메뉴 건너뛰기




Volumn 18, Issue 3, 2016, Pages 329-339

Nuclear factor-κB in glioblastoma: Insights into regulators and targeted therapy

Author keywords

glioblastoma; glioma; inhibitor; NF B

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BARDOXOLONE; BORTEZOMIB; CELECOXIB; CELL PROTEIN; CURCUMIN; EC 70124; EPIDERMAL GROWTH FACTOR RECEPTOR; I KAPPA B ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRINOTECAN; NONSTEROID ANTIINFLAMMATORY AGENT; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEASOME INHIBITOR; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 1; RESVERATROL; SALAZOSULFAPYRIDINE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84960103245     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nov265     Document Type: Article
Times cited : (109)

References (105)
  • 1
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • Rayet B, Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene. 1999;18(49):6938-6947.
    • (1999) Oncogene. , vol.18 , Issue.49 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 2
    • 34548799835 scopus 로고    scopus 로고
    • Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotype
    • Raychaudhuri B, Han Y, Lu T, Vogelbaum MA. Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotype. J Neurooncol. 2007;85(1): 39-47.
    • (2007) J Neurooncol. , vol.85 , Issue.1 , pp. 39-47
    • Raychaudhuri, B.1    Han, Y.2    Lu, T.3    Vogelbaum, M.A.4
  • 3
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
    • Wang H, Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest. 2004;84(8):941-951.
    • (2004) Lab Invest. , vol.84 , Issue.8 , pp. 941-951
    • Wang, H.1    Wang, H.2    Zhang, W.3    Huang, H.J.4    Liao, W.S.5    Fuller, G.N.6
  • 4
    • 0036235624 scopus 로고    scopus 로고
    • Aberrant nuclear factor-kB activity and its participation in the growth of human malignant astrocytoma
    • Nagai S, Washiyama K, Kurimoto M, Takaku A, Endo S, Kumanishi T. Aberrant nuclear factor-kB activity and its participation in the growth of human malignant astrocytoma. J Neurosurg. 2002; 96(5):909-917.
    • (2002) J Neurosurg. , vol.96 , Issue.5 , pp. 909-917
    • Nagai, S.1    Washiyama, K.2    Kurimoto, M.3    Takaku, A.4    Endo, S.5    Kumanishi, T.6
  • 5
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007;8(1):49-62.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , Issue.1 , pp. 49-62
    • Perkins, N.D.1
  • 6
    • 84856641109 scopus 로고    scopus 로고
    • NF-kappaB, the first quarter-century: Remarkable progress and outstanding questions
    • Hayden MS, Ghosh S. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 2012;26(3):203-234.
    • (2012) Genes Dev. , vol.26 , Issue.3 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 7
    • 77957284071 scopus 로고    scopus 로고
    • Signaling to NF-kappaB: Regulation by ubiquitination
    • Wertz IE, Dixit VM. Signaling to NF-kappaB: regulation by ubiquitination. Cold Spring Harb Perspect Biol. 2010;2(3): a003350.
    • (2010) Cold Spring Harb Perspect Biol. , vol.2 , Issue.3 , pp. a003350
    • Wertz, I.E.1    Dixit, V.M.2
  • 8
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • Senftleben U, Cao Y, Xiao G, et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001;293(5534):1495-1499.
    • (2001) Science. , vol.293 , Issue.5534 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 9
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-kappaB signaling pathway
    • Sun SC. Non-canonical NF-kappaB signaling pathway. Cell Res. 2011;21(1):71-85.
    • (2011) Cell Res. , vol.21 , Issue.1 , pp. 71-85
    • Sun, S.C.1
  • 10
    • 84923624001 scopus 로고    scopus 로고
    • S-phase-dependent p50/NF-kB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability
    • Crawley CD, Kang S, Bernal GM, et al. S-phase-dependent p50/NF-kB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability. Cell Cycle. 2015;14(4): 566-760.
    • (2015) Cell Cycle. , vol.14 , Issue.4 , pp. 566-760
    • Crawley, C.D.1    Kang, S.2    Bernal, G.M.3
  • 11
    • 35448960010 scopus 로고    scopus 로고
    • Many faces of NF-kappaB signaling induced by genotoxic stress
    • Wu ZH, Miyamoto S. Many faces of NF-kappaB signaling induced by genotoxic stress. J Mol Med. 2007;85(11):1187-1202.
    • (2007) J Mol Med. , vol.85 , Issue.11 , pp. 1187-1202
    • Zh, W.1    Miyamoto, S.2
  • 12
    • 0344305376 scopus 로고    scopus 로고
    • Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    • Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell. 2003;115(5):565-576.
    • (2003) Cell. , vol.115 , Issue.5 , pp. 565-576
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Zh, W.3    Miyamoto, S.4
  • 13
    • 84875474816 scopus 로고    scopus 로고
    • DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-kappaB p50 and a single nucleotide in the kappaB-site
    • Crawley CD, Raleigh DR, Kang S, et al. DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-kappaB p50 and a single nucleotide in the kappaB-site. Nucleic Acids Res. 2013;41(2):764-774.
