 1:CAS:528:DC%2BC3sXhtFequ7fK, PID: 23804714
    • Ghoneim HE, Thomas PG, McCullers JA (2013) Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections. J Immunol 191:1250–1259. doi:10.4049/jimmunol.1300014
    • (2013) J Immunol , vol.191 , pp. 1250-1259
    • Ghoneim, H.E.1    Thomas, P.G.2    McCullers, J.A.3
  • 66
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • COI: 1:CAS:528:DC%2BC38XkvV2rsrc%3D, PID: 22442384
    • Schulz C, Gomez PE, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K et al (2012) A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336:86–90. doi:10.1126/science.1219179
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1    Gomez, P.E.2    Chorro, L.3    Szabo-Rogers, H.4    Cagnard, N.5    Kierdorf, K.6
  • 67
    • 49049114350 scopus 로고    scopus 로고
    • Ciliated epithelial cell lifespan in the mouse trachea and lung
    • COI: 1:CAS:528:DC%2BD1cXoslygtLw%3D, PID: 18487354
    • Rawlins EL, Hogan BL (2008) Ciliated epithelial cell lifespan in the mouse trachea and lung. Am J Physiol Lung Cell Mol Physiol 295:L231–L234. doi:10.1152/ajplung.90209.2008
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. L231-L234
    • Rawlins, E.L.1    Hogan, B.L.2
  • 68
    • 84872930976 scopus 로고    scopus 로고
    • Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation
    • COI: 1:CAS:528:DC%2BC38XhvVaisrjN, PID: 23235830
    • Juncadella IJ, Kadl A, Sharma AK, Shim YM, Hochreiter-Hufford A, Borish L et al (2013) Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature 493:547–551. doi:10.1038/nature11714
    • (2013) Nature , vol.493 , pp. 547-551
    • Juncadella, I.J.1    Kadl, A.2    Sharma, A.K.3    Shim, Y.M.4    Hochreiter-Hufford, A.5    Borish, L.6
  • 69
    • 0035077330 scopus 로고    scopus 로고
    • Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema
    • COI: 1:STN:280:DC%2BD3M3itFGlsw%3D%3D, PID: 11254533
    • Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF (2001) Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 163:737–744. doi:10.1164/ajrccm.163.3.2002117
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 737-744
    • Kasahara, Y.1    Tuder, R.M.2    Cool, C.D.3    Lynch, D.A.4    Flores, S.C.5    Voelkel, N.F.6
  • 70
    • 0037438551 scopus 로고    scopus 로고
    • Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia
    • PID: 12406830
    • Knapp S, Leemans JC, Florquin S, Branger J, Maris NA, Pater J et al (2003) Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med 167:171–179. doi:10.1164/rccm.200207-698OC
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 171-179
    • Knapp, S.1    Leemans, J.C.2    Florquin, S.3    Branger, J.4    Maris, N.A.5    Pater, J.6
  • 71
    • 80054969912 scopus 로고    scopus 로고
    • Role of apoptosis in amplifying inflammatory responses in lung diseases
    • PID: 22081757
    • Schmidt EP, Tuder RM (2010) Role of apoptosis in amplifying inflammatory responses in lung diseases. J Cell Death 2010:41–53. doi:10.4137/JCD.S5375
    • (2010) J Cell Death , vol.2010 , pp. 41-53
    • Schmidt, E.P.1    Tuder, R.M.2
  • 72
    • 77956924042 scopus 로고    scopus 로고
    • Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases
    • COI: 1:CAS:528:DC%2BC3cXhtVyru77N, PID: 20449769
    • Krysko O, Vandenabeele P, Krysko DV, Bachert C (2010) Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases. Apoptosis 15:1137–1146. doi:10.1007/s10495-010-0504-x
    • (2010) Apoptosis , vol.15 , pp. 1137-1146
    • Krysko, O.1    Vandenabeele, P.2    Krysko, D.V.3    Bachert, C.4
  • 73
    • 84878613009 scopus 로고    scopus 로고
    • Efferocytosis and lung disease
    • COI: 1:CAS:528:DC%2BC3sXhtVSntb3M, PID: 23732585
    • McCubbrey AL, Curtis JL (2013) Efferocytosis and lung disease. Chest 143:1750–1757. doi:10.1378/chest.12-2413
    • (2013) Chest , vol.143 , pp. 1750-1757
    • McCubbrey, A.L.1    Curtis, J.L.2
  • 74
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BD1cXisVKjsrs%3D, PID: 18274560
    • Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8:183–192. doi:10.1038/nri2254
    • (2008) Nat Rev Immunol , vol.8 , pp. 183-192
    • Barnes, P.J.1
  • 75
    • 33745905620 scopus 로고    scopus 로고
    • Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
    • PID: 16571143, COI: 1:CAS:528:DC%2BD28XktVGisLk%3D
    • Demedts IK, Demoor T, Bracke KR, Joos GF, Brusselle GG (2006) Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res 7:53. doi:10.1186/1465-9921-7-53
    • (2006) Respir Res , vol.7 , pp. 53
    • Demedts, I.K.1    Demoor, T.2    Bracke, K.R.3    Joos, G.F.4    Brusselle, G.G.5
  • 76
    • 13844266182 scopus 로고    scopus 로고
