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Volumn 10, Issue 2, 2014, Pages 280-294

Human Fetal Liver Stromal Cell Co-Culture Enhances the Differentiation of Pancreatic Progenitor Cells into Islet-Like Cell Clusters

Author keywords

Diabetes; IGF1; Liver stromal cells; Pancreatic progenitor cells; Stem cells

Indexed keywords

CYTOKINE; FIBROBLAST GROWTH FACTOR; IGF1 PROTEIN, HUMAN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A;

EID: 84897466695     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-013-9491-y     Document Type: Article
Times cited : (10)

References (56)
  • 1
    • 0141987875 scopus 로고    scopus 로고
    • Edmonton's islet success has indeed been replicated elsewhere
    • Shapiro, A. M., Ricordi, C., & Hering, B. (2003). Edmonton's islet success has indeed been replicated elsewhere. Lancet, 362, 1242.
    • (2003) Lancet , vol.362 , pp. 1242
    • Shapiro, A.M.1    Ricordi, C.2    Hering, B.3
  • 2
    • 21344462346 scopus 로고    scopus 로고
    • Five-year follow-up after clinical islet transplantation
    • Ryan, E. A., Paty, B. W., Senior, P. A., et al. (2005). Five-year follow-up after clinical islet transplantation. Diabetes, 54, 2060-2069.
    • (2005) Diabetes , vol.54 , pp. 2060-2069
    • Ryan, E.A.1    Paty, B.W.2    Senior, P.A.3
  • 4
    • 84884383929 scopus 로고    scopus 로고
    • Current progress in stem cell research and its potential for islet cell transplantation
    • Leung, P. S., & Ng, K. Y. (2013). Current progress in stem cell research and its potential for islet cell transplantation. Current Molecular Medicine, 13, 109-125.
    • (2013) Current Molecular Medicine , vol.13 , pp. 109-125
    • Leung, P.S.1    Ng, K.Y.2
  • 6
    • 75749108616 scopus 로고    scopus 로고
    • Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis
    • Juhl, K., Bonner-Weir, S., & Sharma, A. (2010). Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Current Opinion in Organ Transplantation, 15, 79-85.
    • (2010) Current Opinion in Organ Transplantation , vol.15 , pp. 79-85
    • Juhl, K.1    Bonner-Weir, S.2    Sharma, A.3
  • 7
    • 39649092092 scopus 로고    scopus 로고
    • PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells
    • Suen, P. M., Zou, C., Zhang, Y. A., et al. (2008). PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. International Journal of Biochemistry and Cell Biology, 40, 789-803.
    • (2008) International Journal of Biochemistry and Cell Biology , vol.40 , pp. 789-803
    • Suen, P.M.1    Zou, C.2    Zhang, Y.A.3
  • 8
    • 70349414656 scopus 로고    scopus 로고
    • PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization
    • Leung, K. K., Suen, P. M., Lau, T. K., Ko, W. H., Yao, K. M., & Leung, P. S. (2009). PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization. Stem Cells and Development, 18, 979-990.
    • (2009) Stem Cells and Development , vol.18 , pp. 979-990
    • Leung, K.K.1    Suen, P.M.2    Lau, T.K.3    Ko, W.H.4    Yao, K.M.5    Leung, P.S.6
  • 9
    • 79953207642 scopus 로고    scopus 로고
    • Reduced immunogenicity of pancreatic progenitor cells derived from first-trimester human fetal pancreas
    • Ma, M. T., Leung, K. K., Tsang, K. S., & Leung, P. S. (2011). Reduced immunogenicity of pancreatic progenitor cells derived from first-trimester human fetal pancreas. International Journal of Biochemistry and Cell Biology, 43, 812-820.
    • (2011) International Journal of Biochemistry and Cell Biology , vol.43 , pp. 812-820
    • Ma, M.T.1    Leung, K.K.2    Tsang, K.S.3    Leung, P.S.4
  • 10
    • 84857460623 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation
    • Leung, K. K., Liang, J., Ma, M. T., & Leung, P. S. (2012). Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells, 30, 525-536.
    • (2012) Stem Cells , vol.30 , pp. 525-536
    • Leung, K.K.1    Liang, J.2    Ma, M.T.3    Leung, P.S.4
  • 11
    • 78751647214 scopus 로고    scopus 로고
    • Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas
    • Ng, K. Y., Ma, M. T., Leung, K. K., & Leung, P. S. (2011). Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas. Stem Cell Reviews, 7, 53-63.
    • (2011) Stem Cell Reviews , vol.7 , pp. 53-63
    • Ng, K.Y.1    Ma, M.T.2    Leung, K.K.3    Leung, P.S.4
  • 13
    • 72949113024 scopus 로고    scopus 로고
    • Stromal cells and integrins: conforming to the needs of the tumor microenvironment
    • Alphonso, A., & Alahari, S. K. (2009). Stromal cells and integrins: conforming to the needs of the tumor microenvironment. Neoplasia, 11, 1264-1271.