    • (2013) Nucleic Acids Res. , vol.41 , Issue.2 , pp. 764-774
    • Crawley, C.D.1    Raleigh, D.R.2    Kang, S.3
  • 14
    • 4644252538 scopus 로고    scopus 로고
    • One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
    • Leung TH, Hoffmann A, Baltimore D. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell. 2004;118(4):453-464.
    • (2004) Cell. , vol.118 , Issue.4 , pp. 453-464
    • Leung, T.H.1    Hoffmann, A.2    Baltimore, D.3
  • 15
    • 17144422434 scopus 로고    scopus 로고
    • Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
    • Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND. Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005;24(6): 1157-1169.
    • (2005) EMBO J. , vol.24 , Issue.6 , pp. 1157-1169
    • Rocha, S.1    Garrett, M.D.2    Campbell, K.J.3    Schumm, K.4    Perkins, N.D.5
  • 16
    • 25144473970 scopus 로고    scopus 로고
    • ARF the integrator: Linking NF-kappaB, p53 and checkpoint kinases
    • Rocha S, Perkins ND. ARF the integrator: linking NF-kappaB, p53 and checkpoint kinases. Cell Cycle. 2005;4(6):756-759.
    • (2005) Cell Cycle. , vol.4 , Issue.6 , pp. 756-759
    • Rocha, S.1    Perkins, N.D.2
  • 17
    • 83455201681 scopus 로고    scopus 로고
    • P50 (NF-kappaB1) is an effector protein in the cytotoxic response to DNA methylation damage
    • Schmitt AM, Crawley CD, Kang S, et al. p50 (NF-kappaB1) is an effector protein in the cytotoxic response to DNA methylation damage. Mol Cell. 2011;44(5):785-796.
    • (2011) Mol Cell. , vol.44 , Issue.5 , pp. 785-796
    • Schmitt, A.M.1    Crawley, C.D.2    Kang, S.3
  • 18
    • 47949129452 scopus 로고    scopus 로고
    • Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
    • Wu ZH, Miyamoto S. Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. EMBO J. 2008;27(14):1963-1973.
    • (2008) EMBO J. , vol.27 , Issue.14 , pp. 1963-1973
    • Zh, W.1    Miyamoto, S.2
  • 19
    • 2442670292 scopus 로고    scopus 로고
    • Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
    • Stojic L, Mojas N, Cejka P, et al. Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Devel. 2004;18(11):1331-1344.
    • (2004) Genes Devel. , vol.18 , Issue.11 , pp. 1331-1344
    • Stojic, L.1    Mojas, N.2    Cejka, P.3
  • 20
    • 80051982064 scopus 로고    scopus 로고
    • Return to homeostasis: Downregulation of NF-kappaB responses
    • Ruland J. Return to homeostasis: downregulation of NF-kappaB responses. Nat Immunol. 2011;12(8):709-714.
    • (2011) Nat Immunol. , vol.12 , Issue.8 , pp. 709-714
    • Ruland, J.1
  • 21
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell. 2006;9(3):157-173.
    • (2006) Cancer Cell. , vol.9 , Issue.3 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 22
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17(1):98-110.
    • (2010) Cancer Cell. , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 23
    • 84894573670 scopus 로고    scopus 로고
    • Paediatric and adult glioblastoma: Multiform (epi)genomic culprits emerge
    • Sturm D, Bender S, Jones DT, et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer. 2014;14(2):92-107.
    • (2014) Nat Rev Cancer. , vol.14 , Issue.2 , pp. 92-107
    • Sturm, D.1    Bender, S.2    Jones, D.T.3
  • 24
    • 84883656941 scopus 로고    scopus 로고
    • Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma
    • Bhat KP, Balasubramaniyan V, Vaillant B, et al. Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma. Cancer Cell. 2013;24(3):331-346.
    • (2013) Cancer Cell. , vol.24 , Issue.3 , pp. 331-346
    • Bhat, K.P.1    Balasubramaniyan, V.2    Vaillant, B.3
  • 26
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061-1068.
    • (2008) Nature. , vol.455 , Issue.7216 , pp. 1061-1068
    • Cancer Genome Atlas Research N1
  • 27
    • 0346725939 scopus 로고    scopus 로고
    • Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells
    • Kapoor GS, Zhan Y, Johnson GR, O'Rourke DM. Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. Mol Cell Biol 2004;24(2):823-836.
    • (2004) Mol Cell Biol , vol.24 , Issue.2 , pp. 823-836
    • Kapoor, G.S.1    Zhan, Y.2    Johnson, G.R.3    O'Rourke, D.M.4
  • 28
    • 36149000984 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha
    • Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB. Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha. Oncogene. 2007;26(52):7324-7332.
    • (2007) Oncogene. , vol.26 , Issue.52 , pp. 7324-7332
    • Sethi, G.1    Ahn, K.S.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 29
    • 84860816141 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance
    • Tanaka K, Babic I, Nathanson D, et al. Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance. Cancer Discov. 2011;1(6):524-538.
