Review: The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 6, 2007, Pages 2017-2029

  Pittas, Anastassios G ^a   Lau, Joseph ^a   Hu, Frank B ^b   Dawson Hughes, Bess ^a,c  

^a TUFTS MEDICAL CENTER   (United States)

^b CHANNING LABORATORY   (United States)

^c U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALFACALCIDOL; CALCITRIOL; CALCIUM; CITRATE CALCIUM; COLECALCIFEROL; VITAMIN D;

CALCIUM DEFICIENCY; CALCIUM INTAKE; CLINICAL TRIAL; DISEASE ASSOCIATION; HUMAN; INCIDENCE; MEDLINE; META ANALYSIS; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SYSTEMATIC REVIEW; VITAMIN D DEFICIENCY; VITAMIN INTAKE; ANIMAL; METABOLISM;

ANIMALS; CALCIUM; DIABETES MELLITUS, TYPE 2; HUMANS; PREVALENCE; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 34347266963     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-0298     Document Type: Review

References (124)

1. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS 2003 Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76-79
2. Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC 2001 Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790-797
3. Benjamin SM, Valdez R, Geiss LS, Rolka DB, Narayan KM 2003 Estimated number of adults with prediabetes in the US in 2000: opportunities for prevention. Diabetes Care 26:645-649
4. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B 2006 Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 84:18-28
5. Holick MF 2006 High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81:353-373
6. Mathieu C, Badenhoop K 2005 Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab 16:261-266
7. Toma M, McAlister FA, Bialy L, Adams D, Vandermeer B, Armstrong PW 2006 Transition from meeting abstract to full-length journal article for randomized controlled trials. JAMA 295:1281-1287
8. Bloch CA, Clemons P, Sperling MA 1987 Puberty decreases insulin sensitivity. J Pediatr 110:481-487
9. Polonsky KS, Given BD, Hirsch L, Shapiro ET, Tillil H, Beebe C, Galloway JA, Frank BH, Karrison T, Van Cauter E 1988 Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 81:435-441
10. DerSimonian R, Laird N 1986 Meta-analysis in clinical trials. Control Clin Trials 7:177-188
11. Weyer C, Bogardus C, Mott DM, Pratley RE 1999 The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794
12. Hu FB, Meigs JB, Li TY, Rifai N, Manson JE 2004 Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 53:693-700
13. Bourlon PM, Billaudel B, Faure-Dussert A 1999 Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol 160:87-95
14. Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG 2003 Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 17:509-511
15. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, Hewison M 2004 Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 89-90:121-125
16. Milner RD, Hales CN 1967 The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 3:47-49
17. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ 1995 Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 38:1239-1245
18. Baynes KC, Boucher BJ, Feskens EJ, Kromhout D 1997 Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 40:344-347
19. Chiu KC, Chu A, Go VL, Saad MF 2004 Hypovitaminosis D is associated with insulin resistance and β-cell dysfunction. Am J Clin Nutr 79:820-825
20. Gedik O, Akalin S 1986 Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 29:142-145
21. Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R 2003 The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 57:258-261
22. Lind L, Pollare T, Hvarfner A, Lithell H, Sorensen OH, Ljunghall S 1989 Long-term treatment with active vitamin D (α-calcidol) in middle-aged men with impaired glucose tolerance. Effects on insulin secretion and sensitivity, glucose tolerance and blood pressure. Diabetes Res 11:141-147
23. Orwoll E, Riddle M, Prince M 1994 Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr 59:1083-1087
24. Inomata S, Kadowaki S, Yamatani T, Fukase M, Fujita T 1986 Effect of 1 α (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone Miner 1:187-192
25. Nyomba BL, Auwerx J, Bormans V, Peeters TL, Pelemans W, Reynaert J, Bouillon R, Vantrappen G, De Moor P 1986 Pancreatic secretion in man with subclinical vitamin D deficiency. Diabetologia 29:34-38
26. Maestro B, Campion J, Davila N, Calle C 2000 Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J 47:383-391
27. Ojuka EO 2004 Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proc Nutr Soc 63:275-278
28. Wright DC, Hucker KA, Holloszy JO, Han DH 2004 Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes 53:330-335
29. Williams PF, Caterson ID, Cooney GJ, Zilkens RR, Turtle JR 1990 High affinity insulin binding and insulin receptor-effector coupling: modulation by Ca2+. Cell Calcium 11:547-556
30. Draznin B, Sussman K, Kao M, Lewis D, Sherman N 1987 The existence of an optimal range of cytosolic free calcium for insulin-stimulated glucose transport in rat adipocytes. J Biol Chem 262:14385-14388
