Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia

American Journal of Respiratory and Critical Care Medicine

Volumn 167, Issue 2, 2003, Pages 171-179

  Knapp, Sylvia ^a,b   Leemans, Jaklien C ^a,b   Florquin, Sandrine ^a,b   Branger, Judith ^a,b   Maris, Nico A ^a,b   Pater, Jennie ^a,b   Van Rooijen, Nico ^a,b   Van der Poll, Tom ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Apoptosis; Bacterial; Inflammation; Lung; Macrophage

Indexed keywords

BUFFER; CASPASE 3; CLODRONIC ACID; CYTOKINE; LIPOSOME; PHOSPHATE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FUNCTION; CELL INFILTRATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FEMALE; HOST RESISTANCE; IMMUNE RESPONSE; INFLAMMATION; INOCULATION; LOBAR PNEUMONIA; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; PROTECTION; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; LUNG; MACROPHAGES, ALVEOLAR; MICE; NEUTROPHILS; PNEUMONIA, PNEUMOCOCCAL; RANDOM ALLOCATION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0037438551     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200207-698OC     Document Type: Article

References (48)

1. Bernstein JM. Treatment of community-acquired pneumonia: IDSA guidelines. Infectious Diseases Society of America. Chest 1999;115(3 Suppl):9S-13S.
2. Campbell GD Jr, Silberman R. Drug-resistant Streptococcus pneumoniae. Clin Infect Dis 1998;26:1188-1195.
3. Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, Dean N, File T, Fine MJ, Gross PA, et al. Guidelines for the management of adults with community-acquired pneumonia: Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 2001;163:1730-1754.
4. Campbell GD Jr. Commentary on the 1993 American Thoracic Society guidelines for the treatment of community-acquired pneumonia. Chest 1999;115(3 Suppl):14S-18S.
5. Sibille Y, Reynolds HY. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 1990;141:471-501.
6. Franke-Ullmann G, Pfortner C, Walter P, Steinmuller C, Lohmann-Matthes ML, Kobzik L. Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro. J Immunol 1996;157:3097-3104.
7. Kooguchi K, Hashimoto S, Kobayashi A, Kitamura Y, Kudoh I, Wiener-Kronish J, Sawa T. Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia. Infect Immun 1998;66:3164-3169.
8. Broug-Holub E, Toews GB, van Iwaarden JF, Strieter RM, Kunkel SL, Paine R III, Standiford TJ. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: Elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect Immun 1997;65:1139-1146.
9. Cheung DO, Halsey K, Speert DP. Role of pulmonary alveolar macrophages in defense of the lung against Pseudomonas aeruginosa. Infect Immun 2000;68:4585-4592.
10. Gordon SB, Irving GR, Lawson RA, Lee ME, Read RC. Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins. Infect Immun 2000;68:2286-2293.
11. Jonsson S, Musher DM, Chapman A, Goree A, Lawrence EC. Phagocytosis and killing of common bacterial pathogens of the lung by human alveolar macrophages. J Infect Dis 1985;152:4-13.
12. Hof DG, Repine JE, Peterson PK, Hoidal JR. Phagocytosis by human alveolar macrophages and neutrophils: Qualitative differences in the opsonic requirements for uptake of Staphylococcus aureus and Streptococcus pneumoniae in vitro. Am Rev Respir Dis 1980;121:65-71.
13. Stokes RW, Thorson LM, Speert DP. Nonopsonic and opsonic association of mycobacterium tuberculosis with resident alveolar macrophages is inefficient. J Immunol 1998;160:5514-5521.
14. Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 1999;160:S5-S11.
15. Cox G, Crossley J, Xing Z. Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am J Respir Cell Mol Biol 1995;12:232-237.
16. Van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications. J Immunol Methods 1994;174:83-93.
17. Leemans JC, Juffermans NP, Florquin S, van Rooijen N, Vervoordeldonk MJ, Verbon A, van Deventer SJ, van der Poll T. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J Immunol 2001;166:4604-4611.
18. Rijneveld AW, Florquin S, Branger J, Speelman P, Van Deventer SJ, van Der Poll T. TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia. J Immunol 2001;167:5240-5246.
19. Rijneveld AW, Levi M, Florquin S, Speelman P, Carmeliet P, van Der Poll T. Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J Immunol 2002;168:3507-3511.
20. Rijneveld AW, Lauw FN, Schultz MJ, Florquin S, Te Velde AA, Speelman P, Van Deventer SJ, Van Der Poll T. The role of interferon-gamma in murine pneumococcal pneumonia. J Infect Dis 2002;185:91-97.
21. Leemans JC, Vervoordeldonk MJ, Florquin S, Van Kessel KP, Van Der Poll T. Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus. Am J Respir Crit Care Med 2002:165:1445-1450.