    • (2011) Cancer Discov. , vol.1 , Issue.6 , pp. 524-538
    • Tanaka, K.1    Babic, I.2    Nathanson, D.3
  • 30
    • 84870885534 scopus 로고    scopus 로고
    • EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis
    • Yang W, Xia Y, Cao Y, et al. EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell. 2012; 48(5):771-784.
    • (2012) Mol Cell. , vol.48 , Issue.5 , pp. 771-784
    • Yang, W.1    Xia, Y.2    Cao, Y.3
  • 31
    • 3042757984 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    • Aldape KD, Ballman K, Furth A, et al. Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance. J Neuropathol Exp Neurol. 2004;63(7):700-707.
    • (2004) J Neuropathol Exp Neurol. , vol.63 , Issue.7 , pp. 700-707
    • Aldape, K.D.1    Ballman, K.2    Furth, A.3
  • 32
    • 84883276560 scopus 로고    scopus 로고
    • Opposing effect of EGFRWT on EGFRvIII-mediated NF-kappaB activation with RIP1 as a cell death switch
    • Puliyappadamba VT, Chakraborty S, Chauncey SS, et al. Opposing effect of EGFRWT on EGFRvIII-mediated NF-kappaB activation with RIP1 as a cell death switch. Cell Rep. 2013;4(4):764-775.
    • (2013) Cell Rep. , vol.4 , Issue.4 , pp. 764-775
    • Puliyappadamba, V.T.1    Chakraborty, S.2    Chauncey, S.S.3
  • 33
    • 84866061138 scopus 로고    scopus 로고
    • EGFRvIII promotes glioma angiogenesis and growth through the NF-kappaB, interleukin-8 pathway
    • Bonavia R, Inda MM, Vandenberg S, et al. EGFRvIII promotes glioma angiogenesis and growth through the NF-kappaB, interleukin-8 pathway. Oncogene. 2012;31(36):4054-4066.
    • (2012) Oncogene. , vol.31 , Issue.36 , pp. 4054-4066
    • Bonavia, R.1    Inda, M.M.2    Vandenberg, S.3
  • 34
    • 66149128126 scopus 로고    scopus 로고
    • The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma
    • Park S, Hatanpaa KJ, Xie Y, et al. The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma. Cancer Res. 2009;69(7): 2809-2816.
    • (2009) Cancer Res. , vol.69 , Issue.7 , pp. 2809-2816
    • Park, S.1    Hatanpaa, K.J.2    Xie, Y.3
  • 35
  • 36
    • 84889817926 scopus 로고    scopus 로고
    • Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres
    • Patane M, Porrati P, Bottega E, et al. Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres. Mol Cancer. 2013;12:160.
    • (2013) Mol Cancer. , vol.12 , pp. 160
    • Patane, M.1    Porrati, P.2    Bottega, E.3
  • 37
    • 31644442040 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) and glial tumorigenesis
    • Shih AH, Holland EC. Platelet-derived growth factor (PDGF) and glial tumorigenesis. Cancer Lett. 2006;232(2):139-147.
    • (2006) Cancer Lett. , vol.232 , Issue.2 , pp. 139-147
    • Shih, A.H.1    Holland, E.C.2
  • 38
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature. 1999;401(6748):86-90.
    • (1999) Nature. , vol.401 , Issue.6748 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 39
    • 84863261004 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-kappaB network
    • Holmes KM, Annala M, Chua CY, et al. Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-kappaB network. Proc Natl Acad Sci USA. 2012; 109(9):3475-3480.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , Issue.9 , pp. 3475-3480
    • Holmes, K.M.1    Annala, M.2    Chua, C.Y.3
  • 40
    • 36949000268 scopus 로고    scopus 로고
    • NF-kappaB controls growth of glioblastomas/astrocytomas
    • Smith D, Shimamura T, Barbera S, Bejcek BE. NF-kappaB controls growth of glioblastomas/astrocytomas. Mol Cell Biochem. 2008; 307(1-2):141-147.
    • (2008) Mol Cell Biochem. , vol.307 , Issue.1-2 , pp. 141-147
    • Smith, D.1    Shimamura, T.2    Barbera, S.3    Bejcek, B.E.4
  • 41
    • 0042317231 scopus 로고    scopus 로고
    • Oncoprotein suppression of tumor necrosis factor-induced NF kappa B activation is independent of Raf-controlled pathways
    • Hanson JL, Anest V, Reuther-Madrid J, Baldwin AS. Oncoprotein suppression of tumor necrosis factor-induced NF kappa B activation is independent of Raf-controlled pathways. J Biol Chem. 2003;278(37):34910-34917.
    • (2003) J Biol Chem. , vol.278 , Issue.37 , pp. 34910-34917
    • Hanson, J.L.1    Anest, V.2    Reuther-Madrid, J.3    Baldwin, A.S.4
  • 42
    • 0030882666 scopus 로고    scopus 로고
    • Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
    • Finco TS, Westwick JK, Norris JL, Beg AA, Der CJ, Baldwin AS Jr. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J Biol Chem. 1997;272(39):24113-24116.