    • (2009) Neoplasia , vol.11 , pp. 1264-1271
    • Alphonso, A.1    Alahari, S.K.2
  • 15
    • 78650985032 scopus 로고    scopus 로고
    • Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch
    • Lee, K. Y., Fong, B. S., Tsang, K. S., et al. (2011). Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch. Stem Cells and Development, 20, 31-38.
    • (2011) Stem Cells and Development , vol.20 , pp. 31-38
    • Lee, K.Y.1    Fong, B.S.2    Tsang, K.S.3
  • 17
    • 75349108811 scopus 로고    scopus 로고
    • Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function
    • Sordi, V., Melzi, R., Mercalli, A., et al. (2010). Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function. Stem Cells, 28, 140-151.
    • (2010) Stem Cells , vol.28 , pp. 140-151
    • Sordi, V.1    Melzi, R.2    Mercalli, A.3
  • 18
    • 0035072545 scopus 로고    scopus 로고
    • A bipotential precursor population for pancreas and liver within the embryonic endoderm
    • Deutsch, G., Jung, J., Zheng, M., Lora, J., & Zaret, K. S. (2001). A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development, 128, 871-881.
    • (2001) Development , vol.128 , pp. 871-881
    • Deutsch, G.1    Jung, J.2    Zheng, M.3    Lora, J.4    Zaret, K.S.5
  • 19
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • Zaret, K. S., & Grompe, M. (2008). Generation and regeneration of cells of the liver and pancreas. Science, 322, 1490-1494.
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 21
    • 56749171368 scopus 로고    scopus 로고
    • Regulation of pancreatic beta cell mass by neuronal signals from the liver
    • Imai, J., Katagiri, H., Yamada, T., et al. (2008). Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science, 322, 1250-1254.
    • (2008) Science , vol.322 , pp. 1250-1254
    • Imai, J.1    Katagiri, H.2    Yamada, T.3
  • 23
    • 0031887206 scopus 로고    scopus 로고
    • Augmenter of liver regeneration enhances the success rate of fetal pancreas transplantation in rodents
    • Adams, G. A., Maestri, M., Squiers, E. C., Alfrey, E. J., Starzl, T. E., & Dafoe, D. C. (1998). Augmenter of liver regeneration enhances the success rate of fetal pancreas transplantation in rodents. Transplantation, 65, 32-36.
    • (1998) Transplantation , vol.65 , pp. 32-36
    • Adams, G.A.1    Maestri, M.2    Squiers, E.C.3    Alfrey, E.J.4    Starzl, T.E.5    Dafoe, D.C.6
  • 24
    • 0031587697 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors
    • Le Roith, D. (1997). Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. New England Journal of Medicine, 336, 633-640.
    • (1997) New England Journal of Medicine , vol.336 , pp. 633-640
    • Le Roith, D.1
  • 25
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker, J., Liu, J. P., Robertson, E. J., & Efstratiadis, A. (1993). Role of insulin-like growth factors in embryonic and postnatal growth. Cell, 75, 73-82.
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 26
    • 0036224165 scopus 로고    scopus 로고
    • Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation
    • Lingohr, M. K., Dickson, L. M., McCuaig, J. F., Hugl, S. R., Twardzik, D. R., & Rhodes, C. J. (2002). Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes, 51, 966-976.
    • (2002) Diabetes , vol.51 , pp. 966-976
    • Lingohr, M.K.1    Dickson, L.M.2    McCuaig, J.F.3    Hugl, S.R.4    Twardzik, D.R.5    Rhodes, C.J.6
  • 27
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
    • Hugl, S. R., White, M. F., & Rhodes, C. J. (1998). Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. Journal of Biological Chemistry, 273, 17771-17779.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 17771-17779
    • Hugl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 28
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers, D. J., Burks, D. J., Towery, H. H., Altamuro, S. L., Flint, C. L., & White, M. F. (1999). Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nature Genetics, 23, 32-40.
    • (1999) Nature Genetics , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 30
    • 51249114293 scopus 로고    scopus 로고
    • IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice
    • Agudo, J., Ayuso, E., Jimenez, V., et al. (2008). IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice. Diabetologia, 51, 1862-1872.
    • (2008) Diabetologia , vol.51 , pp. 1862-1872
    • Agudo, J.1    Ayuso, E.2    Jimenez, V.3
  • 31
    • 33644844361 scopus 로고    scopus 로고
    • In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice
    • Suen, P. M., Li, K., Chan, J. C., & Leung, P. S. (2006). In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice. International Journal of Biochemistry and Cell Biology, 38, 951-960.
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , pp. 951-960
    • Suen, P.M.1    Li, K.2    Chan, J.C.3    Leung, P.S.4
  • 32
    • 84870294610 scopus 로고    scopus 로고
    • Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme
    • Sneddon, J. B., Borowiak, M., & Melton, D. A. (2012). Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 491, 765-768.
    • (2012) Nature , vol.491 , pp. 765-768
    • Sneddon, J.B.1    Borowiak, M.2    Melton, D.A.3
  • 33
    • 37549021136 scopus 로고    scopus 로고
    • Global gene expression profiling and histochemical analysis of the developing human fetal pancreas
    • Sarkar, S. A., Kobberup, S., Wong, R., et al. (2008). Global gene expression profiling and histochemical analysis of the developing human fetal pancreas. Diabetologia, 51, 285-297.
    • (2008) Diabetologia , vol.51 , pp. 285-297
    • Sarkar, S.A.1    Kobberup, S.2    Wong, R.3
  • 35
    • 56149087044 scopus 로고    scopus 로고
    • The stem cell niche of human livers: symmetry between development and regeneration
    • Zhang, L., Theise, N., Chua, M., & Reid, L. M. (2008). The stem cell niche of human livers: symmetry between development and regeneration. Hepatology, 48, 1598-1607.
    • (2008) Hepatology , vol.48 , pp. 1598-1607
    • Zhang, L.1    Theise, N.2    Chua, M.3    Reid, L.M.4
  • 37
    • 33746868358 scopus 로고    scopus 로고
    • Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers
    • Mitchell, J. B., McIntosh, K., Zvonic, S., et al. (2006). Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells, 24, 376-385.
    • (2006) Stem Cells , vol.24 , pp. 376-385
    • Mitchell, J.B.1    McIntosh, K.2    Zvonic, S.3
  • 38
    • 1642398160 scopus 로고    scopus 로고
    • Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1
    • Jensen, C. H., Jauho, E. I., Santoni-Rugiu, E., et al. (2004). Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. American Journal of Pathology, 164, 1347-1359.
    • (2004) American Journal of Pathology , vol.164 , pp. 1347-1359
    • Jensen, C.H.1    Jauho, E.I.2    Santoni-Rugiu, E.3
  • 39
    • 48649109860 scopus 로고    scopus 로고
    • Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches
    • Ledran, M. H., Krassowska, A., Armstrong, L., et al. (2008). Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell, 3, 85-98.
    • (2008) Cell Stem Cell , vol.3 , pp. 85-98
    • Ledran, M.H.1    Krassowska, A.2    Armstrong, L.3
  • 40
    • 0034653503 scopus 로고    scopus 로고
    • Circulating hematopoietic progenitor cells in first trimester fetal blood
    • Campagnoli, C., Fisk, N., Overton, T., Bennett, P., Watts, T., & Roberts, I. (2000). Circulating hematopoietic progenitor cells in first trimester fetal blood. Blood, 95, 1967-1972.
    • (2000) Blood , vol.95 , pp. 1967-1972
    • Campagnoli, C.1    Fisk, N.2    Overton, T.3    Bennett, P.4    Watts, T.5    Roberts, I.6
  • 41
    • 67349263504 scopus 로고    scopus 로고
    • Side population cells in developing human liver are primarily haematopoietic progenitor cells
    • Terrace, J. D., Hay, D. C., Samuel, K., et al. (2009). Side population cells in developing human liver are primarily haematopoietic progenitor cells. Experimental Cell Research, 315, 2141-2153.
    • (2009) Experimental Cell Research , vol.315 , pp. 2141-2153
    • Terrace, J.D.1    Hay, D.C.2    Samuel, K.3
  • 42
    • 2942615532 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into insulin-producing clusters
    • Segev, H., Fishman, B., Ziskind, A., Shulman, M., & Itskovitz-Eldor, J. (2004). Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells, 22, 265-274.
    • (2004) Stem Cells , vol.22 , pp. 265-274
    • Segev, H.1    Fishman, B.2    Ziskind, A.3    Shulman, M.4    Itskovitz-Eldor, J.5
  • 43
    • 25844454068 scopus 로고    scopus 로고
    • Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells
    • Brolen, G. K., Heins, N., Edsbagge, J., & Semb, H. (2005). Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes, 54, 2867-2874.
    • (2005) Diabetes , vol.54 , pp. 2867-2874
    • Brolen, G.K.1    Heins, N.2    Edsbagge, J.3    Semb, H.4
  • 44
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour, K. A., Bang, A. G., Eliazer, S., et al. (2006). Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nature Biotechnology, 24, 1392-1401.
