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Volumn 1, Issue 1, 2015, Pages 25-36

The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity

Author keywords

[No Author keywords available]

Indexed keywords

AXL RECEPTOR; GROWTH ARREST SPECIFIC PROTEIN 6; LIGAND; PHOSPHATIDYLSERINE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

EID: 84938406332     PISSN: 24054712     EISSN: 24054720     Source Type: Journal    
DOI: 10.1016/j.cels.2015.06.002     Document Type: Article
Times cited : (43)

References (49)
  • 1
    • 42949090307 scopus 로고    scopus 로고
    • Nonsmooth optimization through Mesh Adaptive Direct Search and Variable Neighborhood Search
    • C. Audet, V. Béchard, and S. Le Digabel Nonsmooth optimization through Mesh Adaptive Direct Search and Variable Neighborhood Search J. Glob. Optim. 41 2008 299 318
    • (2008) J. Glob. Optim. , vol.41 , pp. 299-318
    • Audet, C.1    Béchard, V.2    Le Digabel, S.3
  • 5
    • 84871382164 scopus 로고    scopus 로고
    • Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis
    • T. Burstyn-Cohen, E.D. Lew, P.G. Través, P.G. Burrola, J.C. Hash, and G. Lemke Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis Neuron 76 2012 1123 1132
    • (2012) Neuron , vol.76 , pp. 1123-1132
    • Burstyn-Cohen, T.1    Lew, E.D.2    Través, P.G.3    Burrola, P.G.4    Hash, J.C.5    Lemke, G.6
  • 7
    • 84861520898 scopus 로고    scopus 로고
    • Spatial regulation of receptor tyrosine kinases in development and cancer
    • J.B. Casaletto, and A.I. McClatchey Spatial regulation of receptor tyrosine kinases in development and cancer Nat. Rev. Cancer 12 2012 387 400
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 387-400
    • Casaletto, J.B.1    McClatchey, A.I.2
  • 9
    • 71049179042 scopus 로고    scopus 로고
    • Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice
    • Y. Chen, H. Wang, N. Qi, H. Wu, W. Xiong, J. Ma, Q. Lu, and D. Han Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice Reproduction 138 2009 655 666
    • (2009) Reproduction , vol.138 , pp. 655-666
    • Chen, Y.1    Wang, H.2    Qi, N.3    Wu, H.4    Xiong, W.5    Ma, J.6    Lu, Q.7    Han, D.8
  • 11
    • 0034710974 scopus 로고    scopus 로고
    • Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6)
    • S.P. Dormady, X.M. Zhang, and R.S. Basch Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6) Proc. Natl. Acad. Sci. USA 97 2000 12260 12265
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12260-12265
    • Dormady, S.P.1    Zhang, X.M.2    Basch, R.S.3
  • 13
    • 77952683864 scopus 로고    scopus 로고
    • Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood
    • C. Ekman, J. Stenhoff, and B. Dahlbäck Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood J. Thromb. Haemost. 8 2010 838 844
    • (2010) J. Thromb. Haemost. , vol.8 , pp. 838-844
    • Ekman, C.1    Stenhoff, J.2    Dahlbäck, B.3
  • 14
    • 0030743087 scopus 로고    scopus 로고
    • Controlling receptor/ligand trafficking: effects of cellular and molecular properties on endosomal sorting
    • A.R. French, and D.A. Lauffenburger Controlling receptor/ligand trafficking: effects of cellular and molecular properties on endosomal sorting Ann. Biomed. Eng. 25 1997 690 707
    • (1997) Ann. Biomed. Eng. , vol.25 , pp. 690-707
    • French, A.R.1    Lauffenburger, D.A.2
  • 18
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • P.B. Gupta, C.M. Fillmore, G. Jiang, S.D. Shapira, K. Tao, C. Kuperwasser, and E.S. Lander Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells Cell 146 2011 633 644
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 19
    • 0036034289 scopus 로고    scopus 로고
    • Gas6 binding to photoreceptor outer segments requires γ-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro
    • M.O. Hall, M.S. Obin, A.L. Prieto, B.L. Burgess, and T.A. Abrams Gas6 binding to photoreceptor outer segments requires γ-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro Exp. Eye Res. 75 2002 391 400
    • (2002) Exp. Eye Res. , vol.75 , pp. 391-400
    • Hall, M.O.1    Obin, M.S.2    Prieto, A.L.3    Burgess, B.L.4    Abrams, T.A.5
  • 20
    • 29244489555 scopus 로고    scopus 로고
    • The role of gamma-carboxylation in the anti-apoptotic function of gas6
    • I. Hasanbasic, I. Rajotte, and M. Blostein The role of gamma-carboxylation in the anti-apoptotic function of gas6 J. Thromb. Haemost. 3 2005 2790 2797
    • (2005) J. Thromb. Haemost. , vol.3 , pp. 2790-2797
    • Hasanbasic, I.1    Rajotte, I.2    Blostein, M.3
  • 22
    • 76749123429 scopus 로고    scopus 로고
    • R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
    • S.J. Holland, A. Pan, C. Franci, Y. Hu, B. Chang, W. Li, M. Duan, A. Torneros, J. Yu, T.J. Heckrodt, and et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer Cancer Res. 70 2010 1544 1554