    • (1997) J Biol Chem. , vol.272 , Issue.39 , pp. 24113-24116
    • Finco, T.S.1    Westwick, J.K.2    Norris, J.L.3    Beg, A.A.4    Der, C.J.5    Baldwin, A.S.6
  • 43
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NFkappaB signalling in a mouse model of lung adenocarcinoma
    • Meylan E, Dooley AL, Feldser DM, et al. Requirement for NFkappaB signalling in a mouse model of lung adenocarcinoma. Nature. 2009;462(7269):104-107.
    • (2009) Nature. , vol.462 , Issue.7269 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3
  • 44
    • 78650572907 scopus 로고    scopus 로고
    • NFkappaB/p53 crosstalk-A promising new therapeutic target
    • Schneider G, Kramer OH. NFkappaB/p53 crosstalk-A promising new therapeutic target. Biochim Biophys Acta. 2011;1815(1): 90-103.
    • (2011) Biochim Biophys Acta. , vol.1815 , Issue.1 , pp. 90-103
    • Schneider, G.1    Kramer, O.H.2
  • 45
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kappaB in p53-mediated programmed cell death
    • Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-kappaB in p53-mediated programmed cell death. Nature. 2000; 404(6780):892-897.
    • (2000) Nature. , vol.404 , Issue.6780 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 46
    • 34047263449 scopus 로고    scopus 로고
    • Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells
    • Weisz L, Damalas A, Liontos M, et al. Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. Cancer Res. 2007;67(6):2396-2401.
    • (2007) Cancer Res. , vol.67 , Issue.6 , pp. 2396-2401
    • Weisz, L.1    Damalas, A.2    Liontos, M.3
  • 47
    • 84867164086 scopus 로고    scopus 로고
    • TGF-beta induces miR-182 to sustain NF-kappaB activation in glioma subsets
    • Song L, Liu L, Wu Z, et al. TGF-beta induces miR-182 to sustain NF-kappaB activation in glioma subsets. J Clin Invest. 2012; 122(10):3563-3578.
    • (2012) J Clin Invest. , vol.122 , Issue.10 , pp. 3563-3578
    • Song, L.1    Liu, L.2    Wu, Z.3
  • 48
    • 1642586297 scopus 로고    scopus 로고
    • The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
    • Garkavtsev I, Kozin SV, Chernova O, et al. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004;428(6980):328-332.
    • (2004) Nature. , vol.428 , Issue.6980 , pp. 328-332
    • Garkavtsev, I.1    Kozin, S.V.2    Chernova, O.3
  • 49
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell. , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 50
    • 33749380913 scopus 로고    scopus 로고
    • PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells
    • Koul D, Takada Y, Shen R, Aggarwal BB, Yung WK. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochem Biophys Res Commun. 2006;350(2):463-471.
    • (2006) Biochem Biophys Res Commun. , vol.350 , Issue.2 , pp. 463-471
    • Koul, D.1    Takada, Y.2    Shen, R.3    Aggarwal, B.B.4    Yung, W.K.5
  • 52
    • 0033053058 scopus 로고    scopus 로고
    • Cyclin D1 expression in astrocytomas is associated with cell proliferation activity and patient prognosis
    • Sallinen SL, Sallinen PK, Kononen JT, et al. Cyclin D1 expression in astrocytomas is associated with cell proliferation activity and patient prognosis. J Pathol. 1999;188(3):289-293.
    • (1999) J Pathol. , vol.188 , Issue.3 , pp. 289-293
    • Sallinen, S.L.1    Sallinen, P.K.2    Kononen, J.T.3
  • 53
    • 84857064430 scopus 로고    scopus 로고
    • Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells
    • Wang J, Wang Q, Cui Y, et al. Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells. J Neurooncol. 2012; 106(3):473-484.
    • (2012) J Neurooncol. , vol.106 , Issue.3 , pp. 473-484
    • Wang, J.1    Wang, Q.2    Cui, Y.3
  • 54
    • 33644822862 scopus 로고    scopus 로고
    • Tumor necrosis factoralpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
    • Bredel M, Bredel C, Juric D, et al. Tumor necrosis factoralpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006;24(2):274-287.
    • (2006) J Clin Oncol. , vol.24 , Issue.2 , pp. 274-287
    • Bredel, M.1    Bredel, C.2    Juric, D.3
  • 55
    • 0030851721 scopus 로고    scopus 로고
    • Genomic organization of human and mouse genes for vascular endothelial growth factor C
    • Chilov D, Kukk E, Taira S, et al. Genomic organization of human and mouse genes for vascular endothelial growth factor C. J Biol Chem. 1997;272(40):25176-25183.
    • (1997) J Biol Chem. , vol.272 , Issue.40 , pp. 25176-25183
    • Chilov, D.1    Kukk, E.2    Taira, S.3
  • 56
    • 17844396959 scopus 로고    scopus 로고
    • Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1
    • Loeffler S, Fayard B, Weis J, Weissenberger J. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer. 2005;115(2):202-213.
    • (2005) Int J Cancer. , vol.115 , Issue.2 , pp. 202-213
    • Loeffler, S.1    Fayard, B.2    Weis, J.3    Weissenberger, J.4
  • 57
    • 17844397949 scopus 로고    scopus 로고
    • The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
    • Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005;7(2):122-133.
