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Volumn 13, Issue 7, 2007, Pages 2178-2190

Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-κB transcriptional activity

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; P65 ANTIBODY; PROTEIN ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; UROKINASE RECEPTOR; VASCULOTROPIN;

EID: 34247528447     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-1711     Document Type: Article
Times cited : (36)

References (43)
  • 1
    • 0001872876 scopus 로고    scopus 로고
    • Diffusely infiltrating astrocytomas
    • Kleihues P, Cavenee WK, editors, Lyon: IARC Press;
    • Cavenee WK, Furnari FB, Nagane M. Diffusely infiltrating astrocytomas. In: Kleihues P, Cavenee WK, editors. Tumors of the nervous system. Lyon: IARC Press; 2000. p. 9-51.
    • (2000) Tumors of the nervous system , pp. 9-51
    • Cavenee, W.K.1    Furnari, F.B.2    Nagane, M.3
  • 2
    • 0021803702 scopus 로고
    • Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications
    • Burger PC, Vogel FS, Green SB, Strike TA. Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications. Cancer 1985;56:1106-11.
    • (1985) Cancer , vol.56 , pp. 1106-1111
    • Burger, P.C.1    Vogel, F.S.2    Green, S.B.3    Strike, T.A.4
  • 3
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-10.
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 4
    • 1842607516 scopus 로고    scopus 로고
    • NF-κB in cancer - a friend turned foe
    • Ravi R, Bedi A. NF-κB in cancer - a friend turned foe. Drug Resist Updat 2004;7:53-67.
    • (2004) Drug Resist Updat , vol.7 , pp. 53-67
    • Ravi, R.1    Bedi, A.2
  • 6
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt, NFκB, and Stat3 in human diffuse gliomas
    • Wang H, Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN. Analysis of the activation status of Akt, NFκB, and Stat3 in human diffuse gliomas. Lab Invest 2004;84:941-51.
    • (2004) Lab Invest , vol.84 , pp. 941-951
    • Wang, H.1    Wang, H.2    Zhang, W.3    Huang, H.J.4    Liao, W.S.5    Fuller, G.N.6
  • 7
    • 9644262497 scopus 로고    scopus 로고
    • Phosphorylation of serine 468 by GSK-3β negatively regulates basal p65 NF-κB activity
    • Buss H, Dorrie A, Schmitz ML, et al. Phosphorylation of serine 468 by GSK-3β negatively regulates basal p65 NF-κB activity. J Biol Chem 2004;279:49571-4.
    • (2004) J Biol Chem , vol.279 , pp. 49571-49574
    • Buss, H.1    Dorrie, A.2    Schmitz, M.L.3
  • 8
    • 0033543545 scopus 로고    scopus 로고
    • Inhibition of interleukin-1- stimulated NF-κB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
    • Egan LJ, Mays DC, Huntoon CJ, et al. Inhibition of interleukin-1- stimulated NF-κB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J Biol Chem 1999;274:26448-53.
    • (1999) J Biol Chem , vol.274 , pp. 26448-26453
    • Egan, L.J.1    Mays, D.C.2    Huntoon, C.J.3
  • 9
    • 0034693133 scopus 로고    scopus 로고
    • Tumor necrosis factor α-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II
    • Wang D, Westerheide SD, Hanson JL, Baldwin AS, Jr. Tumor necrosis factor α-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J Biol Chem 2000;275:32592-7.
    • (2000) J Biol Chem , vol.275 , pp. 32592-32597
    • Wang, D.1    Westerheide, S.D.2    Hanson, J.L.3    Baldwin Jr., A.S.4
  • 10
    • 0029058962 scopus 로고
    • Transactivation domain 2 (TA2) of p65 NF-κB. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells
    • Schmitz ML, dos Santos Silva MA, Baeuerle PA. Transactivation domain 2 (TA2) of p65 NF-κB. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J Biol Chem 1995;270:15576-84.