31. Segal S, Lloyd S, Sherman N, Sussman K, Draznin B 1990 Postprandial changes in cytosolic free calcium and glucose uptake in adipocytes in obesity and non-insulin-dependent diabetes mellitus. Horm Res 34:39-44
32. Byyny RL, LoVerde M, Lloyd S, Mitchell W, Draznin B 1992 Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. Am J Hypertens 5:459-464
33. Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Otsuka K, Saruta T 1993 Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: possible role of disturbed calcium metabolism. J Hypertens 11:421-426
34. Zemel MB 1998 Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension. Mol Cell Biochem 188:129-136
35. Draznin B, Sussman KE, Eckel RH, Kao M, Yost T, Sherman NA 1988 Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia. J Clin Invest 82:1848-1852
36. Draznin B, Sussman KE, Kao M, Sherman N 1988 Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats. Endocrinology 122:2578-2583
37. Draznin B, Lewis D, Houlder N, Sherman N, Adamo M, Garvey WT, LeRoith D, Sussman K 1989 Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes. Endocrinology 125:2341-2349
38. Reusch JE, Begum N, Sussman KE, Draznin B 1991 Regulation of GLUT-4 phosphorylation by intracellular calcium in adipocytes. Endocrinology 129:3269-3273
39. Lind L, Hanni A, Lithell H, Hvarfner A, Sorensen OH, Ljunghall S 1995 Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens 8:894-901
40. Scragg R, Sowers M, Bell C 2004 Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 27:2813-2818
41. Ljunghall S, Lind L, Lithell H, Skarfors E, Selinus I, Sorensen OH, Wide L 1987 Treatment with one-α-hydroxycholecalciferol in middle-aged men with impaired glucose tolerance-a prospective randomized double-blind study. Acta Med Scand 222:361-367
42. Fliser D, Stefanski A, Franek E, Fode P, Gudarzi A, Ritz E 1997 No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects. Eur J Clin Invest 27:629-633
43. Barr SI, McCarron DA, Heaney RP, Dawson-Hughes B, Berga SL, Stern JS, Oparil S 2000 Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. J Am Diet Assoc 100:810-817
44. Bowen J, Noakes M, Clifton PM 2005 Effect of calcium and dairy foods in high protein, energy-restricted diets on weight loss and metabolic parameters in overweight adults. Int J Obes (Lond) 29:957-965
45. Thompson WG, Rostad Holdman N, Janzow DJ, Slezak JM, Morris KL, Zemel MB 2005 Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults. Obes Res 13:1344-1353
46. Sanchez M, de la Sierra A, Coca A, Poch E, Giner V, Urbano-Marquez A 1997 Oral calcium supplementation reduces intraplatelet free calcium concentration and insulin resistance in essential hypertensive patients. Hypertension 29:531-536
47. Zemel MB, Thompson W, Milstead A, Morris K, Campbell P 2004 Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 12:582-590
48. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B 2007 The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in non-diabetic adults. Diabetes Care 30:980-986
49. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM 2001 C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
50. Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A, Hoogeveen R, Folsom AR, Heiss G 2003 Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52:1799-1805
51. Cigolini M, Iagulli MP, Miconi V, Galiotto M, Lombardi S, Targher G 2006 Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Diabetes Care 29:722-724
52. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB 2006 Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 29:650-656
53. Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D, Aganna E, Price CP, Boucher BJ 2002 Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM 95:787-796
54. Campbell IT, Jarrett RJ, Keen H 1975 Diurnal and seasonal variation in oral glucose tolerance: studies in the Antarctic. Diabetologia 11:139-145
55. Behall KM, Scholfield DJ, Hallfrisch JG, Kelsay JL, Reiser S 1984 Seasonal variation in plasma glucose and hormone levels in adult men and women. Am J Clin Nutr 40:1352-1356
56. Ishii H, Suzuki H, Baba T, Nakamura K, Watanabe T 2001 Seasonal variation of glycemic control in type 2 diabetic patients (letter). Diabetes Care 24:1503
57. Ford ES, Ajani UA, McGuire LC, Liu S 2005 Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 28:1228-1230
58. Need AG, O'Loughlin PD, Horowitz M, Nordin BE 2005 Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women. Clin Endocrinol (Oxf) 62:738-741
59. Hypponen E, Power C 2006 Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care 29:2244-2246
60. Wareham NJ, Byrne CD, Carr C, Day NE, Boucher BJ, Hales CN 1997 Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality. Metabolism 46:1171-1177