    • (2010) Cancer Res. , vol.70 , pp. 1544-1554
    • Holland, S.J.1    Pan, A.2    Franci, C.3    Hu, Y.4    Chang, B.5    Li, W.6    Duan, M.7    Torneros, A.8    Yu, J.9    Heckrodt, T.J.10
  • 23
    • 40749123639 scopus 로고    scopus 로고
    • Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme
    • M. Hutterer, P. Knyazev, A. Abate, M. Reschke, H. Maier, N. Stefanova, T. Knyazeva, V. Barbieri, M. Reindl, A. Muigg, and et al. Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme Clin. Cancer Res. 14 2008 130 138
    • (2008) Clin. Cancer Res. , vol.14 , pp. 130-138
    • Hutterer, M.1    Knyazev, P.2    Abate, A.3    Reschke, M.4    Maier, H.5    Stefanova, N.6    Knyazeva, T.7    Barbieri, V.8    Reindl, M.9    Muigg, A.10
  • 26
    • 80052211582 scopus 로고    scopus 로고
    • Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
    • L.B. Kleiman, T. Maiwald, H. Conzelmann, D.A. Lauffenburger, and P.K. Sorger Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding Mol. Cell 43 2011 723 737
    • (2011) Mol. Cell , vol.43 , pp. 723-737
    • Kleiman, L.B.1    Maiwald, T.2    Conzelmann, H.3    Lauffenburger, D.A.4    Sorger, P.K.5
  • 28
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • G. Lemke, and C.V. Rothlin Immunobiology of the TAM receptors Nat. Rev. Immunol. 8 2008 327 336
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 30
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
    • R.M.A. Linger, A.K. Keating, H.S. Earp, and D.K. Graham TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer Adv. Cancer Res. 100 2008 35 83
    • (2008) Adv. Cancer Res. , vol.100 , pp. 35-83
    • Linger, R.M.A.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 31
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • Q. Lu, and G. Lemke Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family Science 293 2001 306 311
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 33
    • 84860476820 scopus 로고    scopus 로고
    • Computational analysis of the regulation of EGFR by protein tyrosine phosphatases
    • C.S. Monast, C.M. Furcht, and M.J. Lazzara Computational analysis of the regulation of EGFR by protein tyrosine phosphatases Biophys. J. 102 2012 2012 2021
    • (2012) Biophys. J. , vol.102 , pp. 2012-2021
    • Monast, C.S.1    Furcht, C.M.2    Lazzara, M.J.3
  • 34
    • 0030966057 scopus 로고    scopus 로고
    • Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells
    • T. Nakano, K. Kawamoto, J. Kishino, K. Nomura, K. Higashino, and H. Arita Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells Biochem. J. 323 1997 387 392
    • (1997) Biochem. J. , vol.323 , pp. 387-392
    • Nakano, T.1    Kawamoto, K.2    Kishino, J.3    Nomura, K.4    Higashino, K.5    Arita, H.6
  • 37
    • 52049114343 scopus 로고    scopus 로고
    • Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine
    • I. Rajotte, I. Hasanbasic, and M. Blostein Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine Biochem. Biophys. Res. Commun. 376 2008 70 73
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , pp. 70-73
    • Rajotte, I.1    Hasanbasic, I.2    Blostein, M.3
  • 38
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • C.V. Rothlin, S. Ghosh, E.I. Zuniga, M.B.A. Oldstone, and G. Lemke TAM receptors are pleiotropic inhibitors of the innate immune response Cell 131 2007 1124 1136
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.A.4    Lemke, G.5
  • 41
    • 2942566011 scopus 로고    scopus 로고
    • Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
    • J. Stenhoff, B. Dahlbäck, and S. Hafizi Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts Biochem. Biophys. Res. Commun. 319 2004 871 878
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 871-878
    • Stenhoff, J.1    Dahlbäck, B.2    Hafizi, S.3
  • 42
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    • T.N. Stitt, G. Conn, M. Gore, C. Lai, J. Bruno, C. Radziejewski, K. Mattsson, J. Fisher, D.R. Gies, P.F. Jones, and et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases Cell 80 1995 661 670
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1    Conn, G.2    Gore, M.3    Lai, C.4    Bruno, J.5    Radziejewski, C.6    Mattsson, K.7    Fisher, J.8    Gies, D.R.9    Jones, P.F.10
  • 44
    • 0031587026 scopus 로고    scopus 로고
    • Roles of γ-carboxylation and a sex hormone-binding globulin-like domain in receptor-binding and in biological activities of Gas6
    • K. Tanabe, K. Nagata, K. Ohashi, T. Nakano, H. Arita, and K. Mizuno Roles of γ-carboxylation and a sex hormone-binding globulin-like domain in receptor-binding and in biological activities of Gas6 FEBS Lett. 408 1997 306 310
    • (1997) FEBS Lett. , vol.408 , pp. 306-310
    • Tanabe, K.1    Nagata, K.2    Ohashi, K.3    Nakano, T.4    Arita, H.5    Mizuno, K.6


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