    • (1995) J Biol Chem , vol.270 , pp. 15576-15584
    • Schmitz, M.L.1    dos Santos Silva, M.A.2    Baeuerle, P.A.3
  • 11
    • 85022917932 scopus 로고    scopus 로고
    • Down-regulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth
    • Gondi CS, Lakka SS, Dinh D, Olivero W, Gujrati M, Rao JS. Down-regulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth. Neuron Glia Biology 2004;1:165-76.
    • (2004) Neuron Glia Biology , vol.1 , pp. 165-176
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.3    Olivero, W.4    Gujrati, M.5    Rao, J.S.6
  • 12
    • 0038181212 scopus 로고    scopus 로고
    • Synergistic down-regulation of urokinase plasminogen activator receptor and matrix metalloproteinase-9 in SNB19 glioblastoma cells efficiently inhibits glioma cell invasion, angiogenesis, and tumor growth
    • Lakka SS, Gondi CS, Yanamandra N, et al. Synergistic down-regulation of urokinase plasminogen activator receptor and matrix metalloproteinase-9 in SNB19 glioblastoma cells efficiently inhibits glioma cell invasion, angiogenesis, and tumor growth. Cancer Res 2003;63:2454-61.
    • (2003) Cancer Res , vol.63 , pp. 2454-2461
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3
  • 13
    • 17044398110 scopus 로고    scopus 로고
    • Making cell-permeable antibodies (Transbody) through fusion of protein transduction domains (PTD) with single chain variable fragment (scFv) antibodies: Potential advantages over antibodies expressed within the intracellular environment (Intrabody)
    • Heng BC, Cao T. Making cell-permeable antibodies (Transbody) through fusion of protein transduction domains (PTD) with single chain variable fragment (scFv) antibodies: potential advantages over antibodies expressed within the intracellular environment (Intrabody). Med Hypotheses 2005;64:1105-8.
    • (2005) Med Hypotheses , vol.64 , pp. 1105-1108
    • Heng, B.C.1    Cao, T.2
  • 14
    • 2942622466 scopus 로고    scopus 로고
    • Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library
    • Popkov M, Jendreyko N, Gonzalez-Sapienza G, Mage RG, Rader C, Barbas CF III. Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library. J Immunol Methods 2004;288:149-64.
    • (2004) J Immunol Methods , vol.288 , pp. 149-164
    • Popkov, M.1    Jendreyko, N.2    Gonzalez-Sapienza, G.3    Mage, R.G.4    Rader, C.5    Barbas III, C.F.6
  • 15
    • 0141521636 scopus 로고    scopus 로고
    • Intrabody and intrakine strategies for molecular therapy
    • Wheeler YY, Chen SY, Sane DC. Intrabody and intrakine strategies for molecular therapy. Mol Ther 2003;8:355-66.
    • (2003) Mol Ther , vol.8 , pp. 355-366
    • Wheeler, Y.Y.1    Chen, S.Y.2    Sane, D.C.3
  • 16
    • 0031426571 scopus 로고    scopus 로고
    • Antisense technology and prospects for therapy of viral infections and cancer
    • Wagner RW, Flanagan WM. Antisense technology and prospects for therapy of viral infections and cancer. Mol Med Today 1997;3:31-8.
    • (1997) Mol Med Today , vol.3 , pp. 31-38
    • Wagner, R.W.1    Flanagan, W.M.2
  • 17
    • 0036168937 scopus 로고    scopus 로고
    • Engineering polydactyl zinc-finger transcription factors
    • Beerli RR, Barbas CF III. Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol 2002;20:135-41.
    • (2002) Nat Biotechnol , vol.20 , pp. 135-141
    • Beerli, R.R.1    Barbas III, C.F.2
  • 18
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon GJ. RNA interference. Nature 2002;418:244-51.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 19
    • 0005382256 scopus 로고    scopus 로고
    • Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments
    • Caron dF, Gruel N, Venot C, et al. Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments. Oncogene 1999;18:551-7.