    • Correlation of lung surface area to apoptosis and proliferation in human emphysema
    • COI: 1:STN:280:DC%2BD2M%2FlsFyqtA%3D%3D, PID: 15684288
    • Imai K, Mercer BA, Schulman LL, Sonett JR, D’Armiento JM (2005) Correlation of lung surface area to apoptosis and proliferation in human emphysema. Eur Respir J 25:250–258. doi:10.1183/09031936.05.00023704
    • (2005) Eur Respir J , vol.25 , pp. 250-258
    • Imai, K.1    Mercer, B.A.2    Schulman, L.L.3    Sonett, J.R.4    D’Armiento, J.M.5
  • 77
    • 67649200156 scopus 로고    scopus 로고
    • Increased apoptosis of neutrophils in induced sputum of COPD patients
    • PID: 19329291
    • Makris D, Vrekoussis T, Izoldi M, Alexandra K, Katerina D, Dimitris T et al (2009) Increased apoptosis of neutrophils in induced sputum of COPD patients. Respir Med 103:1130–1135. doi:10.1016/j.rmed.2009.03.002
    • (2009) Respir Med , vol.103 , pp. 1130-1135
    • Makris, D.1    Vrekoussis, T.2    Izoldi, M.3    Alexandra, K.4    Katerina, D.5    Dimitris, T.6
  • 78
    • 0038070219 scopus 로고    scopus 로고
    • Alveolar wall apoptosis causes lung destruction and emphysematous changes
    • COI: 1:CAS:528:DC%2BD3sXjs1aruro%3D, PID: 12707011
    • Aoshiba K, Yokohori N, Nagai A (2003) Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol 28:555–562. doi:10.1165/rcmb.2002-0090OC
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 555-562
    • Aoshiba, K.1    Yokohori, N.2    Nagai, A.3
  • 79
    • 0041346077 scopus 로고    scopus 로고
    • Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells
    • PID: 12848850
    • Hodge S, Hodge G, Scicchitano R, Reynolds PN, Holmes M (2003) Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol 81:289–296. doi:10.1046/j.1440-1711.2003.t01-1-01170.x
    • (2003) Immunol Cell Biol , vol.81 , pp. 289-296
    • Hodge, S.1    Hodge, G.2    Scicchitano, R.3    Reynolds, P.N.4    Holmes, M.5
  • 80
    • 84901254158 scopus 로고    scopus 로고
    • Animal models of chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BC2cXoslCitLs%3D, PID: 24754714
    • Fricker M, Deane A, Hansbro PM (2014) Animal models of chronic obstructive pulmonary disease. Expert Opin Drug Discov 9:629–645. doi:10.1517/17460441.2014.909805
    • (2014) Expert Opin Drug Discov , vol.9 , pp. 629-645
    • Fricker, M.1    Deane, A.2    Hansbro, P.M.3
  • 81
    • 79955486468 scopus 로고    scopus 로고
    • Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine
    • COI: 1:CAS:528:DC%2BC3MXot1Kjsbs%3D, PID: 20595463
    • Hodge S, Matthews G, Mukaro V, Ahern J, Shivam A, Hodge G et al (2011) Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine. Am J Respir Cell Mol Biol 44:673–681. doi:10.1165/rcmb.2009-0459OC
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 673-681
    • Hodge, S.1    Matthews, G.2    Mukaro, V.3    Ahern, J.4    Shivam, A.5    Hodge, G.6
  • 82
    • 66249127897 scopus 로고    scopus 로고
    • Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA
    • COI: 1:CAS:528:DC%2BD1MXnt1artLc%3D, PID: 19264974
    • Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL et al (2009) Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med 179:1011–1021. doi:10.1164/rccm.200807-1148OC
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 1011-1021
    • Richens, T.R.1    Linderman, D.J.2    Horstmann, S.A.3    Lambert, C.4    Xiao, Y.Q.5    Keith, R.L.6
  • 83
    • 56049106702 scopus 로고    scopus 로고
    • High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine
    • COI: 1:CAS:528:DC%2BD1cXhtVKntbvO, PID: 18768881
    • Liu G, Wang J, Park YJ, Tsuruta Y, Lorne EF, Zhao X et al (2008) High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol 181:4240–4246. doi:10.4049/jimmunol.181.6.4240
    • (2008) J Immunol , vol.181 , pp. 4240-4246
    • Liu, G.1    Wang, J.2    Park, Y.J.3    Tsuruta, Y.4    Lorne, E.F.5    Zhao, X.6
  • 84
    • 78649673357 scopus 로고    scopus 로고
    • HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin
    • COI: 1:CAS:528:DC%2BC3cXhs1aisbvN, PID: 20826760
    • Friggeri A, Yang Y, Banerjee S, Park YJ, Liu G, Abraham E (2010) HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am J Physiol Cell Physiol 299:C1267–C1276. doi:10.1152/ajpcell.00152.2010
    • (2010) Am J Physiol Cell Physiol , vol.299 , pp. C1267-C1276
    • Friggeri, A.1    Yang, Y.2    Banerjee, S.3    Park, Y.J.4    Liu, G.5    Abraham, E.6
  • 85
    • 79960726338 scopus 로고    scopus 로고
    • High mobility group protein B1 (HMGB1) in asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls
    • COI: 1:CAS:528:DC%2BC3MXhtVemurrN, PID: 21380479
