Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets

Diabetologia

Volumn 47, Issue 2, 2004, Pages 240-248

  Lau, T ^a   Carlsson, P O ^b   Leung, P S ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

AT1 receptor; Diabetes; Glucose oxidation; Insulin biosynthesis; Islet transplantation; Losartan

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSINOGEN; GLUCOSE; INSULIN; LOSARTAN; MESSENGER RNA; PROINSULIN;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DRUG ACTIVITY; GENE EXPRESSION; GLUCOSE OXIDATION; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; INSULIN RELEASE; ISOGRAFT; MALE; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULATION; WESTERN BLOTTING;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSINOGEN; ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GLUCOSE; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LOSARTAN; MALE; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PEPTIDYL-DIPEPTIDASE A; PROINSULIN; PROTEIN BIOSYNTHESIS; PYRIDINES; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 1542374750     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1295-1     Document Type: Article

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