    • (1999) Oncogene , vol.18 , pp. 551-557
    • dF, C.1    Gruel, N.2    Venot, C.3
  • 20
    • 0033552912 scopus 로고    scopus 로고
    • A tumor specific single chain antibody dependent gene expression system
    • Mary MN, Venot C, Caron de Fromentel C, et al. A tumor specific single chain antibody dependent gene expression system. Oncogene 1999;18:559-64.
    • (1999) Oncogene , vol.18 , pp. 559-564
    • Mary, M.N.1    Venot, C.2    Caron de Fromentel, C.3
  • 21
    • 0035980086 scopus 로고    scopus 로고
    • Intracellular stability of anti-caspase-3 intrabodies determines efficacy in retargeting the antigen
    • Rajpal A, Turi TG. Intracellular stability of anti-caspase-3 intrabodies determines efficacy in retargeting the antigen. J Biol Chem 2001;276:33139-46.
    • (2001) J Biol Chem , vol.276 , pp. 33139-33146
    • Rajpal, A.1    Turi, T.G.2
  • 22
    • 0033538557 scopus 로고    scopus 로고
    • Removal of the conserved disulfide bridges from the scFv fragment of an antibody: Effects on folding kinetics and aggregation
    • Ramm K, Gehrig P, Pluckthun A. Removal of the conserved disulfide bridges from the scFv fragment of an antibody: effects on folding kinetics and aggregation. J Mol Biol 1999;290:535-46.
    • (1999) J Mol Biol , vol.290 , pp. 535-546
    • Ramm, K.1    Gehrig, P.2    Pluckthun, A.3
  • 23
    • 0029880867 scopus 로고    scopus 로고
    • Binding of intracellular anti-Rev single chain variable fragments to different epitopes of human immunodeficiency virus type 1 rev: Variations in viral inhibition
    • Wu Y, Duan L, Zhu M, et al. Binding of intracellular anti-Rev single chain variable fragments to different epitopes of human immunodeficiency virus type 1 rev: variations in viral inhibition. J Virol 1996;70:3290-7.
    • (1996) J Virol , vol.70 , pp. 3290-3297
    • Wu, Y.1    Duan, L.2    Zhu, M.3
  • 24
    • 0033499632 scopus 로고    scopus 로고
    • Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7
    • Zhu Q, Zeng C, Huhalov A, et al. Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7. J Immunol Methods 1999;231:207-22.
    • (1999) J Immunol Methods , vol.231 , pp. 207-222
    • Zhu, Q.1    Zeng, C.2    Huhalov, A.3
  • 25
    • 0035424963 scopus 로고    scopus 로고
    • In vitro display technologies: Novel developments and applications
    • Amstutz P, Forrer P, Zahnd C, Pluckthun A. In vitro display technologies: novel developments and applications. Curr Opin Biotechnol 2001;12:400-5.
    • (2001) Curr Opin Biotechnol , vol.12 , pp. 400-405
    • Amstutz, P.1    Forrer, P.2    Zahnd, C.3    Pluckthun, A.4
  • 26
    • 0347997286 scopus 로고    scopus 로고
    • Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework
    • der Maur AA, Zahnd C, Fischer F, et al. Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework. J Biol Chem 2002;277:45075-85.
    • (2002) J Biol Chem , vol.277 , pp. 45075-45085
    • der Maur, A.A.1    Zahnd, C.2    Fischer, F.3
  • 27
    • 4143087064 scopus 로고    scopus 로고
    • Enhanced intracellular stability of sFv-Fc fusion intrabodies
    • Strube RW, Chen SY. Enhanced intracellular stability of sFv-Fc fusion intrabodies. Methods 2004;34:179-83.
    • (2004) Methods , vol.34 , pp. 179-183
    • Strube, R.W.1    Chen, S.Y.2
  • 28
    • 0035793208 scopus 로고    scopus 로고
    • Stability engineering of antibody single-chain Fv fragments
    • Worn A, Pluckthun A. Stability engineering of antibody single-chain Fv fragments. J Mol Biol 2001;305:989-1010.