    • Hou C, Zhao H, Liu L, Li W, Zhou X, Lv Y et al (2011) High mobility group protein B1 (HMGB1) in asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls. Mol Med 17:807–815. doi:10.2119/molmed.2010.00173
    • (2011) Mol Med , vol.17 , pp. 807-815
    • Hou, C.1    Zhao, H.2    Liu, L.3    Li, W.4    Zhou, X.5    Lv, Y.6
  • 86
    • 0035903289 scopus 로고    scopus 로고
    • C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    • COI: 1:CAS:528:DC%2BD3MXmvFGgsrc%3D, PID: 11560994
    • Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA et al (2001) C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 194:781–795. doi:10.1084/jem.194.6.781
    • (2001) J Exp Med , vol.194 , pp. 781-795
    • Ogden, C.A.1    deCathelineau, A.2    Hoffmann, P.R.3    Bratton, D.4    Ghebrehiwet, B.5    Fadok, V.A.6
  • 87
    • 74549186388 scopus 로고    scopus 로고
    • Therapeutic role for mannose-binding lectin in cigarette smoke-induced lung inflammation? Evidence from a murine model
    • COI: 1:CAS:528:DC%2BC3cXhsFaqtLw%3D, PID: 19411612
    • Hodge S, Matthews G, Dean MM, Ahern J, Djukic M, Hodge G et al (2010) Therapeutic role for mannose-binding lectin in cigarette smoke-induced lung inflammation? Evidence from a murine model. Am J Respir Cell Mol Biol 42:235–242. doi:10.1165/rcmb.2008-0486OC
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 235-242
    • Hodge, S.1    Matthews, G.2    Dean, M.M.3    Ahern, J.4    Djukic, M.5    Hodge, G.6
  • 88
    • 84902455831 scopus 로고    scopus 로고
    • Oxidative stress decreases functional airway mannose binding lectin in COPD
    • PID: 24901869, COI: 1:CAS:528:DC%2BC2cXhsVKht77J
    • Tran HB, Ahern J, Hodge G, Holt P, Dean MM, Reynolds PN et al (2014) Oxidative stress decreases functional airway mannose binding lectin in COPD. PLoS One 9, e98571. doi:10.1371/journal.pone.0098571
    • (2014) PLoS One , vol.9
    • Tran, H.B.1    Ahern, J.2    Hodge, G.3    Holt, P.4    Dean, M.M.5    Reynolds, P.N.6
  • 89
    • 46849087364 scopus 로고    scopus 로고
    • Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha
    • COI: 1:CAS:528:DC%2BD1cXpsFOrsb4%3D, PID: 18420961
    • Janssen WJ, McPhillips KA, Dickinson MG, Linderman DJ, Morimoto K, Xiao YQ et al (2008) Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am J Respir Crit Care Med 178:158–167. doi:10.1164/rccm.200711-1661OC
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 158-167
    • Janssen, W.J.1    McPhillips, K.A.2    Dickinson, M.G.3    Linderman, D.J.4    Morimoto, K.5    Xiao, Y.Q.6
  • 90
    • 0035865463 scopus 로고    scopus 로고
    • Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils
    • COI: 1:CAS:528:DC%2BD3MXht1Ghs7o%3D, PID: 11160338
    • Schagat TL, Wofford JA, Wright JR (2001) Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J Immunol 166:2727–2733. doi:10.4049/jimmunol.166.4.2727
    • (2001) J Immunol , vol.166 , pp. 2727-2733
    • Schagat, T.L.1    Wofford, J.A.2    Wright, J.R.3
  • 91
    • 40649096344 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study
    • PID: 18226251, COI: 1:CAS:528:DC%2BD1cXntlektrY%3D
    • Sims MW, Tal-Singer RM, Kierstein S, Musani AI, Beers MF, Panettieri RA et al (2008) Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir Res 9:13. doi:10.1186/1465-9921-9-13
    • (2008) Respir Res , vol.9 , pp. 13
    • Sims, M.W.1    Tal-Singer, R.M.2    Kierstein, S.3    Musani, A.I.4    Beers, M.F.5    Panettieri, R.A.6
  • 92
    • 84922273103 scopus 로고    scopus 로고
    • The immunology of asthma
    • COI: 1:CAS:528:DC%2BC2cXitFKltL3E, PID: 25521684
    • Lambrecht BN, Hammad H (2015) The immunology of asthma. Nat Immunol 16:45–56. doi:10.1038/ni.3049
    • (2015) Nat Immunol , vol.16 , pp. 45-56
    • Lambrecht, B.N.1    Hammad, H.2
  • 93
    • 0035984581 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    • COI: 1:CAS:528:DC%2BD38Xmt12jsLo%3D, PID: 12151309
    • Bucchieri F, Puddicombe SM, Lordan JL, Richter A, Buchanan D, Wilson SJ et al (2002) Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. Am J Respir Cell Mol Biol 27:179–185. doi:10.1165/ajrcmb.27.2.4699
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 179-185
    • Bucchieri, F.1    Puddicombe, S.M.2    Lordan, J.L.3    Richter, A.4    Buchanan, D.5    Wilson, S.J.6
  • 94
    • 0035216793 scopus 로고    scopus 로고
    • Human alveolar epithelial cells engulf apoptotic eosinophils by means of integrin- and phosphatidylserine receptor-dependent mechanisms: a process upregulated by dexamethasone
    • COI: 1:CAS:528:DC%2BD38XltVOhuw%3D%3D, PID: 11742274