    • (2005) Neuro Oncol. , vol.7 , Issue.2 , pp. 122-133
    • Brat, D.J.1    Bellail, A.C.2    Van Meir, E.G.3
  • 58
    • 70350567644 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma
    • Atkinson GP, Nozell SE, Harrison DK, Stonecypher MS, Chen D, Benveniste EN. The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma. Oncogene. 2009;28(42):3735-3745.
    • (2009) Oncogene. , vol.28 , Issue.42 , pp. 3735-3745
    • Atkinson, G.P.1    Nozell, S.E.2    Harrison, D.K.3    Stonecypher, M.S.4    Chen, D.5    Benveniste, E.N.6
  • 59
    • 40449089338 scopus 로고    scopus 로고
    • Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    • Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res. 2008;68(5):1478-1484.
    • (2008) Cancer Res. , vol.68 , Issue.5 , pp. 1478-1484
    • Sarkar, D.1    Park, E.S.2    Emdad, L.3    Lee, S.G.4    Su, Z.Z.5    Fisher, P.B.6
  • 60
    • 84886796988 scopus 로고    scopus 로고
    • Essential role of cooperative NF-kappaB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma
    • Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS. Essential role of cooperative NF-kappaB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma. Oncogene. 2013;32(43):5144-5155.
    • (2013) Oncogene. , vol.32 , Issue.43 , pp. 5144-5155
    • Kesanakurti, D.1    Chetty, C.2    Rajasekhar Maddirela, D.3    Gujrati, M.4    Rao, J.S.5
  • 61
    • 0037377706 scopus 로고    scopus 로고
    • The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors
    • Tran NL, McDonough WS, Donohue PJ, et al. The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors. Am J Pathol. 2003;162(4):1313-1321.
    • (2003) Am J Pathol. , vol.162 , Issue.4 , pp. 1313-1321
    • Tran, N.L.1    McDonough, W.S.2    Donohue, P.J.3
  • 62
    • 33750300516 scopus 로고    scopus 로고
    • Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome
    • Tran NL, McDonough WS, Savitch BA, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res. 2006;66(19): 9535-9542.
    • (2006) Cancer Res. , vol.66 , Issue.19 , pp. 9535-9542
    • Tran, N.L.1    McDonough, W.S.2    Savitch, B.A.3
  • 63
    • 41349091447 scopus 로고    scopus 로고
    • Glioma cells on the run-The migratory transcriptome of 10 human glioma cell lines
    • Demuth T, Rennert JL, Hoelzinger DB, et al. Glioma cells on the run-The migratory transcriptome of 10 human glioma cell lines. BMC Genomics. 2008;9:54.
    • (2008) BMC Genomics. , vol.9 , pp. 54
    • Demuth, T.1    Rennert, J.L.2    Hoelzinger, D.B.3
  • 64
    • 79961245372 scopus 로고    scopus 로고
    • Effect of brain-and tumor-derived connective tissue growth factor on glioma invasion
    • Edwards LA, Woolard K, Son MJ, et al. Effect of brain-and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst. 2011;103(15):1162-1178.
    • (2011) J Natl Cancer Inst. , vol.103 , Issue.15 , pp. 1162-1178
    • Edwards, L.A.1    Woolard, K.2    Son, M.J.3
  • 65
    • 84863926995 scopus 로고    scopus 로고
    • Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-kappaB activation
    • Tao T, Cheng C, Ji Y, et al. Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-kappaB activation. Mol Biol Cell. 2012;23(14):2635-2644.
    • (2012) Mol Biol Cell. , vol.23 , Issue.14 , pp. 2635-2644
    • Tao, T.1    Cheng, C.2    Ji, Y.3
  • 66
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009;1(5):a000141.
    • (2009) Cold Spring Harb Perspect Biol. , vol.1 , Issue.5 , pp. a000141
    • Karin, M.1
  • 67
    • 82255162738 scopus 로고    scopus 로고
    • Targeting inflammation-induced transcription factor activation: An open frontier for glioma therapy
    • Sen E. Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy. Drug Discov Today. 2011;16(23-24):1044-1051.
    • (2011) Drug Discov Today. , vol.16 , Issue.23-24 , pp. 1044-1051
    • Sen, E.1
  • 68
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756-760.
    • (2006) Nature. , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 69
    • 84883682803 scopus 로고    scopus 로고
    • Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway
    • Garner JM, Fan M, Yang CH, et al. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway. J Biol Chem. 2013;288(36): 26167-26176.
    • (2013) J Biol Chem. , vol.288 , Issue.36 , pp. 26167-26176
    • Garner, J.M.1    Fan, M.2    Yang, C.H.3
  • 70
    • 33644554814 scopus 로고    scopus 로고
    • Potential role of NF-kappaB in adult neural stem cells: The underrated steersman?
    • Widera D, Mikenberg I, Kaltschmidt B, Kaltschmidt C. Potential role of NF-kappaB in adult neural stem cells: The underrated steersman? Int J Dev Neurosci. 2006;24(2-3):91-102.