22. Vermes I, Haanen C, Reutelingsperger C. Flow cytometry of apoptotic cell death. J Immunol Methods 2000;243:167-190.
23. Lichtman SN, Wang J, Hummel B, Lacey S, Sartor RB. A rat model of ileal pouch-rectal anastomosis. Inflamm Bowel Dis 1998;4:187-195.
24. Hashimoto S, Pittet JF, Hong K, Folkesson H, Bagby G, Kobzik L, Frevert C, Watanabe K, Tsurufuji S, Wiener-Kronish J. Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections. Am J Physiol 1996;270:L819-L828.
25. Hickman-Davis JM, Michalek SM, Gibbs-Erwin J, Lindsey JR. Depletion of alveolar macrophages exacerbates respiratory mycoplasmosis in mycoplasma-resistant C57BL mice but not mycoplasma-susceptible C3H mice. Infect Immun 1997;65:2278-2282.
26. Zhang P, Summer WR, Bagby GJ, Nelson S. Innate immunity and pulmonary host defense. Immunol Rev 2000;173:39-51.
27. Moore TA, Standiford TJ. Cytokine immunotherapy during bacterial pneumonia: From benchtop to bedside. Semin Respir Infect 2001;16:27-37.
28. Thornberry NA, Lazebnik Y. Caspases: Enemies within. Science 1998;281:1312-1316.
29. Hussain N, Wu F, Zhu L, Thrall RS, Kresch MJ. Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat. Am J Respir Cell Mol Biol 1998;19:867-874.
30. Ishii Y, Hashimoto K, Nomura A, Sakamoto T, Uchida Y, Ohtsuka M, Hasegawa S, Sagai M. Elimination of neutrophils by apoptosis during the resolution of acute pulmonary inflammation in rats. Lung 1998;176:89-98.
31. Droemann D, Aries SP, Hansen F, Moellers M, Braun J, Katus HA, Dalhoff K. Decreased apoptosis and increased activation of alveolar neutrophils in bacterial pneumonia. Chest 2000;117:1679-1684.
32. Matute-Bello G, Liles WC, Radella F II, Steinberg KP, Ruzinski JT, Jonas M, Chi EY, Hudson LD, Martin TR. Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 1997;156:1969-1977.
33. Keel M, Ungethum U, Steckholzer U, Niederer E, Hartung T, Trentz O, Ertel W. Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis. Blood 1997;90:3356-3363.
34. Murray J, Barbara JA, Dunkley SA, Lopez AF, Van Ostade X, Condliffe AM, Dransfield I, Haslett C, Chilvers ER. Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood 1997;90:2772-2783.
35. van den Berg JM, Weyer S, Weening JJ, Roos D, Kuijpers TW. Divergent effects of tumor necrosis factor alpha on apoptosis of human neutrophils. J Leukoc Biol 2001:69:467-473.
36. Villunger A, O'Reilly LA, Holler N, Adams J, Strasser A. Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. J Exp Med 2000;192:647-658.
37. Slee EA, Adrain C, Martin SJ. Serial killers: Ordering caspase activation events in apoptosis. Cell Death Differ 1999;6:1067-1074.
38. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998;101:890-898.
39. Fadok VA, Bratton DL, Guthrie L, Henson PM. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: Role of proteases. J Immunol 2001;166:6847-6854.
40. Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen Y, Mayadas TN, Savill J. Nonphlogistic clearance of late apoptotic neutrophils by macrophages: Efficient phagocytosis independent of beta 2 integrins. J Immunol 2001;166:4743-4750.
41. Warshamana GS, Corti M, Brody AR. TNF-alpha, PDGF, and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: TNF-alpha induces TGF-beta(1). Exp Mol Pathol 2001;71:13-33.
42. Pechkovsky DV, Zissel G, Ziegenhagen MW, Einhaus M, Taube C, Rabe KF, Magnussen H, Papadopoulos T, Schlaak M, Muller-Quernheim J. Effect of proinflammatory cytokines on interleukin-8 mRNA expression and protein production by isolated human alveolar epithelial cells type II in primary culture. Eur Cytokine Netw 2000;11:618-625.
43. Koyama S, Sato E, Nomura H, Kubo K, Miura M, Yamashita T, Nagai S, Izumi T. Monocyte chemotactic factors released from type II pneumocyte-like cells in response to TNF-alpha and IL-1alpha. Eur Respir J 1999;13:820-828.
44. DeForge LE, Preston AM, Takeuchi E, Kenney J, Boxer LA, Remick DG. Regulation of interleukin 8 gene expression by oxidant stress. J Biol Chem 1993;268:25568-25576.
45. Salez L, Singer M, Balloy V, Creminon C, Chignard M. Lack of IL-10 synthesis by murine alveolar macrophages upon lipopolysaccharide exposure: Comparison with peritoneal macrophages. J Leukoc Biol 2000;67:545-552.
46. Berg JT, Lee ST, Thepen T, Lee CY, Tsan MF. Depletion of alveolar macrophages by liposome-encapsulated dichloromethylene diphosphonate. J Appl Physiol 1993;74:2812-2819.
47. de Haan A, Groen G, Prop J, van Rooijen N, Wilschut J. Mucosal immunoadjuvant activity of liposomes: Role of alveolar macrophages. Immunology 1996;89:488-493.
48. Maus U, Huwe J, Maus R, Seeger W, Lohmeyer J. Alveolar JE/MCP-1 and endotoxin synergize to provoke lung cytokine upregulation, sequential neutrophil and monocyte influx, and vascular leakage in mice. Am J Respir Crit Care Med 2001;164:406-411.