    • Sexton DW, Blaylock MG, Walsh GM (2001) Human alveolar epithelial cells engulf apoptotic eosinophils by means of integrin- and phosphatidylserine receptor-dependent mechanisms: a process upregulated by dexamethasone. J Allergy Clin Immunol 108:962–969. doi:10.1067/mai.2001.119414
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 962-969
    • Sexton, D.W.1    Blaylock, M.G.2    Walsh, G.M.3
  • 95
    • 0030035298 scopus 로고    scopus 로고
    • Eosinophil apoptosis and the resolution of airway inflammation in asthma
    • COI: 1:STN:280:DyaK283ptFWlsQ%3D%3D, PID: 8680686
    • Woolley KL, Gibson PG, Carty K, Wilson AJ, Twaddell SH, Woolley MJ (1996) Eosinophil apoptosis and the resolution of airway inflammation in asthma. Am J Respir Crit Care Med 154:237–243. doi:10.1164/ajrccm.154.1.8680686
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 237-243
    • Woolley, K.L.1    Gibson, P.G.2    Carty, K.3    Wilson, A.J.4    Twaddell, S.H.5    Woolley, M.J.6
  • 96
    • 84905669404 scopus 로고    scopus 로고
    • Eosinophils in the lung—modulating apoptosis and efferocytosis in airway inflammation
    • PID: 25071763, COI: 1:CAS:528:DC%2BC2MXht1ehtbfL
    • Felton JM, Lucas CD, Rossi AG, Dransfield I (2014) Eosinophils in the lung—modulating apoptosis and efferocytosis in airway inflammation. Front Immunol 5:302. doi:10.3389/fimmu.2014.00302
    • (2014) Front Immunol , vol.5 , pp. 302
    • Felton, J.M.1    Lucas, C.D.2    Rossi, A.G.3    Dransfield, I.4
  • 97
    • 26944476623 scopus 로고    scopus 로고
    • Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages
    • PID: 16040786
    • Huynh ML, Malcolm KC, Kotaru C, Tilstra JA, Westcott JY, Fadok VA et al (2005) Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages. Am J Respir Crit Care Med 172:972–979. doi:10.1164/rccm.200501-035OC
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 972-979
    • Huynh, M.L.1    Malcolm, K.C.2    Kotaru, C.3    Tilstra, J.A.4    Westcott, J.Y.5    Fadok, V.A.6
  • 98
    • 84871706214 scopus 로고    scopus 로고
    • Impaired macrophage phagocytosis in non-eosinophilic asthma
    • COI: 1:STN:280:DC%2BC3s3lslOntw%3D%3D, PID: 23278878
    • Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN et al (2013) Impaired macrophage phagocytosis in non-eosinophilic asthma. Clin Exp Allergy 43:29–35. doi:10.1111/j.1365-2222.2012.04075.x
    • (2013) Clin Exp Allergy , vol.43 , pp. 29-35
    • Simpson, J.L.1    Gibson, P.G.2    Yang, I.A.3    Upham, J.4    James, A.5    Reynolds, P.N.6
  • 99
    • 33947588653 scopus 로고    scopus 로고
    • Innate immune activation in neutrophilic asthma and bronchiectasis
    • PID: 16844729
    • Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG (2007) Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 62:211–218. doi:10.1136/thx.2006.061358
    • (2007) Thorax , vol.62 , pp. 211-218
    • Simpson, J.L.1    Grissell, T.V.2    Douwes, J.3    Scott, R.J.4    Boyle, M.J.5    Gibson, P.G.6
  • 100
    • 84876838050 scopus 로고    scopus 로고
    • Obesity and asthma: impact on severity, asthma control, and response to therapy
    • PID: 23258582
    • Juel CT, Ulrik CS (2013) Obesity and asthma: impact on severity, asthma control, and response to therapy. Respir Care 58:867–873. doi:10.4187/respcare.02202
    • (2013) Respir Care , vol.58 , pp. 867-873
    • Juel, C.T.1    Ulrik, C.S.2
  • 102
    • 1442308176 scopus 로고    scopus 로고
    • TIM-1, a novel allergy and asthma susceptibility gene
    • PID: 15007635
    • McIntire JJ, Umetsu DT, DeKruyff RH (2004) TIM-1, a novel allergy and asthma susceptibility gene. Springer Semin Immunopathol 25:335–348. doi:10.1007/s00281-003-0141-3
    • (2004) Springer Semin Immunopathol , vol.25 , pp. 335-348
    • McIntire, J.J.1    Umetsu, D.T.2    DeKruyff, R.H.3
  • 103
    • 77951673268 scopus 로고    scopus 로고
    • TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    • COI: 1:CAS:528:DC%2BC3cXnt1Kjtrs%3D, PID: 20536563
    • Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH (2010) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 235:172–189. doi:10.1111/j.0105-2896.2010.00903.x
    • (2010) Immunol Rev , vol.235 , pp. 172-189
    • Freeman, G.J.1    Casasnovas, J.M.2    Umetsu, D.T.3    DeKruyff, R.H.4
  • 104
    • 78149486214 scopus 로고    scopus 로고
    • Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity
    • COI: 1:CAS:528:DC%2BC3cXhtlWhsrvJ, PID: 20889552
    • Lee HH, Meyer EH, Goya S, Pichavant M, Kim HY, Bu X et al (2010) Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. J Immunol 185:5225–5235. doi:10.4049/jimmunol.1001116
    • (2010) J Immunol , vol.185 , pp. 5225-5235
    • Lee, H.H.1    Meyer, E.H.2    Goya, S.3    Pichavant, M.4    Kim, H.Y.5    Bu, X.6
  • 105