    • (2006) Int J Dev Neurosci. , vol.24 , Issue.2-3 , pp. 91-102
    • Widera, D.1    Mikenberg, I.2    Kaltschmidt, B.3    Kaltschmidt, C.4
  • 71
    • 80051800349 scopus 로고    scopus 로고
    • Blockade of the NFkappaB pathway drives differentiating glioblastomainitiating cells into senescence both in vitro and in vivo
    • Nogueira L, Ruiz-Ontanon P, Vazquez-Barquero A, et al. Blockade of the NFkappaB pathway drives differentiating glioblastomainitiating cells into senescence both in vitro and in vivo. Oncogene. 2011;30(32):3537-3548.
    • (2011) Oncogene. , vol.30 , Issue.32 , pp. 3537-3548
    • Nogueira, L.1    Ruiz-Ontanon, P.2    Vazquez-Barquero, A.3
  • 72
    • 78650698830 scopus 로고    scopus 로고
    • NFkappaB inhibitors induce cell death in glioblastomas
    • Zanotto-Filho A, Braganhol E, Schroder R, et al. NFkappaB inhibitors induce cell death in glioblastomas. Biochem Pharmacol. 2011;81(3):412-424.
    • (2011) Biochem Pharmacol. , vol.81 , Issue.3 , pp. 412-424
    • Zanotto-Filho, A.1    Braganhol, E.2    Schroder, R.3
  • 73
    • 84863690805 scopus 로고    scopus 로고
    • BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets
    • Lee J, Rhee MH, Kim E, Cho JY. BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm. 2012;2012:416036.
    • (2012) Mediators Inflamm. , vol.2012 , pp. 416036
    • Lee, J.1    Rhee, M.H.2    Kim, E.3    Cho, J.Y.4
  • 74
    • 78049236980 scopus 로고    scopus 로고
    • MiR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-beta
    • Song L, Huang Q, Chen K, et al. miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-beta. Biochem Biophys Res Commun. 2010;402(1):135-140.
    • (2010) Biochem Biophys Res Commun. , vol.402 , Issue.1 , pp. 135-140
    • Song, L.1    Huang, Q.2    Chen, K.3
  • 75
    • 84875716955 scopus 로고    scopus 로고
    • MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOPmediated suppression of NF-kappaB activity
    • Xia H, Yan Y, Hu M, et al. MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOPmediated suppression of NF-kappaB activity. Neuro Oncol. 2013;15(4):413-422.
    • (2013) Neuro Oncol. , vol.15 , Issue.4 , pp. 413-422
    • Xia, H.1    Yan, Y.2    Hu, M.3
  • 76
    • 68749103771 scopus 로고    scopus 로고
    • The NF-kappaB-independent functions of IKK subunits in immunity and cancer
    • Chariot A. The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol. 2009;19(8): 404-413.
    • (2009) Trends Cell Biol. , vol.19 , Issue.8 , pp. 404-413
    • Chariot, A.1
  • 77
    • 84936130843 scopus 로고    scopus 로고
    • Non-conventional functions for NF-kappaB members: The dark side of NF-kappaB
    • Espinosa L, Margalef P, Bigas A. Non-conventional functions for NF-kappaB members: The dark side of NF-kappaB. Oncogene. 2014;34(18):2279-2287.
    • (2014) Oncogene. , vol.34 , Issue.18 , pp. 2279-2287
    • Espinosa, L.1    Margalef, P.2    Bigas, A.3
  • 78
    • 0345269064 scopus 로고    scopus 로고
    • Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas
    • Weaver K, Yeyeodu S, Cusack J Jr, Baldwin A Jr, Ewend M. Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas. J Neurooncol. 2003;61(3):187-196.
    • (2003) J Neurooncol. , vol.61 , Issue.3 , pp. 187-196
    • Weaver, K.1    Yeyeodu, S.2    Cusack, J.3    Baldwin, A.4    Ewend, M.5
  • 79
    • 18244372933 scopus 로고    scopus 로고
    • Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase
    • Moriuchi S, Glorioso JC, Maruno M, et al. Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. Cancer Gene Ther. 2005;12(5):487-496.
    • (2005) Cancer Gene Ther. , vol.12 , Issue.5 , pp. 487-496
    • Moriuchi, S.1    Glorioso, J.C.2    Maruno, M.3
  • 80
    • 34247528447 scopus 로고    scopus 로고
    • Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity
    • Li L, Gondi CS, Dinh DH, Olivero WC, Gujrati M, Rao JS. Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity. Clin Cancer Res. 2007;13(7):2178-2190.
    • (2007) Clin Cancer Res. , vol.13 , Issue.7 , pp. 2178-2190
    • Li, L.1    Gondi, C.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 81
    • 52449131840 scopus 로고    scopus 로고
    • Inactivation of NF-kB components by covalent binding of (2)-dehydroxymethylepoxyquinomicin to specific cysteine residues
    • Yamamoto M, Horie R, Takeiri M, Kozawa I, Umezawa K. Inactivation of NF-kB components by covalent binding of (2)-dehydroxymethylepoxyquinomicin to specific cysteine residues. J Med Chem. 2008;51(18):5780-5788.