    • (2006) Nature Biotechnology , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1    Bang, A.G.2    Eliazer, S.3
  • 45
    • 79952810720 scopus 로고    scopus 로고
    • Endothelial cells in pancreatic islet development and function
    • Ranjan, A. K., Joglekar, M. V., & Hardikar, A. A. (2009). Endothelial cells in pancreatic islet development and function. Islets, 1, 2-9.
    • (2009) Islets , vol.1 , pp. 2-9
    • Ranjan, A.K.1    Joglekar, M.V.2    Hardikar, A.A.3
  • 46
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert, E., Cleaver, O., & Melton, D. (2001). Induction of pancreatic differentiation by signals from blood vessels. Science, 294, 564-567.
    • (2001) Science , vol.294 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 47
    • 0029026716 scopus 로고
    • Presence of nerve growth factor and its receptors in an in vitro model of islet cell development: implication in normal islet morphogenesis
    • Kanaka-Gantenbein, C., Dicou, E., Czernichow, P., & Scharfmann, R. (1995). Presence of nerve growth factor and its receptors in an in vitro model of islet cell development: implication in normal islet morphogenesis. Endocrinology, 136, 3154-3162.
    • (1995) Endocrinology , vol.136 , pp. 3154-3162
    • Kanaka-Gantenbein, C.1    Dicou, E.2    Czernichow, P.3    Scharfmann, R.4
  • 48
    • 0038235819 scopus 로고    scopus 로고
    • Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells
    • Movassat, J., Beattie, G. M., Lopez, A. D., Portha, B., & Hayek, A. (2003). Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells. Diabetologia, 46, 822-829.
    • (2003) Diabetologia , vol.46 , pp. 822-829
    • Movassat, J.1    Beattie, G.M.2    Lopez, A.D.3    Portha, B.4    Hayek, A.5
  • 49
    • 33644846139 scopus 로고    scopus 로고
    • Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation
    • Li, J., Goodyer, C. G., Fellows, F., & Wang, R. (2006). Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation. International Journal of Biochemistry and Cell Biology, 38, 961-972.
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , pp. 961-972
    • Li, J.1    Goodyer, C.G.2    Fellows, F.3    Wang, R.4
  • 50
    • 75349111313 scopus 로고    scopus 로고
    • FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner
    • Ameri, J., Stahlberg, A., Pedersen, J., et al. (2010). FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner. Stem Cells, 28, 45-56.
    • (2010) Stem Cells , vol.28 , pp. 45-56
    • Ameri, J.1    Stahlberg, A.2    Pedersen, J.3
  • 51
    • 0037183994 scopus 로고    scopus 로고
    • Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance
    • Kido, Y., Nakae, J., Hribal, M. L., Xuan, S., Efstratiadis, A., & Accili, D. (2002). Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. Journal of Biological Chemistry, 277, 36740-36747.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 36740-36747
    • Kido, Y.1    Nakae, J.2    Hribal, M.L.3    Xuan, S.4    Efstratiadis, A.5    Accili, D.6
  • 52
    • 0036578921 scopus 로고    scopus 로고
    • Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
    • Kulkarni, R. N., Holzenberger, M., Shih, D. Q., et al. (2002). Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nature Genetics, 31, 111-115.
    • (2002) Nature Genetics , vol.31 , pp. 111-115
    • Kulkarni, R.N.1    Holzenberger, M.2    Shih, D.Q.3
  • 54
    • 0028793314 scopus 로고
    • Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
    • Wang, R. N., Kloppel, G., & Bouwens, L. (1995). Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia, 38, 1405-1411.
    • (1995) Diabetologia , vol.38 , pp. 1405-1411
    • Wang, R.N.1    Kloppel, G.2    Bouwens, L.3
  • 55
    • 0347363709 scopus 로고    scopus 로고
    • IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis
    • Warzecha, Z., Dembinski, A., Ceranowicz, P., et al. (2003). IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis. Journal of Physiology and Pharmacology, 54, 575-590.
    • (2003) Journal of Physiology and Pharmacology , vol.54 , pp. 575-590
    • Warzecha, Z.1    Dembinski, A.2    Ceranowicz, P.3
  • 56
    • 24744434956 scopus 로고    scopus 로고
    • New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass
    • Kulkarni, R. N. (2005). New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Reviews in Endocrine & Metabolic Disorders, 6, 199-210.
    • (2005) Reviews in Endocrine & Metabolic Disorders , vol.6 , pp. 199-210
    • Kulkarni, R.N.1


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