    • 44649183243 scopus 로고    scopus 로고
    • Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
    • COI: 1:CAS:528:DC%2BD1cXmvV2ktb0%3D
    • Fitzpatrick AM, Holguin F, Teague WG, Brown LA (2008) Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol 121:1372.e3–1378. doi:10.1016/j.jaci.2008.03.008
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1372-1378
    • Fitzpatrick, A.M.1    Holguin, F.2    Teague, W.G.3    Brown, L.A.4
  • 106
    • 6344258651 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells
    • COI: 1:CAS:528:DC%2BD2cXpvF2qs78%3D, PID: 15479265
    • Sexton DW, Al-Rabia M, Blaylock MG, Walsh GM (2004) Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells. Clin Exp Allergy 34:1514–1524. doi:10.1111/j.1365-2222.2004.02054.x
    • (2004) Clin Exp Allergy , vol.34 , pp. 1514-1524
    • Sexton, D.W.1    Al-Rabia, M.2    Blaylock, M.G.3    Walsh, G.M.4
  • 107
    • 84887488043 scopus 로고    scopus 로고
    • Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications
    • PID: 23704228
    • Cohen-Cymberknoh M, Kerem E, Ferkol T, Elizur A (2013) Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications. Thorax 68:1157–1162. doi:10.1136/thoraxjnl-2013-203204
    • (2013) Thorax , vol.68 , pp. 1157-1162
    • Cohen-Cymberknoh, M.1    Kerem, E.2    Ferkol, T.3    Elizur, A.4
  • 108
    • 54049139979 scopus 로고    scopus 로고
    • Potential role of high-mobility group box 1 in cystic fibrosis airway disease
    • COI: 1:CAS:528:DC%2BD1cXhtlaisLfI, PID: 18658107
    • Rowe SM, Jackson PL, Liu G, Hardison M, Livraghi A, Solomon GM et al (2008) Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med 178:822–831. doi:10.1164/rccm.200712-1894OC
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 822-831
    • Rowe, S.M.1    Jackson, P.L.2    Liu, G.3    Hardison, M.4    Livraghi, A.5    Solomon, G.M.6
  • 109
    • 37849043150 scopus 로고    scopus 로고
    • Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa
    • COI: 1:CAS:528:DC%2BD1cXht12mt78%3D, PID: 17916805
    • Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW et al (2008) Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa. Am J Respir Crit Care Med 177:35–43. doi:10.1164/rccm.200612-1804OC
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 35-43
    • Bianchi, S.M.1    Prince, L.R.2    McPhillips, K.3    Allen, L.4    Marriott, H.M.5    Taylor, G.W.6
  • 110
    • 84918796351 scopus 로고    scopus 로고
    • Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance
    • COI: 1:CAS:528:DC%2BC2cXhtFGmtbjI, PID: 25027418
    • McCaslin CA, Petrusca DN, Poirier C, Serban KA, Anderson GG, Petrache I (2015) Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance. J Cyst Fibros 14:70–77. doi:10.1016/j.jcf.2014.06.009
    • (2015) J Cyst Fibros , vol.14 , pp. 70-77
    • McCaslin, C.A.1    Petrusca, D.N.2    Poirier, C.3    Serban, K.A.4    Anderson, G.G.5    Petrache, I.6
  • 111
    • 70349759567 scopus 로고    scopus 로고
    • Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences
    • COI: 1:CAS:528:DC%2BD1MXhtlentr3J, PID: 19633071
    • Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD et al (2009) Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol 297:L677–L686. doi:10.1152/ajplung.00030.2009
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L677-L686
    • Vandivier, R.W.1    Richens, T.R.2    Horstmann, S.A.3    deCathelineau, A.M.4    Ghosh, M.5    Reynolds, S.D.6
  • 112
    • 84867744232 scopus 로고    scopus 로고
    • Defective efferocytosis by alveolar macrophages in IPF patients
    • PID: 22999220
    • Morimoto K, Janssen WJ, Terada M (2012) Defective efferocytosis by alveolar macrophages in IPF patients. Respir Med 106:1800–1803. doi:10.1016/j.rmed.2012.08.020
    • (2012) Respir Med , vol.106 , pp. 1800-1803
    • Morimoto, K.1    Janssen, W.J.2    Terada, M.3
  • 113
  • 114
    • 84864763371 scopus 로고    scopus 로고
    • Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction
    • PID: 22441736, COI: 1:CAS:528:DC%2BC38XhtlCrtb%2FE
    • Lee YJ, Moon C, Lee SH, Park HJ, Seoh JY, Cho MS et al (2012) Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction. Eur Respir J 40:424–435. doi:10.1183/09031936.00096711
    • (2012) Eur Respir J , vol.40 , pp. 424-435
    • Lee, Y.J.1    Moon, C.2    Lee, S.H.3    Park, H.J.4    Seoh, J.Y.5    Cho, M.S.6
  • 115
    • 84937250748 scopus 로고    scopus 로고
    • Viral apoptotic mimicry
    • COI: 1:CAS:528:DC%2BC2MXhtFaisbbO, PID: 26052667
    • Amara A, Mercer J (2015) Viral apoptotic mimicry. Nat Rev Microbiol 13:461–469. doi:10.1038/nrmicro3469
    • (2015) Nat Rev Microbiol , vol.13 , pp. 461-469