    • (2008) J Med Chem. , vol.51 , Issue.18 , pp. 5780-5788
    • Yamamoto, M.1    Horie, R.2    Takeiri, M.3    Kozawa, I.4    Umezawa, K.5
  • 82
    • 84856249399 scopus 로고    scopus 로고
    • Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-kappaB, on glioblastoma
    • Fukushima T, Kawaguchi M, Yorita K, et al. Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-kappaB, on glioblastoma. Neuro Oncol. 2012; 14(1):19-28.
    • (2012) Neuro Oncol. , vol.14 , Issue.1 , pp. 19-28
    • Fukushima, T.1    Kawaguchi, M.2    Yorita, K.3
  • 83
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    • Campbell KJ, Rocha S, Perkins ND. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell. 2004;13(6):853-865.
    • (2004) Mol Cell. , vol.13 , Issue.6 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 84
    • 0033773607 scopus 로고    scopus 로고
    • Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release
    • Wagenknecht B, Hermisson M, Groscurth P, Liston P, Krammer PH, Weller M. Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release. J Neurochem. 2000;75(6):2288-2297.
    • (2000) J Neurochem. , vol.75 , Issue.6 , pp. 2288-2297
    • Wagenknecht, B.1    Hermisson, M.2    Groscurth, P.3    Liston, P.4    Krammer, P.H.5    Weller, M.6
  • 85
    • 84872601365 scopus 로고    scopus 로고
    • Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage
    • Premkumar DR, Jane EP, Agostino NR, DiDomenico JD, Pollack IF. Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage. Mol Carcinog. 2013;52(2):118-133.
    • (2013) Mol Carcinog. , vol.52 , Issue.2 , pp. 118-133
    • Premkumar, D.R.1    Jane, E.P.2    Agostino, N.R.3    DiDomenico, J.D.4    Pollack, I.F.5
  • 86
    • 13244262655 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
    • Yin D, Zhou H, Kumagai T, et al. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene. 2005;24(3):344-354.
    • (2005) Oncogene. , vol.24 , Issue.3 , pp. 344-354
    • Yin, D.1    Zhou, H.2    Kumagai, T.3
  • 87
    • 11244334168 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory agents differ in their ability to suppress NFkappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
    • Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NFkappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004;23(57):9247-9258.
    • (2004) Oncogene. , vol.23 , Issue.57 , pp. 9247-9258
    • Takada, Y.1    Bhardwaj, A.2    Potdar, P.3    Aggarwal, B.B.4
  • 88
    • 83055194567 scopus 로고    scopus 로고
    • The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-kappaB pathway
    • Sareddy GR, Geeviman K, Ramulu C, Babu PP. The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-kappaB pathway. J Neurooncol. 2012;106(1):99-109.
    • (2012) J Neurooncol. , vol.106 , Issue.1 , pp. 99-109
    • Sareddy, G.R.1    Geeviman, K.2    Ramulu, C.3    Babu, P.P.4
  • 89
    • 33745728903 scopus 로고    scopus 로고
    • Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity
    • Kundu JK, Shin YK, Kim SH, Surh YJ. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis. 2006;27(7):1465-1474.
    • (2006) Carcinogenesis. , vol.27 , Issue.7 , pp. 1465-1474
    • Kundu, J.K.1    Shin, Y.K.2    Kim, S.H.3    Surh, Y.J.4
  • 90
    • 23844478190 scopus 로고    scopus 로고
    • Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex
    • Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol. 2005;175(5):3339-3346.
    • (2005) J Immunol. , vol.175 , Issue.5 , pp. 3339-3346
    • Youn, H.S.1    Lee, J.Y.2    Fitzgerald, K.A.3    Young, H.A.4    Akira, S.5    Hwang, D.H.6
  • 91
    • 18044393290 scopus 로고    scopus 로고
    • Resveratrol-induced apoptotic death in human U251 glioma cells
    • Jiang H, Zhang L, Kuo J, et al. Resveratrol-induced apoptotic death in human U251 glioma cells. Mol Cancer Ther. 2005;4(4): 554-561.
    • (2005) Mol Cancer Ther. , vol.4 , Issue.4 , pp. 554-561
    • Jiang, H.1    Zhang, L.2    Kuo, J.3
  • 92
    • 1642382931 scopus 로고    scopus 로고
    • Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats
    • Tseng S-H, Lin S-M, Chen J-C, et al. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clin Cancer Res. 2004;10(6):2190-2202.
    • (2004) Clin Cancer Res. , vol.10 , Issue.6 , pp. 2190-2202
    • Tseng, S.-H.1    Lin, S.-M.2    Chen, J.-C.3
  • 93
    • 33845976705 scopus 로고    scopus 로고
    • Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179
    • Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D. Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. J Biol Chem. 2006;281(47):35764-35769.
    • (2006) J Biol Chem. , vol.281 , Issue.47 , pp. 35764-35769
    • Ahmad, R.1    Raina, D.2    Meyer, C.3    Kharbanda, S.4    Kufe, D.5
  • 94
    • 34547621658 scopus 로고    scopus 로고
    • Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling
    • Gao X, Deeb D, Jiang H, Liu Y, Dulchavsky SA, Gautam SC. Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. J Neurooncol. 2007;84(2):147-157.