61. Snijder M, van Dam R, Visser M, Deeg D, Seidell J, Lips P 2006 To: Mathieu C, Gysemans C, Giulietti A, Bouillon R. [Comment on: Vitamin D and diabetes; 48:1247-1257 (2005)] Diabetologia 49:217-218
62. Bell NH, Greene A, Epstein S, Oexmann MJ, Shaw S, Shary J 1985 Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest 76:470-473
63. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E 1995 Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract 27:181-188
64. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF 2000 Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690-693
65. Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA 2004 The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89:1196-1199
66. Liu S, Song Y, Ford ES, Manson JE, Buring JE, Ridker PM 2005 Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care 28:2926-2932
67. Christiansen C, Christensen MS, McNair P, Nielsen B, Madsbad S 1982 Vitamin D metabolites in diabetic patients: decreased serum concentration of 24,25-dihydroxyvitamin D. Scand J Clin Lab Invest 42:487-491
68. Stepan J, Wilczek H, Justova V, Havranek T, Skrha F, Wildtova Z, Formankova J, Pacovsky V 1982 Plasma 25-hydroxycholecalciferol in oral sulfonylurea treated diabetes mellitus. Horm Metab Res 14:98-100
69. Nyomba BL, Bouillon R, Bidingija M, Kandjingu K, De Moor P 1986 Vitamin D metabolites and their binding protein in adult diabetic patients. Diabetes 35:911-915
70. Pietschmann P, Schernthaner G, Woloszczuk W 1988 Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications. Diabetologia 31:892-895
71. Aksoy H, Akcay F, Kurtul N, Baykal O, Avci B 2000 Serum 1,25 dihydroxy vitamin D (1,25(OH)2D3), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy. Clin Biochem 33:47-51
72. Isaia G, Giorgino R, Adami S 2001 High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care 24:1496
73. Ishida H, Seino Y, Matsukura S, Ikeda M, Yawata M, Yamashita G, Ishizuka S, Imura H 1985 Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes. Metabolism 34:797-801
74. Heath 3rd H, Lambert PW, Service FJ, Arnaud SB 1979 Calcium homeostasis in diabetes mellitus. J Clin Endocrinol Metab 49:462-466
75. Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE 1992 Diet and risk of clinical diabetes in women. Am J Clin Nutr 55:1018-1023
76. van Dam RM, Hu FB, Rosenberg L, Krishnan S, Palmer JR 2006 Dietary calcium and magnesium, major food sources, and risk of type 2 diabetes in U.S. black women. Diabetes Care 29:2238-2243
77. Pereira MA, Jacobs Jr DR, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS 2002 Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA 287:2081-2089
78. Mennen LI, Lafay L, Feskens EJM, Novak M, Lepinay P, Balkau B 2000 Possible protective effect of bread and dairy products on the risk of the metabolic syndrome. Nutr Res 20:335-347
79. Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi F 2005 Dairy consumption is inversely associated with the prevalence of the metabolic syndrome in Tehranian adults. Am J Clin Nutr 82:523-530
80. Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB 2005 Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med 165:997-1003
81. Liu S, Choi HK, Ford E, Song Y, Klevak A, Buring JE, Manson JE 2006 A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 29:1579-1584
82. Nilas L, Christiansen C 1984 Treatment with vitamin D or its analogues does not change body weight or blood glucose level in postmenopausal women. Int J Obes 8:407-411
83. Zemel MB, Richards J, Milstead A, Campbell P 2005 Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res 13:1218-1225
84. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM 2002 Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
85. Food and Nutrient Board, Institute of Medicine 2003 Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and fluoride. Washington, DC: National Academy Press
86. Hollis BW 2005 Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 135:317-322
87. Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR 2002 Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 30:771-777
88. McKenna MJ 1992 Differences in vitamin D status between countries in young adults and the elderly. Am J Med 93:69-77
89. Gloth 3rd FM, Gundberg CM, Hollis BW, Haddad Jr JG, Tobin JD 1995 Vitamin D deficiency in homebound elderly persons. JAMA 274:1683-1686
90. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS 1998 Hypovitaminosis D in medical inpatients. N Engl J Med 338:777-783
91. Fleming KH, Heimbach JT 1994 Consumption of calcium in the U.S.: food sources and intake levels. J Nutr 124:1426S-1430S
92. Subar AF, Krebs-Smith SM, Cook A, Kahle LL 1998 Dietary sources of nutrients among US adults, 1989 to 1991. J Am Diet Assoc 98:537-547
93. Nusser SM, Carriquiry AL, Dodd KW, Fuller WA 1996 A semiparametric transformation approach to estimating usual daily intake distributions. J Am Stat Assoc 91:1440-1449