    • Amara, A.1    Mercer, J.2
  • 116
    • 84907690970 scopus 로고    scopus 로고
    • Phosphatidylserine receptors: enhancers of enveloped virus entry and infection
    • PID: 25277499, COI: 1:CAS:528:DC%2BC2cXhsF2mu7fM
    • Moller-Tank S, Maury W (2014) Phosphatidylserine receptors: enhancers of enveloped virus entry and infection. Virology 468–470:565–580. doi:10.1016/j.virol.2014.09.009
    • (2014) Virology , vol.468-470 , pp. 565-580
    • Moller-Tank, S.1    Maury, W.2
  • 117
    • 84876011067 scopus 로고    scopus 로고
    • TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine
    • COI: 1:CAS:528:DC%2BC3sXmtVejtr0%3D, PID: 23555248
    • Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S et al (2013) TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoS Pathog 9, e1003232. doi:10.1371/journal.ppat.1003232
    • (2013) PLoS Pathog , vol.9
    • Jemielity, S.1    Wang, J.J.2    Chan, Y.K.3    Ahmed, A.A.4    Li, W.5    Monahan, S.6
  • 118
    • 84867647748 scopus 로고    scopus 로고
    • The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry
    • COI: 1:CAS:528:DC%2BC38XhsFClurzK, PID: 23084921
    • Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E et al (2012) The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe 12:544–557. doi:10.1016/j.chom.2012.08.009
    • (2012) Cell Host Microbe , vol.12 , pp. 544-557
    • Meertens, L.1    Carnec, X.2    Lecoin, M.P.3    Ramdasi, R.4    Guivel-Benhassine, F.5    Lew, E.6
  • 119
    • 84889641431 scopus 로고    scopus 로고
    • Macrophages clean up: efferocytosis and microbial control
    • COI: 1:CAS:528:DC%2BC2cXjs1Ohsbg%3D, PID: 24581688
    • Martin CJ, Peters KN, Behar SM (2014) Macrophages clean up: efferocytosis and microbial control. Curr Opin Microbiol 17:17–23. doi:10.1016/j.mib.2013.10.007
    • (2014) Curr Opin Microbiol , vol.17 , pp. 17-23
    • Martin, C.J.1    Peters, K.N.2    Behar, S.M.3
  • 120
    • 77955661920 scopus 로고    scopus 로고
    • Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?
    • COI: 1:CAS:528:DC%2BC3cXpsFWkt7w%3D, PID: 20676146
    • Behar SM, Divangahi M, Remold HG (2010) Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy? Nat Rev Microbiol 8:668–674. doi:10.1038/nrmicro2387
    • (2010) Nat Rev Microbiol , vol.8 , pp. 668-674
    • Behar, S.M.1    Divangahi, M.2    Remold, H.G.3
  • 122
    • 0035884268 scopus 로고    scopus 로고
    • Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis
    • COI: 1:STN:280:DC%2BD3Mvnt1SrtQ%3D%3D, PID: 11517432
    • Dockrell DH, Lee M, Lynch DH, Read RC (2001) Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis. J Infect Dis 184:713–722. doi:10.1086/323084
    • (2001) J Infect Dis , vol.184 , pp. 713-722
    • Dockrell, D.H.1    Lee, M.2    Lynch, D.H.3    Read, R.C.4
  • 123
    • 84961287867 scopus 로고    scopus 로고
    • Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection
    • PID: 25562320
    • Tzelepis F, Verway M, Daoud J, Gillard J, Hassani-Ardakani K, Dunn J et al (2015) Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest 125:752–768. doi:10.1172/JCI77014
    • (2015) J Clin Invest , vol.125 , pp. 752-768
    • Tzelepis, F.1    Verway, M.2    Daoud, J.3    Gillard, J.4    Hassani-Ardakani, K.5    Dunn, J.6
  • 124
    • 0034054028 scopus 로고    scopus 로고
    • Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages
    • COI: 1:CAS:528:DC%2BD3cXhvVejur0%3D, PID: 10708457
    • Fujimoto I, Pan J, Takizawa T, Nakanishi Y (2000) Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages. J Virol 74:3399–3403
    • (2000) J Virol , vol.74 , pp. 3399-3403
    • Fujimoto, I.1    Pan, J.2    Takizawa, T.3    Nakanishi, Y.4
  • 125
    • 79951945330 scopus 로고    scopus 로고
    • Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections
    • PID: 20585334
    • Mares CA, Sharma J, Li Q, Rangel EL, Morris EG, Enriquez MI et al (2011) Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections. Immunol Cell Biol 89:167–172. doi:10.1038/icb.2010.81
    • (2011) Immunol Cell Biol , vol.89 , pp. 167-172
    • Mares, C.A.1    Sharma, J.2    Li, Q.3    Rangel, E.L.4    Morris, E.G.5    Enriquez, M.I.6
  • 126
    • 84932091853 scopus 로고    scopus 로고
    • Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function
    • COI: 1:CAS:528:DC%2BC2MXhtVagtbjI, PID: 25987742
    • Stolberg VR, McCubbrey AL, Freeman CM, Brown JP, Crudgington SW, Taitano SH et al (2015) Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function. J Immunol 195:174–184. doi:10.4049/jimmunol.1402217
    • (2015) J Immunol , vol.195 , pp. 174-184
    • Stolberg, V.R.1    McCubbrey, A.L.2    Freeman, C.M.3    Brown, J.P.4    Crudgington, S.W.5    Taitano, S.H.6
