Corticospinal motor neurons are susceptible to increased ER stress and display profound degeneration in the absence of UCHL1 function

Cerebral Cortex

Volumn 25, Issue 11, 2015, Pages 4259-4272

  Jara, Javier H ^a   Genç, Bariş ^a   Cox, Gregory A ^b   Bohn, Martha C ^a   Roos, Raymond P ^c   Macklis, Jeffrey D ^d   Ulupinar, Emel ^e   Özdinler, P Hande ^a,f  

^a NORTHWESTERN UNIVERSITY   (United States)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^d Harvard University   (United States)

^e ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^f NORTHWESTERN UNIVERSITY   (United States)

Author keywords

AAV2 mediated transduction; Apical dendrite; CSMN; ER stress

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ARTICLE; CELL LOSS; CONTROLLED STUDY; CORTICOSPINAL MOTOR NEURON DEGENERATION; CRANIOTOMY; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE; GENETIC STABILITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR PERFORMANCE; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PYRAMIDAL NERVE CELL; UBIQUITIN CARBOXY TERMINAL HYDROLASE L1 GENE; AGE; ANIMAL; C57BL MOUSE; CYTOLOGY; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM; MIDDLE AGED; MOTOR CORTEX; MUSCLE STRENGTH; NEWBORN; PATHOLOGY; PHYSIOLOGY; SENSORY NERVE; SPINAL CORD; TRANSGENIC MOUSE;

DNA BINDING PROTEIN; NERVE PROTEIN; UBIQUITIN THIOLESTERASE; UCHL1 PROTEIN, HUMAN; ZFP312 PROTEIN, MOUSE;

AFFERENT PATHWAYS; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; MOTOR CORTEX; MUSCLE STRENGTH; NERVE DEGENERATION; NERVE TISSUE PROTEINS; SPINAL CORD; UBIQUITIN THIOLESTERASE;

EID: 84940442582     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhu318     Document Type: Article

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