    • (2007) J Neurooncol. , vol.84 , Issue.2 , pp. 147-157
    • Gao, X.1    Deeb, D.2    Jiang, H.3    Liu, Y.4    Dulchavsky, S.A.5    Gautam, S.C.6
  • 95
    • 14844303304 scopus 로고    scopus 로고
    • Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization
    • Bava SV, Puliappadamba VT, Deepti A, Nair A, Karunagaran D, Anto RJ. Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. J Biol Chem. 2005;280(8):6301-6308.
    • (2005) J Biol Chem. , vol.280 , Issue.8 , pp. 6301-6308
    • Bava, S.V.1    Puliappadamba, V.T.2    Deepti, A.3    Nair, A.4    Karunagaran, D.5    Anto, R.J.6
  • 96
    • 34347221946 scopus 로고    scopus 로고
    • Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors
    • Dhandapani KM, Mahesh VB, Brann DW. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem. 2007; 102(2):522-538.
    • (2007) J Neurochem. , vol.102 , Issue.2 , pp. 522-538
    • Dhandapani, K.M.1    Mahesh, V.B.2    Brann, D.W.3
  • 97
    • 70450228522 scopus 로고    scopus 로고
    • Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
    • Robe PA, Martin DH, Nguyen-Khac MT, et al. Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults. BMC Cancer. 2009;9:372.
    • (2009) BMC Cancer. , vol.9 , pp. 372
    • Robe, P.A.1    Martin, D.H.2    Nguyen-Khac, M.T.3
  • 98
    • 84859538161 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: A north central cancer treatment group study
    • Friday BB, Anderson SK, Buckner J, et al. Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: A north central cancer treatment group study. Neuro Oncol. 2012;14(2):215-221.
    • (2012) Neuro Oncol. , vol.14 , Issue.2 , pp. 215-221
    • Friday, B.B.1    Anderson, S.K.2    Buckner, J.3
  • 99
    • 67349138194 scopus 로고    scopus 로고
    • Phase i trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies
    • Kubicek GJ, Werner-Wasik M, Machtay M, et al. Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys. 2009;74(2):433-439.
    • (2009) Int J Radiat Oncol Biol Phys. , vol.74 , Issue.2 , pp. 433-439
    • Kubicek, G.J.1    Werner-Wasik, M.2    Machtay, M.3
  • 100
    • 79952194923 scopus 로고    scopus 로고
    • Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma
    • Phuphanich S, Supko JG, Carson KA, et al. Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma. J Neurooncol. 2010;100(1):95-103.
    • (2010) J Neurooncol. , vol.100 , Issue.1 , pp. 95-103
    • Phuphanich, S.1    Supko, J.G.2    Carson, K.A.3
  • 101
    • 19944430348 scopus 로고    scopus 로고
    • Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma
    • Reardon DA, Quinn JA, Vredenburgh J, et al. Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. Cancer. 2005;103(2):329-338.
    • (2005) Cancer. , vol.103 , Issue.2 , pp. 329-338
    • Reardon, D.A.1    Quinn, J.A.2    Vredenburgh, J.3
  • 102
    • 55849093794 scopus 로고    scopus 로고
    • Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults
    • Kesari S, Schiff D, Henson JW, et al. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol. 2008;10(3): 300-308.
    • (2008) Neuro Oncol. , vol.10 , Issue.3 , pp. 300-308
    • Kesari, S.1    Schiff, D.2    Henson, J.W.3
  • 103
    • 33646860738 scopus 로고    scopus 로고
    • Combination chemotherapy with 13-cis-retinoic acid and celecoxib in the treatment of glioblastoma multiforme
    • Levin VA, Giglio P, Puduvalli VK, et al. Combination chemotherapy with 13-cis-retinoic acid and celecoxib in the treatment of glioblastoma multiforme. J Neurooncol. 2006;78(1):85-90.
    • (2006) J Neurooncol. , vol.78 , Issue.1 , pp. 85-90
    • Levin, V.A.1    Giglio, P.2    Puduvalli, V.K.3
  • 104
    • 0032945307 scopus 로고    scopus 로고
    • Irinotecan therapy in adults with recurrent or progressive malignant glioma
    • Friedman HS, Petros WP, Friedman AH, et al. Irinotecan therapy in adults with recurrent or progressive malignant glioma. J Clin Oncol. 1999;17(5):1516.
    • (1999) J Clin Oncol. , vol.17 , Issue.5 , pp. 1516
    • Friedman, H.S.1    Petros, W.P.2    Friedman, A.H.3
  • 105
    • 84942912196 scopus 로고    scopus 로고
    • Decoy Receptor DcR1 is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide
    • Mansour NM, Bernal GM, Wu L, et al. Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide. Cancer Res. 2015;75(10):2039-2048.
    • (2015) Cancer Res. , vol.75 , Issue.10 , pp. 2039-2048
    • Mansour, N.M.1    Bernal, G.M.2    Wu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.