  • 127
    • 0033559878 scopus 로고    scopus 로고
    • Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes
    • COI: 1:CAS:528:DyaK1MXhvFSju7s%3D, PID: 10092825
    • Liu Y, Cousin JM, Hughes J, Van DJ, Seckl JR, Haslett C et al (1999) Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J Immunol 162:3639–3646
    • (1999) J Immunol , vol.162 , pp. 3639-3646
    • Liu, Y.1    Cousin, J.M.2    Hughes, J.3    Van, D.J.4    Seckl, J.R.5    Haslett, C.6
  • 128
    • 68149164365 scopus 로고    scopus 로고
    • Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages
    • COI: 1:CAS:528:DC%2BD1MXoslCrtrk%3D, PID: 19597001
    • McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C et al (2009) Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J Immunol 183:2167–2175. doi:10.4049/jimmunol.0803503
    • (2009) J Immunol , vol.183 , pp. 2167-2175
    • McColl, A.1    Bournazos, S.2    Franz, S.3    Perretti, M.4    Morgan, B.P.5    Haslett, C.6
  • 129
    • 84866554651 scopus 로고    scopus 로고
    • Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction
    • COI: 1:CAS:528:DC%2BC38XhtlOmurbI, PID: 22942426
    • Zizzo G, Hilliard BA, Monestier M, Cohen PL (2012) Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol 189:3508–3520. doi:10.4049/jimmunol.1200662
    • (2012) J Immunol , vol.189 , pp. 3508-3520
    • Zizzo, G.1    Hilliard, B.A.2    Monestier, M.3    Cohen, P.L.4
  • 130
    • 84862864316 scopus 로고    scopus 로고
    • Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPalpha
    • COI: 1:CAS:528:DC%2BC38XovV2jsrs%3D, PID: 22615206
    • McCubbrey AL, Sonstein J, Ames TM, Freeman CM, Curtis JL (2012) Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPalpha. J Immunol 189:112–119. doi:10.4049/jimmunol.1200984
    • (2012) J Immunol , vol.189 , pp. 112-119
    • McCubbrey, A.L.1    Sonstein, J.2    Ames, T.M.3    Freeman, C.M.4    Curtis, J.L.5
  • 131
    • 0037224290 scopus 로고    scopus 로고
    • Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages
    • COI: 1:CAS:528:DC%2BD3sXis12itw%3D%3D, PID: 12499168
    • Yamaryo T, Oishi K, Yoshimine H, Tsuchihashi Y, Matsushima K, Nagatake T (2003) Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages. Antimicrob Agents Chemother 47:48–53
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 48-53
    • Yamaryo, T.1    Oishi, K.2    Yoshimine, H.3    Tsuchihashi, Y.4    Matsushima, K.5    Nagatake, T.6
  • 132
    • 80052157895 scopus 로고    scopus 로고
    • Azithromycin for prevention of exacerbations of COPD
    • COI: 1:CAS:528:DC%2BC3MXhtV2lurjM, PID: 21864166
    • Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA Jr, Criner GJ et al (2011) Azithromycin for prevention of exacerbations of COPD. N Engl J Med 365:689–698. doi:10.1056/NEJMoa1104623
    • (2011) N Engl J Med , vol.365 , pp. 689-698
    • Albert, R.K.1    Connett, J.2    Bailey, W.C.3    Casaburi, R.4    Cooper, J.A.5    Criner, G.J.6
  • 133
    • 1642493927 scopus 로고    scopus 로고
    • Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages
    • PID: 14563653
    • Asada K, Sasaki S, Suda T, Chida K, Nakamura H (2004) Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. Am J Respir Crit Care Med 169:195–200. doi:10.1164/rccm.200207-740OC
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 195-200
    • Asada, K.1    Sasaki, S.2    Suda, T.3    Chida, K.4    Nakamura, H.5
  • 134
    • 84893461621 scopus 로고    scopus 로고
    • The effect of peroxisome proliferator-activated receptor-gamma ligands on in vitro and in vivo models of COPD
    • COI: 1:CAS:528:DC%2BC2cXls1Ggsbo%3D, PID: 23794466
    • Lea S, Plumb J, Metcalfe H, Spicer D, Woodman P, Fox JC et al (2014) The effect of peroxisome proliferator-activated receptor-gamma ligands on in vitro and in vivo models of COPD. Eur Respir J 43:409–420. doi:10.1183/09031936.00187812
    • (2014) Eur Respir J , vol.43 , pp. 409-420
    • Lea, S.1    Plumb, J.2    Metcalfe, H.3    Spicer, D.4    Woodman, P.5    Fox, J.C.6
  • 135
    • 33744906761 scopus 로고    scopus 로고
    • Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BD28Xlt1CksL0%3D, PID: 16751413
    • Morimoto K, Janssen WJ, Fessler MB, McPhillips KA, Borges VM, Bowler RP et al (2006) Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol 176:7657–7665
    • (2006) J Immunol , vol.176 , pp. 7657-7665
    • Morimoto, K.1    Janssen, W.J.2    Fessler, M.B.3    McPhillips, K.A.4    Borges, V.M.5    Bowler, R.P.6
  • 136
    • 33846931592 scopus 로고    scopus 로고
    • Statin use is associated with reduced mortality in COPD
    • COI: 1:STN:280:DC%2BD2s%2FlvVSktw%3D%3D, PID: 17050558