    • (2001) J Mol Biol , vol.305 , pp. 989-1010
    • Worn, A.1    Pluckthun, A.2
  • 29
    • 0032844761 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their biological function in human gliomas
    • Chintala SK, Tonn JC, Rao JS. Matrix metalloproteinases and their biological function in human gliomas. Int J Dev Neurosci 1999;17:495-502.
    • (1999) Int J Dev Neurosci , vol.17 , pp. 495-502
    • Chintala, S.K.1    Tonn, J.C.2    Rao, J.S.3
  • 30
    • 0142188116 scopus 로고    scopus 로고
    • Urokinase plasminogen activator system: A multifunctional role in tumor progression and metastasis
    • Choong PF, Nadesapillai AP. Urokinase plasminogen activator system: a multifunctional role in tumor progression and metastasis. Clin Orthop Relat Res 2003;(415 Suppl):S46-58.
    • (2003) Clin Orthop Relat Res , vol.415 , Issue.SUPPL.
    • Choong, P.F.1    Nadesapillai, A.P.2
  • 33
    • 0029117223 scopus 로고
    • Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
    • Ikeda E, Achen MG, Breier G, Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 1995;270:19761-6.
    • (1995) J Biol Chem , vol.270 , pp. 19761-19766
    • Ikeda, E.1    Achen, M.G.2    Breier, G.3    Risau, W.4
  • 34
    • 20444490772 scopus 로고    scopus 로고
    • Targeting angiogenesis in cancer: Clinical development of bevacizumab
    • Kerr DJ. Targeting angiogenesis in cancer: clinical development of bevacizumab. Nat Clin Pract Oncol 2004;1:39-43.
    • (2004) Nat Clin Pract Oncol , vol.1 , pp. 39-43
    • Kerr, D.J.1
  • 35
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-4.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 36
    • 0031965353 scopus 로고    scopus 로고
    • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor
    • Lin P, Sankar S, Shan S, et al. Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ 1998;9:49-58.
    • (1998) Cell Growth Differ , vol.9 , pp. 49-58
    • Lin, P.1    Sankar, S.2    Shan, S.3
  • 37
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992;359:845-8.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 38
    • 27744435789 scopus 로고    scopus 로고
    • RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo
    • Pulukuri SM, Gondi CS, Lakka SS, et al. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. J Biol Chem 2005;280: 36529-40.
    • (2005) J Biol Chem , vol.280 , pp. 36529-36540
    • Pulukuri, S.M.1    Gondi, C.S.2    Lakka, S.S.3
  • 39
    • 2942718949 scopus 로고    scopus 로고
    • Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    • Lakka SS, Gondi CS, Yanamandra N, et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 2004;23:4681-9.
    • (2004) Oncogene , vol.23 , pp. 4681-4689
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3
  • 40
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001;20:4188-97.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 41
    • 0036479114 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and NF-κB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator
    • Sliva D, Rizzo MT, English D. Phosphatidylinositol 3-kinase and NF-κB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator. J Biol Chem 2002;277:3150-7.
    • (2002) J Biol Chem , vol.277 , pp. 3150-3157
    • Sliva, D.1    Rizzo, M.T.2    English, D.3
  • 42
    • 0036299205 scopus 로고    scopus 로고
    • Protein kinase C induces motility of breast cancers by up-regulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-κB
    • Sliva D, English D, Lyons D, Lloyd FP, Jr. Protein kinase C induces motility of breast cancers by up-regulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-κB. Biochem Biophys Res Commun 2002;290:552-7.
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 552-557
    • Sliva, D.1    English, D.2    Lyons, D.3    Lloyd Jr., F.P.4
  • 43
    • 0036181371 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor PS-341
    • Adams J. Development of the proteasome inhibitor PS-341. Oncologist 2002;7:9-16.
    • (2002) Oncologist , vol.7 , pp. 9-16
    • Adams, J.1


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