94. Johnson JA, Grande JP, Roche PC, Kumar R 1994 Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol 267:E356-E360
95. Maestro B, Davila N, Carranza MC, Calle C 2003 Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 84:223-230
96. Maestro B, Molero S, Bajo S, Davila N, Calle C 2002 Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Funct 20:227-232
97. Norman AW, Frankel JB, Heldt AM, Grodsky GM 1980 Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 209:823-825
98. Kadowaki S, Norman AW 1984 Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. J Clin Invest 73:759-766
99. Tanaka Y, Seino Y, Ishida M, Yamaoka K, Yabuuchi H, Ishida H, Seino S, Seino Y, Imura H 1984 Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin. Acta Endocrinol (Copenh) 105:528-533
100. Cade C, Norman AW 1986 Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo. Endocrinology 119:84-90
101. Chertow BS, Sivitz WI, Baranetsky NG, Clark SA, Waite A, Deluca HF 1983 Cellular mechanisms of insulin release: the effects of vitamin D deficiency and repletion on rat insulin secretion. Endocrinology 113:1511-1518
102. Clark SA, Stumpf WE, Sar M 1981 Effect of 1,25 dihydroxyvitamin D3 on insulin secretion. Diabetes 30:382-386
103. Sooy K, Schermerhorn T, Noda M, Surana M, Rhoten WB, Meyer M, Fleischer N, Sharp GW, Christakos S. 1999 Calbindin-D(28k) controls [Ca(2+)] (i) and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and β-cell lines. J Biol Chem 274:34343-34349
104. Beaulieu C, Kestekian R, Havrankova J, Gascon-Barre M 1993 Calcium is essential in normalizing intolerance to glucose that accompanies vitamin D depletion in vivo. Diabetes 42:35-43
105. Yasuda K, Hurukawa Y, Okuyama M, Kikuchi M, Yoshinaga K 1975 Glucose tolerance and insulin secretion in patients with parathyroid disorders. Effect of serum calcium on insulin release. N Engl J Med 292:501-504
106. Gedik O, Zileli MS 1977 Effects of hypocalcemia and theophylline on glucose tolerance and insulin release in human beings. Diabetes 26:813-819
107. Fujita T, Sakagami Y, Tomita T, Okamoto Y, Oku H 1978 Insulin secretion after oral calcium load. Endocrinol Jpn 25:645-648
108. Hochberg Z, Borochowitz Z, Benderli A, Vardi P, Oren S, Spirer Z, Heyman I, Weisman Y 1985 Does 1,25-dihydroxyvitamin D participate in the regulation of hormone release from endocrine glands? J Clin Endocrinol Metab 60:57-61
109. Visser M, Deeg DJ, Lips P 2003 Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 88:5766-5772
110. Simpson RU, Thomas GA, Arnold AJ 1985 Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 260:8882-8891
111. Dunlop TW, Vaisanen S, Frank C, Molnar F, Sinkkonen L, Carlberg C 2005 The human peroxisome proliferator-activated receptor δ gene is a primary target of 1α,25-dihydroxyvitamin D3 and its nuclear receptor. J Mol Biol 349:248-260
112. Luquet S, Gaudel C, Holst D, Lopez-Soriano J, Jehl-Pietri C, Fredenrich A, Grimaldi PA 2005 Roles of PPAR δ in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes. Biochim Biophys Acta 1740:313-317
113. Plehwe WE, Williams PF, Caterson ID, Harrison LC, Turtle JR 1983 Calcium-dependence of insulin receptor phosphorylation. Biochem J 214:361-366
114. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC 2000 Regulation of adiposity by dietary calcium. FASEB J 14:1132-1138
115. McCarty MF, Thomas CA 2003 PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses 61:535-542
116. Levy J 1999 Abnormal cell calcium homeostasis in type 2 diabetes mellitus: a new look on old disease. Endocrine 10:1-6
117. Riachy R, Vandewalle B, Kerr Conte J, Moerman E, Sacchetti P, Lukowiak B, Gmyr V, Bouckenooghe T, Dubois M, Pattou F 2002 1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20. Endocrinology 143:4809-4819
118. Gysemans CA, Cardozo AK, Callewaert H, Giulietti A, Hulshagen L, Bouillon R, Eizirik DL, Mathieu C 2005 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology 146:1956-1964
119. van Etten E, Mathieu C 2005 Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 97:93-101
120. D'Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, Sinigaglia F, Panina-Bordignon P 1998 Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-κB downregulation in transcriptional repression of the p40 gene. J Clin Invest 101:252-262
121. Pittas AG, Joseph NA, Greenberg AS 2004 Adipocytokines and insulin resistance. J Clin Endocrinol Metab 89:447-452
122. Rabinovitch A, Suarez-Pinzon WL, Sooy K, Strynadka K, Christakos S 2001 Expression of calbindin-D(28k) in a pancreatic islet β-cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology 142:3649-3655
123. Kadowaki S, Norman AW 1984 Pancreatic vitamin D-dependent calcium binding protein: biochemical properties and response to vitamin D. Arch Biochem Biophys 233:228-236
124. Christakos S, Barletta F, Huening M, Dhawan P, Liu Y, Porta A, Peng X 2003 Vitamin D target proteins: function and regulation. J Cell Biochem 88:238-244