    • Soyseth V, Brekke PH, Smith P, Omland T (2007) Statin use is associated with reduced mortality in COPD. Eur Respir J 29:279–283. doi:10.1183/09031936.00106406
    • (2007) Eur Respir J , vol.29 , pp. 279-283
    • Soyseth, V.1    Brekke, P.H.2    Smith, P.3    Omland, T.4
  • 137
    • 84879163490 scopus 로고    scopus 로고
    • Statin use and risk of COPD exacerbation requiring hospitalization
    • COI: 1:CAS:528:DC%2BC3sXnvVOhu7c%3D, PID: 23684060
    • Wang MT, Lo YW, Tsai CL, Chang LC, Malone DC, Chu CL et al (2013) Statin use and risk of COPD exacerbation requiring hospitalization. Am J Med 126:598–606. doi:10.1016/j.amjmed.2013.01.036
    • (2013) Am J Med , vol.126 , pp. 598-606
    • Wang, M.T.1    Lo, Y.W.2    Tsai, C.L.3    Chang, L.C.4    Malone, D.C.5    Chu, C.L.6
  • 138
    • 84901817055 scopus 로고    scopus 로고
    • Simvastatin for the prevention of exacerbations in moderate-to-severe COPD
    • PID: 24836125, COI: 1:CAS:528:DC%2BC2cXhsFemtLzO
    • Criner GJ, Connett JE, Aaron SD, Albert RK, Bailey WC, Casaburi R et al (2014) Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med 370:2201–2210. doi:10.1056/NEJMoa1403086
    • (2014) N Engl J Med , vol.370 , pp. 2201-2210
    • Criner, G.J.1    Connett, J.E.2    Aaron, S.D.3    Albert, R.K.4    Bailey, W.C.5    Casaburi, R.6
  • 139
    • 84922481128 scopus 로고    scopus 로고
    • The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer
    • COI: 1:CAS:528:DC%2BC2cXhvFKmu7jK, PID: 25568918
    • Graham DK, DeRyckere D, Davies KD, Earp HS (2014) The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer. Nat Rev Cancer 14:769–785. doi:10.1038/nrc3847
    • (2014) Nat Rev Cancer , vol.14 , pp. 769-785
    • Graham, D.K.1    DeRyckere, D.2    Davies, K.D.3    Earp, H.S.4
  • 140
    • 84872730516 scopus 로고    scopus 로고
    • Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation
    • COI: 1:CAS:528:DC%2BC3sXhsFKiu7k%3D, PID: 23197771
    • Choi JY, Park HJ, Lee YJ, Byun J, Youn YS, Choi JH et al (2013) Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation. J Pharmacol Exp Ther 344:447–458. doi:10.1124/jpet.112.199778
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 447-458
    • Choi, J.Y.1    Park, H.J.2    Lee, Y.J.3    Byun, J.4    Youn, Y.S.5    Choi, J.H.6
  • 141
    • 84861951340 scopus 로고    scopus 로고
    • Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury
    • COI: 1:CAS:528:DC%2BC38XotlWrtrY%3D, PID: 22427680
    • Lee YJ, Han JY, Byun J, Park HJ, Park EM, Chong YH et al (2012) Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury. J Leukoc Biol 91:921–932. doi:10.1189/jlb.0611289
    • (2012) J Leukoc Biol , vol.91 , pp. 921-932
    • Lee, Y.J.1    Han, J.Y.2    Byun, J.3    Park, H.J.4    Park, E.M.5    Chong, Y.H.6
  • 142
    • 84938406332 scopus 로고    scopus 로고
    • The AXL receptor is a sensor of ligand spatial heterogeneity
    • PID: 26236777
    • Meyer AS, Zweemer AJ, Lauffenburger DA (2015) The AXL receptor is a sensor of ligand spatial heterogeneity. Cell Syst 1:25–36. doi:10.1016/j.cels.2015.06.002
    • (2015) Cell Syst , vol.1 , pp. 25-36
    • Meyer, A.S.1    Zweemer, A.J.2    Lauffenburger, D.A.3
  • 143
    • 33846872571 scopus 로고    scopus 로고
    • A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    • COI: 1:CAS:528:DC%2BD2sXjtFertrk%3D, PID: 17047157
    • Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM et al (2007) A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood 109:1026–1033. doi:10.1182/blood-2006-05-021634
    • (2007) Blood , vol.109 , pp. 1026-1033
    • Sather, S.1    Kenyon, K.D.2    Lefkowitz, J.B.3    Liang, X.4    Varnum, B.C.5    Henson, P.M.6
  • 144
    • 77955799154 scopus 로고    scopus 로고
    • Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes
    • PID: 20731857
    • Ekman C, Linder A, Akesson P, Dahlback B (2010) Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes. Crit Care 14:R158. doi:10.1186/cc9233
    • (2010) Crit Care , vol.14 , pp. R158
    • Ekman, C.1    Linder, A.2    Akesson, P.3    Dahlback, B.4
  • 145
    • 79955100531 scopus 로고    scopus 로고
    • Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
    • COI: 1:CAS:528:DC%2BC3MXltV2rt70%3D, PID: 21496228
    • Wu J, Ekman C, Jonsen A, Sturfelt G, Bengtsson AA, Gottsater A et al (2011) Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis. Arthritis Res Ther 13:R62. doi:10.1186/ar3316
    • (2011) Arthritis Res Ther , vol.13 , pp. R62
    • Wu, J.1    Ekman, C.2    Jonsen, A.3    Sturfelt, G.4    Bengtsson, A.A.5    Gottsater, A.6


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